Self‐reported food and drug allergy in Maputo, Mozambique

Public Health. 2005 Jul;119(7):587-9. Self-reported food and drug allergy in Maputo, Mozambique. Lunet N, Falcão H, Sousa M, Bay N, Barros H. SourceDepartment of Hygiene and Epidemiology, University of Porto Medical School, Portugal. [email protected] PMID: 15925673 [PubMed - indexed for MEDLINE

Pirt, a TRPV1 Modulator, Is Required for Histamine-Dependent and -Independent Itch

Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also necessary for proper itch sensation. Pirt−/− mice exhibit deficits in cellular and behavioral responses to various itch-inducing compounds, or pruritogens. Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent. Our findings demonstrate that the function of Pirt extends beyond nociception via TRPV1 regulation to its role as a critical component in several itch signaling pathways

Purinergic signalling and immune cells

This review article provides a historical perspective on the role of purinergic signalling in the regulation of various subsets of immune cells from early discoveries to current understanding. It is now recognised that adenosine 5'-triphosphate (ATP) and other nucleotides are released from cells following stress or injury. They can act on virtually all subsets of immune cells through a spectrum of P2X ligand-gated ion channels and G protein-coupled P2Y receptors. Furthermore, ATP is rapidly degraded into adenosine by ectonucleotidases such as CD39 and CD73, and adenosine exerts additional regulatory effects through its own receptors. The resulting effect ranges from stimulation to tolerance depending on the amount and time courses of nucleotides released, and the balance between ATP and adenosine. This review identifies the various receptors involved in the different subsets of immune cells and their effects on the function of these cells

Anti-inflammarory activity of new pyrazolon drug

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Supporting data for The Nature and Transfer Effects of Computational Thinking in STEM

The dataset is the primary data that supported three enclosed studies (study 3, study 4, and study 5) in the project entitled "The Nature and Transfer Effects of Computational Thinking in STEM". Study 3 investigates the efficacy of the project-first approach to programming in a technology-deprived environment. The data shows the daily Python programming artefacts of the students and their scores. Study 4 is an inquiry into the nature of computational thinking (CT) problem-solving. The data is a qualitative response from seven students to demonstrate how CT is operationalized in everyday route planning task. Study 5 is an experimental study (n = 59) that investigated if learning with abstraction model enhances students’ programming knowledge and CT skill. The data contains participants response to quesstionaire, performance in programming knowledge test and CT test scores.</p