386 research outputs found
Simultaneous Border-Collision and Period-Doubling Bifurcations
We unfold the codimension-two simultaneous occurrence of a border-collision
bifurcation and a period-doubling bifurcation for a general piecewise-smooth,
continuous map. We find that, with sufficient non-degeneracy conditions, a
locus of period-doubling bifurcations emanates non-tangentially from a locus of
border-collision bifurcations. The corresponding period-doubled solution
undergoes a border-collision bifurcation along a curve emanating from the
codimension-two point and tangent to the period-doubling locus here. In the
case that the map is one-dimensional local dynamics are completely classified;
in particular, we give conditions that ensure chaos.Comment: 22 pages; 5 figure
Neumark Operators and Sharp Reconstructions, the finite dimensional case
A commutative POV measure with real spectrum is characterized by the
existence of a PV measure (the sharp reconstruction of ) with real
spectrum such that can be interpreted as a randomization of . This paper
focuses on the relationships between this characterization of commutative POV
measures and Neumark's extension theorem. In particular, we show that in the
finite dimensional case there exists a relation between the Neumark operator
corresponding to the extension of and the sharp reconstruction of . The
relevance of this result to the theory of non-ideal quantum measurement and to
the definition of unsharpness is analyzed.Comment: 37 page
Spreading of a Macroscopic Lattice Gas
We present a simple mechanical model for dynamic wetting phenomena. Metallic
balls spread along a periodically corrugated surface simulating molecules of
liquid advancing along a solid substrate. A vertical stack of balls mimics a
liquid droplet. Stochastic motion of the balls, driven by mechanical vibration
of the corrugated surface, induces diffusional motion. Simple theoretical
estimates are introduced and agree with the results of the analog experiments,
with numerical simulation, and with experimental data for microscopic spreading
dynamics.Comment: 19 pages, LaTeX, 9 Postscript figures, to be published in Phy. Rev. E
(September,1966
Brain\u2013Computer Interface-Based Adaptive Automation to Prevent Out-Of-The-Loop Phenomenon in Air Traffic Controllers Dealing With Highly Automated Systems
Increasing the level of automation in air traffic management is seen as a measure to increase the performance of the service to satisfy the predicted future demand. This is expected to result in new roles for the human operator: he will mainly monitor highly automated systems and seldom intervene. Therefore, air traffic controllers (ATCos) would often work in a supervisory or control mode rather than in a direct operating mode. However, it has been demonstrated how human operators in such a role are affected by human performance issues, known as Out-Of-The-Loop (OOTL) phenomenon, consisting in lack of attention, loss of situational awareness and de-skilling. A countermeasure to this phenomenon has been identified in the adaptive automation (AA), i.e., a system able to allocate the operative tasks to the machine or to the operator depending on their needs. In this context, psychophysiological measures have been highlighted as powerful tool to provide a reliable, unobtrusive and real-time assessment of the ATCo's mental state to be used as control logic for AA-based systems. In this paper, it is presented the so-called "Vigilance and Attention Controller", a system based on electroencephalography (EEG) and eye-tracking (ET) techniques, aimed to assess in real time the vigilance level of an ATCo dealing with a highly automated human-machine interface and to use this measure to adapt the level of automation of the interface itself. The system has been tested on 14 professional ATCos performing two highly realistic scenarios, one with the system disabled and one with the system enabled. The results confirmed that (i) long high automated tasks induce vigilance decreasing and OOTL-related phenomena; (ii) EEG measures are sensitive to these kinds of mental impairments; and (iii) AA was able to counteract this negative effect by keeping the ATCo more involved within the operative task. The results were confirmed by EEG and ET measures as well as by performance and subjective ones, providing a clear example of potential applications and related benefits of AA
Cross-Reactive Human IgM-Derived Monoclonal Antibodies that Bind to HIV-1 Envelope Glycoproteins
Elicitation of antibodies with potent and broad neutralizing activity against HIV by immunization remains a challenge. Several monoclonal antibodies (mAbs) isolated from humans with HIV-1 infection exhibit such activity but vaccine immunogens based on structures containing their epitopes have not been successful for their elicitation. All known broadly neutralizing mAbs (bnmAbs) are immunoglobulin (Ig) Gs (IgGs) and highly somatically hypermutated which could impede their elicitation. Ig Ms (IgMs) are on average significantly less divergent from germline antibodies and are relevant for the development of vaccine immunogens but are underexplored compared to IgGs. Here we describe the identification and characterization of several human IgM-derived mAbs against HIV-1 which were selected from a large phage-displayed naive human antibody library constructed from blood, lymph nodes and spleens of 59 healthy donors. These antibodies bound with high affinity to recombinant envelope glycoproteins (gp140s, Envs) of HIV-1 isolates from different clades. They enhanced or did not neutralize infection by some of the HIV-1 primary isolates using CCR5 as a coreceptor but neutralized all CXCR4 isolates tested although weakly. One of these antibodies with relatively low degree of somatic hypermutation was more extensively characterized. It bound to a highly conserved region partially overlapping with the coreceptor binding site and close to but not overlapping with the CD4 binding site. These results suggest the existence of conserved structures that could direct the immune response to non-neutralizing or even enhancing antibodies which may represent a strategy used by the virus to escape neutralizing immune responses. Further studies will show whether such a strategy plays a role in HIV infection of humans, how important that role could be, and what the mechanisms of infection enhancement are. The newly identified mAbs could be used as reagents to further characterize conserved non-neutralizing, weakly neutralizing or enhancing epitopes and modify or remove them from candidate vaccine immunogens
Visuospatial exploration and art therapy intervention in patients with Parkinson's disease: an exploratory therapeutic protocol
Abstract Though abnormalities of visuospatial function occur in Parkinson's disease, the impact of such deficits on functional independence and psychological wellbeing has been historically under- recognized, and effective treatments for this impairment are unknown. These symptoms can be encountered at any stage of the disease, affecting many activities of daily living, and negatively influencing mood, self-efficacy, independence, and overall quality of life. Furthermore, visuospatial dysfunction has been recently linked to gait impairment and falls, symptoms that are known to be poor prognostic factors. Here, we aim to present an original modality of neurorehabilitation designed to address visuospatial dysfunction and related symptoms in Parkinson's disease, known as "Art Therapy". Art creation relies on sophisticated neurologic mechanisms including shape recognition, motion perception, sensory-motor integration, abstraction, and eye-hand coordination. Furthermore, art therapy may enable subjects with disability to understand their emotions and express them through artistic creation and creative thinking, thus promoting self-awareness, relaxation, confidence and self-efficacy. The potential impact of this intervention on visuospatial dysfunction will be assessed by means of combined clinical, behavioral, gait kinematic, neuroimaging and eye tracking analyses. Potential favorable outcomes may drive further trials validating this novel paradigm of neurorehabilitation
Cognitive Information Processing
Contains reports on four research projects.National Science Foundation (Grant SED76-81985)Associated Press (Grant)Providence Gravure, Inc. (Grant)Taylor Publishing Company (Grant
Cognitive Information Processing
Contains reports on four research projects.Associated Press (Grant)Providence Gravure, Inc. (Grant)Taylor Publishing Company (Grant
Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia
In schizophrenia (SCZ), higher angiotensin I-converting enzyme (ACE) levels have been reported in patient's blood and cerebrospinal fluid (CSF). Hereby, we propose to explore whether the ACE activity levels are associated to cognitive performance in SCZ. Seventy-two patients with SCZ or schizoaffective disorder diagnosis, and 69 healthy controls (HCs) underwent a cognitive battery with parallel collection of peripheral blood samples to measure ACE activity. Significant higher ACE activity levels were confirmed in the plasma of SCZ patients compared with HCs (Student's t=−5.216; P<0.001). ACE activity significantly correlated to Hopkins delayed recall measures (r=−0.247; P=0.004) and Hopkins total (r=−0.214; P=0.012). Subjects grouped as high ACE activity (above average) had worse performance compared with low ACE activity level group for Hopkins delayed recall measure, even after correction for clinical condition, age, gender and years of education (P=0.029). The adjusted R squared for this final model was 0.343. This result was evident only comparing extreme groups for ACE activity, when splitting the sample in three groups with similar number of subjects. To clarify this finding, we performed an evaluation of the cognitive performance of transgenic mice with three copies of ACE gene in novel object recognition (NOR) test, which showed that such animals presented impairment in NOR (P<0.05) compared with two copies of wild-type animals. The results observed in SCZ patients and animal model suggest both the association of ACE to cognitive deficits in SCZ. This finding may support the evaluation of novel treatment protocols and/or of innovative drugs for specific intervention of cognitive deficits in SCZ envisioning concomitant ACE activity and behavior evaluations
Bohrification of operator algebras and quantum logic
Following Birkhoff and von Neumann, quantum logic has traditionally been
based on the lattice of closed linear subspaces of some Hilbert space, or, more
generally, on the lattice of projections in a von Neumann algebra A.
Unfortunately, the logical interpretation of these lattices is impaired by
their nondistributivity and by various other problems. We show that a possible
resolution of these difficulties, suggested by the ideas of Bohr, emerges if
instead of single projections one considers elementary propositions to be
families of projections indexed by a partially ordered set C(A) of appropriate
commutative subalgebras of A. In fact, to achieve both maximal generality and
ease of use within topos theory, we assume that A is a so-called Rickart
C*-algebra and that C(A) consists of all unital commutative Rickart
C*-subalgebras of A. Such families of projections form a Heyting algebra in a
natural way, so that the associated propositional logic is intuitionistic:
distributivity is recovered at the expense of the law of the excluded middle.
Subsequently, generalizing an earlier computation for n-by-n matrices, we
prove that the Heyting algebra thus associated to A arises as a basis for the
internal Gelfand spectrum (in the sense of Banaschewski-Mulvey) of the
"Bohrification" of A, which is a commutative Rickart C*-algebra in the topos of
functors from C(A) to the category of sets. We explain the relationship of this
construction to partial Boolean algebras and Bruns-Lakser completions. Finally,
we establish a connection between probability measure on the lattice of
projections on a Hilbert space H and probability valuations on the internal
Gelfand spectrum of A for A = B(H).Comment: 31 page
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