A formative evaluation of the Ontario breast cancer information exchange project

In 1993 The Government of Canada allocated 2.7 million dollars to fund five Breast Cancer Information Exchange Pilot Projects for five years. The Ontario Breast Cancer Information Exchange Project (OBCIEP) is one site of this innovative approach to linking breast cancer stakeholders and women with breast cancer and coordinating available information sources to improve access to information about breast cancer for women, their families and health care professionals. Formative evaluations are conducted to learn from a novel program such as the OBCIEP. This paper outlines a collaborative approach to evaluation using qualitative methods and analyses. The results of the evaluation are discussed in terms of community psychology and evaluation theory and practice, as well as the historical roots of the women\u27s health movement

Auditing Ranked Voting Elections with Dirichlet-Tree Models: First Steps

Ranked voting systems, such as instant-runo voting (IRV) and single transferable vote (STV), are used in many places around the world. They are more complex than plurality and scoring rules, pre- senting a challenge for auditing their outcomes: there is no known risk- limiting audit (RLA) method for STV other than a full hand count. We present a new approach to auditing ranked systems that uses a sta- tistical model, a Dirichlet-tree, that can cope with high-dimensional pa- rameters in a computationally e cient manner. We demonstrate this ap- proach with a ballot-polling Bayesian audit for IRV elections. Although the technique is not known to be risk-limiting, we suggest some strategies that might allow it to be calibrated to limit risk

CRF Mediates Stress-Induced Pathophysiological High-Frequency Oscillations in Traumatic Brain Injury

Copyright © 2019 Narla et al. It is not known why there is increased risk to have seizures with increased anxiety and stress after traumatic brain injury (TBI). Stressors cause the release of corticotropin-releasing factor (CRF) both from the hypothalamic pituitary adrenal (HPA) axis and from CNS neurons located in the central amygdala and GABAergic interneurons. We have previously shown that CRF signaling is plastic, becoming excitatory instead of inhibitory after the kindling model of epilepsy. Here, using Sprague Dawley rats we have found that CRF signaling increased excitability after TBI. Following TBI, CRF type 1 receptor (CRFR1)-mediated activity caused abnormally large electrical responses in the amygdala, including fast ripples, which are considered to be epileptogenic. After TBI, we also found the ripple (120-250 Hz) and fast ripple activity (\u3e250 Hz) was cross-frequency coupled with θ (3-8 Hz) oscillations. CRFR1 antagonists reduced the incidence of phase coupling between ripples and fast ripples. Our observations indicate that pathophysiological signaling of the CRFR1 increases the incidence of epileptiform activity after TBI. The use for CRFR1 antagonist may be useful to reduce the severity and frequency of TBI associated epileptic seizures

Sub-lunar Tap Yielding eXplorer (STYX) & Surface Telemetry Operations and Next-generation Excavation System (STONES)

The NASA RASC-AL Moon to Mars competition challenges student teams to develop a lightweight, durable, and hands-off method for extracting water from Martian/lunar subsurface ice layers while mapping soil density profiles. Future interplanetary expeditions are dependent on the availability of clean water and this project aims to accomplish this task. The challenge description enumerates several criteria to be met for successful designs. For further information, the STYX & STONES team conducted research on Cal Poly’s competition project from last year to consider the areas for redesign. As such, the team has utilized the background research from relevant patents and journal articles to consider brainstorming potentially viable solutions. Based on these solutions for each subsystem, the team converged the ideas using a series of decision matrices into a final design direction. In addition to reviewing the STYX design, several new considerations were made for the scope of this project. Primarily, this year’s team focused on developing a prototype that has the capability of operating in an extraterrestrial environment and thoroughly fulfilling the requirements posed by NASA. To visualize the requirements, the team created a list of customer needs, a House of Quality diagram, and an engineering specifications table. Additionally, the STYX & STONES team discussed the design process it plans to follow including major project milestones. Specifically, the team plans to excel in collecting more than five quarts of water autonomously while successfully identifying the overburden layers – tasks that previous teams have struggled with. The team’s design direction includes two main components: a masonry drill bit and an auger- heater probe hybrid tool. The masonry drill bit will create a hole in the overburden using the force from a rotary hammer. The heater probe tool will then be moved to align with the hole and be driven into the loosened overburden using the force of a small gear motor. The heater probe will then melt ice using a hot waterjet and deliver water via a peristaltic pump and a two-stage filtration system. To verify the design, the team completed a multitude of analyses and tests for each subsystem and the prototype as a whole. Through drilling tests, the team found that the rotary hammer and masonry bit can easily cut through all overburden layers while keeping weight on bit (WOB) below 150N. Similarly, the load cells attached to the drill carriage were tested and proven to be accurate at recording WOB data and providing feedback to the controller to monitor WOB. Furthermore, the load cells proved successful at recording accurate WOB data that can be analyzed to determine overburden composition. The pumping system was also tested and was capable of effectively moving water through all filters and delivering fluid to the waterjet. More tests were completed to verify the heater probe tool; these tests included controlling heater temperature, melting ice, expelling water through the waterjet, and removing loose material from the hole. To verify the design requirements, the team has completed analysis pertaining to each subsystem including the drill, heater probe, frame, and control systems. The team is confident in the drilling design based on testing and vibrations analysis. In the same manner, the team verified that the 12V peristaltic pump will have enough pressure head rise based on analysis and prototype testing. Using the prototype heater probe as a reference, the team fully characterized the heat transfer parameters of the final design and is confident the auger will be effective considering surrounding debris. Finally, the team tested the water jet design using 120oF water which provided optimistic results that the water jet will significantly expand the melt radius per hole. As a next step, the team will be testing the mechanical and controls systems simultaneously using manufactured parts. The following report details the subsystems and relevant information

Identification of a Novel Synaptic Protein, TMTC3, Involved in Periventricular Nodular Heterotopia with Intellectual Disability and Epilepsy

Defects in neuronal migration cause brain malformations, which are associated with intellectual disability (ID) and epilepsy. Using exome sequencing, we identified compound heterozygous variants (p.Arg71His and p. Leu729ThrfsTer6) in TMTC3, encoding transmembrane and tetratricopeptide repeat containing 3, in four siblings with nocturnal seizures and ID. Three of the four siblings have periventricular nodular heterotopia (PVNH), a common brain malformation caused by failure of neurons to migrate from the ventricular zone to the cortex. Expression analysis using patient-derived cells confirmed reduced TMTC3 transcript levels and loss of the TMTC3 protein compared to parental and control cells. As TMTC3 function is currently unexplored in the brain, we gathered support for a neurobiological role for TMTC3 by generating flies with post-mitotic neuron-specific knockdown of the highly conserved Drosophila melanogaster TMTC3 ortholog, CG4050/tmtc3. Neuron-specific knockdown of tmtc3 in flies resulted in increased susceptibility to induced seizures. Importantly, this phenotype was rescued by neuron-specific expression of human TMTC3, suggesting a role for TMTC3 in seizure biology. In addition, we observed co-localization of TMTC3 in the rat brain with vesicular GABA transporter (VGAT), a presynaptic marker for inhibitory synapses. TMTC3 is localized at VGAT positive pre-synaptic terminals and boutons in the rat hypothalamus and piriform cortex, suggesting a role for TMTC3 in the regulation of GABAergic inhibitory synapses. TMTC3 did not co-localize with Vglut2, a presynaptic marker for excitatory neurons. Our data identified TMTC3 as a synaptic protein that is involved in PVNH with ID and epilepsy, in addition to its previously described association with cobblestone lissencephaly

Digital Words: Moving Forward with Measuring the Readability of Online Texts

The readability of a digital text can influence people’s information acquisition (Wikipedia articles), online security (how-to articles), and even health (WebMD). Readability metrics can also alter search rankings and are used to evaluate AI system performance. However, prior work on measuring readability has significant gaps, especially for HCI applications. Prior work has (a) focused on grade-school texts, (b) ignored domain-specific, jargon-heavy texts (e.g., health advice), and (c) failed to compare metrics, especially in the context of scaling to use with online corpora. This paper addresses these shortcomings by comparing well-known readability measures and a novel domain-specific approach across four different corpora: crowd-worker generated stories, Wikipedia articles, security and privacy advice, and health information. We evaluate the convergent, discriminant, and content validity of each measure and detail tradeoffs in domain-specificity and participant burden. These results provide a foundation for more accurate readability measurements in HCI

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations.

OBJECTIVES: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. PARTICPANTS AND METHODS: Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. RESULTS: A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. CONCLUSION: This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening

Cancer in the mass print media: Fear, uncertainty and the medical model

Cancer is increasing in incidence and prevalence in North America and around the world. The mass print media play an important role in information provision about prevention, diagnosis and treatment of this disease, as well as informing health policy and personal experience. This paper reports on a content analysis of the portrayal of cancer in the highest circulating magazines available in Canada and published in Canada or the USA in 1991, 1996, 2001. It includes both manifest and latent analysis of the framing and content of cancer stories. Manifest analysis documented the dominance of the medical as compared to the lifestyle and political economy frames and the predominance of articles on breast as compared to other cancers. Latent themes included: an emphasis on fear of cancer in that: (1) cancer and fear are frequently conflated; cancer is said to grow outside of awareness; cancer is portrayed as (almost) inevitable; cancer is associated with normal experiences; early detection is associated with diagnosis; and scary statistics are emphasized; (2) contradictions and confusion exist within and between articles; and (3) metaphors of war and battle are used frequently. The paper concludes with a discussion of the implications of the linking of fear with cancer in the context of medicine as the solution.Media Cancer Fear Medical model North America

The paradoxical reliance on allopathic medicine and positivist science among skeptical audiences

A number of studies have found an association between what people see, hear and read in the mass media and their corresponding actions and beliefs. This link has been demonstrated both at the micro and at the macro levels of analysis. However, when people are asked directly about the impact of mass media they tend to deny that they are personally affected. In fact, they tend to describe themselves as critical and skeptical media consumers. The purpose of this paper is to explore this contradiction through 12 in-depth focus group discussions undertaken in Ontario, Canada in 2004. Findings from the focus group interviews confirm earlier research in that people claimed that they were not susceptible to media influence. At the same time as they said that they took information from the mass media "with a grain of salt", they articulated sophisticated and nuanced accounts of how and why they evaluated some information as good and some as bad. In general they evaluated media stories on the basis of the values of allopathic medicine and positivistic science. Moreover, in the context of the focus groups and their explicit comments on their skepticism, they discussed health information from the magazine articles that they were given to read (on either HIV/AIDS, Alzheimer's disease, or a heart disease). Possible explanations for these paradoxical findings are discussed.Canada Health Media Audience interpretation Medicalization