Optimal control problem for 3D micropolar fluid equations

In this paper we study an optimal control problem related to strong solutions of 3D micropolar fluid equations. We deduce the existence of a global optimal solution with distributed control and, using a Lagrange multipliers theorem, we derive first-order optimality conditions for local optimal solutions

Optimal control problem for 3D micropolar fluid equations

In this paper we study an optimal control problem related to strong solutions of 3D micropolar fluid equations. We deduce the existence of a global optimal solution with distributed control and, using a Lagrange multipliers theorem, we derive firstorder optimality conditions for local optimal solutions

Historical Biogeography of the Leptodactylus fuscus Group (Anura, Leptodactylidae): Identification of Ancestral Areas and Events that Modeled their Distribution

The objective of the present study was to reconstruct the biogeographic history of the monophyletic group Leptodactylus fuscus. We carried out two complementary historical biogeographic approaches: one estimates the ancestral areas with the statistical dispersion and vicariance method (S-DIVA). The other detects disjoint distributions among sister groups, which provides information about barriers that separate populations through a spatial analysis of vicariance (VIP method). For that, we used a database of species presence records and a topology of a phylogenetic cladogram, both obtained from updated published data that incorporates the current phylogenetic, taxonomic and distributional arrangements for the group. For the analysis of ancestral areas, the following areas of the L. fuscus group distribution were used: the Carribean, Chacoan, Parana, Amazonian and North American in Pacific subregions. The optimal reconstruction obtained with S-DIVA showed five vicariance events, two extinctions and 50 dispersals. The spatial analysis of vicariance revealed 19 disjointed sibling nodes and two distributions on nodes removed in the consensus tree. The results suggest that the ancestor of the Leptodactylus fuscus group occupied large areas within the Amazon and Chacoan subregions. Due to several dispersal events, the ancestor distribution range may have expanded to the Caribbean subregion. This expansion could have occurred during wetter periods, when forests were more extensive, which would have allowed the invasion of open habitats within humid forest systems. It is important to note that ecological factors and marine transgressions that occurred during the Miocene could have had a great influence on the current distribution of the group.Fil: Caffaro, Matias Exequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Medina, Regina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biodiversidad Neotropical. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto de Biodiversidad Neotropical. Instituto de Biodiversidad Neotropical; Argentina. Pontificia Universidad Católica de Chile; ChileFil: Ponssa, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; ArgentinaFil: Diaz Gomez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; Argentin

Revista del Consejo Superior de Investigaciones Científicas

Actividad trófica de limícolas invernantes en salinas y cultivos piscícolas de la bahía de CádizUso de microhábitat del ratón de campo (Apodemus sylvatycus L.) en robledales y áreas ecotonales del Pirineo.Dieta de los pollos de tres especies simpátricas de alcaudones (Lanius spp.): variaciones con la edad, estacionales e interespecíficasOcupación de distintos modelos de nidal por el estornino negro (Sturnus unicolor)Estudio comparado sobre la biología de la reproducción de tres especies simpátricas de alcaudones (real Lanius excubitor, dorsirrojo L. collurio y común L. senatorFluctuación estacional del peso corporal de los machos adultos de Arvicola sapidus MILLER, 1908 (Rodentia, Arvicolidae)Acerca del significado de los ataques de alcaudones Lanius spp. sobre aves.Distribución de los emididos Mauremys leprosa, SCHW (1812) y Emys orbicularis, L. (1758) de la provincia de Badajoz. Factores que puedieran influir en sus áreas de ocupaciónDeterminación de la edad relativa en la rata de agua meridional, Arvicola sapidus MILLER, 1908 (Rodentia, Arvicolidae)Activity pattern, home range and habitat preference by coyotes (Canis latrans) in the Mapimi Biosphere Reserve of the Chihuahuan Desert, Mexico.Características de los refugios diarios y estacionales de Testudo graeca en DoñanaDieta del gato cimarrón (Felis catus L.) en el piso basal del Macízo de Teno (Noroeste de Tenerife)Peer reviewe

Estudio de tres niveles de humedad en cultivos Maiz (Zea mays L.), Tomate (Solanum lycopersicum L.), Camote (Ipomoea batatas L.), bajo riego por goteo en la produccion biointensivo, Totogalpa, Madriz, 2019

El modelo de huertos biointensivo surge como una necesidad para dar respuesta a la demanda de alimentos sanos para una población que está en crecimiento, así como una solución al problema de pérdida y deterioro del suelo. Este estudio se llevó a cabo con el objetivo de evaluar parámetros de riego y tres niveles de humedad, Tı (22.98 mm), T2 (34.92 mm) y T3 (40.11 mm) para conocer los efectos sobre el rendimiento de los cultivos, maíz (Zea mays, L), tomate (solanum Lycopersicum, L.) y camote (ipomea batata, L) realizado en el Instituto de Promoción Humana (INPRHU) ubicado en el municipio de Totogalpa, Madriz, a 13°29'02.07” LN y 86°35'03.44” LO, a una elevación 702 msnm y un rango de temperaturas medias que oscilan entre 22.5 a 23.6° C en el periodo 2018 – 2019, la unidad experimental contó con nueve camas, con dimensiones de 1.25 m de ancho y 8 m de longitud. El ensayo se estableció bajo un diseño experimental en parcelas apareadas, a todas las variables se les realizo el ANDEVA y separación de medias según LSD (∞ = 0.05). La variable rendimiento no mostraron diferencias significativas con medias T1 (maíz, 0.98 kg ha-1, tomate 38.38 kg ha-1y camote 14.69 kg ha-1) T2 (maíz 0.61 kg ha-1, tomate 34.09 kg ha-1 camote 57.70 kg ha-1) y T3 (maíz 0.21 kg ha-1, tomate 42.23 kg ha-1 y camote con 26.20 kg ha-1) estos rendimientos están dentro de un rango de producción en una cama de 10 m². El coeficiente de uniformidad promedio para los caudales fue de ˃ 90% y un coeficiente de uniformidad de presiones ˃ 90% considerado excelente

Human FoxP Transcription Factors as Tractable Models of the Evolution and Functional Outcomes of Three-Dimensional Domain Swapping

The association of two or more proteins to adopt a quaternary complex is one of the most widespread mechanisms by which protein function is modulated. In this scenario, three-dimensional domain swapping (3D-DS) constitutes one plausible pathway for the evolution of protein oligomerization that exploits readily available intramolecular contacts to be established in an intermolecular fashion. However, analysis of the oligomerization kinetics and thermodynamics of most extant 3D-DS proteins shows its dependence on protein unfolding, obscuring the elucidation of the emergence of 3D-DS during evolution, its occurrence under physiological conditions, and its biological relevance. Here, we describe the human FoxP subfamily of transcription factors as a feasible model to study the evolution of 3D-DS, due to their significantly faster dissociation and dimerization kinetics and lower dissociation constants in comparison to most 3D-DS models. Through the biophysical and functional characterization of FoxP proteins, relevant structural aspects highlighting the evolutionary adaptations of these proteins to enable efficient 3D-DS have been ascertained. Most biophysical studies on FoxP suggest that the dynamics of the polypeptide chain are crucial to decrease the energy barrier of 3D-DS, enabling its fast oligomerization under physiological conditions. Moreover, comparison of biophysical parameters between human FoxP proteins in the context of their minute sequence differences suggests differential evolutionary strategies to favor homoassociation and presages the possibility of heteroassociations, with direct impacts in their gene regulation function

Characterization of the domain swapping mechanism of the forkhead domain of human FoxP1 at a single-molecule level

Fondecyt 1130510 11140601 2113047

The protonation state of an evolutionarily conserved histidine modulates domainswapping stability of FoxP1

Forkhead box P (FoxP) proteins are members of the versatile Fox transcription factors, which control the timing and expression of multiple genes for eukaryotic cell homeostasis. Compared to other Fox proteins, they can form domain-swapped dimers through their DNA-binding –forkhead– domains, enabling spatial reorganization of distant chromosome elements by tethering two DNA molecules together. Yet, domain swapping stability and DNA binding affinity varies between different FoxP proteins. Experimental evidence suggests that the protonation state of a histidine residue conserved in all Fox proteins is responsible for pH-dependent modulation of these interactions. Here, we explore the consequences of the protonation state of another histidine (H59), only conserved within FoxM/O/P subfamilies, on folding and dimerization of the forkhead domain of human FoxP1. Dimer dissociation kinetics and equilibrium unfolding experiments demonstrate that protonation of H59 leads to destabilization of the domain-swapped dimer due to an increase in free energy difference between the monomeric and transition states. This pH–dependence is abolished when H59 is mutated to alanine. Furthermore, anisotropy measurements and molecular dynamics evidence that H59 has a direct impact in the local stability of helix H3. Altogether, our results highlight the relevance of H59 in domain swapping and folding stability of FoxP1

Biophysical and evolutionary aspects of domain swapping in the forkhead domain of human FoxP protein

FONDECYT 11140601 113051