YouTube as a repository : the creative practice of students as producers of Open Educational Resources

In this paper we present an alternative view of Open Educational Resources (OERs). Rather than focusing on open media resources produced by expert practitioners for use by peers and learners, we examine the practice of learners as active agents, producing open media resources using the devices in their pockets: their mobile phones. In this study, students are the producers and operate simultaneously as legitimate members of the YouTube community and producers of educational content for future cohorts. Taking an Action Research approach we investigated how student’s engagement with open media resources related to their creativity. Using Kleiman’s framework of fives conceptual themes which emerged from academics experiences of creativity (constraint, process, product, transformation, fulfillment), we found that these themes revealed the opportunities designed into the assessed task and provided a useful lens with which to view students’ authentic creative experiences. Students’ experience of creativity mapped on to Kleiman’s framework, and was affected by assessment. Dimensions of openness changed across platforms, although the impact of authenticity and publication on creativity was evident, and the production of open media resources that have a dual function as OERs has clear benefits in terms of knowledge sharing and community participation.The transformational impacts for students were evident in the short term but would merit a longitudinal study. A series of conclusions are drawn to inform future practice and research

Exploring flow occurrence in elite golf

Research on flow (Csikszentmihalyi, 1975) has traditionally focused on reactive, externally-paced sports (e.g., tennis) without exploring those that are self-paced and stop-start in nature. This study investigated the occurrence of flow in a sample of thirteen elite golfers by conducting semi-structured interviews discussing: (i) their experiences of flow, (ii) factors that influenced flow occurrence, and (iii) the controllability of these experiences. Results shared similarity with existing research in terms of the majority of influencing factors reported, including motivation, preparation, focus, psychological state, environmental and situational conditions, and arousal, and that flow was reported to be at least potentially controllable. Golf-specific influences were also noted, including pre-shot routines, use of psychological interventions, standard of performance, and maintenance of physical state, suggesting that flow may have occurred differently for this sample. Findings are discussed and applied recommendations are made that may help golfers put relevant factors in place to increase the likelihood of experiencing flow

Progress report on the ultra heavy cosmic ray experiment (AO178)

The Ultra Heavy Cosmic Ray Experiment (UHCRE) is based on a modular array of 192 side-viewing solid state nuclear track detector stacks. These stacks were mounted in sets of four in 48 pressure vessels employing sixteen peripheral Long Duration Exposure Facility (LDEF) trays. The extended duration of the LDEF mission has resulted in a greatly enhanced scientific yield from the UHCRE. The geometry factor for high energy cosmic ray nuclei, allowing for Earth shadowing, was 30 sq m-sr, giving a total exposure factor of 170 sq m-sr-y at an orbital inclination of 28.4 degrees. Scanning results indicate that about 3000 cosmic ray nuclei in the charge region with Z greater than 65 were collected. This sample is more than ten times the current world data in the field (taken to be the data set from the HEAO-3 mission plus that from the Ariel-6 mission) and is sufficient to provide the world's first statistically significant sample of actinide (Z greater than 88) cosmic rays. Results to date are presented including details of ultra-heavy cosmic ray nuclei, analysis of pre-flight and post-flight calibration events and details of track response in the context of detector temperature history. The integrated effect of all temperature and age related latent track variations cause a maximum charge shift of +/- 0.8 e for uranium and +/- 0.6 e for the platinum-lead group. The precision of charge assignment as a function of energy is derived and evidence for remarkably good charge resolution achieved in the UHCRE is considered. Astrophysical implications of the UHCRE charge spectrum are discussed

Contextualizing Byron's homographic signature: Explorations of his other self and voice.

The redefinition of the sodomite in the eighteenth- and nineteenth-century discourses on sexuality produced a new sexual subjectivity in England. The sodomite became a more visible figure in the eighteenth century, but in Regency England, this new subject was increasingly represented as the abject other to what Foucault has called the Malthusian couple. By considering these new representations of the sodomite and George Gordon, Lord Byron's own writings on and experiences of same sex desire, this study contextualizes the influence of homosexuality on Byron's emergence as a public writer and on his development of the Byronic hero in a series of poems he suggested be read together: Childe Harold I and II, The Giaour, The Bride of Abydos, The Corsair, and Lara.Byron's movement into public writing is a critical juncture that forces a displacement of the homoerotic into his poetics and his stylization of the persona of the Byronic hero. His self-dramatizations within these poems reveal a homographic inscription, which my deconstructive and queer reading gives both psychological and social significance. I argue that the creation of the Byronic persona and the Byronic hero are deeply indebted to Byron's relationship to conflicted homosexual meanings within his age and that reading these conflicts exposes the ways discursive constructions of (homo)sexual, gendered, and national identity are imbricated in the emerging heterosexual imperatives of Byron's age

Docosahexaenoic acid enrichment of layer hen tissues and eggs through dietary supplementation with heterotrophically grown Aurantiochytrium limacinum

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Residue contacts predicted by evolutionary covariance extend the application of ab initio molecular replacement to larger and more challenging protein folds

For many protein families, the deluge of new sequence information together with new statistical protocols now allow the accurate prediction of contacting residues from sequence information alone. This offers the possibility of more accurate ab initio (non-homology-based) structure prediction. Such models can be used in structure solution by molecular replacement (MR) where the target fold is novel or is only distantly related to known structures. Here, AMPLE, an MR pipeline that assembles search-model ensembles from ab initio structure predictions (`decoys'), is employed to assess the value of contact-assisted ab initio models to the crystallographer. It is demonstrated that evolutionary covariance-derived residue–residue contact predictions improve the quality of ab initio models and, consequently, the success rate of MR using search models derived from them. For targets containing β-structure, decoy quality and MR performance were further improved by the use of a β-strand contact-filtering protocol. Such contact-guided decoys achieved 14 structure solutions from 21 attempted protein targets, compared with nine for simple Rosetta decoys. Previously encountered limitations were superseded in two key respects. Firstly, much larger targets of up to 221 residues in length were solved, which is far larger than the previously benchmarked threshold of 120 residues. Secondly, contact-guided decoys significantly improved success with β-sheet-rich proteins. Overall, the improved performance of contact-guided decoys suggests that MR is now applicable to a significantly wider range of protein targets than were previously tractable, and points to a direct benefit to structural biology from the recent remarkable advances in sequencing

Crystal structure of the type IV secretion system component CagX from Helicobacter pylori.

This is the final version.Available from the International Union of Crystallography via the DOI in this record.Helicobacter pylori, a Gram-negative bacterial pathogen prevalent in the human population, is the causative agent of severe gastric diseases. An H. pylori type IV secretion (T4S) system encoded by the cytotoxin-associated gene pathogenicity island (cagPAI) is responsible for communication with host cells. As a component of the cagPAI T4S system core complex, CagX plays an important role in virulence-protein translocation into the host cells. In this work, the crystal structure of the C-terminal domain of CagX (CagXct), which is a homologue of the VirB9 protein from the VirB/D4 T4S system, is presented. CagXct is only the second three-dimensional structure to be elucidated of a VirB9-like protein. Another homologue, TraO, which is encoded on the Escherichia coli conjugative plasmid pKM101, shares only 19% sequence identity with CagXct; however, there is a remarkable similarity in tertiary structure between these two β-sandwich protein domains. Most of the residues that are conserved between CagXct and TraO are located within the protein core and appear to be responsible for the preservation of this domain fold. The studies presented here will contribute to our understanding of different bacterial T4S systems.The authors thank the staff of beamline BL17U1 at Shanghai Synchrotron Radiation Facility (SSRF) for support during diffraction data collection. We thank the National Natural Science Foundation of China (Grant Nos. 31470741 and 31270790) and the National Thousand Talents Program of China for their support of this work

A New Smartphone-Based Optic Nerve Head Biometric for Verification and Change Detection

Purpose: Lens adapted smartphones are being used regularly instead of ophthalmoscopes. The most common causes of preventable blindness in the world, which are glaucoma and diabetic retinopathy, can develop asymptomatic changes to the optic nerve head (ONH) especially in the developing world where there is a dire shortage of ophthalmologists but ubiquitous mobile phones. We developed a proof-of-concept ONH biometric (application [APP]) to use as a routine biometric on a mobile phone. The unique blood vessel pattern is verified if it maps on to a previously enrolled image. Methods: The iKey APP platform comprises three deep neural networks (DNNs) developed from anonymous ONH images: the graticule blood vessel (GBV) and the blood vessel specific feature (BVSF) DNNs were trained on unique blood vessel vectors. A non-feature specific (NFS) baseline ResNet50 DNN was trained for comparison. Results: Verification reached an accuracy of 97.06% with BVSF, 87.24% with GBV and 79.8% using NFS. Conclusions: A new ONH biometric was developed with a hybrid platform of ONH algorithms for use as a verification biometric on a smartphone. Failure to verify will alert the user to possible changes to the image, so that silent changes may be observed before sight threatening disease progresses. The APP retains a history of all ONH images. Future longitudinal analysis will explore the impact of ONH changes to the iKey biometric platform. Translational Relevance: Phones with iKey will host ONH images for biometric protection of both health and financial data. The ONH may be used for automatic screening by new disease detection DNNs