Hadronic B and D studies at BABAR

We present new results on hadronic B and D decays from the BABAR experiment. The first part of this document presents searches for new channels which may be used for CP measurements. The second part is dedicated to hadronic decays with tests of QCD factorization predictions and other models for B structure and decay mechanisms. A new result on the reference branching ratio Ds+ -->phi pi+ is also reported.Comment: 4 pages, 1 eps figure, contributed to the proceedings of 40th Rencontres de Moriond QCD 200

Obstacles, levers and impacts of organic farming development in Camargue

We are presenting an analysis of the obstacles and levers for the development of organic cropping systems in Camargue, documented with a multicriteria analysis of scenarios of organic farming (OF) development. This communication is built using results from on-farm agronomic monitoring, stakeholders and farmers’ interviews and the use of models for integrated assessment of scenarios. At the farm level, the obstacles are related to identification of profitable cropping systems and rotations that include enough rice, conversion being therefore risky as impacting financial management and requiring a labour reorganisation. At the regional level, the constraints are related to the absence of advisory services for technical issues, and to the lack of coordination among the different stakeholders, to the low incentive of the public policies to convert, and to a relatively opaque organization of the supply chains. At the regional level, we analysed the consequences of two scenarios related to OF development on criteria such as the rice surface area, the quantity and quality of water, energy consumption or the employment generated. These results are expected to contribute to the definition of an action plan about OF development by the local stakeholders

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs

Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication. We analyse the cellular pathways in which human proviral genes are involved and identify druggable targets. Twenty-one small-molecule inhibitors, some of which are FDA approved, targeting six proviral factors or pathways, have high antiviral activity in vitro, with low toxicity. Three identified inhibitors have prophylactic antiviral effects in mouse models of chikungunya infection. Two of them, the calmodulin inhibitor pimozide and the fatty acid synthesis inhibitor TOFA, have a therapeutic effect in vivo when combined. These results demonstrate the value of loss-of-function screening and pathway analysis for the rational identification of small molecules with therapeutic potential and pave the way for the development of new, host-directed, antiviral agents

Plane waves in periodic, quadratically nonlinear slab waveguides: stability and exact Fourier structure

We consider the propagation of broad optical beams through slab waveguides with a purely quadratic nonlinearity and containing linear and nonlinear long-period quasi-phase-matching gratings. An exact Floquet analysis on the periodic, plane-wave solution shows that the periodicity can drastically alter the growth rate of the modulational instability but that it never completely removes the instability. The results are confirmed by direct numerical simulation, as well as through a simpler, approximate theory for the averaged fields that accurately predicts the low-frequency part of the spectrum.Comment: 10 Pages, 13 figures (some in two parts) new version has some typos removed and extra references and explanation adde

3D time-domain beam mapping for studying nonlinear dynamics in multimode optical fibers

The characterization of the complex spatiotemporal dynamics of optical beam propagation in nonlinear multimode fibers requires the development of advanced measurement methods, capable of capturing the real-time evolution of beam images. We present a new space-time mapping technique, permitting the direct detection, with picosecond temporal resolution, of the intensity from repetitive laser pulses over a grid of spatial samples from a magnified image of the output beam. By using this time-resolved mapping, we provide the first unambiguous experimental observation of instantaneous intrapulse nonlinear coupling processes among the modes of a graded index fiber.Comment: 4 pages, 6 figure

3D time-domain beam mapping for studying nonlinear dynamics in multimode optical fibers

Characterization of the complex spatiotemporal dynamics of optical beam propagation in nonlinear multimode fibers requires the development of advanced measurement methods, capable of capturing the real-time evolution of beam images. We present a new space–time mapping technique, permitting the direct detection, with picosecond temporal resolution, of the intensity from repetitive laser pulses over a grid of spatial samples from a magnified image of the output beam. By using this time-resolved mapping, we provide, to the best of our knowledge, the first unambiguous experimental observation of instantaneous intrapulse nonlinear coupling processes among the modes of a graded index fiber

Spatial beam self-cleaning in second-harmonic generation

We experimentally demonstrate the spatial self-cleaning of a highly multimode optical beam, in the process of second-harmonic generation in a quadratic nonlinear potassium titanyl phosphate crystal. As the beam energy grows larger, the output beam from the crystal evolves from a highly speckled intensity pattern into a single, bell-shaped spot, sitting on a low energy background. We demonstrate that quadratic beam cleanup is accompanied by significant self-focusing of the fundamental beam, for both positive and negative signs of the linear phase mismatch close to the phase-matching condition