39 research outputs found
The neurobiological foundations of learning disabilities
Learning disabilities constitute a heterogeneous group of disorders that involve significant alterations in different cognitive domains (acquisition and use of language, reasoning, mathematical skills, visuospatial abilities, and so forth) that are not accounted for by a low level of intelligence, inadequate sociocultural development or lack of academic
opportunities. They result from an alteration in basic psychological processes, developmentally linked to an alteration in the central nervous system. Current functional neuroimaging techniques have made it possible to develop a new type of approach
to the neurofunctional foundations underlying these disorders, especially with regard to difficulties in the realm of reading/writing (developmental dyslexia) and attention deficit hyperactivity disorder (ADHD), which have their highest incidence among the infantile population of school-age children. Development. Neuroimaging studies have revealed a pattern of atypical activity in both kinds of disorders. In the case of dyslexia, alterations have been observed in the perisylvian circuits that underlie the mechanisms involved in reading skills. Studies into ADHD suggest a fronto-striatal dysfunction linked to the difficulties encountered to achieve inhibitory control, as well as alterations in the inferior parietal and posterior temporal cortex. Conclusions. Functional neuroimaging studies have shown that the clinical manifestations of these disorders are not only due to a dysfunction in specific areas of the brain, but also to alterations in the pattern of connectivityLas dificultades de aprendizaje comprenden un grupo heterogéneo de trastornos que implican alteraciones significativas en diferentes dominios cognitivos (adquisición y uso del lenguaje, razonamiento, habilidades matemáticas, visuoespaciales,
etc.) no justificadas por bajo nivel intelectual, desarrollo sociocultural inadecuado o falta de oportunidades académicas. Éstas son el resultado de una alteración en los procesos psicológicos básicos, evolutivamente ligados a una alteración del sistema nervioso central. Las actuales técnicas de neuroimagen funcional han permitido un nuevo tipo de acercamiento a las bases neurofuncionales de estos trastornos, particularmente de las dificultades en el ámbito de la lectoescritura (dislexia evolutiva) y del trastorno
por déficit de atención e hiperactividad (TDAH), los cuales tienen el mayor nivel de incidencia en la población escolar infantil. Desarrollo. Los estudios de neuroimagen han revelado un patrón de actividad atípico en ambos tipos de trastorno. En el caso de la dislexia, se han observado alteraciones de los circuitos perisilvianos que sustentan los mecanismos de lectura. Los estudios sobre TDAH sugieren una disfunción frontoestriatal ligada a las dificultades para el control inhibitorio, así como alteraciones en la corteza
temporal posterior y parietal inferior. Conclusiones. Los estudios de neuroimagen funcional revelan que las manifestaciones clínicas de estos trastornos no se deben sólo a la disfunción de áreas cerebrales concretas, sino también a alteraciones en el patrón de conectividadAs dificuldades de aprendizagem compreendem um grupo heterogéneo de perturbações que implicam alterações significativas em diferentes domínios cognitivos (aquisição e uso da linguagem, raciocínio, habilidades matemáticas, visuo-espaciais,
etc.) não justificadas por baixo nível intelectual, desenvolvimento sócio-cultural inadequado ou falta de oportunidades académicas. Estas são o resultado de uma alteração nos processos psicológicos básicos, evolutivamente ligados a uma alteração do sistema
nervoso central. As técnicas actuais de neuroimagem funcional permitiram um novo tipo de abordagem às bases neuro-funcionais destas perturbações, particularmente das dificuldades no âmbito da leitura e da escrita (dislexia evolutiva) e da perturbação por défice de atenção e hiperactividade (PDAH), as quais têm o maior nível de incidência na população escolar infantil. Desenvolvimento. Os estudos das neuroimagens revelaram um padrão de actividade atípico em ambos os tipos de perturbação. No caso da dislexia,
foram observadas alterações dos circuitos perisilvícos que sustentam os mecanismos de leitura. Os estudos sobre o PDAH sugerem uma disfunção fronto-estriatal ligada às dificuldades no controlo inibitório, assim como alterações no córtex temporal posterior
e parietal inferior. Conclusões. Os estudos de neuroimagem funcional revelam que as manifestações clínicas destas perturbações não se devem apenas à disfunção de áreas cerebrais concretas, como também a alterações no padrão de conectividad
Brain electrical traits of logical validity
p. 1-13Neuroscience has studied deductive reasoning over the last 20 years under the assumption that deductive inferences are not only de jure but also de facto distinct from other forms of inference. The objective of this research is to verify if logically valid deductions leave any cerebral electrical trait that is distinct from the trait left by non-valid deductions. 23 subjects with an average age of 20.35 years were registered with MEG and placed into a two conditions paradigm (100 trials for each condition) which each presented the exact same relational complexity (same variables and content) but had distinct logical complexity. Both conditions show the same electromagnetic components (P3, N4) in the early temporal window (250–525 ms) and P6 in the late temporal window (500–775 ms). The significant activity in both valid and invalid conditions is found in sensors from medial prefrontal regions, probably corresponding to the ACC or to the medial prefrontal cortex. The amplitude and intensity of valid deductions is significantly lower in both temporal windows (p = 0.0003). The reaction time was 54.37% slower in the valid condition. Validity leaves a minimal but measurable hypoactive electrical trait in brain processing. The minor electrical demand is attributable to the recursive and automatable character of valid deductions, suggesting a physical indicator of computational deductive properties. It is hypothesized that all valid deductions are recursive and hypoactive.S
Magnetoencephalographic assessment of changes in brain activity in normal aging when performing a task under interference conditions
Determinar si la realización de una tarea de reconocimiento con interferencia activa, producía cambios en los patrones de activación cerebral con respecto a la presentación de otra con interferencia pasiva. Población y metodología: en veinte ancianos sanos se midió con magnetoencefalografía. Se realizó a cada uno de
ellos la escala de Memoria de Wechsler-III (WMS-III), la escala de Inteligencia de Wechsler, el Boston Naming Test, el test de fluidez verbal, el test de clasificación de tarjetas de Wisconsin, el trail Making Test y el test de colores y palabras (STROOP). Los registros se llevaron a cabo mediante un magnetoencefalógrafo de 148 canales capaz de medir la actividad magnética generada en toda la convexidad craneal.
Resultados: encontramos una mayor activación en la condición de interferencia activa en las regiones mediales temporales, corteza visual, y región ventral anterior durante los primeros 400 milisegundos en el hemisferio izquierdo y únicamente en el derecho para la corteza visual, mientras que en la condición de interferencia pasiva, se obtuvo una
mayor activación en la región ventral anterior durante los 700-800 milisegundos en el hemisferio izquierdo. Conclusión: la presentación de estos dos tipos de interferencia, activa y pasiva, modula los patrones de activación fronto-temporales en el envejecimiento normalTo determine whether performing a recognition task under interference conditions produces changes in brain activity pattern compared with the activity seen under conditions of passive interference. Population and methods: Twenty healthy elderly subjects were subjected to magnetoencephalography. In each patient we applied the Wechsler Memory Scale-III (WMS-III), the Wechsler Intelligence Scale, the Boston Naming Test, the verbal fluency test, the Wisconsin card classification test, the Trail Making Test and the colors and words test (STROOP). The recordings were made using a 148-channel magnetoencephalograph capable of measuring the magnetic activity generated within the entire cranial convexity. Results: Greater activation was recorded under active interference conditions in the medial temporal regions, visual cortex and anterior ventral area in the first 400 ms in the left hemisphere and only in the right hemisphere for the visual cortex, while under passive interference conditions, increased activation was obtained in the anterior ventral region during the 700-800 ms in the left hemisphere. Conclusion: The presentation of both types of interference, active and passive, modulates the fronto-temporal activation patterns in normal agin
Changes in brain activity in normal aging in an interference task tested by magnetoencephalography
La presentación de estímulos que interfieren en el mantenimiento de una información previa dificulta el reconocimiento posterior de ésta. La resistencia a la interferencia
disminuye en el envejecimiento normal, aspecto que se traduce en una peor ejecución de tareas que comprometen a la memoria operativa y que podría estar relacionado
con una disfunción ejecutiva. Nuestro objetivo consistió en comprobar si la realización de una tarea de reconocimiento con interferencia activa, producía cambios en los
patrones de activación cerebral con respecto a la presentación de otra con interferencia pasiva, en una muestra de veinte ancianos sanos y medido con magnetoencefalografía.
Los resultados mostraron la presencia de una mayor activación en la condición de interferencia activa en las regiones mediales temporales, corteza visual, y región
ventral anterior durante los primeros 400 milisegundos en el hemisferio izquierdo y únicamente en el derecho para la corteza visual, mientras que en la condición de interferencia pasiva, se obtuvo una mayor activación en la región ventral anterior durante los 700-800 milisegundos en el hemisferio izquierdo. Todo ello sugiere que la presentación de estos dos tipos de interferencia, activa y pasiva, modula los patrones de activación fronto-temporales en el envejecimiento normalThe presentation of stimuli interfering with the maintenance of previous information makes difficult the subsequent recognition of it. The interference resistance decreases in
normal aging, which is evidenced as a worse performance in tasks affecting working memory and that could be related to an executive dysfunction. Our aim was to establish
if performing a recognition task under active interference conditions caused changes in brain activation patterns from the performance of another task under passive interference
conditions in a sample of 20 healthy elderly patients, measured with magnetoencephalography. The results evidenced the presence of a greater activation under active interference conditions in the medial temporal regions, visual cortex and anterior ventral area in the first 400 milliseconds in the left hemisphere and only in the
right hemisphere for the visual cortex, while under passive interference conditions, a greater activation was obtained in the anterior ventral region during the 700-800 milliseconds in the left hemisphere. All of this suggests that the presentation of both types of interference, active and passive, modulates the fronto-temporal activation patterns in
normal agin
Do cognitive patterns of brain magnetic activity correlate with hippocampal atrophy in Alzheimer’s disease
Background: Many reports support the clinical validity of volumetric MRI measurements in Alzheimer's disease. Objective: To integrate functional brain imaging data derived from magnetoencephalography (MEG) and volumetric data in patients with Alzheimer's disease and in age matched controls. Methods: MEG data were obtained in the context of a probe-letter memory task. Volumetric measurements were obtained for lateral and mesial temporal lobe regions. Results: As expected, Alzheimer's disease patients showed greater hippocampal atrophy than controls bilaterally. MEG derived indices of the degree of activation in left parietal and temporal lobe areas, occurring after 400 ms from stimulus onset, correlated significantly with the relative volume of lateral and mesial temporal regions. In addition, the size of the right hippocampus accounted for a significant portion of the variance in cognitive scores independently of brain activity measures. Conclusions: These data support the view that there is a relation between hippocampal atrophy and the degree of neurophysiological activity in the left temporal lobe
Lateral Orbitofrontal Cortex Involvement in Initial Negative Aesthetic Impression Formation
It is well established that aesthetic appreciation is related with activity in several different brain regions. The identification of the neural correlates of beauty or liking ratings has been the focus of most prior studies. Not much attention has been directed towards the fact that humans are surrounded by objects that lead them to experience aesthetic indifference or leave them with a negative aesthetic impression. Here we explore the neural substrate of such experiences. Given the neuroimaging techniques that have been used, little is known about the temporal features of such brain activity. By means of magnetoencephalography we registered the moment at which brain activity differed while participants viewed images they considered to be beautiful or not. Results show that the first differential activity appears between 300 and 400 ms after stimulus onset. During this period activity in right lateral orbitofrontal cortex (lOFC) was greater while participants rated visual stimuli as not beautiful than when they rated them as beautiful. We argue that this activity is associated with an initial negative aesthetic impression formation, driven by the relative hedonic value of stimuli regarded as not beautiful. Additionally, our results contribute to the understanding of the nature of the functional roles of the lOFC