The interstellar oxygen-K absorption edge as observed by XMM-Newton

High resolution X-ray spectra of the Reflection Grating Spectrometer (RGS) on board the XMM satellite are used to resolve the oxygen K absorption edge. By combining spectra of low and high extinction sources, the observed absorption edge can be split in the true interstellar (ISM) extinction and the instrumental absorption. The detailed ISM edge structure closely follows the edge structure of neutral oxygen as derived by theoretical R-matrix calculations. However, the position of the theoretical edge requires a wavelength shift. In addition the detailed instrumental RGS absorption edge structure is presented. All results are verified by comparing to a subset of Chandra LETG-HRC observations.Comment: LaTeX2e A&A style, 10 pages, 12 postscript figures, accepted for publication in Astronomy and Astrophysic

Generic method for deriving the general shaking force balance conditions of parallel manipulators with application to a redundant planar 4-RRR parallel manipulator

This paper proposes a generic method for deriving\ud the general shaking force balance conditions of parallel\ud manipulators. Instead of considering the balancing of a parallel\ud manipulator link-by-link or leg-by-leg, the architecture is\ud considered altogether.\ud The first step is to write the linear momentum of each element.\ud The second step is to substitute the derivatives of the\ud loop equations, by which the general force balance conditions\ud are obtained. Subsequently specific kinematic conditions are\ud investigated in order to find advantageous, simple balance solutions.\ud As an example, the method is applied to a planar 4-RRR parallel\ud manipulator, for which the force balance conditions and\ud solutions are discussed and illustrated for each step respectively.\ud By including the loop equations, linear relations of the\ud motion among mechanism elements lead to an increase of balance\ud possibilities.For specific kinematic conditions, additional\ud linear relations among the motion of mechanism elements may\ud be obtained, resulting in another increase of balance possibilities.\ud For the latter, symmetric motion is an important feature\ud for which a 4-RRR manipulator is advantageou

What Is Carcinoid Syndrome? A Critical Appraisal of Its Proposed Mediators:A critical appraisal of its proposed mediators

Carcinoid syndrome (CS) is a debilitating disease that affects approximately 20% of patients with neuroendocrine neoplasms (NEN). Due to the increasing incidence and improved overall survival of patients with NEN over recent decades, patients are increasingly suffering from chronic and refractory CS symptoms. At present, symptom control is hampered by an incomplete understanding of the pathophysiology of this syndrome. This systematic review is the first to critically appraise the available evidence for the various hormonal mediators considered to play a causative role in CS. Overall, evidence for the putative mediators of CS was scarce and often of poor quality. Based on the available literature, data are only sufficient to agree on the role of serotonin as a mediator of CS-associated diarrhea and fibrosis. A direct role for tachykinins and an indirect role of catecholamines in the pathogenesis of CS is suggested by several studies. Currently, there is insufficient evidence to link histamine, bradykinin, kallikrein, prostaglandins, or motilin to CS. To summarize, available literature only sufficiently appoints serotonin and suggests a role for tachykinins and catecholamines as mediators of CS, with insufficient evidence for other putative mediators. Descriptions of CS should be revised to focus on these proven hormonal associations to be more accurate, and further research is needed into other potential mediators.</p

Studying the WHIM with Gamma Ray Bursts

We assess the possibility to detect and characterize the physical state of the missing baryons at low redshift by analyzing the X-ray absorption spectra of the Gamma Ray Burst [GRB] afterglows, measured by a micro calorimeters-based detector with 3 eV resolution and 1000 cm2 effective area and capable of fast re-pointing, similar to that on board of the recently proposed X-ray satellites EDGE and XENIA. For this purpose we have analyzed mock absorption spectra extracted from different hydrodynamical simulations used to model the properties of the Warm Hot Intergalactic Medium [WHIM]. These models predict the correct abundance of OVI absorption lines observed in UV and satisfy current X-ray constraints. According to these models space missions like EDGE and XENIA should be able to detect about 60 WHIM absorbers per year through the OVII line. About 45 % of these have at least two more detectable lines in addition to OVII that can be used to determine the density and the temperature of the gas. Systematic errors in the estimates of the gas density and temperature can be corrected for in a robust, largely model-independent fashion. The analysis of the GRB absorption spectra collected in three years would also allow to measure the cosmic mass density of the WHIM with about 15 % accuracy, although this estimate depends on the WHIM model. Our results suggest that GRBs represent a valid, if not preferable, alternative to Active Galactic Nuclei to study the WHIM in absorption. The analysis of the absorption spectra nicely complements the study of the WHIM in emission that the spectrometer proposed for EDGE and XENIA would be able to carry out thanks to its high sensitivity and large field of view.Comment: 16 pages, 16 figures, accepted for publication by Ap

First Light Measurements with the XMM-Newton Reflection Grating Spectrometers: Evidence for an Inverse First Ionisation Potential Effect and Anomalous Ne A bundance in the Coronae of HR 1099

The RS CVn binary system HR 1099 was extensively observed by the XMM-Newton observatory in February 2000 as its first-light target. A total of 570 ks of exposure time was accumulated with the Reflection Grating Spectrometers (RGS). The integrated X-ray spectrum between 5-35 Angstrom is of unprecedented quality and shows numerous features attributed to transitions of the elements C, N, O, Ne, Mg, Si, S, Fe, and Ni. We perform an in-depth study of the elemental composition of the average corona of this system, and find that the elemental abundances strongly depend on the first ionisation potential (FIP) of the elements. But different from the solar coronal case, we find an inverse FIP effect, i.e., the abundances (relative to oxygen) increase with increasing FIP. Possible scenarios, e.g., selective enrichment due to Ne-rich flare-like events, are discussed.Comment: 5 pages, 4 figures. Accepted by A&A Letters, XMM issu

High Resolution X-Ray Spectroscopy of SN 1987A: Monitoring with XMM-Newton

We report the results of our XMM-Newton monitoring of SN 1987A. The ongoing propagation of the supernova blast wave through the inner circumstellar ring caused a drastic increase in X-ray luminosity during the last years, enabling detailed high resolution X-ray spectroscopy with the Reflection Grating Spectrometer. The observations can be used to follow the detailed evolution of the arising supernova remnant. The fluxes and broadening of the numerous emission lines seen in the dispersed spectra provide information on the evolution of the X-ray emitting plasma and its dynamics. These were analyzed in combination with the EPIC-pn spectra, which allow a precise determination of the higher temperature plasma. We modeled individual emission lines and fitted plasma emission models. Especially from the observations between 2003 and 2007 we can see a significant evolution of the plasma parameters and a deceleration of the radial velocity of the lower temperature plasma regions. We found an indication (3-sigma-level) of an iron K feature in the co-added EPIC-pn spectra. The comparison with Chandra grating observations in 2004 yields a clear temporal coherence of the spectral evolution and the sudden deceleration of the expansion velocity seen in X-ray images ~6100 days after the explosion.Comment: 10 pages, 8 Figures; accepted by A&

The XMM-Newton view of the Crab

Aims. We discuss the current X-ray view of the Crab Nebula and Pulsar, summarising our analysis of observations of the source with the EPIC-pn camera on board the XMM-Newton observatory. Different modes of EPIC-pn were combined in order to yield a complete scenario of the spectral properties of the Crab resolved in space and time (pulse phase). In addition we give a description of the special EPIC-pn Burst mode and guidance for data reduction in that mode. Methods. We analysed spectra for the nebula and pulsar separately in the 0.6−12.0 keV energy band. All data were processed with the SAS 6.0.0 XMM-Newton Scientific Analysis System package; models were fitted to the data with XSPEC 11. The high time resolution of EPIC-pn in its Burst mode (7 μs) was used for a phase resolved analysis of the pulsar spectrum, after determination of the period with epoch folding techniques. Data from the SmallWindow mode were processed and corrected for pile-up allowing for spectroscopy simultaneously resolved in space and time. Results. The spatial variation of the spectrum over the entire region of the Crab shows a gradual spectral softening from the inner pulsar region to the outer nebula region with a variation in photon index, Γ, from 2.0 to 2.4. Pulse phase resolved spectroscopy of the Crab Pulsar reveals a phase dependent modulation of the photon index in form of a significant hardening of the spectrum in the inter-peak phase from Γ = 1.7 during the pulse peak to Γ = 1.5

The search for decaying Dark Matter

We propose an X-ray mission called Xenia to search for decaying superweakly interacting Dark Matter particles (super-WIMP) with a mass in the keV range. The mission and its observation plan are capable of providing a major break through in our understanding of the nature of Dark Matter (DM). It will confirm, or reject, predictions of a number of particle physics models by increasing the sensitivity of the search for decaying DM by about two orders of magnitude through a wide-field imaging X-ray spectrometer in combination with a dedicated observation program. The proposed mission will provide unique limits on the mixing angle and mass of neutral leptons, right handed partners of neutrinos, which are important Dark Matter candidates. The existence of these particles is strongly motivated by observed neutrino flavor oscillations and the problem of baryon asymmetry of the Universe. In super-WIMP models, the details of the formation of the cosmic web are different from those of LambdaCDM. The proposed mission will, in addition to the search for decaying Dark Matter, provide crucial insight into the nature of DM by studying the structure of the "cosmic web". This will be done by searching for missing baryons in emission, and by using gamma-ray bursts as backlight to observe the warm-hot intergalactic media in absorption.Comment: A white paper submitted in response to the Fundamental Physics Roadmap Advisory Team (FPR-AT) Call for White Paper

Inflammatory Adipokines, High Molecular Weight Adiponectin, and Insulin Resistance: A Population-Based Survey in Prepubertal Schoolchildren

BackgroundThe aim of this study was to investigate sex differences and associations of high molecular weight (HMW) adiponectin, leptin and proinflammatory adipokines, individually or in combinations, with adiposity and insulin resistance (IR) measures in prepubertal childhood.MethodologyWe studied 305 prepubertal children (boys/girls: 144/161; Tanner stage 1; age: 5-13 yr), included in a cohort of 44,231 adolescents who participated in an extensive Italian school-based survey. According to Cole's criteria, 105 individuals were lean (L; boys/girls: 59/46), 60 overweight (OW; boys/girls: 32/28) and 140 obese (OB; boys/girls: 70/70). Measurements comprised total and HMW adiponectin, leptin, as well as a panel of proinflammatory adipokines/chemokines associated with diabetes risk.Principal findingsLeptin-, and the leptin-to-HMW adiponectin ratio (L/HMW)-, increased progressively (pConclusionsIn prepubertal children, leptin emerges as a sex-independent discrimination marker of adiposity degree and as a useful, sex-associated predictor of the systemic insulin resistance