Amlodipine-induced gingival overgrowth in a child after liver transplant

Drug-induced gingival overgrowth (GO) has been associated with phenytoin, cyclosporine, and calcium channel blocker therapies. This study reports the case of an 11-year-old girl who was referred for evaluation of GO, which had occurred over the last 6 months. Her medical history included a liver transplant due to biliary atresia 3 years ago, immunosuppressive therapy, and hypertension, which is why she was started on a daily intake of amlodipine. The intraoral examination showed generalized GO, and the treatment consisted of a gingivectomy. Subsequently, amlodipine was replaced with captopril and oral hygiene instructions. There was no recurrence of GO after 28 months of follow-up. Although GO may be related to the chronic use of amlodipine, such an association is uncommon in pediatrics, and the treatment consists of the replacement of medication combined with a surgical approach and plaque contro

Odontogenic myxoma in a child treated with enucleation and curettage

Odontogenic myxoma is an aggressive benign odontogenic tumor, accounting for 3-6% of all the odontogenic tumors in adults. The incidence among children is lower. Due to its clinical behavior, there is no consensus on the best treatment. In this paper, the authors report the case of a 9-year-old girl with the diagnosis of odontogenic myxoma. The panoramic X-ray showed an extensive radiolucent lesion involving the left mandibular body causing teeth displacement. The treatment consisted of tumor enucleation followed by vigorous curettage of the bone walls. Both the base of the mandible and the inferior alveolar nerve were preserved. The patient is asymptomatic after 6 months of surgery. The age of the patient and the radiographic features were taken into account when deciding in favor of the conservative treatment

Modalidades de imagem na osteonecrose dos maxilares relacionada à medicamentos: revisão de literatura

Osteonecrosis occurs by cellular death of the bone tissue due to an irreversible external factor. This disorder may be clinically unidentified in the early stages and result in degradation of the bone architectural structure, leading to pain, bone destruction, and loss of function. Thus, imaging exams become relevant to the recognition and definition of the bone necroses. The aim of this study was to review the literature on imaging exams frequently used for the diagnosis and evaluation of patients undergoing drug therapies associated with osteonecrosis of the jaw, such as panoramic radiography, computed tomography, magnetic resonance imaging and bone scintigraphy.A osteonecrose ocorre pela morte celular do tecido ósseo devido a um fator externo irreversível. Esse distúrbio pode não ser clinicamente identificado nos estágios iniciais gerando quadros de dor, destruição da arquitetura óssea e perda de função. Assim, os exames de imagem se tornam relevantes para o reconhecimento e a definição das necroses ósseas. O objetivo deste estudo foi revisar a literatura a respeito das diferentes modalidades de exames de imagem frequentemente utilizados para diagnóstico e avaliação de pacientes submetidos a terapias medicamentosas associadas à osteonecrose dos maxilares, como a radiografia panorâmica, tomografia computadorizada, ressonância magnética e cintilografia óssea

Secondary primary tumor mimicking osteoradionecrosis

Nasopharyngeal carcinoma (NPC) is a malignant tumor rarely found in the head and neck, representing about 1% of all malignancies. The main treatment for NPC is radiation therapy, which is often given in combination with chemotherapy. However, such treatment may lead to long‐term complications, including second primary tumors (SPTs) and osteoradionecrosis (ORN). Both complications have similar radiological characteristics, which can lead to erroneous diagnoses. This paper describes a case of a second primary tumor in a patient after 20 years of radiotherapy in the area where a previous extraction was performed, mimicking an osteoradionecrosis process

Oral focal mucinosis of the hard palate and gingiva

Oral focal mucinosis (OFM) is an uncommon, asymptomatic, submucosal, slow-growing nodule representing a counterpart of the cutaneous focal mucinosis (CFM). OFM has a female predilection with the highest prevalence in the fifth decade of life. About 68% of OFMs occur in the gingiva and 14% in the palate. We present the case of a 41-year-old woman presenting a progressively growing mass on the palate, since the last 8 months. The diagnostic workup led to the diagnosis of an unusual OFM with the clinical presentation involving the gingiva and hard palate. This case report discusses the clinical and histopathological differential diagnosis

Avaliação da Pós-Graduação em Educação: entrevista com Ângelo Ricardo de Souza (UFPR/CAPES)

O prof. Ângelo Ricardo de Souza, Coordenador Adjunto de Programas Acadêmicos da Área de Educação junto à CAPES e docente do Programa de Pós-Graduação em Educação da Universidade Federal do Paraná, faz um balanço, bem como apresenta os principais desafios que a Área da Educação precisará enfrentar nas próximas avaliações. Desse modo, o percurso acadêmico do entrevistado, questões sobre as mudanças paradigmáticas que estão ocorrendo na avaliação da Pós-Graduação no país, autoavaliação, internacionalização, Qualis/CAPES, fator de impacto, entre outros assuntos são discutidos ao longo do texto

Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider

Immune checkpoint inhibitors (ICIs) are a revolutionary class of antineoplastic therapy that restore anti-tumor immunity. Consequences of this enhanced immune response include a multitude of immune related adverse events (irAEs) that can affect any body system, including the mouth. Orofacial irAEs reproduce features of numerous immune-mediated conditions, including oral lichen planus, mucous membrane pemphigoid, and Sjögren syndrome, among others. The aim of this review is to summarize known orofacial irAEs and to familiarize oral healthcare providers with how to identify and manage these toxicities as part of the care team for patients treated with ICIs

A história da ciência (distorcida ou ausente) em livros didáticos: o conteúdo sobre o “experimento de Torricelli” como estudo de caso

Esse trabalho apresenta uma pesquisa direcionada à avaliação crítica da História da Ciência presente em livros didáticos brasileiros. Particularmente, o objetivo dessa pesquisa foi contribuir para a compreensão de como os elementos relacionados ao processo de construção histórica do conceito de pressão atmosférica aparecem nos livros didáticos. São discutidos especificamente os resultados da análise realizada de acordo com os seguintes critérios: fundamentos historiográficos atuais; apontamentos da legislação educacional para a inserção didática da História da Ciência, fontes primárias e secundárias da História da Ciência relacionadas ao desenvolvimento do conceito de pressão atmosférica.  Dentre os problemas notados destacam-se o anacronismo, a pseudohistória, visões simplistas sobre a ciência, a ausência de explicações sustentadas por pensadores do passado e uma abordagem (totalmente) descontextualizada do experimento de Torricelli

Amlodipine-induced gingival overgrowth in a child after liver transplant

Drug-induced gingival overgrowth (GO) has been associated with phenytoin, cyclosporine, and calcium channel blocker therapies. This study reports the case of an 11-year-old girl who was referred for evaluation of GO, which had occurred over the last 6 months. Her medical history included a liver transplant due to biliary atresia 3 years ago, immunosuppressive therapy, and hypertension, which is why she was started on a daily intake of amlodipine. The intraoral examination showed generalized GO, and the treatment consisted of a gingivectomy. Subsequently, amlodipine was replaced with captopril and oral hygiene instructions. There was no recurrence of GO after 28 months of follow-up. Although GO may be related to the chronic use of amlodipine, such an association is uncommon in pediatrics, and the treatment consists of the replacement of medication combined with a surgical approach and plaque contro

Atualização sobre tratamento medicamentoso de infecções causadas por Staphylococcus aureuse resistência a drogas antiestafilocócicas

Desde os primeiros casos de resistência a penicilina e depois meticilina,o Staphylococcus aureusse tornou degrande importância no ambiente hospitalar e atualmente também na comunidade. Glicopeptídeos são a primeiralinha de tratamento para infecções graves por MRSA, porém a alta toxicidade dos mesmos e, resistência,fazem com que as outras alternativas terapêuticas sejam adotadas na prática clínica para o tratamento de infecçõescausadas por S. aureus. Esta revisão pretende abordar as principais opções de tratamento antiestafilocócicos