Asymptotics and zeros of Sobolev orthogonal polynomials on unbounded supports

In this paper we present a survey about analytic properties of polynomials orthogonal with respect to a weighted Sobolev inner product such that the vector of measures has an unbounded support. In particular, we are focused in the study of the asymptotic behaviour of such polynomials as well as in the distribution of their zeros. Some open problems as well as some new directions for a future research are formulated.Comment: Changed content; 34 pages, 41 reference

Resectable IIIA-N2 non-small-cell lung cancer (NSCLC): In search for the proper treatment

Locally advanced non-small cell lung cancer accounts for one third of non-small cell lung cancer (NSCLC) at the time of initial diagnosis and presents with a wide range of clinical and pathological heterogeneity. To date, the combined multimodality approach involving both local and systemic control is the gold standard for these patients, since occult distant micrometastatic disease should always be suspected. With the rapid increase in treatment options, the need for an interdisciplinary discussion involving oncologists, surgeons, radiation oncologists and radiologists has become essential. Surgery should be recommended to patients with non-bulky, discrete, or single-level N2 involvement and be included in the multimodality treatment. Resectable stage IIIA patients have been the subject of a number of clinical trials and retrospective analysis, discussing the efficiency and survival benefits on patients treated with the available therapeutic approaches. However, most of them have some limitations due to their retrospective nature, lack of exact pretreatment staging, and the involvement of heterogeneous populations leading to the awareness that each patient should undergo a tailored therapy in light of the nature of his tumor, its extension and his performance status

The Front-end for the new focal plane detector for the NUMEN project

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Management of osteoporosis in men: A narrative review

Male osteoporosis is a still largely underdiagnosed pathological condition. As a conse-quence, bone fragility in men remains undertreated mainly due to the low screening frequency and to controversies in the bone mineral density (BMD) testing standards. Up to the 40% of overall osteo-porotic fractures affect men, in spite of the fact that women have a significant higher prevalence of osteoporosis. In addition, in males, hip fractures are associated with increased morbidity and mortality as compared to women. Importantly, male fractures occur about 10 years later in life than women, and, therefore, due to the advanced age, men may have more comorbidities and, consequently, their mortality is about twice the rate in women. Gender differences, which begin during puberty, lead to wider bones in males as compared with females. In men, follicle-stimulating hormones, testosterone, estrogens, and sex hormone-binding levels, together with genetic factors, interact in determining the peak of bone mass, BMD maintenance, and lifetime decrease. As compared with women, men are more frequently affected by secondary osteoporosis. Therefore, in all osteoporotic men, a complete clinical history should be collected and a careful physical examination should be done, in order to find clues of a possible underlying diseases and, ultimately, to guide laboratory testing. Currently, the pharmacological therapy of male osteoporosis includes aminobisphosphonates, denosumab, and teriparatide. Hypogonadal patients may be treated with testosterone replacement therapy. Given that the fractures related to mortality are higher in men than in women, treating male subjects with osteoporosis is of the utmost importance in clinical practice, as it may impact on mortality even more than in women

AXTAR: Mission Design Concept

The Advanced X-ray Timing Array (AXTAR) is a mission concept for X-ray timing of compact objects that combines very large collecting area, broadband spectral coverage, high time resolution, highly flexible scheduling, and an ability to respond promptly to time-critical targets of opportunity. It is optimized for submillisecond timing of bright Galactic X-ray sources in order to study phenomena at the natural time scales of neutron star surfaces and black hole event horizons, thus probing the physics of ultradense matter, strongly curved spacetimes, and intense magnetic fields. AXTAR's main instrument, the Large Area Timing Array (LATA) is a collimated instrument with 2-50 keV coverage and over 3 square meters effective area. The LATA is made up of an array of supermodules that house 2-mm thick silicon pixel detectors. AXTAR will provide a significant improvement in effective area (a factor of 7 at 4 keV and a factor of 36 at 30 keV) over the RXTE PCA. AXTAR will also carry a sensitive Sky Monitor (SM) that acts as a trigger for pointed observations of X-ray transients in addition to providing high duty cycle monitoring of the X-ray sky. We review the science goals and technical concept for AXTAR and present results from a preliminary mission design study.Comment: 19 pages, 10 figures, to be published in Space Telescopes and Instrumentation 2010: Ultraviolet to Gamma Ray, Proceedings of SPIE Volume 773

Challenges for high rate signal processing for the NUMEN experiment

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Modelación productiva, económica y emisión de metano en sistemas de cría vacuna de Bahía Blanca y Coronel Rosales

El objetivo de este estudio de simulación fue evaluar la respuesta productiva, económica, emisión de metano y el valor marginal del agregado de alimento extra (VMA) en diferentes sistemas la cría vacuna de Bahía Blanca y Coronel Rosales. Se utilizó información regional y un modelo de simulación dinámico bioeconómico y ambiental (SIMUGAN) para evaluar cuatro planteos ganaderos basados en la incorporación tecnológica de pasturas perennes y prácticas de manejo como el tipo de destete: Tradicional (Trad), Transicional 1 (Trans1), Transicional 2 (Trans2) y Tecnificado (Tecn). El aumento en productividad se asoció positivamente con el margen bruto [MB($/ha)=-1488,6+30,2 x producción de carne kg/ha/año, R2 0,99] y con menor intensidad de emisión de metano [IMC(kgCH4 CO2 -e/kg peso vivo producido)=20,4-0,1x producción de carne, R2 0,98]. El VMA ($/KgMS/ha), en calidad de indicador sistémico de oportunidades de suplementación estratégica, fueron mayores en los planteos Trad y Trans1 que en Trans2 y Tecn. En líneas generales, los distintos planteos simulados presentaron un mayor VMA durante las estaciones de invierno y primavera por sobre la distribución anual de alimento extra. El presente análisis integral permitió identificar y cuantificar oportunidades de mejora en la productividad de estos sistemas incorporando pasturas permanentes.The aim of this study was to evaluate the productive, economic, methane emissions performance and the marginal value of additional feed (MVF) for the different cow-calf systems from Bahía Blanca and Coronel Rosales. A dynamic “whole-farm” model (SIMUGAN) and regional data was used to evaluate four cow-calf system scenarios based on changes in pasture area and management policies as the weaning date: Traditional (Trad), Transitional 1 (Trans1), Transitional 2 (Trans2) and High Technology (HTech). The increase in productivity was positively associated with gross margin GM($/ha)=-1488.6+30.2 x beef production, R2 0.99] and negatively associated with methane emission intensity [IMC(kgCH4 CO2 -e/kg live weight produced)= 20.4-0.1 x production, R2 0.98]. The MVF ($/KgMS/ha) is a systemic indicator for strategic supplementation opportunities, and Trad and Trans1 achieved higher values than Trans2 and Tecn. Overall, the scenarios showed higher VMA when during winter and spring seasons, followed by the annual feeding. This global assessment showed positive opportunities for improving system productivity based on perennial pasturesEEA BordenaveFil: Fernandez Rosso, Catalina. Universidad Nacional del Centro de la provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión de Investigaciones Científicas de la provincia de Buenos Aires; Argentina.Universidad Nacional del Centro de la provincia de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Lauric, Miriam Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bordenave. Agencia de Extensión Rural Bahía Blanca; ArgentinaFil: De Leo, Geronimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bordenave. Agencia de Extensión Rural Bahía Blanca; ArgentinaFil: Bilotto, Franco. Universidad Nacional del Centro de la provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión de Investigaciones Científicas de la provincia de Buenos Aires; Argentina.Universidad Nacional del Centro de la provincia de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Torres Carbonell, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bordenave. Agencia de Extensión Rural Bahía Blanca; ArgentinaFil: Machado, Claudio F. Universidad Nacional del Centro de la provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Red Interinstitucional de Modelación Agropecuaria Buenos Aires Sur; Argentin