Simultaneous Ratio Derivative Spectrophotometric Determination of Paracetamol, Caffeine and Ibuprofen in Their Ternary Form

تم اقتراح طريقتين جديدتين و دقبقتبن و متوافقتين و اقتصاديتين للتقدير الطيفي لكل من الباراسيتامول و الايبويروفين و الكافايين. والطريقتان هما المشتقة النسبية الاولى و الثانية ثنائية المقسوم عليه. و قد اعطى كل من الباراسيتامول و الايبوبروفين و الكافايين قمم مفيدة في التقدير الكمي لكل منهما. و قد تم تقييم جميع انواع تقنيات التقدير للمكونات الثلاثة و هي ارتفاع القمة الى خط الاساس ومساحة القمة و قمة الى قمة بالاستناد الى ICH. كان التناسب خطيا لكلا الطريقتين ما بين 5 مكغم/مل كاقل تركيز و 50 مكغم/مل كأعلى تركيز للمكونات الثلاثة. كانت الاسترجاعية المئوية حوالي 100% و الانحراف المعياري النسبي كان اقل من 2.6%. طبقت الطريقة بنجاح في تقدير كل من الباراسيتامول و الايبوبروفين و الكافايين في مكوناتها الصيدلانية.A new, accurate, precise and economic two spectrophotometric methods for determination of Paracetamol (Par), Ibuprofen (Ibu), and Caffeine (Caf) were suggested. Those methods were the first and second ratio derivative spectrum using a double devisor. Par, Ibu, and Caf showed many useful peaks for their quantified determination. The validity of all analysis modes for determination of the three compounds, peak to baseline, peak area and peak to peak were according to ICH. The linearity of two methods was between 5 µg/ml as a lower concentration and 50 µg/ml as the highest concentration for three compounds. Recovery percentage was around 100% and relative standard deviation was less than 2.6%. The methods were applied successfully in the determination of Par, Ibu, and Caf in pure and pharmaceutical forms

Contemplation Impact of Pulp Seeds Cucurbita Pepo L. and its Paste on Oxidative Stress in Rats

Cucurbita Pepo L. seeds and seeds paste which are rich sources of phytochemicals and act as a rich source of antioxidants. The most important phytochemicals present in the cucurbits are cucurbitacin’s, saponins, carotenoids, phytosterols, and polyphenols. These bioactive phyto-constituents are responsible for the pharmacological effects including antioxidant effect. Aim of this study was to investigate the effect of Cucurbita Pepo L. seeds and seeds paste on rats suffering from oxidative stress. Thirty-six male albino rats were used in the experiment (Sprague-Dawley strain). The animals randomly divided 6 rats each group according to the following the first Group: Rats were fed basal diet and set as negative control. The other rats (n = 30) were fed on basal diet containing monosodium glutamate (120 mg/kg) for induce stress condition. After that, rats further divided into 5 groups (n = 6) each for six weeks as follows: -2nd Group: Rats were fed on basal diet containing monosodium glutamate and set as positive control. 3rd Group: Rats were fed on diet containing monosodium glutamate with addition of Cucurbita Pepo L. seeds 5%. 4th Group: Rats were fed on diet containing monosodium glutamate with addition of Cucurbita Pepo L. seeds 10%. 5th Group: Rats were fed on diet containing monosodium glutamate with addition of Cucurbita Pepo L. seeds paste 5%. 6th Group: Rats were fed on diet containing monosodium glutamate with addition of Cucurbita Pepo L. seeds paste 10%. The experimental period was six weeks; Blood samples were collected. At the end of the experiment, the results showed that using seeds 5% & 10% and seeds paste 5% & 10% in feeding the stressed rats increased (BWG%, FI, FER, Superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx)) with highest results in group fed on 10% seeds paste and decreased (Urea, Creatinine, ALT, AST, IL-6 and INF-gamma) with lowest results in group fed on 10% Cucurbita Pepo L. seeds paste

Harris lines of the tibia across centuries: a comparison of two populations, medieval and contemporary in Central Europe

Objective: To determine the incidence of Harris lines in two medieval populations which inhabited the Canton of Berne, in Central Switzerland, and to compare the results with those of a contemporary population living in the same geographical area. A simplified method is described for measuring the age of the individual at the time of formation of Harris lines, with possible future applications. Design and patients: Radiographs of 112 well-preserved tibiae of skeletons of two medieval populations from the eighth to fifteenth centuries were reviewed for the incidence of Harris lines. The results were compared with those of 138 current patients living in the same geographic location in Central Switzerland. Age and gender of the medieval individual were determined using known anthropological methods. Age of bone at the time of formation of Harris lines was estimated according to the method of Maat. Results: Harris lines were found in 88 of 112 (80%) of the examined medieval skeletons and in 28 of 138 (20%) of the living individuals. Higher incidences of Harris lines were found at the age of 2years and at ages between 8 and 12years in both populations. No gender difference was found regarding the incidence of Harris lines. In both populations the occurrence of Harris lines was associated with certain diseases such as degenerative bone disease, trauma, osteoporosis, rheumatoid arthritis, peripheral vascular diseases, rickets and bony deformities. Conclusion: A high incidence of Harris lines was found in the medieval population, perhaps reflecting difficult living and hygienic conditions, but also the poor care and neglect of the children population. Measuring the age of the individual at the time of formation of Harris lines is simple and may have future clinical applications in the paediatric population for medico-legal purposes. The application of Harris lines as a marker in follow-up of osteoporosis may need further evaluatio

Temperature and water level measurement of liquid in a tank using fiber Bragg Grating

In this work, measurement of temperature and liquid level were performed simultaneously using fiber Bragg grating (FBG) sensors. A multi-channel Fibre Interrogator with built-in ASE laser source operating around 1552 to 1568 nm was employed to record a shift in Bragg wavelength due to contribution from both temperature and hydrostatic pressure of liquid weight in the tank. Results show a linear response between liquid level and temperature readings against the shift in Bragg wavelength for liquid level up to 85 cm in height and the temperature range of 27 to 77 ºC. The sensitivity of the sensor head for water level measurement is 10.57 pmcm-1, while the sensitivity for temperature measurement is 11.28 pm/ºC respectively

Highly Saline Water Desalination Using Direct Contact Membrane Distillation (DCMD): Experimental and Simulation Study

The path for water molecules transported across a membrane in real porous membranes has been considered to be a constant factor in the membrane distillation (MD) process (i.e., constant tortuosity); as such, its effect on membrane performance at various operating conditions has been ignored by researchers. Therefore, a simultaneous heat and mass transfer model throughout the direct contact membrane distillation (DCMD) module was developed in this study by taking into account the hypothetical path across the membrane as a variable factor within the operating conditions because it exhibits the changes to the mass transfer resistance across the membrane under the DCMD run. The DCMD process was described by the developed model using a system of nonlinear equations and solved numerically by MATLAB software. The performance of the poly-tetra-fluoroethylene (PTFE) membrane was examined to treat 200 g/L NaCl saline at various operating conditions. The simulation results in the present work showed that the hypothetical proposed path across the membrane has a variable value and was affected by changing the feed temperature and feed concentration. The results estimated by the developed model showed an excellent conformity with the experimental results. The salt rejection remained high (greater than 99.9%) in all cases. The temperature polarization coefficient for the DCMD ranged between 0.88 and 0.967, and the gain output ratio (GOR) was 0.893. The maximum thermal efficiency of the system was 84.5%

Tight glycemic control and computerized decision-support systems: a systematic review

Objective: To identify and summarize characteristics of computerized decision-support systems (CDSS) for tight glycemic control (TGC) and to review their effects on the quality of the TGC process in critically ill patients. Methods: We searched Medline (1950-2008) and included studies on critically ill adult patients that reported original data from a clinical trial or observational study with a main objective of evaluating a given TGC protocol with a CDSS. Results: Seventeen articles met the inclusion criteria. Eleven out of seventeen studies evaluated the effect of a new TGC protocol that was introduced simultaneously with a CDSS implementation. Most of the reported CDSSs were stand-alone, were not integrated in any other clinical information systems and used the "passive'' mode requiring the clinician to ask for advice. Different implementation sites, target users, and time of advice were used, depending on local circumstances. All controlled studies reported on at least one quality indicator of the blood glucose regulatory process that was improved by introducing the CDSS. Nine out of ten controlled studies either did not report on the number of hypoglycemia events (one study), or reported on no change (six studies) or even a reduction in this number (two studies). Conclusions: While most studies evaluating the effect of CDSS on the quality of the TGC process found improvement when evaluated on the basis of the quality indicators used, it is impossible to define the exact success factors, because of simultaneous implementation of the CDSS with a new or modified TGC protocol and the hybrid solutions used to integrate the CDSS into the clinical workflo

Synthesis and Characterization of Zinc Oxide Nanoparticle for the Adsorptive Remediation of Petrochemical Effluents

The zinc oxide nanoparticle was synthesized via precipitation method. It was characterized using SEM-EDX, FTIR and TEM for morphology, elemental, functional groups and internal structure respectively. The physicochemical behaviour of a refinery effluent was assessed. The untreated raw refinery effluent from the point of discharge contained very high concentrations of pollutants for all the parameters, ranging between, pH (6.52-6.82), Turbidity (10-12 NTU), conductivity (266-289μs/cm), COD (116-138 mg/l), BOD (14-18.5 mg/l), DO (7.5-15.6 mg/l), TDS (436-486 mg/l), TSS (127-133 mg/l), Oil and grease (14.8-16.3 mg/l), sulphate (113-125 mg/l) and chloride (240-280 mg/l). The effluent was treated with ZnO nanoparticle and reduced the pollutants to the normal permissible limit set by WHO, FEPA and NESREA standard for portable water. The treated effluent sample showed values ranging between, pH (6.55-6.6), Turbidity (4.2-4.5 NTU), conductivity (245-246 μs/cm), COD (39-40 mg/l), BOD (10 mg/l), DO (5.6-10.4 mg/l), TDS (151-183 mg/l), TSS (24-28 mg/l), Oil and grease (7.3-9.5 mg/l), sulphate (100 mg/l) and chloride (200 mg/l). The heavy metals profile that was investigated are Fe, Cu, Zn, Pb, Cd and Cr of which were found above the WHO and FEPA permissible limit, however, on the contact with the adsorbent therefore reduced the metals to the permissible limit. It can be ascertain that ZnO nanoparticle can be used as an effective adsorbent for the treatment of petrochemical effluent

Equivalence of pathologists' and rule-based parser's annotations of Dutch pathology reports

Introduction: In the Netherlands, pathology reports are annotated using a nationwide pathology network (PALGA) thesaurus. Annotations must address topography, procedure, and diagnosis. The Pathology Report Annotation Module (PRAM) can be used to annotate the report conclusion with PALGA-compliant code series. The equivalence of these generated annotations to manual annotations is unknown. We assess the equivalence of annotations by authoring pathologists, pathologists participating in this study, and PRAM. Methods: New annotations were created for one thousand histopathology reports by the PRAM and a pathologist panel. We calculated dissimilarity of annotations using a semantic distance measure, Minimal Transition Cost (MTC). In absence of a gold standard, we compared dissimilarity scores having one common annotator. The resulting comparisons yielded a measure for the coding dissimilarity between PRAM, the pathologist panel and the authoring pathologist. To compare the comprehensiveness of the coding methods, we assessed number and length of the annotations. Results: Eight of the twelve comparisons of dissimilarity scores were significantly equivalent. Non-equivalent score pairs involved dissimilarity between the code series by the original pathologist and the panel pathologists. Coding dissimilarity was lowest for procedures, highest for diagnoses: MTC overall = 0.30, topographies = 0.22, procedures = 0.13, diagnoses = 0.33. Both number and length of annotations per report increased with report conclusion length, mostly in PRAM-annotated conclusions: conclusion length ranging from 2 to 373 words, number of annotations ranged from 1 to 10 for pathologists, 1–19 for PRAM, annotation length ranged from 3 to 43 codes for pathologists, 4–123 for PRAM. Conclusions: We measured annotation similarity among PRAM, authoring pathologists and panel pathologists. Annotating by PRAM, the panel pathologists and to a lesser extent by the authoring pathologist was equivalent. Therefore, the use of annotations by PRAM in a practical setting is justified. PRAM annotations are equivalent to study-setting annotations, and more comprehensive than routine coding. Further research on annotation quality is needed