364 research outputs found
Holographic quenches and fermionic spectral functions
Using holographic methods we investigate the behaviour of fermionic spectral functions of strongly coupled 2+1 dimensional field theories as both temperature and chemical potential are quenched
Assembly of the Inner Perivitelline Layer, a Homo log of the Mammalian Zona Pellucida: An Immunohistochemical and Ultrastructural Study
The avian inner perivitelline layer (IPVL), a homologous structure to the mammalian zona pellucida, is deposited between the granulosa cells and the oocyte cell membrane during folliculogenesis. The glycoprotein meshwork of the IPVL forms a 3-dimensional matrix and possesses important functions in the fertilization process: it contributes to the binding of avian spermatozoa to the oocyte and induces acrosomal exocytosis. In contrast to the zona pellucida of mammals, the IPVL does not prevent the physiological polyspermy found in birds. Previous studies have shown that in the Japanese quail (Cotumix japonica) at least 5 glycoproteins are constituents of the IPVL (ZP1, ZP2, ZP3, ZP4, and ZPD). In this study, we investigated the spatiotennporal assembly pattern of the IPVL during folliculogenesis using immunohistochemical and ultrastructural methods. The obtained results clearly show that these glycoproteins are incorporated into the IPVL at distinct points during follicular development, supporting the hypothesis that ZP2 and ZP4 form a type of prematrix into which ZP1, ZP3, and ZPD are integrated at a later stage of development. Copyright (C) 2011 S. Karger AG, Base
MRD codes with maximum idealizers
Left and right idealizers are important invariants of linear rank-distance
codes. In the case of maximum rank-distance (MRD for short) codes in
the idealizers have been proved to be isomorphic to
finite fields of size at most . Up to now, the only known MRD codes with
maximum left and right idealizers are generalized Gabidulin codes, which were
first constructed in 1978 by Delsarte and later generalized by Kshevetskiy and
Gabidulin in 2005. In this paper we classify MRD codes in
for with maximum left and right idealizers
and connect them to Moore-type matrices. Apart from generalized Gabidulin
codes, it turns out that there is a further family of rank-distance codes
providing MRD ones with maximum idealizers for , odd and for ,
. These codes are not equivalent to any previously known MRD
code. Moreover, we show that this family of rank-distance codes does not
provide any further examples for .Comment: Reviewers' comments implemented, we changed the titl
Inverse magnetic catalysis in field theory and gauge-gravity duality
We investigate the surface of the chiral phase transition in the
three-dimensional parameter space of temperature, baryon chemical potential and
magnetic field in two different approaches, the field-theoretical
Nambu-Jona-Lasinio (NJL) model and the holographic Sakai-Sugimoto model. The
latter is a top-down approach to a gravity dual of QCD with an asymptotically
large number of colors and becomes, in a certain limit, dual to an NJL-like
model. Our main observation is that, at nonzero chemical potential, a magnetic
field can restore chiral symmetry, in apparent contrast to the phenomenon of
magnetic catalysis. This "inverse magnetic catalysis" occurs in the
Sakai-Sugimoto model and, for sufficiently large coupling, in the NJL model and
is related to the physics of the lowest Landau level. While in most parts our
discussion is a pedagogical review of previously published results, we include
new analytical results for the NJL approach and a thorough comparison of
inverse magnetic catalysis in the two approaches.Comment: 37 pages, 11 figures, to appear in Lect. Notes Phys. "Strongly
interacting matter in magnetic fields" (Springer), edited by D. Kharzeev, K.
Landsteiner, A. Schmitt, H.-U. Ye
Holographic rho mesons in an external magnetic field
We study the rho meson in a uniform magnetic field eB using a holographic
QCD-model, more specifically a D4/D8/Dbar8 brane setup in the confinement phase
at zero temperature with two quenched flavours. The parameters of the model are
fixed by matching to corresponding dual field theory parameters at zero
magnetic field. We show that the up- and down-flavour branes respond
differently to the presence of the magnetic field in the dual QCD-like theory,
as expected because of the different electromagnetic charge carried by up- and
down-quark. We discuss how to recover the Landau levels, indicating an
instability of the QCD vacuum at eB = m_rho^2 towards a phase where charged rho
mesons are condensed, as predicted by Chernodub using effective QCD-models. We
improve on these existing effective QCD-model analyses by also taking into
account the chiral magnetic catalysis effect, which tells us that the
constituent quark masses rise with eB. This turns out to increase the value of
the critical magnetic field for the onset of rho meson condensation to eB = 1.1
m_rho^2 = 0.67 GeV^2. We briefly discuss the influence of pions, which turn out
to be irrelevant for the condensation in the approximation made.Comment: 26 pages, 10 .pdf figures, v2: version accepted for publication in
JHE
The emerging structure of the Extended Evolutionary Synthesis: where does Evo-Devo fit in?
The Extended Evolutionary Synthesis (EES) debate is gaining ground in contemporary evolutionary biology. In parallel, a number of philosophical standpoints have emerged in an attempt to clarify what exactly is represented by the EES. For Massimo Pigliucci, we are in the wake of the newest instantiation of a persisting Kuhnian paradigm; in contrast, Telmo Pievani has contended that the transition to an EES could be best represented as a progressive reformation of a prior Lakatosian scientific research program, with the extension of its Neo-Darwinian core and the addition of a brand-new protective belt of assumptions and auxiliary hypotheses. Here, we argue that those philosophical vantage points are not the only ways to interpret what current proposals to ‘extend’ the Modern Synthesis-derived ‘standard evolutionary theory’ (SET) entail in terms of theoretical change in evolutionary biology. We specifically propose the image of the emergent EES as a vast network of models and interweaved representations that, instantiated in diverse practices, are connected and related in multiple ways. Under that assumption, the EES could be articulated around a paraconsistent network of evolutionary theories (including some elements of the SET), as well as models, practices and representation systems of contemporary evolutionary biology, with edges and nodes that change their position and centrality as a consequence of the co-construction and stabilization of facts and historical discussions revolving around the epistemic goals of this area of the life sciences. We then critically examine the purported structure of the EES—published by Laland and collaborators in 2015—in light of our own network-based proposal. Finally, we consider which epistemic units of Evo-Devo are present or still missing from the EES, in preparation for further analyses of the topic of explanatory integration in this conceptual framework
C-Terminal Mutants of Apolipoprotein L-I Efficiently Kill Both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T. brucei subspecies rhodesiense and gambiense resist this lytic activity and can infect humans, causing sleeping sickness. In the case of T. b. rhodesiense, resistance to lysis involves interaction of the Serum Resistance-Associated (SRA) protein with the C-terminal helix of apoL1. We undertook a mutational and deletional analysis of the C-terminal helix of apoL1 to investigate the linkage between interaction with SRA and lytic potential for different T. brucei subspecies. We confirm that the C-terminal helix is the SRA-interacting domain. Although in E. coli this domain was dispensable for ionic pore-forming activity, its interaction with SRA resulted in inhibition of this activity. Different mutations affecting the C-terminal helix reduced the interaction of apoL1 with SRA. However, mutants in the L370-L392 leucine zipper also lost in vitro trypanolytic activity. Truncating and/or mutating the C-terminal sequence of human apoL1 like that of apoL1-like sequences of Papio anubis resulted in both loss of interaction with SRA and acquired ability to efficiently kill human serum-resistant T. b. rhodesiense parasites, in vitro as well as in transgenic mice. These findings demonstrate that SRA interaction with the C-terminal helix of apoL1 inhibits its pore-forming activity and determines resistance of T. b. rhodesiense to human serum. In addition, they provide a possible explanation for the ability of Papio serum to kill T. b. rhodesiense, and offer a perspective to generate transgenic cattle resistant to both T. b. brucei and T. b. rhodesiense
A Review of Magnetic Phenomena in Probe-Brane Holographic Matter
Gauge/gravity duality is a useful and efficient tool for addressing and
studying questions related to strongly interacting systems described by a gauge
theory. In this manuscript we will review a number of interesting phenomena
that occur in such systems when a background magnetic field is turned on.
Specifically, we will discuss holographic models for systems that include
matter fields in the fundamental representation of the gauge group, which are
incorporated by adding probe branes into the gravitational background dual to
the gauge theory. We include three models in this review: the D3-D7 and D4-D8
models, that describe four-dimensional systems, and the D3-D7' model, that
describes three-dimensional fermions interacting with a four-dimensional gauge
field.Comment: 35 pages, 27 figures, to appear in Lect. Notes Phys. "Strongly
interacting matter in magnetic fields" (Springer), edited by D. Kharzeev, K.
Landsteiner, A. Schmitt, H.-U. Yee; references adde
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