The 1987 Chesapeake Bay Agreement: A Model of Intergovernmental and Multi-State Cooperation in Estuary/Coastal Resource Management

The 1980s witnessed an increased awareness of the problems of estuary and coastal water pollution. The medical waste problems of 1988 heightened public awareness of this problem and showed that coastal pollution is not just isolated but rather is a regional problem which requires regional solutions. During the 1980x the Environmental Protection Agency (EPA), and the States of Maryland, Virginia, Pennsylvania, and the District of Columbia worked together to forge two agreements, one in 1983, and more significantly a broader agreement in 1987, in which they agreed to work together to develop specific goals and objectives to address and solve the problems confronting Chesapeake Bay. These agreements are significant because the signatories recognized that the Chesapeake Bay\u27s importance and problems transcend regional boundaries and they committed to managing the Chesapeake Bay as an integrated ecosystem. The 1987 Agreement established a framework for governance through the Chesapeake Executive Council and outline 29 specific commitment strategies, and deadlines, to work towards the protection and restoration of the Bay\u27s significant living resources. This landmark agreement established new initiatives and specific goals, deadlines and objectives for addressing key issues such as nutrient and toxic pollution, the decline of the bay\u27s aquatic resources, population growth and land use. All objectives which will set the course of efforts over the next several years

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine

Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate levels in the extrasynaptic space. The existence of extrasynaptic receptors, including metabotropic group II glutamate receptors (mGluR), pose nonvesicular release mechanisms as unrecognized targets capable of contributing to pathological glutamate signaling. We tested the hypothesis that activation of cystine–glutamate antiporters using the cysteine prodrug N-acetylcysteine would blunt psychotomimetic effects in the rodent phencyclidine (PCP) model of schizophrenia. First, we demonstrate that PCP elevates extracellular glutamate in the prefrontal cortex, an effect that is blocked by N-acetylcysteine pretreatment. To determine the relevance of the above finding, we assessed social interaction and found that N-acetylcysteine reverses social withdrawal produced by repeated PCP. In a separate paradigm, acute PCP resulted in working memory deficits assessed using a discrete trial t-maze task, and this effect was also reversed by N-acetylcysteine pretreatment. The capacity of N-acetylcysteine to restore working memory was blocked by infusion of the cystine–glutamate antiporter inhibitor (S)-4-carboxyphenylglycine into the prefrontal cortex or systemic administration of the group II mGluR antagonist LY341495 indicating that the effects of N-acetylcysteine requires cystine–glutamate exchange and group II mGluR activation. Finally, protein levels from postmortem tissue obtained from schizophrenic patients revealed significant changes in the level of xCT, the active subunit for cystine–glutamate exchange, in the dorsolateral prefrontal cortex. These data advance cystine–glutamate antiporters as novel targets capable of reversing the psychotomimetic effects of PCP

Improvement of CO2 retention of PET bottles for carbonated soft drinks

One of the major aims pursued by the carbonated soft drinks industry is to extend the shelf-life of PET-packaged products, in order to guarantee the consumers with the original characteristics and quality. Most of the responsibility in the shelf-life extension of such products has to be attributed to the bottle material performances, such as the barrier properties to gases with special regards for the ability to maintain the internal CO2 through the shelf-life. Tests on carbonated soft drinks bottles are performed at every change (design, volume, etc.) of the package, in order to verify the performances of the new bottle with special regards for the CO2 retention properties. The research aims at the evaluation of new bottles addressed to the packaging of a sugar free and a caffeine free carbonated soft drink (Coca-Cola Light e Coca-Cola Caffeine Free), recently launched on the Italian market. The start of commercialisation for these new products is the result of a project named "Silver and Gold", which takes the name from the new colours of the new bottles. Such bottles are produced using the same PET resin as the standard ones, with the only exception of master batch dyes used in the test materials. The CO2 retention performances of Silver and Gold bottles were investigated in comparison with the standard bottle used as a control. Results showed that CO2 retention was improved in the Silver and Gold bottles, which retained averagely 88% of the initial CO2 level after 14 weeks of storage, approximately 10% more than the standard bottles