105 research outputs found
Sparse Coding Predicts Optic Flow Specificities of Zebrafish Pretectal Neurons
Zebrafish pretectal neurons exhibit specificities for large-field optic flow
patterns associated with rotatory or translatory body motion. We investigate
the hypothesis that these specificities reflect the input statistics of natural
optic flow. Realistic motion sequences were generated using computer graphics
simulating self-motion in an underwater scene. Local retinal motion was
estimated with a motion detector and encoded in four populations of
directionally tuned retinal ganglion cells, represented as two signed input
variables. This activity was then used as input into one of two learning
networks: a sparse coding network (competitive learning) and backpropagation
network (supervised learning). Both simulations develop specificities for optic
flow which are comparable to those found in a neurophysiological study (Kubo et
al. 2014), and relative frequencies of the various neuronal responses are best
modeled by the sparse coding approach. We conclude that the optic flow neurons
in the zebrafish pretectum do reflect the optic flow statistics. The predicted
vectorial receptive fields show typical optic flow fields but also "Gabor" and
dipole-shaped patterns that likely reflect difference fields needed for
reconstruction by linear superposition.Comment: Published Conference Paper from ICANN 2018, Rhode
Comparison of Strangeness Production between A+A and p+p Reactions from 2 to 160 AGeV
The measured K ratios from heavy-ion reactions are compared with
the K ratios from p+p reactions over the energy range 2-160 AGeV. The
K/ enhancement in heavy-ion reactions is largest at the lower energies,
consistent with strangeness production in secondary scattering becoming
relatively more important than initial collisions near the kaon production
threshold. The enhancement decreases steadily from 4 to 160 AGeV, suggesting
that the same enhancement mechanism of hadronic rescattering and decay of
strings may be applicable over this full energy range. Based on existing data,
the mid-rapidity K ratio is predicted to be for the
forthcoming Pb+Pb reactions at 40 AGeV/c.Comment: 14 pages, 4 figures, submitted to Phys. Rev.
Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer
Background: Genetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymorphic variants. However, these loci only explain around 1‑4% of CRC heritability, highlighting the dire need of identifying novel risk loci. In this study, we focused our attention on the genetic variability of the TAS2R16 gene, encoding for one of the bitter taste receptors that selectively binds to salicin, a natural antipyretic that resembles aspirin. Given the importance of inflammation in CRC, we tested whether polymorphic variants in this gene could affect the risk of developing this neoplasia hypothesizing a role of TAS2R16 in modulating chronic inflammation within the gut. Methods: We performed an association study using 6 tagging SNPs, (rs860170, rs978739, rs1357949, rs1525489, rs6466849, rs10268496) that cover all TAS2R16 genetic variability. The study was carried out on 1902 CRC cases and 1532 control individuals from four European countries. Results: We did not find any statistically significant association between risk of developing CRC and selected SNPs. However, after stratification by histology (colon vs. rectum) we found that rs1525489 was associated with increased risk of rectal cancer with a (Ptrend of = 0.0071). Conclusions: Our data suggest that polymorphisms within TAS2R16 gene do not have a strong influence on colon cancer susceptibility, but a possible role in rectal cancer should be further evaluated in larger cohorts
Micro-Canonical Hadron Production in pp collisions
We apply a microcanonical statistical model to investigate hadron production
in pp collisions. The parameters of the model are the energy E and the volume V
of the system, which we determine via fitting the average multiplicity of
charged pions, protons and antiprotons in pp collisions at different collision
energies. We then make predictions of mean multiplicities and mean transverse
momenta of all identified hadrons. Our predictions on nonstrange hadrons are in
good agreement with the data, the mean transverse momenta of strange hadron as
well. However, the mean multiplicities of strange hadrons are overpredicted.
This agrees with canonical and grandcanonical studies, where a strange
suppression factor is needed. We also investigate the influence of
event-by-event fluctuations of the E parameter.Comment: 15 pages 11 figure
Hadronic observables from SIS to SPS energies - anything strange with strangeness ?
We calculate and (+) rapidity
distributions and compare to experimental data from SIS to SPS energies within
the UrQMD and HSD transport approaches that are both based on string, quark,
diquark () and hadronic degrees of freedom. The
two transport models do not include any explicit phase transition to a
quark-gluon plasma (QGP). It is found that both approaches agree rather well
with each other and with the experimental rapidity distributions for protons,
's, and . Inspite of this apparent agreement both
transport models fail to reproduce the maximum in the excitation function for
the ratio found experimentally between 11 and 40 AGeV. A
comparison to the various experimental data shows that this 'failure' is
dominantly due to an insufficient description of pion rapidity distributions
rather than missing 'strangeness'. The modest differences in the transport
model results -- on the other hand -- can be attributed to different
implementations of string formation and fragmentation, that are not
sufficiently controlled by experimental data for the 'elementary' reactions in
vacuum.Comment: 46 pages, including 15 eps figures, to be published in Phys. Rev.
Baryon Stopping and Charged Particle Distributions in Central Pb+Pb Collisions at 158 GeV per Nucleon
Net proton and negative hadron spectra for central \PbPb collisions at 158
GeV per nucleon at the CERN SPS were measured and compared to spectra from
lighter systems. Net baryon distributions were derived from those of net
protons, utilizing model calculations of isospin contributions as well as data
and model calculations of strange baryon distributions. Stopping (rapidity
shift with respect to the beam) and mean transverse momentum \meanpt of net
baryons increase with system size. The rapidity density of negative hadrons
scales with the number of participant nucleons for nuclear collisions, whereas
their \meanpt is independent of system size. The \meanpt dependence upon
particle mass and system size is consistent with larger transverse flow
velocity at midrapidity for \PbPb compared to \SS central collisions.Comment: This version accepted for publication in PRL. 4 pages, 3 figures.
Typos corrected, some paragraphs expanded in response to referee comments, to
better explain details of analysi
Neonatal Imitation in Rhesus Macaques
The emergence of social behaviors early in life is likely crucial for the development of mother–infant relationships. Some of these behaviors, such as the capacity of neonates to imitate adult facial movements, were previously thought to be limited to humans and perhaps the ape lineage. Here we report the behavioral responses of infant rhesus macaques (Macaca mulatta) to the following human facial and hand gestures: lip smacking, tongue protrusion, mouth opening, hand opening, and opening and closing of eyes (control condition). In the third day of life, infant macaques imitate lip smacking and tongue protrusion. On the first day of life, the model's mouth openings elicited a similar matched behavior (lip smacking) in the infants. These imitative responses are present at an early stage of development, but they are apparently confined to a narrow temporal window. Because lip smacking is a core gesture in face-to-face interactions in macaques, neonatal imitation may serve to tune infants' affiliative responses to the social world. Our findings provide a quantitative description of neonatal imitation in a nonhuman primate species and suggest that these imitative capacities, contrary to what was previously thought, are not unique to the ape and human lineage. We suggest that their evolutionary origins may be traced to affiliative gestures with communicative functions
Comparison of Atmospheric Neutrino Flux Calculations at Low Energies
We compare several different calculations of the atmospheric neutrino flux in
the energy range relevant for contained neutrino interactions, and we identify
the major sources of difference among the calculations. We find nothing that
would affect the predicted ratio of , which is nearly the same
in all calculations. Significant differences in normalization arise primarily
from different treatment of pion production by interactions of protons in the
atmosphere. Different assumptions about the primary spectrum and treatment of
the geomagnetic field are also of some importance.Comment: 15 pages, RevTeX , 5 postscript figures, submitted to Phys. Rev.
Heterochrony and Cross-Species Intersensory Matching by Infant Vervet Monkeys
Understanding the evolutionary origins of a phenotype requires understanding the relationship between ontogenetic and phylogenetic processes. Human infants have been shown to undergo a process of perceptual narrowing during their first year of life, whereby their intersensory ability to match the faces and voices of another species declines as they get older. We investigated the evolutionary origins of this behavioral phenotype by examining whether or not this developmental process occurs in non-human primates as well.We tested the ability of infant vervet monkeys (Cercopithecus aethiops), ranging in age from 23 to 65 weeks, to match the faces and voices of another non-human primate species (the rhesus monkey, Macaca mulatta). Even though the vervets had no prior exposure to rhesus monkey faces and vocalizations, our findings show that infant vervets can, in fact, recognize the correspondence between rhesus monkey faces and voices (but indicate that they do so by looking at the non-matching face for a greater proportion of overall looking time), and can do so well beyond the age of perceptual narrowing in human infants. Our results further suggest that the pattern of matching by vervet monkeys is influenced by the emotional saliency of the Face+Voice combination. That is, although they looked at the non-matching screen for Face+Voice combinations, they switched to looking at the matching screen when the Voice was replaced with a complex tone of equal duration. Furthermore, an analysis of pupillary responses revealed that their pupils showed greater dilation when looking at the matching natural face/voice combination versus the face/tone combination.Because the infant vervets in the current study exhibited cross-species intersensory matching far later in development than do human infants, our findings suggest either that intersensory perceptual narrowing does not occur in Old World monkeys or that it occurs later in development. We argue that these findings reflect the faster rate of neural development in monkeys relative to humans and the resulting differential interaction of this factor with the effects of early experience
Understanding the retinal basis of vision across species
The vertebrate retina first evolved some 500 million years ago in ancestral marine chordates. Since then, the eyes of different species have been tuned to best support their unique visuoecological lifestyles. Visual specializations in eye designs, large-scale inhomogeneities across the retinal surface and local circuit motifs mean that all species' retinas are unique. Computational theories, such as the efficient coding hypothesis, have come a long way towards an explanation of the basic features of retinal organization and function; however, they cannot explain the full extent of retinal diversity within and across species. To build a truly general understanding of vertebrate vision and the retina's computational purpose, it is therefore important to more quantitatively relate different species' retinal functions to their specific natural environments and behavioural requirements. Ultimately, the goal of such efforts should be to build up to a more general theory of vision
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