Effect of Current Frequency and Annealing on Magnetic Properties of [Co70Fe30]97Sn3 Nanowire Arrays

[Co70Fe30]97Sn3 alloy nanowire arrays have been fabricated by alternative current (ac) electrodeposition of Co2+, Fe2+ and Sn2+ into anodic aluminum oxide (AAO) templates. The samples were deposited at current frequency 50, 100, 200, 300, 400, 500, 800 and 1000 Hz, respectively. The structure and magnetic properties of [Co70Fe30]97Sn3 nanowire arrays dependence on different current frequency were analyzed by XRD and alternating gradient field magnetometer (AGFM). The X-ray diffraction patterns are shown an amorphous structure of the[Co70Fe30]97Sn3 nanowires. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3535

Effect of length-to-diameter ratio on axial velocity and hydrodynamic entrance length in air-water two-phase flow in vertical pipes

Peer reviewedPublisher PD

Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations

Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer. Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug. Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy cell line, while being toxic against cancer cells. Haemolysis test was performed to evaluate the blood-compatibility characteristic of nanosponge and complex and the results showed 0.54% haemolysis in the lowest complex concentration (50μgml−1) and 5.09% at the highest concentration (200μgml−1). Conclusions: Thus, the introduced system could be widely considered in cancer treatment as a drug delivery system

Prediction of rock strength parameters for an Iranian oil field using neuro-fuzzy method

Uniaxial compressive strength (UCS) and internal friction coefficient (µ) are the most important strength parameters of rock. They could be determined either by laboratory tests or from empirical correlations. The laboratory analysis sometimes is not possible for many reasons. On the other hand, Due to changes in rock compositions and properties, none of the correlations could be applied as an exact universal correlation. In such conditions, the artificial intelligence could be an appropriate candidate method for estimation of the strength parameters. In this study, the Adaptive Neuro-Fuzzy Inference System (ANFIS) which is one of the artificial intelligence techniques was used as dominant tool to predict the strength parameters in one of the Iranian southwest oil fields. A total of 655 data sets (including depth, compressional wave velocity and density data) were used. 436 and 219 data sets were randomly selected among the data for constructing and verification of the intelligent model, respectively. To evaluate the performance of the model, root mean square error (RMSE) and correlation coefficient (R2) between the reported values from the drilling site and estimated values was computed. A comparison between the RMSE of the proposed model and recently intelligent models shows that the proposed model is more accurate than others. Acceptable accuracy and using conventional well logging data are the highlight advantages of the proposed intelligent model

Fuzzy genetic-based noise removal filter for digital panoramic X-ray images

This paper proposed a novel fuzzy genetic-based noise removal filter and surveyed the gain of popular filters for noise removal in the digital orthopantomography (OPG) images. The proposed filter is a non-invasive technique for attaining sub-clinical information from the areas of interest in each tooth, both jaws and maxillofacial. The proposed Poisson removal filter combines 4th-order partial differential equations (PDE), total variation (TV) and Bayes shrink threshold accompanied by fuzzy genetic algorithm (FGA) and the exact unbiased inverse of generalized Anscombe transformation (EUIGAT). Experiments were performed in order to show the effect of noise removal filters on 110 simulated, 106 phantom and 104 panoramic radiographic images for subjects (aged 30�60 years old, 50 males and 54 females). Various noises degraded filters and Canny edge detection was performed separately in three kinds of images. The program measured mean square error (MSE), peak signal to noise ratio (PSNR), image quality index (IQI), structural similarity index metric (SSIM) and figure of merit (FOM). The results verify that the proposed filter enhances physicians� and dentists� skill of diagnosing normal and pathological events in the teeth, jaws, temporomandibular joint (TMJ) regions and changeable anatomical panoramic landmarks related to osteoporosis progress in the mandible bone using noise removal and improving images quality. Experimental results show the superiority of this filter over other noise removal filters. © 2018 The Author

C-Terminal Domain Deletion Enhances the Protective Activity of cpa/cpb Loaded Solid Lipid Nanoparticles against Leishmania major in BALB/c Mice

Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis with an annual incidence of approximately 2 million cases and is endemic in 88 countries, including Iran. CL's continued spread, along with rather ineffectual treatments and drug-resistant variants emergence has increased the need for advanced preventive strategies. We studied Type II cysteine proteinase (CPA) and Type I (CPB) with its C-terminal extension (CTE) as cocktail DNA vaccine against murine and canine leishmaniasis. However, adjuvants' success in enhancing immune responses to selected antigens led us to refocus our vaccine development programs. Herein, we discuss cationic solid lipid nanoparticles' (cSLN) ability to improve vaccine-induced protective efficacy against CL and subsequent lesion size and parasite load reduction in BALB/c mice. For this work, we evaluated five different conventional as well as novel parasite detection techniques, i.e., footpad imaging, footpad flowcytometry and lymph node flowcytometry for disease progression assessments. Vaccination with cSLN-cpa/cpb-CTE formulation showed highest parasite inhibition at 3-month post vaccination. Immunized mice showed reduced IL-5 level and significant IFN-ã increase, compared to control groups. We think our study represents a potential future and a major step forward in vaccine development against leishmaniasis

Physicians’ and nurses’ decision making to encounter neonates with poor prognosis in the neonatal intensive care unit

This is an Accepted Manuscript of an article published by Sage in Clinical Ethics on 03/06/2020. Available online: https://journals.sagepub.com/doi/abs/10.1177/1477750920927173This is an Accepted Manuscript of an article published by Sage in Clinical Ethics on 03/06/2020.Available online: https://journals.sagepub.com/doi/abs/10.1177/1477750920927173acceptedVersio

Antitumor effect of IP-10 by using two different approaches: Live delivery system and gene therapy

Purpose: Immunotherapy is one of the treatment strategies for breast cancer, the most common cancer in women worldwide. In this approach, the patient�s immune system is stimulated to attack microscopic tumors and control metastasis. Here, we used interferon γ-induced protein 10 (IP-10), which induces and strengthens antitumor immunity, as an immunotherapeutic agent. We employed Leishmania tarentolae, a nonpathogenic lizard parasite that lacks the ability to persist in mammalian macrophages, was used as a live delivery system for carrying the immunotherapeutic agent. It has been already shown that arginase activity, and consequently, polyamine production, are associated with tumor progression. Methods: A live delivery system was constructed by stable transfection of pLEXSY plasmid containing the IP-10-enhanced green fluorescent protein (IP-10- egfp) fusion gene into L. tarentolae. Then, the presence of the IP-10-egfp gene and the accurate integration location into the parasite genome were confirmed. The therapeutic efficacy of IP- 10 delivered via L. tarentolae and recombinant pcDNA-(IP- 10-egfp) plasmid was compared by determining the arginase activity in a mouse 4T1 breast cancer model. Results: The pcDNA- (IP-10-egfp) group showed a significant reduction in tumor weight and growth. Histological evaluation also revealed that only this group demonstrated inhibition of metastasis to the lung tissue. The arginase activity in the tissue of the pcDNA-(IP- 10-egfp) mice significantly decreased in comparison with that in normal mice. No significant difference was observed in arginase activity in the sera of mice receiving other therapeutic strategies. Conclusion: Our data indicates that IP-10 immunotherapy is a promising strategy for breast cancer treatment, as shown in the 4T1-implanted BALB/c mouse model. However, the L. tarentolae- (IP-10-EGFP) live delivery system requires dose modifications to achieve efficacy in the applied regimen (six injections in 3 weeks). Our results indicate that the arginase assay could be a good biomarker to differentiate tumoral tissues from the normal ones. © 2016 Korean Breast Cancer Society. All rights reserved

Histonedeacetylase 1 mRNA has elevated expression in clinical specimen of bladder cancer

OBJECTIVE: HDACs are among transcriptional regulatory elements that regulate key features of proliferation and differentiation in all cell types including cancerous. They may also interfere in such stages of cancer development as migration, invasion, multi-drug resistance and angiogenesis. Proven information about HDAC1 role in development of bladder cancer is limited only to cell lines in vitro. The lack of a comprehensive clinical in vivo study led us to evaluate HDAC1 expression in human clinical specimens. METHODS: We analyzed a large group of bladder cancer patients. The presence of hHDAC1 mRNAs were tracked using specific HDAC1 primers in cancer samples and the quantity of HDAC1 transcripts were quantified using real time qPCR method and was compared to those of normal bladder samples from healthy patients. RESULTS: HDAC1 mRNA expression was significantly elevated in Bladder cancer specimens. To our knowledge, this result is the first, showing an elevation in vivo in HDAC1 mRNA levels in clinically cancerous tissue of patients with bladder cancer. CONCLUSIONS: We conclude that hHDAC1 overexpression might be implicated in bladder cancer tumorigenesis and that the over-expressed HDAC1 mRNA might be a potential diagnostic marker and, a target for treatment of bladder cancer using HDACi-drugs in future