Firm Capabilities, Competition and Industrial Policies in a History-Friendly Model of the Computer Industry

In this paper, we explore some problems that industrial policy faces in industries characterized by dynamic increasing returns on the basis of a 'history friendly model' of the evolution of the computer industry. How does policy affect industry structure over the course of industry evolution? Is the timing of the intervention important? Do policy interventions have indirect and perhaps unintended consequences on different markets at different times? We focus on two sets of policies: antitrust and interventions aiming at supporting the entry of new forms in the industry. The results of our simulations show that, if strong dynamic increasing returns are operative, both through technological capabilities and through customer tendency to stick with a brand, there is little that antitrust and entry policy could have done to avert the rise of a dominant firm in mainframes. On the other hand, if the customer lock in effect had been smaller, either by chance or through policies that discouraged efforts of firms to lock in their customers, the situation might have been somewhat different. In the first place, even in the absence of antitrust or entry encouraging policies, market concentration would have been lower, albeit a dominant firm would emerge anyhow. Second, antitrust and entry encouraging policies would have been more effective in assuring that concentration would decrease. The leading firm would continue to dominate the market, but its relative power would be reduced. © Elsevier Science B.V

Variables influencing industrial funding of academic research in Italy. An empirical analysis

This paper aims at an empirical analysis of industry-academia links by using Italian data on performance of university departments and institutes to attract funding from industrial sources. The investigation shows that conventional political strategies to support industry-academia links by building up intermediary organisations might fail, as industry is mainly interested in excellent academic quality

Public policies and changing boundaries of firms in a “history-friendly” model of the co-evolution of the computer and semiconductor industries

In this paper, we explore the effects of alternative policies, ranging from antitrust to public procurement, open standards, information diffusion and basic research support on the dynamics of two vertically related industries in changing and uncertain technological and market environments. The two industries are a system industry and a component industry, and the evolution of these industries is characterized by periods of technological revolutions punctuating periods of relative technological stability and smooth technical progress. We have been inspired by the co-evolution of the computer and component industries from their inceptions to the 1980s. On the basis of that evolution, we have developed a history friendly-model this co-evolution. In sum, this paper has stressed that various types of policies may sometimes have contrasting effects on the industry, mainly on concentration and technical change and innovation. It has also shown that the consequences of policies may spillover from one industry to another, and from one type of firms to another. Policies that aim at a specific industry may provoke major changes in a related industry through the product market, the changing boundaries of firms or knowledge and technological interdependencies. The policy maker has to be aware of that. Finally, a major point of the paper regards the unintended consequences of policies

The influence of surfactants on the frog skin ion and water permeability

It is well known that sublethal doses of surfactants affect the cellular adhesion in the superficial layers of the exposed epithelia of aquatic animals, introducing a shunt in the active transport pathway, and that they are adsorbed by the cellular membranes, interacting with proteins and lipids and influencing the ion end water permeabilities. It has also been shown that the electrical behaviour of both the isolated and the \u201cin situ\u201d frog skin is heavily affected and that the isoosmotic, active transport coupled, water flow is abolished. We will propose a model for the toxic action of surfactants, based on the analysis of the decay of the electrical potential difference (pd) and short circuit current (scc), which accounts for the mentioned observations

Drought avoidance adaptive traits in seed germination and seedling growth of Citrullus amarus landraces

Abstract Citrullus lanatus cultivation is affected by drought stress. Citrullus species that grow wild and domesticated in arid areas, are considered potential useful donors of drought tolerance traits. Here, we evaluated the response of seed germination, seedling establishment and growth to different water availabilities in eleven landraces of C. amarus, from most of their cultivation range and in one C. lanatus commercial cultivar ('Sugar Baby'). 'Sugar Baby' germinated to lower water potential better than all C. amarus landraces, while seedling establishment was much higher in C. amarus than in C. lanatus. Finally, seedling growth of C. amarus landraces and the C. lanatus cultivar followed different patterns depending on water availability, showing enhanced biomass growth under wet conditions and no changes between dry and wet growing treatments, respectively. The different water use strategies in seed germination and seedling growth found in the two crops highlight drought avoidance strategies linked to the species growing environment in C. amarus, not present in the C. lanatus cultivar. The high seedling establishment, the plastic responses to water availabilities and the strong root system, indicate that genetic resources of C. amarus may have important applications in breeding programmes and in the selection of water-use efficient rootstock lines

Predictors of morbidity and mortality in patients submitted to cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for ovarian carcinomatosis: A multicenter study

The aim of this retrospective study is to assess the incidence of morbidity and mortality related to cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) and to evaluate their predictors, in patients with peritoneal metastasis of ovarian origin. A retrospective multicenter study was carried out investigating results from eight Italian institutions. A total of 276 patients met inclusion criteria. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis. Overall morbidity was 71.4%, and severe complications occurred in 23.9% of the sample; 60-day mortality was 4.3%. According to univariate logistic regression models, grade 3-4 morbidity was related to Peritoneal Cancer Index (PCI) (OR 1.06; 95% CI 1.02-1.09; p<0.001), number of intraoperative blood transfusions (OR 1.21; 95% CI 1.10-1.34; p<0.001), Completeness of Cytoreduction (CC) score (OR 1.68; 95% CI 1.16-2.44; p=0.006) and number of anastomoses (OR 1.32; 95% CI 1.00-1.73; p=0.046). However, at the multivariate logistic regression analysis, only the number of intraoperative blood transfusions (OR 1.17; 95% CI 1.5-1.30; p=0.004) and PCI (OR 1.04; 95% CI 1.01-1.08; p=0.010) resulted as key predictors of severe morbidity. Furthermore, using multivariate logistic regression model, ECOG score (OR 2.45; 95% CI 1.21-4.93; p=0.012) and the number of severe complications (OR 2.16; 95% CI 1.03-4.52; p=0.042) were recorded as predictors of exitus within 60 days. The combination of CRS and HIPEC for treating peritoneal metastasis of ovarian origin has acceptable morbidity and mortality and, therefore, it can be considered as an option in selected patients

Apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer

Objective: To investigate the role of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) when applied to the 7th TNM classification in the staging and prognosis of gastric cancer (GC). Methods: Between October 2009 and May 2014, a total of 89 patients with non-metastatic, biopsy proven GC underwent 1.5T DW-MRI, and then treated with radical surgery. Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging (local invasion, nodal involvement and according to the different groups — stage I, II and III). Kaplan-Meier curves were also generated. The follow-up period is updated to May 2016. Results: Median follow-up period was 33 months and 45/89 (51%) deaths from GC were observed. ADC was significantly different both for local invasion and nodal involvement (P<0.001). Considering final histology as the reference standard, a preoperative ADC cut-off of 1.80×10–3 mm2 /s could distinguish between stages I and II and an ADC value of ≤1.36×10–3 mm2 /s was associated with stage III (P<0.001). Kaplan-Meier curves demonstrated that the survival rates for the three prognostic groups were significantly different according to final histology and ADC cut-offs (P<0.001). Conclusions: ADC is different according to local invasion, nodal involvement and the 7th TNM stage groups for GC, representing a potential, additional prognostic biomarker. The addition of DW-MRI could aid in the staging and risk stratification of GC