Analyzing Math-to-Mastery through Brief Experimental Analysis

The current study evaluated the effectiveness of individualized math-to-mastery (MTM) interventions, selected though brief experimental analysis (BEA), at increasing math fluency skills for 3 elementary-aged females. As MTM has only been investigated as a multicomponent intervention, the present study utilized BEA to identify those specific components which led to math skills gains in the most efficient manner possible. BEA results indicated that for 2 of 3 participants only a partial MTM intervention was necessary to prompt fluency gains, while the entire intervention was the most effective for the third. During extended analysis all 3 participants displayed math skills gains above those seen during repeated baseline assessments. Results are discussed in terms of further refining MTM through BEA procedures so as to individually target math skill deficits by considering both intervention effectiveness and efficiency

Large Pyroelectric Response from Reactively Sputtered Aluminum Nitride Thin Films

We report the pyroelectric response of c-axis oriented, undoped, wurtzite, aluminum nitride reactively sputtered onto polished silicon wafers. The voltage between a metallic contact on the AlN surface and the n+ -doped silicon substrate was monitored during pulsed infrared, radiant heating. From analysis of the data, a pyroelectric voltage coefficient, PV, in excess of 0.5 x 106 V/m/K was extracted for films in the 600 to 2500 Å thickness range

Multiwavelength Constraints on the Day-Night Circulation Patterns of HD 189733b

We present new Spitzer observations of the phase variation of the hot Jupiter HD 189733b in the MIPS 24 μm bandpass, spanning the same part of the planet's orbit as our previous observations in the IRAC 8 μm bandpass (Knutson et al. 2007). We find that the minimum hemisphere-averaged flux from the planet in this bandpass is 76% ± 3% of the maximum flux; this corresponds to minimum and maximum hemisphere-averaged brightness temperatures of 984 ± 48 K and 1220 ± 47 K, respectively. The planet reaches its maximum flux at an orbital phase of 0.396 ± 0.022, corresponding to a hot region shifted 20°-30° east of the substellar point. Because tidally locked hot Jupiters would have enormous day-night temperature differences in the absence of winds, the small amplitude of the observed phase variation indicates that the planet's atmosphere efficiently transports thermal energy from the day side to the night side at the 24 μm photosphere, leading to modest day-night temperature differences. The similarities between the 8 and 24 μm phase curves for HD 189733b lead us to conclude that the circulation on this planet behaves in a fundamentally similar fashion across the range of pressures sensed by these two wavelengths. One-dimensional radiative transfer models indicate that the 8 μm band should probe pressures 2-3 times greater than at 24 μm, although the uncertain methane abundance complicates the interpretation. If these two bandpasses do probe different pressures, it would indicate that the temperature varies only weakly between the two sensed depths, and hence that the atmosphere is not convective at these altitudes. We also present an analysis of the possible contribution of star spots to the time series at both 8 and 24 μm based on near-simultaneous ground-based observations and additional Spitzer observations. Accounting for the effects of these spots results in a slightly warmer night-side temperature for the planet in both bandpasses, but does not otherwise affect our conclusions

Experimental Probes of the Randall-Sundrum Infinite Extra Dimension

The phenomenological possibilities of the Randall-Sundrum non-compact extra dimension scenario with the AdS horizon increased to approximately a millimeter length, corresponding to an effective brane tension of TeV^4, are investigated. The corrections to the Newtonian potential are found to be the only observationally accessible probe of this scenario, as previously suggested in the literature. In particular, the presence of the continuum of KK modes does not lead to any observable collider signatures. The extent to which experimental tests of Newtonian gravity can distinguish this scenario from the scenario of Arkani-Hamed, Dimopoulos, and Dvali with one and two millimeter size extra dimensions is explicitly demonstrated.Comment: 22 pages, 2 figures, references adde

A Randomized Phase II Study to Assess the Efficacy of Pemetrexed or Sunitinib or Pemetrexed Plus Sunitinib in the Second-Line Treatment of Advanced Non–Small-Cell Lung Cancer

Second-line chemotherapy for advanced non-small cell lung cancer (NSCLC) improves survival modestly but new strategies are needed. This trial was designed to evaluate an antivascular endothelial growth factor strategy with or without standard chemotherapy in previously treated NSCLC

Transiting Exoplanet Studies and Community Targets for JWST's Early Release Science Program

The James Webb Space Telescope will revolutionize transiting exoplanet atmospheric science due to its capability for continuous, long-duration observations and its larger collecting area, spectral coverage, and spectral resolution compared to existing space-based facilities. However, it is unclear precisely how well JWST will perform and which of its myriad instruments and observing modes will be best suited for transiting exoplanet studies. In this article, we describe a prefatory JWST Early Release Science (ERS) program that focuses on testing specific observing modes to quickly give the community the data and experience it needs to plan more efficient and successful future transiting exoplanet characterization programs. We propose a multi-pronged approach wherein one aspect of the program focuses on observing transits of a single target with all of the recommended observing modes to identify and understand potential systematics, compare transmission spectra at overlapping and neighboring wavelength regions, confirm throughputs, and determine overall performances. In our search for transiting exoplanets that are well suited to achieving these goals, we identify 12 objects (dubbed "community targets") that meet our defined criteria. Currently, the most favorable target is WASP-62b because of its large predicted signal size, relatively bright host star, and location in JWST's continuous viewing zone. Since most of the community targets do not have well-characterized atmospheres, we recommend initiating preparatory observing programs to determine the presence of obscuring clouds/hazes within their atmospheres. Measurable spectroscopic features are needed to establish the optimal resolution and wavelength regions for exoplanet characterization. Other initiatives from our proposed ERS program include testing the instrument brightness limits and performing phase-curve observations.(Abridged)Comment: This is a white paper that originated from an open discussion at the Enabling Transiting Exoplanet Science with JWST workshop held November 16 - 18, 2015 at STScI (http://www.stsci.edu/jwst/science/exoplanets). Accepted for publication in PAS

Orbital Refinement and Stellar Properties for the HD 9446, HD 43691, and HD 179079 Planetary Systems

The Transit Ephemeris Refinement and Monitoring Survey is a project that aims to detect transits of intermediate-long period planets by refining orbital parameters of the known radial velocity planets using additional data from ground-based telescopes, calculating a revised transit ephemeris for the planet, then monitoring the planet host star during the predicted transit window. Here we present the results from three systems that had high probabilities of transiting planets: HD 9446 b and c, HD 43691 b, and HD 179079 b. We provide new radial velocity (RV) measurements that are then used to improve the orbital solution for the known planets. We search the RV data for indications of additional planets in orbit and find that HD 9446 shows a strong linear trend of 4.8σ. Using the newly refined planet orbital solutions, which include a new best-fit solution for the orbital period of HD 9446 c, and an improved transit ephemerides, we found no evidence of transiting planets in the photometry for each system. Transits of HD 9446 b can be ruled out completely and transits HD 9446 c and HD 43691 b can be ruled out for impact parameters up to b = 0.5778 and b = 0.898, respectively, due to gaps in the photometry. A transit of HD 179079 b cannot be ruled out, however, due to the relatively small size of this planet compared to the large star and thus low signal to noise. We determine properties of the three host stars through spectroscopic analysis and find through photometric analysis that HD 9446 exhibits periodic variability

Renal Denervation Update From the International Sympathetic Nervous System Summit:JACC State-of-the-Art Review

Three recent renal denervation studies in both drug-naïve and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications