Technológiai Előretekintési Program

Az Országos Mûszaki Fejlesztési Bizottság döntése alapján 1998-ban átfogó elemzés kezdôdött Technoló- giai Elôretekintési Program (TEP) néven. A program célja, hogy a piaci és technológiai lehetôségek feltá- rásával hozzájáruljon a hosszú távú versenyképesség növeléséhez és ezen keresztül az életminôség javításá- hoz. A TEP a gazdasági, társadalmi folyamatok, a tudo- mány és technika eredményeinek elemzésével megje- löli azon kulcskérdéseket, döntési pontokat, amelyek meghatározzák az egyes szakmai területek illetve az ország jövôjét a következô 15-25 évben. Az Irányító Testület és a munkacsoportok elemezték a jelenlegi helyzetet, eltérô jövôképeket vázoltak fel, és a legked- vezôbbnek ítélt – de a mai feltételek mellett, tudatos, összehangolt erôfeszítések nélkül nem feltétlenül a leg- valószínûbb – jövôkép megvalósítását célzó ajánlásokat fogalmaztak meg. A legkedvezôbb jövôképbôl leve- zetett ajánlások tehát mindazoknak szólnak, akik köz- vetlenül vagy közvetve hatással lehetnek az egyes szakterületek vagy a magyar társadalom és gazdaság egészének jövôjére

The European Union, Russia and the Eastern region: The analytics of government for sustainable cohabitation

This article applies the Foucauldian premise of governmentality and the analytics of government framework to demonstrate how exclusive modalities of power – of the European Union (EU) and Russia – and their competing rationalities relate, intersect and become, counter-intuitively, inextricable in their exercise of governance over the eastern neighbourhood. This particular approach focuses on power as a process to gauge the prospects for compatibility and cohabitation between the EU and Russia. Using original primary evidence, this article contends that cohabitation between these two exclusive power modalities is possible and even inevitable, if they were to legitimise their influence over the contested eastern region. It also exposes a fundamental flaw in the existing power systems, as demonstrated so vividly in the case of Ukraine – that is, a neglect for the essential value of freedom in fostering subjection to one’s authority, and the role of ‘the other’ in shaping the EU–Russian power relations in the contested regio

A new method for measuring angle-resolved phases in photoemission

Quantum mechanically, photoionization can be fully described by the complex photoionization amplitudes that describe the transition between the ground state and the continuum state. Knowledge of the value of the phase of these amplitudes has been a central interest in photoionization studies and newly developing attosecond science, since the phase can reveal important information about phenomena such as electron correlation. We present a new attosecond-precision interferometric method of angle-resolved measurement for the phase of the photoionization amplitudes, using two phase-locked Extreme Ultraviolet pulses of frequency $\omega$ and $2\omega$, from a Free-Electron Laser. Phase differences $\Delta \tilde \eta$ between one- and two-photon ionization channels, averaged over multiple wave packets, are extracted for neon $2p$ electrons as a function of emission angle at photoelectron energies 7.9, 10.2, and 16.6 eV. $\Delta \tilde \eta$ is nearly constant for emission parallel to the electric vector but increases at 10.2 eV for emission perpendicular to the electric vector. We model our observations with both perturbation and \textit{ab initio} theory, and find excellent agreement. In the existing method for attosecond measurement, Reconstruction of Attosecond Beating By Interference of Two-photon Transitions (RABBITT), a phase difference between two-photon pathways involving absorption and emission of an infrared photon is extracted. Our method can be used for extraction of a phase difference between single-photon and two-photon pathways and provides a new tool for attosecond science, which is complementary to RABBITT

Syndecan-1 Enhances Proliferation, Migration and Metastasis of HT-1080 Cells in Cooperation with Syndecan-2

Syndecans are transmembrane heparan sulphate proteoglycans. Their role in the development of the malignant phenotype is ambiguous and depends upon the particular type of cancer. Nevertheless, syndecans are promising targets in cancer therapy, and it is important to elucidate the mechanisms controlling their various cellular effects. According to earlier studies, both syndecan-1 and syndecan-2 promote malignancy of HT-1080 human fibrosarcoma cells, by increasing the proliferation rate and the metastatic potential and migratory ability, respectively. To better understand their tumour promoter role in this cell line, syndecan expression levels were modulated in HT-1080 cells and the growth rate, chemotaxis and invasion capacity were studied. For in vivo testing, syndecan-1 overexpressing cells were also inoculated into mice. Overexpression of full length or truncated syndecan-1 lacking the entire ectodomain but containing the four juxtamembrane amino acids promoted proliferation and chemotaxis. These effects were accompanied by a marked increase in syndecan-2 protein expression. The pro-migratory and pro-proliferative effects of truncated syndecan-1 were not observable when syndecan-2 was silenced. Antisense silencing of syndecan-2, but not that of syndecan-1, inhibited cell migration. In vivo, both full length and truncated syndecan-1 increased tumour growth and metastatic rate. Based on our in vitro results, we conclude that the tumour promoter role of syndecan-1 observed in HT-1080 cells is independent of its ectodomain; however, in vivo the presence of the ectodomain further increases tumour proliferation. The enhanced migratory ability induced by syndecan-1 overexpression is mediated by syndecan-2. Overexpression of syndecan-1 also leads to activation of IGF1R and increased expression of Ets-1. These changes were not evident when syndecan-2 was overexpressed. These findings suggest the involvement of IGF1R and Ets-1 in the induction of syndecan-2 synthesis and stimulation of proliferation by syndecan-1. This is the first report demonstrating that syndecan-1 enhances malignancy of a mesenchymal tumour cell line, via induction of syndecan-2 expression

Fractal Analysis on Morphology of Laser Irradiated Vanadium Surfaces Under Different Ambient

Pulsed laser irradiated vanadium surface morphology under different ambient has been prepared and characterized using fractal dimension analysis method on scanning electron microscopy (SEM) images. In presence of different ambient, self-periodic and self-similar surface patterns (e.g. dots, islands, and pins) were grown and appeared in different shapes. The fractal dimension (FD) of this developed vanadium nanostructure was calculated by fractal box count method (FBM). The calculated fractal dimension (FD, Df) shows dependence on the different type on ambient and the number of laser shots