3,636 research outputs found
Emergence Patterns of Delia radicum (Diptera: Anthomyiidae) Populations from North Carolina and New York
Cabbage maggot, Delia radicum (L.), populations from North Carolina (Fletcher and Scaly Mountain) and New York (Geneva and Highland) were surveyed to detect differences in the emergence pattern of flies from overwintered pupae. Populations from all locations consisted of different proportions of early- and later-emerging individuals. However, populations from New York consisted predominately of early-emerging individuals (≥90%), whereas populations from North Carolina were composed of a higher percentage of later-emerging individuals. Emergence patterns of F1 progeny from crosses between early- and later-emerging flies from Scaly Mountain demonstrated that emergence traits were genetically controlled. D. radicum phenology studies in North Carolina suggested that temporal isolation of the two types was halted by an extended period of aestivation during the summer months, which subsequently allowed the two populations to interbreed during the autumn months. The relative proportion of early:late emergers appears to be unstable over time, which may be due to differential mortality factors operating when populations are temporally isolated or due to dominance or recessive factors governing earliness or lateness, or bot
Lower Limb Radiology of Distal Myopathy due to the S60F Myotilin Mutation
Distal myopathies are a clinically and genetically heterogenous group of disorders in which the distal limb musculature is selectively or disproportionately affected. Precisely defining specific categories is a challenge because of overlapping clinical phenotypes, making it difficult to decide which of the many known causative genes to screen in individual cases. In this study we define the distinguishing magnetic resonance imaging findings in myotilin myopathy by studying 8 genealogically unrelated cases due to the same point mutation in TTID. Proximally, the vastii, biceps femoris and semimembranosus were involved with sparing of gracilis and sartorius. Distally, soleus, gastrocnemius, tibialis anterior, extensor hallicus and extensor digitorum were involved. This pattern contrasts with other distal myopathies and provides further support for the role of imaging in the clinical investigation of muscle disease. Copyright (C) 2009 S. Karger AG, Base
A new two-strip TLC method for the quality control of technetium-99m mercaptoacetyl-triglycine (<sup>99m</sup>Tc-MAG3).
<sup>99m</sup> Tc-mercaptoacetyl-triglycine ( <sup>99m</sup> Tc-MAG3) has been used for dynamic renal imaging since about 30 years. Free pertechnetate ( <sup>99m</sup> TcO <sub>4</sub> ), colloidal <sup>99m</sup> Tc (( <sup>99m</sup> TcO <sub>2</sub> ) <sub>n</sub> ), <sup>99m</sup> Tc-tartrate (precursor), precomplexes ( <sup>99m</sup> Tc-(MAG3) <sub>x</sub> ) and lipophilic <sup>99m</sup> Tc-MAG2 are the main radiochemical impurities that may occur in the preparation. The total amount of these impurities has to be identified before release of the product for patient administration to guarantee patient safety and good image quality. The European Pharmacopoeia suggests a method based on high-pressure liquid chromatography analysis in combination with a paper chromatography. This analytical method is time consuming, expensive and requires specially trained technicians. As a consequence, it is not widely applied in nuclear medicine radiopharmacies.
We developed a simple method for radiochemical purity testing of <sup>99m</sup> Tc-MAG3. The method is based on thin layer chromatography with two strips to be developed in parallel. Method validation was carried out in comparison to the official methods of the companies and to the European Pharmacopoeia method. It was tested on specificity, accuracy, robustness and precision.
The proposed method is able to identify and quantify the sum of all impurities occurring in the preparation, respecting the acceptance criteria for the radiochemical purity defined by the official methods. Hydrophilic and lipophilic compounds are identified separately and results are obtained within less than 20 minutes. Our method is simple, cost effective, fast and is suitable for employing dose calibrators or radiometric scanners
Gene therapy in Duchenne muscular dystrophy: Identifying and preparing for the challenges ahead
Production of 26Al in stellar hydrogen-burning environments: spectroscopic properties of states in 27Si
Model predictions of the amount of the radioisotope 26Al produced in
hydrogen-burning environments require reliable estimates of the thermonuclear
rates for the 26gAl(p,{\gamma})27Si and 26mAl(p,{\gamma})27Si reactions. These
rates depend upon the spectroscopic properties of states in 27Si within about 1
MeV of the 26gAl+p threshold (Sp = 7463 keV). We have studied the
28Si(3He,{\alpha})27Si reaction at 25 MeV using a high-resolution
quadrupole-dipole-dipole-dipole magnetic spectrograph. For the first time with
a transfer reaction, we have constrained J{\pi} values for states in 27Si over
Ex = 7.0 - 8.1 MeV through angular distribution measurements. Aside from a few
important cases, we generally confirm the energies and spin-parity assignments
reported in a recent {\gamma}-ray spectroscopy study. The magnitudes of neutron
spectroscopic factors determined from shell-model calculations are in
reasonable agreement with our experimental values extracted using this
reaction.Comment: accepted for publication in Phys. Rev.
Relative Reactivity of the Metal-Amido versus Metal-Imido Bond in Linked Cp-Amido and Half-Sandwich Complexes of Vanadium
Treatment of (η5-C5H4C2H4NR)V(N-t-Bu)Me (R = Me, i-Pr) and CpV(N-p-Tol)(N-i-Pr2)Me (Cp = η5-C5H5) with B(C6F5)3 or [Ph3C][B(C6F5)4] results in formation of the corresponding cations, [(η5-C5H4C2H4NR)V(N-t-Bu)]+ and [CpV(N-p-Tol)(N-i-Pr2)]+. The latter could also be generated as its N,N-dimethylaniline adduct by treatment of the methyl complex with [PhNMe2H][BAr4] (Ar = Ph, C6F5). Instead, the analogous reaction with the linked Cp-amido precursor results in protonation of the imido-nitrogen atom. Sequential cyclometalation of the amide substituents gave cationic imine complexes [(η5-C5H4C2H4NCR'2)V(NH-t-Bu)]+ (R' = H, Me) and methane. Reaction of cationic [(η5-C5H4C2H4NR)V(N-t-Bu)]+ with olefins affords the corresponding olefin adducts, whereas treatment with 1 or 2 equiv of 2-butyne results in insertion of the alkyne into the vanadium-nitrogen single bond, affording the mono- and bis-insertion products [(η5-C5H4C2H4N(i-Pr)C2Me2)V(N-t-Bu)]+ and [(η5-C5H4C2H4N(i-Pr)C4Me4)V(N-t-Bu)]+. The same reaction with the half-sandwich compound [CpV(N-p-Tol)(N-i-Pr2)]+ results in a paramagnetic compound that, upon alcoholysis, affords sec-butylidene-p-tolylamine, suggesting an initial [2+2] cycloaddition reaction. The difference in reactivity between the V-N bond versus the V=N bond was further studied using computational methods. Results were compared to the isoelectronic titanium system CpTi(NH)(NH2). These studies indicate that the kinetic product in each system is derived from a [2+2] cycloaddition reaction. For titanium, this was found as the thermodynamic product as well, whereas the insertion reaction was found to be thermodynamically more favorable in the case of vanadium.
Thin Disk Theory with a Non-Zero Torque Boundary Condition and Comparisons with Simulations
We present an analytical solution for thin disk accretion onto a Kerr black
hole that extends the standard Novikov-Thorne alpha-disk in three ways: (i) it
incorporates nonzero stresses at the inner edge of the disk, (ii) it extends
into the plunging region, and (iii) it uses a corrected vertical gravity
formula. The free parameters of the model are unchanged. Nonzero boundary
stresses are included by replacing the Novikov-Thorne no torque boundary
condition with the less strict requirement that the fluid velocity at the
innermost stable circular orbit is the sound speed, which numerical models show
to be the correct behavior for luminosities below ~30% Eddington. We assume the
disk is thin so we can ignore advection. Boundary stresses scale as alpha*h and
advection terms scale as h^2 (where h is the disk opening angle (h=H/r)), so
the model is self-consistent when h < alpha. We compare our solution with slim
disk models and general relativistic magnetohydrodynamic disk simulations. The
model may improve the accuracy of black hole spin measurements.Comment: 11 pages, 8 figures, MNRAS accepte
100- kyr cyclicity in volcanic ash emplacement: evidence from a 1.1 Myr tephra record from the NW Pacific
It is a longstanding observation that the frequency of volcanism periodically changes at times of global climate change. The existence of causal links between volcanism and Earth’s climate remains highly controversial, partly because most related studies only cover one glacial cycle. Longer records are available from marine sediment profiles in which the distribution of tephras records frequency changes of explosive arc volcanism with high resolution and time precision. Here we show that tephras of IODP Hole U1437B (northwest Pacific) record a cyclicity of explosive volcanism within the last 1.1 Myr. A spectral analysis of the dataset yields a statistically significant spectral peak at the ~100 kyr period, which dominates the global climate cycles since the Middle Pleistocene. A time-domain analysis of the entire eruption and δ18O record of benthic foraminifera as climate/sea level proxy shows that volcanism peaks after the glacial maximum and ∼13 ± 2 kyr before the δ18O minimum right at the glacial/interglacial transition. The correlation is especially good for the last 0.7 Myr. For the period 0.7–1.1 Ma, during the Middle Pleistocene Transition (MPT), the correlation is weaker, since the 100 kyr periodicity in the δ18O record diminishes, while the tephra record maintains its strong 100 kyr periodicity
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