First observations of beam losses due to bound-free pair production in a heavy-ion collider

We report the first observations of beam losses due to bound-free pair production at the interaction point of a heavy-ion collider. This process is expected to be a major luminosity limit for the Large Hadron Collider (LHC) when it operates with 208Pb82+ ions because the localized energy deposition by the lost ions may quench superconducting magnet coils. Measurements were performed at the Relativistic Heavy Ion Collider (RHIC) during operation with 100 GeV/nucleon 63Cu29+ ions. At RHIC, the rate, energy and magnetic field are low enough so that magnet quenching is not an issue. The hadronic showers produced when the single-electron ions struck the RHIC beampipe were observed using an array of photodiodes. The measurement confirms the order of magnitude of the theoretical cross section previously calculated by others.Comment: 4 pages, 5 figures. Added journal ref. Corrected typos. Fixed fig 1. Minor improvements to fig. 1,3,4. Rephrased a small number of sentences (p1,3,4). Added numerical values of the aperture and the displacement for Au (p 2). Changed reference 5, added name in acknowledgments (p 4

Initial evidence for the criterion-related and structural validity of the long versions of the direct and meta-perspectives of the Coach-Athlete Relationship Questionnaire

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 Taylor & Francis.The aim of the present study was to develop and initially validate a longer version of the direct (Jowett & Ntoumanis, 2004) and meta-perspectives (Jowett, 2009a, 2009b) of the Coach-Athlete Relationship Questionnaire (CART-Q). In Study 1, instruments (e.g. questionnaires, scales, and inventories) that have been used to assess relationship quality in the broader psychological literature were examined and items potentially relevant to the coach-athlete relationship were identified. The content validity of the identified items was then assessed using expert panels. A final questionnaire was subsequently prepared and administered to 693 participants (310 coaches and 383 athletes). Confirmatory factor analysis was employed to assess the multidimensional nature of the questionnaire based on the 3Cs (i.e. closeness, commitment, and complementarity) model of the coach-athlete relationship. The findings indicated that the direct and meta-perspective items of the long versions of the CART-Q approached an adequate data fit. Moreover, evidence for the internal consistency and criterion validity of the new instruments was also obtained. In Study 2, the newly developed measure was administered to an independent sample of 251 individuals (145 athletes and 106 coaches). Further statistical support was gained for the factorial validity and reliability of the longer version of the CART-Q

Attachment Styles Within the Coach-Athlete Dyad: Preliminary Investigation and Assessment Development

The present preliminary study aimed to develop and examine the psychometric properties of a new sport-specific self-report instrument designed to assess athletes’ and coaches’ attachment styles. The development and initial validation comprised three main phases. In Phase 1, a pool of items was generated based on pre-existing self-report attachment instruments, modified to reflect a coach and an athlete’s style of attachment. In Phase 2, the content validity of the items was assessed by a panel of experts. A final scale was developed and administered to 405 coaches and 298 athletes (N = 703 participants). In Phase 3, confirmatory factor analysis of the obtained data was conducted to determine the final items of the Coach-Athlete Attachment Scale (CAAS). Confirmatory factor analysis revealed acceptable goodness of fit indexes for a 3-first order factor model as well as a 2-first order factor model for both the athlete and the coach data, respectively. A secure attachment style positively predicted relationship satisfaction, while an insecure attachment style was a negative predictor of relationship satisfaction. The CAAS revealed initial psychometric properties of content, factorial, and predictive validity, as well as reliability

MAD Version 9

The program MAD is widely used for accelerator design and beam dynamics studies. For many years, its input language has been the nearest thing to a world-wide standard for describing accelerator structures. The new Version 9 is a complete rewrite using a systematic object-oriented methodology based on the CLASSIC classes [2] for accelerator physics. It provides many improvements over the previous MAD Version 8. These include: (i) support for multiple beam-lines simultaneously, facilitating, for example, matching constraints that couple the two rings of a two-ring collider, (ii) much improved Lie-algebraic map calculations, (iii) a uniform method and format for exchanging many kinds of structured data with other programs, (iv) an improved and more consistent input language. In addition, we report on a parallel 3D Poisson field solver for space charge calculations in high intensity particle beams. Applied to the PSI injector cyclotron, this shows the general nature of MAD Version 9 as a state-of- the-art problem-solving environment. We describe the current status of the program and how to get it, outline future plans and illustrate some of the new features

A new spatially and temporally variable sigma parameter in degree-day melt modelling of the Greenland Ice Sheet 1870–2013

The degree-day based method of calculating ice-/snow-melt across the Greenland Ice Sheet (GrIS) commonly includes the temperature parameter sigma (σ) accounting for temperature variability on short (sub-monthly down to hourly) timescales, in order to capture melt in months where the mean temperature is below 0 °C. Sigma is typically assumed to be constant in space and time, with values ranging from ~ 2.5 to 5.5 °C. It is unclear in many cases how these values were derived and little sensitivity analysis or validation has been conducted. Here we determine spatially and temporally varying monthly values of σ for the unique, extended 1870–2013 timescale based on downscaled, corrected European Centre for Medium-Range Weather Forecasts (ECMWF) Interim (ERA-I) and Twentieth Century Reanalysis (20CR) meteorological reanalysis 2 m air temperatures on a 5 km × 5 km polar stereographic grid for the GrIS. The resulting monthly σ values reveal a distinct seasonal cycle. The mean summer σ value for the study period is ~ 3.2 °C, around 1 °C lower than the value of 4.2 °C commonly used in the literature. Sigma values for individual summers range from 1.7 to 5.9 °C. Since the summer months dominate the melt calculation, use of the new variable σ parameter would lead to a smaller melt area and a more positive surface mass balance for the GrIS. Validation of our new variable σ dataset shows good agreement with standard deviations calculated from automatic weather station observations across the ice sheet. Trend analysis shows large areas of the ice sheet exhibit statistically significant increasing temperature variability from 1870–2013 in all seasons, with notable exceptions around Summit in spring, and Summit and South Dome in winter. More recently, since 1990, σ has been decreasing, significantly so in the north-west during July. These interannual σ trends reflect climate change and variability processes operating across the ice sheet, several mechanisms of which are briefly discussed

Physics Opportunities with the FCC-hh Injectors

In this chapter we explore a few examples of physics opportunities using the existing chain of accelerators at CERN, including potential upgrades. In this context the LHC ring is also considered as a part of the injector system. The objective is to find examples that constitute sensitive probes of New Physics that ideally cannot be done elsewhere or can be done significantly better at theCERN accelerator complex. Some of these physics opportunities may require a more flexible injector complex with additional functionality than that just needed to inject protons into the FCC-hh at the right energy, intensity and bunch structure. Therefore it is timely to discuss these options concurrently with the conceptual design of the FCC-hh injector system.Comment: 13 pages, chapter 5 in Physics at the FCC-hh, a 100 TeV pp collide

A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness

Objectives: This report reviews the clinical effectiveness and cost-effectiveness of adalimumab, etanercept and infliximab, agents that inhibit tumour necrosis factor-a (TNF-a), when used in the treatment of rheumatoid arthritis (RA) in adults. \ud \ud Data sources: Electronic databases were searched up to February 2005. \ud \ud Review methods: Systematic reviews of the literature on effectiveness and cost-effectiveness were undertaken and industry submissions to the National Institute for Health and Clinical Excellence (NICE) were reviewed. Meta-analyses of effectiveness data were also undertaken for each agent. The Birmingham Rheumatoid Arthritis Model (BRAM), a simulation model, was further developed and used to produce an incremental cost-effectiveness analysis. \ud \ud Results: Twenty-nine randomised controlled trials (RCTs), most of high quality, were included. The only head-to-head comparisons were against methotrexate. For patients with short disease duration (≤3 years) who were naïve to methotrexate, adalimumab was marginally less and etanercept was marginally more effective than methotrexate in reducing symptoms of RA. Etanercept was better tolerated than methotrexate. Both adalimumab and etanercept were more effective than methotrexate in slowing radiographic joint damage. Etanercept was also marginally more effective and better tolerated than methotrexate in patients with longer disease durations who had not failed methotrexate treatment. Infliximab is only licensed for use with methotrexate. All three agents, either alone (where so licensed) or in combination with ongoing disease-modifying antirheumatic drugs (DMARDs), were effective in reducing the symptoms and signs of RA in patients with established disease. At the licensed dose, the numbers needed to treat (NNTs) (95% CI) required to produce an American College for Rheumatology (ACR) response compared with placebo were: ACR20: adalimumab 3.6 (3.1 to 4.2), etanercept 2.1 (1.9 to 2.4), infliximab 3.2 (2.7 to 4.0); ACR50: adalimumab 4.2 (3.7 to 5.0), etanercept 3.1 (2.7 to 3.6), infliximab 5.0 (3.8 to 6.7); and ACR70: adalimumab 7.7 (5.9 to 11.1), etanercept 7.7 (6.3 to 10.0), infliximab 11.1 (7.7 to 20.0). In patients who were naïve to methotrexate, or who had not previously failed methotrexate treatment, a TNF inhibitor combined with methotrexate was significantly more effective than methotrexate alone. Infliximab combined with methotrexate had an increased risk of serious infections. All ten published economic evaluations met standard criteria for quality, but the incremental cost-effectiveness ratios (ICERs) ranged from being within established thresholds to being very high because of varying assumptions and parameters. All three sponsors who submitted economic models made assumptions favourable to their product. BRAM incorporates improvements in quality of life and mortality, but assumes no effect of TNF inhibitors on joint replacement. For use in accordance with current NICE guidance as the third DMARD in a sequence of DMARDs, the base-case ICER was around £30,000 per quality-adjusted life-year (QALY) in early RA and £50,000 per QALY in late RA. Sensitivity analyses showed that the results were sensitive to the estimates of Health Assessment Questionnaire (HAQ) progression while on TNF inhibitors and the effectiveness of DMARDs, but not to changes in mortality ratios per unit HAQ. TNF inhibitors are most cost-effective when used last. The ICER for etanercept used last is £24,000 per QALY, substantially lower than for adalimumab (£30,000 per QALY) or infliximab (£38,000 per QALY). First line use as monotherapy generates ICERs around £50,000 per QALY for adalimumab and etanercept. Using the combination of methotrexate and a TNF inhibitor as first line treatment generates much higher ICERs, as it precludes subsequent use of methotrexate, which is cheap. The ICERs for sequential use are of the same order as using the TNF inhibitor alone. \ud \ud Conclusions: Adalimumab, etanercept and infliximab are effective treatments compared with placebo for RA patients who are not well controlled by conventional DMARDs, improving control of symptoms, improving physical function, and slowing radiographic changes in joints. The combination of a TNF inhibitor with methotrexate was more effective than methotrexate alone in early RA, although the clinical relevance of this additional benefit is yet to be established, particularly in view of the well-established effectiveness of MTX alone. An increased risk of serious infection cannot be ruled out for the combination of methotrexate with adalimumab or infliximab. The results of the economic evaluation based on BRAM are consistent with the observations from the review of clinical effectiveness, including the ranking of treatments. TNF inhibitors are most cost-effective when used as last active therapy. In this analysis, other things being equal, etanercept may be the TNF inhibitor of choice, although this may also depend on patient preference as to route of administration. The next most cost-effective use of TNF inhibitors is third line, as recommended in the 2002 NICE guidance. Direct comparative RCTs of TNF inhibitors against each other and against other DMARDs, and sequential use in patients who have failed a previous TNF inhibitor, are needed. Longer term studies of the quality of life in patients with RA and the impact of DMARDs on this are needed, as are longer studies that directly assess effects on joint replacement, other morbidity and mortality

Facile synthesis of hierarchical Cu2O nanocubes as visible light photocatalysts

Hierarchically structured Cu2O nanocubes have been synthesized by a facile and cost-effective one-pot, solution phase process. Self-assembly of 5 nm Cu2O nanocrystallites induced through reduction by glucose affords a mesoporous 375 nm cubic architecture with superior visible light photocatalytic performance in both methylene blue dye degradation and hydrogen production from water than conventional non-porous analogues. Hierarchical nanocubes offer improved accessible surface active sites and optical/electronic properties, which act in concert to confer 200–300% rate-enhancements for the photocatalytic decomposition of organic pollutants and solar fuels

The Scottish economy [July 1981]

The current economic situation is extremely depressed and recent events suggest that, without significant increases in economic activity, the political and social fabric of this country may be several strained. However, as argued in the UK section, the prospects for recovery are bleak and reliance on a purely financial strategy to restore growth is in itself inadequate. The source of real economic growth lies in the ability of labour, capital and enterprise to come together in a manner conducive to increased productivity over time. It is therefore worthwhile examining these factors of production to determine the effect of current policies upon them

Cross-cultural adaptation and psychometric properties of the Brazilian coach-athlete relationship questionnaire (CART-Q), athlete Version

The aim of this study was to test the psychometric properties of the Brazilian version of the Coach-Athlete Relationship Questionnaire (CART-Q)-Athlete Version. For this, three studies were performed. In the first, four translators and five experts in Sport Psychology adapted the CART-Q contents to the Brazilian context. In the second, 364 athletes of individual and collective sports answered the adapted version of CART-Q. In the third, an independent sample of 185 athletes answered the CART-Q and the Task and Ego Orientation in Sport Questionnaire (TEOSQ) to analyze the external validity of the instrument; and 50 athletes answered the CART-Q in two distinct moments for the analysis of the temporal stability. Study 1 showed that the Portuguese version contains clear and relevant questions (CVC> 0.80). Study 2 showed that the CART-Q presents satisfactory internal consistency (a> 0.70/CC> 0.70). The confirmatory factor analysis showed that the model with 11 items showed good fit [X2/gl = 3.03; CFI = 0.96, GFI =0 94; TLI = 0.94; RMSEA = 0.08] and also the existence of the second-order model. Study 3 showed the external (r> 0.40 with variable task orientation) and internal validity (CFA with an independent sample) and temporal stability (ICC> 0.70). It was concluded that the Brazilian version for of CART-Q proved to be valid to evaluate the perception of athletes about their relationship with the coach in the Brazilian sports context