3,539 research outputs found
Attitude control system Patent
Development of attitude control system for spacecraft orientatio
Recursive estimation of possibly misspecified MA(1) models: Convergence of a general algorithm
We introduce a recursive algorithm of conveniently general form for
estimating the coefficient of a moving average model of order one and obtain
convergence results for both correct and misspecified MA(1) models. The
algorithm encompasses Pseudolinear Regression (PLR--also referred to as AML and
) and Recursive Maximum Likelihood () without monitoring.
Stimulated by the approach of Hannan (1980), our convergence results are
obtained indirectly by showing that the recursive sequence can be approximated
by a sequence satisfying a recursion of simpler (Robbins-Monro) form for which
convergence results applicable to our situation have recently been obtained.Comment: Published at http://dx.doi.org/10.1214/074921706000000932 in the IMS
Lecture Notes Monograph Series
(http://www.imstat.org/publications/lecnotes.htm) by the Institute of
Mathematical Statistics (http://www.imstat.org
Analysis of Accordion DNA Stretching Revealed by The Gold Cluster Ruler
A promising new method for measuring intramolecular distances in solution
uses small-angle X-ray scattering interference between gold nanocrystal labels
(Mathew-Fenn et al, Science, 322, 446 (2008)). When applied to double stranded
DNA, it revealed that the DNA length fluctuations are strikingly strong and
correlated over at least 80 base pair steps. In other words, the DNA behaves as
accordion bellows, with distant fragments stretching and shrinking concertedly.
This hypothesis, however, disagrees with earlier experimental and computational
observations. This Letter shows that the discrepancy can be rationalized by
taking into account the cluster exclusion volume and assuming a moderate
long-range repulsion between them. The long-range interaction can originate
from an ion exclusion effect and cluster polarization in close proximity to the
DNA surface.Comment: 9 pages, 4 figures, to appear in Phys. Rev.
Income, Gift and Estate Tax Smart Ways to Save for College: Section 529 Plans, ESAs & More
Endosome pH measured in single cells by dual fluorescence flow cytometry: rapid acidification of insulin to pH 6
The acidification of various ligands was measured on a cell by cell basis for cell suspensions by correlated dual fluorescence flow cytometry. Mouse 3T3 cells were incubated with a mixture of fluorescein- and rhodamine-conjugated ligands, and the ratio of fluorescein and rhodamine fluorescence was used as a measure of endosome pH. The calibration of this ratio by both fluorometry and flow cytometry is described. Dual parameter histograms of average endosome pH per cell versus amount of internalization were calculated from this data, for samples in the absence and presence of chloroquine added to neutralize acidic cellular vesicles. The kinetics of acidification of insulin were measured and compared with previous results obtained with the chloroquine ratio technique. Rapid acidification of internalized ligand was observed both for insulin, which was mostly internalized via nonspecific pathways, and for alpha 2-macroglobulin, which was mainly internalized by specific receptor-mediated endocytosis. The average pH observed for internalized insulin was less than pH 6 within 10 min after addition of insulin. At 30 min, the average pH began to decrease to approximately pH 5, presumably because of fusion of endosomes with lysosomes
The Yamabe invariant for axially symmetric two Kerr black holes initial data
An explicit 3-dimensional Riemannian metric is constructed which can be
interpreted as the (conformal) sum of two Kerr black holes with aligned angular
momentum. When the separation distance between them is large we prove that this
metric has positive Ricci scalar and hence positive Yamabe invariant. This
metric can be used to construct axially symmetric initial data for two Kerr
black holes with large angular momentum.Comment: 14 pages, 2 figure
The Effects of Stacking on the Configurations and Elasticity of Single Stranded Nucleic Acids
Stacking interactions in single stranded nucleic acids give rise to
configurations of an annealed rod-coil multiblock copolymer. Theoretical
analysis identifies the resulting signatures for long homopolynucleotides: A
non monotonous dependence of size on temperature, corresponding effects on
cyclization and a plateau in the extension force law. Explicit numerical
results for poly(dA) and poly(rU) are presented.Comment: 4 pages and 2 figures. Accepted in Phys. Rev. E Rapid Com
A variational principle for stationary, axisymmetric solutions of Einstein's equations
Stationary, axisymmetric, vacuum, solutions of Einstein's equations are
obtained as critical points of the total mass among all axisymmetric and
symmetric initial data with fixed angular momentum. In this
variational principle the mass is written as a positive definite integral over
a spacelike hypersurface. It is also proved that if absolute minimum exists
then it is equal to the absolute minimum of the mass among all maximal,
axisymmetric, vacuum, initial data with fixed angular momentum. Arguments are
given to support the conjecture that this minimum exists and is the extreme
Kerr initial data.Comment: 21 page
Reachability in Parametric Interval Markov Chains using Constraints
Parametric Interval Markov Chains (pIMCs) are a specification formalism that
extend Markov Chains (MCs) and Interval Markov Chains (IMCs) by taking into
account imprecision in the transition probability values: transitions in pIMCs
are labeled with parametric intervals of probabilities. In this work, we study
the difference between pIMCs and other Markov Chain abstractions models and
investigate the two usual semantics for IMCs: once-and-for-all and
at-every-step. In particular, we prove that both semantics agree on the
maximal/minimal reachability probabilities of a given IMC. We then investigate
solutions to several parameter synthesis problems in the context of pIMCs --
consistency, qualitative reachability and quantitative reachability -- that
rely on constraint encodings. Finally, we propose a prototype implementation of
our constraint encodings with promising results
Microscopic formulation of the Zimm-Bragg model for the helix-coil transition
A microscopic spin model is proposed for the phenomenological Zimm-Bragg
model for the helix-coil transition in biopolymers. This model is shown to
provide the same thermophysical properties of the original Zimm-Bragg model and
it allows a very convenient framework to compute statistical quantities.
Physical origins of this spin model are made transparent by an exact mapping
into a one-dimensional Ising model with an external field. However, the
dependence on temperature of the reduced external field turns out to differ
from the standard one-dimensional Ising model and hence it gives rise to
different thermophysical properties, despite the exact mapping connecting them.
We discuss how this point has been frequently overlooked in the recent
literature.Comment: 11 pages, 2 figure
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