Kainic acid-induced eye enlargement in chickens: differential effects on anterior and posterior segments

Intravitreal injections of kainic acid were used to examine the significance of normal retinal activity for eye growth in chickens, this acid being chosen because of its known, selective neurotoxic effects on cells in the chicken retina. A 6 nmole dose of kainic significantly reduces amacrine cell numbers when used in very young chickens, while higher doses of kainic acid also affect bipolar and horizontal cell numbers. The effects of intravitreal injection of kainic acid on eye growth were assessed 4 weeks after treatment. A 200 nmole dose of kainic acid, used with day-old and 14-day-old chickens, had opposing effects on the anterior and posterior segments of the eye; while growth of the anterior segment was inhibited, the posterior segment was enlarged, predominantly in the equatorial direction. A 20 nmole dose of this acid similarly affected growth in 14-day-old chickens, but in day-old chickens, the anterior segment was also enlarged and the overall eye enlargement had an axial bias. Myopia was the most common refractive error associated with both patterns of development. A 2 nmole dose of kainic acid was without effect on eye growth. Parallels are drawn between these eye enlargement phenomena and those described in chickens whose visual environments have been manipulated. Our results indicate that normal retinal activity is fundamental to normal eye growth in chickens, and furthermore, that growth of the anterior and posterior segments of the chicken eye are independently regulated

Changing the ideological roots of prejudice: Longitudinal effects of ethnic intergroup contact on social dominance orientation

Social Dominance Orientation (SDO) has been reported to be strongly related to a multitude of intergroup phenomena, but little is known about situational experiences that may influence SDO. Drawing from research on intergroup contact theory, we argue that positive intergroup contact is able to reduce SDO-levels. The results of an intergroup contact intervention study among high school students (Study 1, N=71) demonstrated that SDO-levels were indeed attenuated after the intervention. Furthermore, this intervention effect on SDO was especially pronounced among students reporting a higher quality of contact. A cross-lagged longitudinal survey among adults (Study 2, N=363) extended these findings by demonstrating that positive intergroup contact is able to decrease SDO over time. Moreover, we did not obtain evidence for the idea that people high in SDO would engage less in intergroup contact. These findings indicate that intergroup contact erodes one of the important socio-ideological bases of generalized prejudice and discrimination

Reasons, Coherence, and Group Rationality

Philosophy and Phenomenological Research, EarlyView

A method for interactive manipulation and animation of volumetric data

We outline an efficient method for visualizing and manipulating volumetric data, in particular, cardiac MRIdata sets. The approach is designed to allow interactive manipulation and real-time animation of volumetric data sets. The underlying model provides an efficient graphical representation for interactive rendering while not eliminating data from the volume of interest. We believe this model to be a valuable medical imaging tool that is applicable to other volume rendering problems.Directed by James McClella

Systematic evaluation of implementation fidelity of complex interventions in health and social care

<p>Abstract</p> <p>Background</p> <p>Evaluation of an implementation process and its fidelity can give insight into the 'black box' of interventions. However, a lack of standardized methods for studying fidelity and implementation process have been reported, which might be one reason for the fact that few prior studies in the field of health service research have systematically evaluated interventions' implementation processes.</p> <p>The aim of this project is to systematically evaluate implementation fidelity and possible factors influencing fidelity of complex interventions in health and social care.</p> <p>Methods</p> <p>A modified version of The Conceptual Framework for Implementation Fidelity will be used as a conceptual model for the evaluation. The modification implies two additional moderating factors: context and recruitment. A systematic evaluation process was developed. Multiple case study method is used to investigate implementation of three complex health service interventions. Each case will be investigated in depth and longitudinally, using both quantitative and qualitative methods.</p> <p>Discussion</p> <p>This study is the first attempt to empirically test The Conceptual Framework for Implementation Fidelity. The study can highlight mechanism and factors of importance when implementing complex interventions. Especially the role of the moderating factors on implementation fidelity can be clarified.</p> <p>Trial Registration</p> <p>Supported Employment, SE, among people with severe mental illness -- a randomized controlled trial: NCT00960024.</p

The future of Malay–Chinese relations in Malaysia

In this chapter, the Malay–Chinese relation is examined by considering the history and nature of the relationship, the ensuing intergroup conflict, and the steps taken by the government and civil society groups to address the conflict. Finally, a psychocultural approach to building peace between the two groups is proposed