Three and Four Region Multi-sector Linear Modelling Using UK Data : Some Preliminary Results

Scotland and Wales have relatively up-to-date, independently generated, IO tables. These can be separated out from a UK national IO table to construct an inter-regional table. We therefore undertake the detailed analysis at this three-region (Scotland, Wales and the Rest of the UK (RUK)) level, where the Rest of the UK is England and Northern Ireland. However, we also construct a more rudimentary four-region (Scotland, Wales, England and Ireland) set of IO and SAM accounts by constructing a separate Northern Ireland accounts. The inter-regional IO and SAM models are produced for the year 1999. This was determined by the availability of consistent data. In Section II we describe the construction of a three-region Input-Output model for the United Kingdom, which includes the regions of Scotland, Wales and the Rest of the UK (RUK). In Section III we extend the three-region model to construct an inter-regional Social Accounting Matrix. Section IV reports some results using the three-region IO and SAM models. In Section V, we generate a four-region IO and SAM model for the UK, which disaggregates Northern Ireland from the Rest of the UK, and provide some results using the four-region IO and SAM models. Section VI offers our conclusions

Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents

Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes

The archipelago of intervention: governing the awkward citizen

This doctoral thesis examines the changing ways in which the neoliberal state looks to engage with populations of marginalised, excluded and ‘awkward citizens’. Whilst some have argued that the neoliberal state has abandoned and/or adopted a punitive and revanchist stance towards ‘awkward citizens’, this thesis demonstrates that an ‘archipelago of intervention’ has developed which is dirigiste in nature and represents a manifold of assistive and regressive techniques of government. Targeting individuals defined as ‘problematic’ (those with ‘chaotic lifestyles’: substance misuse issues, offending behaviour, vulnerably housed males) the archipelago of intervention represents a spatially expansive, ideationally disparate and operationally intense project of marginal social welfare. In order to more closely analyse these evolving practices of intervention, three case studies are examined through the lens of Foucauldian governmentality: one-to-one case working aimed at those with chaotic lifestyles; two ‘Supported Accommodation’ projects for vulnerably housed males; and the ‘Unpaid Work’/Community Payback order delivered by the Probation Service. Using interviews with service users, staff and managers combined with ethnographies undertaken in Supported Accommodation projects and Visible Unpaid Work sites, the thesis demonstrates how these interventions share a commitment to working with individuals through consent rather than coercion. Located at the cutting edge of ‘roll out’ neoliberal social policy, the thesis shows how these techniques of government operate to reform the subjectivities of their target population through the application of ‘psy’ techniques, contractual governance, embodied discipline and re-worked ideas about the rehabilitation of offenders. Drawing on Lefebvre, space and time emerge as central problematics in attempts to govern awkward citizens. Each case study intervention is shown to carve out re-worked spatio-temporalities which are held to be generative of behavioural and attitudinal reform. Thus, the thesis makes an important contribution to debates on the unfolding neoliberalisation of the state and social policy by pointing to the complex assemblages of power and multiple practices through which the state governs problematic populations. Moreover, the PhD also contributes to theoretical debates around the idea of ‘governmentality’ by arguing for a geographically sensitive and materially open approach to systems of governance

A note on the calculation of the effective range

The closed form of the first order non-linear differential equation that is satisfied by the effective range within the variable phase formulation of scattering theory is discussed. It is shown that the conventional method of determining the effective range, by fitting a numerical solution of the Schr\"odinger equation to known asymptotic boundary conditions, can be modified to include the first order contribution of a long range interaction.Comment: 4 page

Does warfarin prevent venous thromboembolic events in aPL-positive patients?

Yes, warfarin is effective in the secondary prevention of venous thromboembolic events (VTEs) for patients positive for lupus anticoagulant or anticardiolipin antibody (also known as antiphospholipid antibodies [aPL]) (strength of recommendation [SOR]: B, single cohort study, extrapolation from other RCTs). Patients should be treated for at least a year (SOR: C, consensus statement), and possibly indefinitely, with warfarin (SOR: B, small clinical trials and cohort studies). Moderate-intensity therapy (international normalized ratio [INR] range, 2.0-3.0) appears to be the best balance between risks and benefits (SOR: B, based on meta-analysis of 2 small randomized control trials

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor

L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood. The physiological effects of glutamate are mediated through two functionally distinct receptor families. While activation of metabotropic (G-protein coupled) glutamate receptors results in modulation of neuronal excitability and transmission, the ionotropic glutamate receptors (ligand-gated ion channels) are responsible for mediating the fast synaptic response to extracellular glutamate

Retarded dipole-dipole dispersion interaction potential for helium

The retarded dipole-dipole dispersion interaction potential in helium is evaluated from a set of very accurate effective dipole transition frequencies and oscillator strengths already obtained from a variational calculation. The asymptotic form changes from the inverse sixth to the inverse seventh power of the nuclear separation as the atoms move apart. Simple representations of the potential are given for use in scattering and structure calculations. © 1995 The American Physical Society

The variable phase method used to calculate and correct scattering lengths

It is shown that the scattering length can be obtained by solving a Riccati equation derived from variable phase theory. Two methods of solving it are presented. The equation is used to predict how long-range interactions influence the scattering length, and upper and lower bounds on the scattering length are determined. The predictions are compared with others and it is shown how they may be obtained from secular perturbation theory.Comment: 7 pages including 3 figure

A taste of the deep-sea: The roles of gustatory and tactile searching behaviour in the grenadier fish <i>Coryphaenoides armatus</i>

The deep-sea grenadier fishes (Coryphaenoides spp.) are among the dominant predators and scavengers in the ocean basins that cover much of Earth's surface. Baited camera experiments were used to study the behaviour of these fishes. Despite the apparent advantages of rapidly consuming food, grenadiers attracted to bait spend a large proportion of their time in prolonged periods of non-feeding activity. Video analysis revealed that fish often adopted a head-down swimming attitude (mean of 21.3 degrees between the fish and seafloor), with swimming velocity negatively related to attitude. The fish also swam around and along vertical and horizontal structures of the lander with their head immediately adjacent to the structure. We initially hypothesised that this behaviour was associated with the use of the short chin barbel in foraging. Barbel histology showed numerous taste buds in the skin, and a barbel nerve with about 20,000 axons in adult fish. A tracing experiment in one undamaged animal revealed the termination fields of the barbel neurons in the trigeminal and rhombencephalic regions, indicating both a mechanoreceptory and a gustatory role for the barbel. Our conclusion was that olfactory foraging becomes ineffective at close ranges and is followed by a search phase using tactile and gustatory sensing by the barbel. The development of this sensory method probably co-evolved alongside behavioural changes in swimming mechanics to allow postural stability at low swimming speeds