300 research outputs found
A molecular dynamics model to measure forces between cellulose fibril surfaces: on the effect of non-covalent polyelectrolyte adsorption
This study describes the development of representative models of cellulose fibril surface (CFS) as a first approximation to the study of the molecular interactions that are developed between cellulose fibres. In order to assess its sensitivity and representativeness towards the main factors affecting the bonding properties at the fibre scale, these models were non-covalently surface modified with two types of polyelectrolytes, sodium carboxymethyl cellulose (CMC–ONa) and a cationic polyacrylamide (CPAM). From the analysis of pair correlation functions (g(r)) it was possible to assess the main interactions of adsorption of polyelectrolytes towards the (1–10) hydrophilic cellulose, which were due to electrostatic interactions coupled with hydrogen bonding. Besides, the bond strength between fibril surfaces through the (100) hydrophobic surface was calculated from pull out simulations (using steered molecular dynamics). Using a rate of change of force of 0.159 nN ps-1, the calculated bond strength for the neat CFS model (nanometer scale) was two to three orders of magnitude higher than the experimental values observed at the fibre scale (micrometer scale). The results for the polyelectrolyte modified setups supported the validity of the CFS models to reproduce the expected behavior of inter-fibre joints in terms of the specific bond strength and the relative bonded area at the fibre scale in cellulose materials, and thereby the CFS models are a suitable complement, in conjunction with other techniques, for the systematic study of the effect (in qualitative terms) of chemical or physical factors on the bond strength properties of cellulosic materials. Graphical abstract: [Figure not available: see fulltext.]
Controls on space–time distribution of soft-sediment deformation structures: Applying palaeomagnetic dating to approach the apparent recurrence period of paleoseisms at the Concud Fault (eastern Spain)
This work describes soft-sediment deformation structures (clastic dykes, load structures, diapirs, slumps, nodulizations or mudcracks) identified in three sections (Concud, Ramblillas and Masada Cociero) in the Iberian Range, Spain. These sections were logged from boreholes and outcrops in Upper Pliocene-Lower Pleistocene deposits of the Teruel-Concud Residual Basin, close to de Concud normal fault. Timing of the succession and hence of seismic and non-seismic SSDSs, covering a time span between ~ 3.6 and ~ 1.9 Ma, has been constrained from previous biostratigraphic and magnetostratigraphic information, then substantially refined from a new magnetostratigraphic study at Masada Cociero profile. Non-seismic SSDSs are relatively well-correlated between sections, while seismic ones are poorly correlated except for several clusters of structures. Between 29 and 35 seismic deformed levels have been computed for the overall stratigraphic succession. Factors controlling the lateral and vertical distribution of SSDSs are their seismic or non-seismic origin, the distance to the seismogenic source (Concud Fault), the sedimentary facies involved in deformation and the observation conditions (borehole core vs. natural outcrop). In the overall stratigraphic section, seismites show an apparent recurrence period of 56 to 108 ka. Clustering of seismic SSDSs levels within a 91-ka-long interval records a period of high paleoseismic activity with an apparent recurrence time of 4.8 to 6.1 ka, associated with increasing sedimentation rate and fault activity. Such activity pattern of the Concud Fault for the Late Pliocene-Early Pliocene, with alternating periods of faster and slower slip, is similar to that for the most recent Quaternary (last ca. 74 ka BP). Concerning the research methods, time occurrence patterns recognized for peaks of paleoseismic activity from SSDSs in boreholes are similar to those inferred from primary evidence in trenches. Consequently, apparent recurrence periods calculated from SSDS inventories collected in borehole logs close to seismogenic faults are comparable to actual recurrence times of large paleoearthquakes
Vulnerability assessment of buildings due to land subsidence using InSAR data in the ancient historical city of Pistoia (Italy)
Los derechos humanos al medio ambiente adecuado y a su protección
La fábula de Esopo, conocida también en las versiones dadas
por La Fontaine y Samaniego, explica con lucidez las relaciones
entre el ser humano y el planeta Tierra. Conocidas las limitaciones de éste último, sólo una estulticia inexplicable puede llevar
a aquél a sobrexplotar sus recursos hoy, ajeno a las consecuencias
que esto tendrá mañana. La conciencia generalizada de que se
está llevando a cabo un modo de desarrollo fundado en principios análogos a los que determinaron la conducta del dueño de la
gallina de los huevos de oro ha impulsado una respuesta cada vez
más vigorosa de la sociedad para reconducir este estado de cosas.
El Derecho está siendo sensible a esta nueva demanda social y
está dando paulatinamente respuestas jurídicas a los interrogantes
ambientales. De entre todas ellas quizá la de mayor relevancia
teórica es la que concibe él medio ambiente adecuado como un
derecho humano
Paseos escolares : monografía pedagógica ...
Precede al pie de imp. : "Publicada á expensas de la Excma. Diputación foral y provincial
A Comparative Analysis of 2D and 3D Tasks for Virtual Reality Therapies Based on Robotic-Assisted Neurorehabilitation for Post-stroke Patients
Post-stroke neurorehabilitation based on virtual therapies are performed completing repetitive exercises shown in visual electronic devices, whose content represents imaginary or daily life tasks. Currently, there are two ways of visualization of these task. 3D virtual environments are used to get a three dimensional space that represents the real world with a high level of detail, whose realism is determinated by the resolucion and fidelity of the objects of the task. Furthermore, 2D virtual environments are used to represent the tasks with a low degree of realism using techniques of bidimensional graphics. However, the type of visualization can influence the quality of perception of the task, affecting the patient's sensorimotor performance. The purpose of this paper was to evaluate if there were differences in patterns of kinematic movements when post-stroke patients performed a reach task viewing a virtual therapeutic game with two different type of visualization of virtual environment: 2D and 3D. Nine post-stroke patients have participated in the study receiving a virtual therapy assisted by PUPArm rehabilitation robot. Horizontal movements of the upper limb were performed to complete the aim of the tasks, which consist in reaching peripheral or perspective targets depending on the virtual environment shown. Various parameter types such as the maximum speed, reaction time, path length, or initial movement are analyzed from the data acquired objectively by the robotic device to evaluate the influence of the task visualization. At the end of the study, a usability survey was provided to each patient to analysis his/her satisfaction level. For all patients, the movement trajectories were enhanced when they completed the therapy. This fact suggests that patient's motor recovery was increased. Despite of the similarity in majority of the kinematic parameters, differences in reaction time and path length were higher using the 3D task. Regarding the success rates were very similar. In conclusion, the using of 2D environments in virtual therapy may be a more appropriate and comfortable way to perform tasks for upper limb rehabilitation of post-stroke patients, in terms of accuracy in order to effectuate optimal kinematic trajectories
Role of FGFs in the control of programmed cell death during limb development
10 páginas, 8 figuras.We have investigated the role of FGFs in the control of programmed cell death during limb development by analyzing the effects of increasing and blocking FGF signaling in the avian limb bud. BMPs are currently considered as the signals responsible for cell death. Here we show that FGF signaling is also necessary for apoptosis and that the establishment of the areas of cell death is regulated by the convergence of FGF- and BMP-mediated signaling pathways. As previously demonstrated, cell death is inhibited for short intervals (12 hours) after administration of FGFs. However, this initial inhibition is followed (24 hours) by a dramatic increase in cell death, which can be abolished by treatments with a BMP antagonist (Noggin or Gremlin). Conversely, blockage of FGF signaling by applying a specific FGF-inhibitor (SU5402) into the interdigital regions inhibits both physiological cell death and that mediated by exogenous BMPs. Furthermore, FGF receptors 1, 2 and 3 are expressed in the autopodial mesoderm during the regression of the interdigital tissue, and the expression of FGFR3 in the interdigital regions is regulated by FGFs and BMPs in the same fashion as apopotosis. Together our findings indicate that, in the absence of FGF signaling BMPs are not sufficient to trigger apoptosis in the developing limb. Although we provide evidence for a positive influence of FGFs on BMP gene expression, the physiological implication of FGFs in apoptosis appears to result from their requirement for the expression of genes of the apoptotic cascade. We have identified MSX2 and Snail as candidate genes associated with apoptosis the expression of which requires the combined action of FGFs and BMPs.This work was
supported by grants to J. M. H. (DGESIC/PM98-0061 and Fundación
Valdecilla) to M. A. N. (DGESIC/PM98-0125) and to D. Macias
(Junta de Extremadura; IPR99C035). J. J. S.-E. was supported by an MRC programme grant to Cheryll Tickle; J. C.-M. was supported by
DGAPA (UNAM) and J. A. M. by a grant from the Junta de
Extremadura (Consejeria de Educación y Juventud/Fondo Social
Europeo).Peer reviewe
Facies control on seismites in an alluvial–aeolian system: the Pliocene dunefield of the Teruel half-graben basin (eastern Spain)
The recognition of seismically induced soft-sediment deformation structures (SSDS) in sedimentary successions characterized by different facies, and hence by different rheology, is challenging. This is the case for high porosity and high permeability aeolian facies interbedded with muddy wet interdune deposits and alluvial conglomerates and sandstones. Several types of SSDS have been studied in two exposures of the Upper Pliocene (2.9–2.6 Ma) sediments of a fault-bounded intracontinental aeolian dune field in the Teruel Basin (Iberian Chain, eastern Spain). Among SSDS, load and fluid-escape structures, apart from several animal tracks, have been recognized. Those structures show an irregular distribution through the studied stratigraphic sections, being scarce in homogenous aeolian sands and frequent in water-related facies. A detailed study of the distribution and geometry of SSDS and their relationships with respect to the stratigraphic architecture and facies has allowed a critical discrimination of trigger mechanisms, i.e. biological or physical overloading vs. earthquakes. The seismically induced structures are concentrated into seven deformed beds, showing an uneven lateral distribution and geometry closely controlled by the hosting sedimentary facies and their rheology. These seismites resulted from liquefaction during moderate earthquakes (estimated magnitude from 5.0 to 6.8). The most probable seismogenic source was the Sierra del Pobo normal fault zone, located 2 km to the East. Results show how an appropriate recognition of sedimentary facies is crucial to understand the lateral variability of seismites in sedimentary environments characterized by sharp facies changes
Tele-Rehabilitation Versus Local Rehabilitation Therapies Assisted by Robotic Devices: A Pilot Study with Patients
The present study aims to evaluate the advantages of a master-slave robotic rehabilitation therapy in which the patient is assisted in real-time by a therapist. We have also explored if this type of strategy is applicable in a tele-rehabilitation environment. A pilot study has been carried out involving 10 patients who have performed a point-to-point rehabilitation exercise supported by three assistance modalities: fixed assistance (without therapist interaction), local therapist assistance, and remote therapist assistance in a simulated tele-rehabiliation scenario. The rehabilitation exercise will be performed using an upper-limb rehabilitation robotic device that assists the patients through force fields. The results suggest that the assistance provided by the therapist is better adapted to patient needs than fixed assistance mode. Therefore, it maximizes the patient’s level of effort, which is an important aspect to improve the rehabilitation outcomes. We have also seen that in a tele-rehabilitation environment it is more difficult to assess when to assist the patient than locally. However, the assistance suits patients better than the fixed assistance mode.This work was funded by the Conselleria d’Educacio, Cultura i Esport of Generalitat Valenciana by the European Social Fund—Investing in your Future, through the grant ACIF 2018/214, PEJ2018-002684-A and PEJ2018-002670-A, and by the Spanish Ministry of Science and Innovation through the project PID2019-108310RB-I00
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