Hunter-gatherer and Environmental Relations during the Mesolithic of Atlantic Europe.

Environmental change is a major concern for society today. This concern extends the flooding of people’s homes, the reduction of biodiversity due to habitat loss, and the threat to economic prosperity where it is dependent upon the exploitation of wild resources. In terms of past climate change there has been significant amounts of research conducted into the Pleistocene to Holocene transition. This project explores the evidence for environmental change, of a less severe yet potentially disruptive amplitude, and its influence on the behaviour and decisions of Mesolithic hunter-gatherers on the Atlantic façade of Europe. The archaeological record is reviewed with a particular focus on the 8.2K cal bp event and the 2nd half of the 5th millennium cal BC. The resulting datasets are interrogated utilising a multiproxy approach and consideration is given to that which is archaeologically visible and that which is not. The limitations of the archaeological record are addressed through the development of new methodologies and interpretative frameworks. The findings are significant, as the severity of the 8.2k cal bp event at northern latitudes is confirmed, although this falls short of being able to assert a total abandonment at higher latitudes. During the 5th millennium cal BC, a period of instability related to more energetic shoreline conditions has been identified and this is very likely a regional phenomenon. The period of instability is accompanied by changes in hunter-gatherer behaviour, and this includes changes in the spatial organisation of settlement, and adjustments to procurement strategies. The overall situation is that environmental change is the norm during the Mesolithic of the Atlantic façade, almost certainly due to its highly moderated climate. The adaptability of hunter-gatherer societies in response to the changes brought about by fluctuations in the moderating mechanisms is strongly attested. In many ways not much has changed, as flooded homes, reductions in biodiversity and changes in the resources available for exploitation are all observed

Exploring the Equity Impact of Current Digital Health Design Practices:Protocol for a Scoping Review

BACKGROUND: The field of digital health has grown rapidly in part due to digital health tools’ potential to reduce health inequities. However, such potential has not always been realized. The design approaches used in digital health are one of the known aspects that have an impact on health equity. OBJECTIVE: The aim of our scoping review will be to understand how design approaches in digital health have an impact on health equity. METHODS: A scoping review of studies that describe how design practices for digital health have an impact on health equity will be carried out. The scoping review will follow the methodologies laid out by Arksey and O’Malley, the Joanna Briggs Institute, and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist. The PubMed, Embase, Web of Science, and ACM Digital Library databases will be searched for peer-reviewed papers. The ProQuest Dissertations and Theses and Global Index Medicus databases will be searched for gray literature. The results will be screened against our inclusion and exclusion criteria. Subsequently, the data extracted from the included studies will be analyzed. RESULTS: As of March 2022, a preliminary search of the peer-reviewed databases has yielded over 4900 studies, and more are anticipated when gray literature databases are searched. We expect that after duplicates are removed and screening is completed, a much smaller number of studies will meet all of our inclusion criteria. CONCLUSIONS: Although there has been much discussion about the importance of design for lowering barriers to digital health participation, the evidence base demonstrating its impacts on health equity is less obvious. We hope that our findings will contribute to a better understanding of the impact that design in digital health has on health equity and that these findings will translate into action that leads to stronger, more equitable health care systems

The Mechanism of the Iodination of Phenols

Author Institution: Department of Chemistry, Miami University, Oxfor

Antagonistic interactions between honey bee bacterial symbionts and implications for disease

BACKGROUND: Honey bees, Apis mellifera, face many parasites and pathogens and consequently rely on a diverse set of individual and group-level defenses to prevent disease. One route by which honey bees and other insects might combat disease is through the shielding effects of their microbial symbionts. Bees carry a diverse assemblage of bacteria, very few of which appear to be pathogenic. Here we explore the inhibitory effects of these resident bacteria against the primary bacterial pathogen of honey bees, Paenibacillus larvae. RESULTS: Here we isolate, culture, and describe by 16S rRNA and protein-coding gene sequences 61 bacterial isolates from honey bee larvae, reflecting a total of 43 distinct bacterial taxa. We culture these bacteria alongside the primary larval pathogen of honey bees, Paenibacillus larvae, and show that many of these isolates severely inhibit the growth of this pathogen. Accordingly, symbiotic bacteria including those described here are plausible natural antagonists toward this widespread pathogen. CONCLUSION: The results suggest a tradeoff in social insect colonies between the maintenance of potentially beneficial bacterial symbionts and deterrence at the individual and colony level of pathogenic species. They also provide a novel mechanism for recently described social components behind disease resistance in insect colonies, and point toward a potential control strategy for an important bee disease

Implications of austerity for community safety within Merseyside

Community safety sector stakeholders in Merseyside are finding it increasingly difficult to remain financially sustainable and deliver the necessary community safety, crime prevention and diversionary services. Over the course of the immediate past parliament, Merseyside Local Authorities within the Liverpool City Region Combined Authority (LCRCA) and the police force area had to restructure staffing and service provision extensively in order to deliver efficiency savings of over £650m. This research study used a mixed-methodological approach to explain how cuts to funding impacted on the delivery of public safety priorities under the coalition government (2010-2015). We discovered that the cuts had severe repercussions not just in terms of stakeholders capability to provide key services but also for the morale of their staff. Based on feedback from the study participants, we project a further 33% cutback in funding over the course of the current parliament though subsequent more favourable Government announcements suggest a more modest figure of up to 15%. This undoubtedly will result in the further streamlining of public services with potentially serious ramifications for levels of public safety

The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1

BACKGROUND/OBJECTIVE: The extent of influence of BMI and age on C-peptide at the diagnosis of type 1 diabetes (T1D) is unknown. We thus studied the impact of body mass index Z-scores (BMIZ) and age on C-peptide measures at and soon after the diagnosis of T1D. METHODS: Data from Diabetes Prevention Trial-Type 1 (DPT-1) participants <18.0 years at diagnosis was analyzed. Analyses examined associations of C-peptide measures with BMIZ and age in 2 cohorts: oral glucose tolerance tests (OGTTs) at diagnosis (n = 99) and mixed meal tolerance tests (MMTTs) <6 months after diagnosis (n = 80). Multivariable linear regression was utilized. RESULTS: Fasting and area under the curve (AUC) C-peptide from OGTTs (n = 99) at diagnosis and MMTTs (n = 80) after diagnosis were positively associated with BMIZ and age (P < .001 for all). Associations persisted when BMIZ and age were included as independent variables in regression models (P < .001 for all). BMIZ and age explained 31%-47% of the variance of C-peptide measures. In an example, 2 individuals with identical AUC C-peptide values had an approximate 5-fold difference in values after adjustments for BMIZ and age. The association between fasting glucose and C-peptide decreased markedly when fasting C-peptide values were adjusted (r = 0.30, P < .01 to r = 0.07, n.s.). CONCLUSIONS: C-peptide measures are strongly and independently related to BMIZ and age at and soon after the diagnosis of T1D. Adjustments for BMIZ and age cause substantial changes in C-peptide values, and impact the association between glycemia and C-peptide. Such adjustments can improve assessments of β-cell impairment at diagnosis