5 research outputs found
Time-order-errors and duration ranges in the episodic Temporal generalization task
Fil: Mikulan, Ezequiel P. Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina. National Scientific and Technical Research Council (CONICET), Buenos Aires, ArgentinaFil: Bruzzone, Manuel. Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, ArgentinaFil: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, ArgentinaFil: Sigman, Mariano. Universidad Torcuato Di Tella, Escuela de Negocios, Laboratorio de Neurociencia, Buenos Aires, ArgentinaFil: Bekinschtein, Tristan A. Consciousness and Cognition Lab, Department of Psychology, University of Cambridge, Cambridge, UKFil: GarcĂa, Adolfo.Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina. National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina. Faculty of Education, National University of Cuyo (UNCuyo), Mendoza, ArgentinaFil: Sedeño, Lucas. Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina. National Scientific and Technical Research Council (CONICET), Buenos Aires, ArgentinaFil: Ibåñez, AgustĂn. Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina. National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina. Universidad AutĂłnoma del Caribe, Barranquilla, Colombia. Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibañez, Santiago de Chile, Chile. Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, Australi
Enhanced Working Memory Binding by Direct Electrical Stimulation of the Parietal Cortex
Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimerâs disease (AD). These studies suggest a potential role of posterior brain regions in both the neurocognitive deficits of Alzheimerâs patients and STM binding in general. Thereupon, we surmised that stimulation of the posterior parietal cortex (PPC) might be a successful approach to tackle working memory deficits in this condition, especially at early stages. To date, no causal evidence exists of the role of the parietal cortex in STM binding. A unique approach to assess this issue is afforded by single-subject direct intracranial electrical stimulation of specific brain regions during a relevant cognitive task. Electrical stimulation has been used both for clinical purposes and to causally probe brain mechanisms. Previous evidence of electrical currents spreading through white matter along well defined functional circuits indicates that visual working memory mechanisms are subserved by a specific widely distributed network. Here, we stimulated the parietal cortex of a subject with intracranial electrodes as he performed the visual STM task. We compared the ensuing results to those from a non-stimulated condition and to the performance of a matched control group. In brief, direct stimulation of the parietal cortex induced a selective improvement in STM. These results, together with previous studies, provide very preliminary but promising ground to examine behavioral changes upon parietal stimulation in AD. We discuss our results regarding: (a) the usefulness of the task to target prodromal stages of AD; (b) the role of a posterior network in STM binding and in AD; and (c) the potential opportunity to improve STM binding through brain stimulation