465 research outputs found
Etanercept leads to a rapid recovery of a Dabrafenibâ/Trametinibâassociated toxic epidermal necrolysisâlike severe skin reaction
Targeted therapy with BRAFâ and MEKâInhibitors (BRAFi, MEKi) provides
an excellent therapeutic option for patients with malignant melanomas with
a BRAFâMutation. Mild cutaneous adverse events have been common
under the BRAFâ and MEKâInhibitor therapy, on the contrary, severe cutaneous adverse reactions to drugs (SCARs) are rarely reported. We present
the case of a 59â yearâold female patient who after the resection of cutaneous inâtransit metastases of a malignant melanoma received one adjuvant cycle of Nivolumab followed by a switch of the therapy to an oral
BRAFi/MEKi therapy. 3â4 Weeks after the therapy switch she developed
high fever, chills, progredient general weakness, headaches, abdominal
complaints, generalised rash as well as thrombocytopaenia, eosinophilia,
elevated liver enzymes, declining kidney, and pulmonary function as well as
a maculopapular exanthema. She was diagnosed with drug reaction with
eosinophilia and systemic symptoms (DRESS) and quickly started recovery
after initiation of a high steroid substitution. Under steroid dose reduction,
the exanthema worsened and toxic epidermal necrolysis (TEN) was histologically diagnosed. After a series of unsuccessful therapeutic approaches
(high dose steroid, human immunoglobulins and ciclosporin) the patient
received a single dose of the TNFâalpha inhibitor etanercept, which led to a
quick recovery. This case demonstrates that DRESS and TEN can present
a spectrum of possibly transitioning SCARs providing a diagnostic and
therapeutic challenge. Nevertheless, in a such complicated therapeutic
setting, etanercept may be lifesaving even after multiple previous unsuccessful therapies. This effective approach provides evidence SCARs due to
BRAF/MEK targeted therapy may be driven by TNFâalpha
Transport Coefficients from Large Deviation Functions
We describe a method for computing transport coefficients from the direct
evaluation of large deviation function. This method is general, relying on only
equilibrium fluctuations, and is statistically efficient, employing trajectory
based importance sampling. Equilibrium fluctuations of molecular currents are
characterized by their large deviation functions, which is a scaled cumulant
generating function analogous to the free energy. A diffusion Monte Carlo
algorithm is used to evaluate the large deviation functions, from which
arbitrary transport coefficients are derivable. We find significant statistical
improvement over traditional Green-Kubo based calculations. The systematic and
statistical errors of this method are analyzed in the context of specific
transport coefficient calculations, including the shear viscosity, interfacial
friction coefficient, and thermal conductivity.Comment: 11 pages, 5 figure
Role of dimensionality in the Kondo CeT X-2 family: the case of CeCd0.7Sb2
FAPESP - FUNDAĂĂO DE AMPARO Ă PESQUISA DO ESTADO DE SĂO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTĂFICO E TECNOLĂGICOCAPES - COORDENAĂĂO DE APERFEIĂOAMENTO DE PESSOAL DE NĂVEL SUPERIORMotivated by the presence of competing magnetic interactions in the heavy fermion family CeT X-2 (T = transition metal, X = pnictogen), here we study the novel parent compound CeCd0.7Sb2 by combining magnetization, electrical resistivity, and heat-capacity measurements. Contrary to the antiferromagnetic (AFM) ground state observed in most members of this family, the magnetic properties of our CeCd0.7Sb2 single crystals revealed a ferromagnetic ordering at T-c = 3 K with an unusual soft behavior. By using a mean field model including anisotropic nearest-neighbor interactions and the tetragonal crystalline electric field (CEF) Hamiltonian, a systematic analysis of our macroscopic data was obtained. Our fits allowed us to extract a simple but very distinct CEF scheme, as compared to the AFM counterparts. As in the previously studied ferromagnet CeAgSb2, a pure vertical bar +/- 1/2 > ground state is realized, hinting at a general trend within the ferromagnetic members. More generally, we propose a scenario for the understanding of the magnetism in this family of compounds based on the subtle changes of dimensionality in the crystal structure.Motivated by the presence of competing magnetic interactions in the heavy fermion family CeT X-2 (T = transition metal, X = pnictogen), here we study the novel parent compound CeCd0.7Sb2 by combining magnetization, electrical resistivity, and heat-capacity measurements. Contrary to the antiferromagnetic (AFM) ground state observed in most members of this family, the magnetic properties of our CeCd0.7Sb2 single crystals revealed a ferromagnetic ordering at T-c = 3 K with an unusual soft behavior. By using a mean field model including anisotropic nearest-neighbor interactions and the tetragonal crystalline electric field (CEF) Hamiltonian, a systematic analysis of our macroscopic data was obtained. Our fits allowed us to extract a simple but very distinct CEF scheme, as compared to the AFM counterparts. As in the previously studied ferromagnet CeAgSb2, a pure vertical bar +/- 1/2 > ground state is realized, hinting at a general trend within the ferromagnetic members. More generally, we propose a scenario for the understanding of the magnetism in this family of compounds based on the subtle changes of dimensionality in the crystal structure.921316FAPESP - FUNDAĂĂO DE AMPARO Ă PESQUISA DO ESTADO DE SĂO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTĂFICO E TECNOLĂGICOCAPES - COORDENAĂĂO DE APERFEIĂOAMENTO DE PESSOAL DE NĂVEL SUPERIORFAPESP - FUNDAĂĂO DE AMPARO Ă PESQUISA DO ESTADO DE SĂO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTĂFICO E TECNOLĂGICOCAPES - COORDENAĂĂO DE APERFEIĂOAMENTO DE PESSOAL DE NĂVEL SUPERIORFAPESP [2013/17427-7, 2013/20181-0, 2012/04870-7]2012/04870-7, 2013/17427-7, 2013/20181-0Sem informaçãoSem informaçã
Summary of the performances of the superconducting electron cyclotron resonance ion source at 14 GHz
This article deals with the most recent performance of the superconducting electron cyclotron resonance ion source (SERSE) working at 14 GHz with high magnetic fields after the required conditioning and optimization of several operating parameters. SERSE has now achieved an outstanding level of performance in delivering highly charged ion beams in argon and oxygen gases: the results obtained while operating in a stainless steel chamber and with an aluminum liner are shown and discussed
Groundwater ages, recharge conditions and hydrochemical evolution of a barrier island freshwater lens (Spiekeroog, Northern Germany)
Freshwater lenses below barrier islands are dynamic systems affected by changes in morphodynamic
patterns, groundwater recharge and discharge. They are also vulnerable to pollution and overabstraction
of groundwater. Basic knowledge on hydrogeological and hydrochemical processes of freshwater lenses
is important to ensure a sustainable water management, especially when taking into account possible
effects of climate change. This is the first study which gives a compact overview on the age distribution,
recharge conditions and hydrochemical evolution of a barrier island freshwater lens in the southern
North Sea (Spiekeroog Island, Eastfrisian Wadden Sea). Two ground- and surface water sampling campaigns
were carried out in May and July 2011, supplemented by monthly precipitation sampling from
July to October. 3Hâ3He ages, stable oxygen and hydrogen isotopes and major ion concentrations show
that the freshwater lens reaches a depth of 44 mbsl, where an aquitard constrains further expansion in
vertical direction. Groundwater ages are increasing from 4.4 years in 12 mbsl up to >70 years at the freshwaterâ
saltwater interface. Stable isotope signatures reflect average local precipitation signatures. An
annual recharge rate of 300â400 mm was calculated with 3Hâ3He data. Freshwater is primarily of
NaâCaâMgâHCO3â and CaâNaâHCO3âCl type, while lowly mineralized precipitation and saltwater are
of NaâCl types. A trend towards heavier stable isotope signatures and higher electric conductivities in
the shallower, younger groundwater within the freshwater lens may indicate increasing atmospheric
temperatures in the last 30 years
Ready, Set, BABY Live Virtual Prenatal Breastfeeding Education for COVID-19
The COVID-19 pandemic has introduced unforeseen challenges
in the delivery of lactation training, education, and
skilled support worldwide. The World Health Organization
(WHO) has developed global recommendations for the protection,
promotion, and support of breastfeeding when
COVID-19 is suspected or confirmed (World Health
Organization, 2020). This interim guidance, which is
grounded in the best available clinical evidence and epidemiology,
brings attention to the importance of integrating
breastfeeding education and skilled lactation support into the
COVID-19 pandemic response (Gribble, 2018; UNICEF,
2020)
Shopping for Ecological Indices? On the Use of Incidence-Based Species Compositional Similarity Measures
β-diversity has been under continuous debate, with a current need to better understand the way in which a new wave of measures work. We assessed the results of 12 incidence-based β-diversity indices. Our results of gradual species composition overlap between paired assemblages considering progressive differences in species richness show the following: (i) four indices (β-2, β-3, β-3.s, and βr) should be used cautiously given that results with no shared species retrieve results that could be misinterpreted; (ii) all measures conceived specifically as partitioned components of species compositional dissimilarities ought to be used as such and not as independent measures per se; (iii) the non-linear response of some indices to gradual species composition overlap should be interpreted carefully, and further analysis using their results as dependent variables should be performed cautiously; and (iv) two metrics (βsim and βsor) behave predictably and linearly to gradual species composition overlap. We encourage ecologists using measures of β-diversity to fully understand their mathematical nature and type of results under the scenario to be used in order to avoid inappropriate and misleading inferences
Shopping for Ecological Indices? On the Use of Incidence-Based Species Compositional Similarity Measures
β-diversity has been under continuous debate, with a current need to better understand the way in which a new wave of measures work. We assessed the results of 12 incidence-based β-diversity indices. Our results of gradual species composition overlap between paired assemblages considering progressive differences in species richness show the following: (i) four indices (β-2, β-3, β-3.s, and βr) should be used cautiously given that results with no shared species retrieve results that could be misinterpreted; (ii) all measures conceived specifically as partitioned components of species compositional dissimilarities ought to be used as such and not as independent measures per se; (iii) the non-linear response of some indices to gradual species composition overlap should be interpreted carefully, and further analysis using their results as dependent variables should be performed cautiously; and (iv) two metrics (βsim and βsor) behave predictably and linearly to gradual species composition overlap. We encourage ecologists using measures of β-diversity to fully understand their mathematical nature and type of results under the scenario to be used in order to avoid inappropriate and misleading inferences
- âŚ