A likely runaway star cluster in the outer disc of the Large Magellanic Cloud

We present results from photometric and spectroscopic data obtained with SOAR and Gemini observatory facilities in the field of a recently discovered star cluster. The cluster, projected towards the Eastern side of the outer disc of the Large Magellanic Cloud (LMC),was originally placed nearly 10 kpc behind the LMC with an age and metallicity typical of the innermost LMC star cluster population.We assigned radial velocity (RV) memberships to stars observed spectroscopically, and derived the cluster age and distance from theoretical isochrone fitting to the cluster colour-magnitude diagram. The new object turned out to be a 0.9 Gyr old outer LMC disc cluster, which possibly reached the present position after being scattered from the innermost LMC regions where it might have been born. We arrived at this conclusion by examining the spatial distribution of LMC star clusters of similar age, by comparing the derived spectroscopic metallicity with that expected for an outside-in galaxy formation scenario, by considering the cluster internal dynamical stage as inferred from its derived structural parameters and by estimating the circular velocity of a disc that rotates with the corresponding star cluster radial velocity at the cluster's deprojected distance, which resulted to be nearly 60 per cent higher than that of most of the outer LMC disc clusters.Fil: Piatti, Andres Eduardo. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Salinas, Ricardo. Gemini Observatorysouthern Operations Center; ChileFil: Grebel, Eva K.. Ruprecht Karls Universitat Heidelberg. Fakultat Fur Physik And Astronomie.; Alemani

Does open reduction and pinning affect outcome in severely displaced supracondylar humeral fractures in children? A systematic review

Supracondylar fracture of the humerus is the second most common fracture in children (16.6%) and the most common elbow fracture. These fractures are classified using the modified Gartland classification. Type III and type IV are considered to be totally displaced. A totally displaced fracture is one of the most difficult fractures to manage and may lead to proceeding to open procedures to achieve acceptable reductions. Many surgeons are concerned about its outcome compared to closed procedures. We therefore performed a systematic review of the literature to investigate the existing evidence regarding functional and radiological outcomes as well as postsurgical complications of primary open compared to primary closed reduction

DNA barcoding for assessment of exotic molluscs associated with maritime ports in northern Iberia

Ports are gateways for aquatic invasions. New arrivals from maritime traffic and disturbed environmental conditions can promote the settlement of exotic species. Molluscs fall into the most prevalent group of invasive species and can have a tremendous impact on aquatic ecosystems. Here we have investigated exotic molluscs in three ports with different intensities of maritime traffic in the Cantabrian Sea. DNA barcodes were employed to identify the species using BLASTn and BOLD IDS assignment. Deep morphological analysis using diagnostic criteria confirmed BLAST species assignation based on COI and 16S rRNA genes. Results confirmed the usefulness of DNA barcoding for detecting exotic species that are visually similar to native species. Three exotic bivalves were identified: Ostrea stentina (dwarf oyster), the highly invasive Crassostrea gigas (Pacific oyster) and Xenostrobus securis (pygmy mussel). This is the first record of O. stentina in the Bay of Biscay and the second of X. securis in the Cantabrian Sea. Furthermore, we report on the presence of the cryptogenic mussel Mytilaster minimus in the central Cantabrian Sea. These exotic species might have been overlooked due to their phenotypic similarity with co-occurring oyster and mussel species. This study illustrates how combining morphological and DNA taxonomic analysis can help in port and marina biosecurity surveys

Phase 2 Trial (POLA Study) of Lurbinectedin plus Olaparib in Patients with Advanced Solid Tumors: Results of Efficacy, Tolerability, and the Translational Study

Endometrial cancer; Genomic instability; OlaparibCáncer endometrial; Inestabilidad genómica; OlaparibCàncer d'endometri; Inestabilitat genòmica; OlaparibWe hypothesized that the combination of olaparib and lurbinectedin maximizes DNA damage, thus increasing its efficacy. The POLA phase 1 trial established the recommended phase 2 dose of lurbinectedin as being 1.5 mg (day 1) and that of olaparib as being 250 mg/12 h (days 1–5) for a 21-day cycle. In phase 2, we explore the efficacy of the combination in terms of clinical response and its correlation with mutations in the HRR genes and the genomic instability (GI) parameters. Results: A total of 73 patients with high-grade ovarian (n = 46), endometrial (n = 26), and triple-negative breast cancer (n = 1) were treated with lurbinectedin and olaparib. Most patients (62%) received ≥3 lines of prior therapy. The overall response rate (ORR) and disease control rate (DCR) were 9.6% and 72.6%, respectively. The median progression-free survival (PFS) was 4.54 months (95% CI 3.0–5.2). Twelve (16.4%) patients were considered long-term responders (LTR), with a median PFS of 13.3 months. No clinical benefit was observed for cases with HRR gene mutation. In ovarian LTRs, although a direct association with GI and a total loss of heterozygosity (LOH) events was observed, the association did not reach statistical significance (p = 0.055). Globally, the total number of LOHs might be associated with the ORR (p =0.074). The most common grade 3–4 toxicities were anemia and thrombocytopenia, in 6 (8.2%) and 3 (4.1%) patients, respectively. Conclusion: The POLA study provides evidence that the administration of lurbinectedin and olaparib is feasible and tolerable, with a DCR of 72.6%. Different GI parameters showed associations with better responses.This trial was sponsored by AstraZeneca and PharmaMar, including supply of the drugs used in this study

Ensayos en probetas para el estudio del efecto tamaño en la cabeza de compresión de vigas sometidas a esfuerzo cortante: aplicación de la metodología DIC

To evaluate how the size effect affects the stresses developed along the compression chord in a beams subjected to shear forces, a simplified experimental program was developed on 50 prismatic specimens subjected to a splitting test. The studied parameters were: dimensions, slenderness, concrete compressive strength, and maximum aggregate size. To capture the post-peak behavior of the concrete, the load was introduced as a function of the crack width, through appropriate control algorithms. Digital Image Correlation (DIC) in a 2D configuration has also been used to accurately capture the formation, width and propagation of cracks to corroborate the experimental measurements.The financial support provided by the Spanish Ministry of Economy and Competitiveness (MINECO) and the European Funds for Regional Development (FEDER), through the Research projects: BIA2015-64672-C4-1-R and BIA2017-84975-C2-2-P and through the Excellence network BIA2015-71484-REDT.Postprint (published version

Surface Lewis Acidity of Periphery Oxide Species as a General Kinetic Descriptor for CO2 Hydrogenation to Methanol on Supported Copper Nanoparticles

[EN] Oxide-supported copper nanoparticles exhibit promising properties as catalysts for the selective hydrogenation of CO2 to methanol. Both reaction rate and selectivity depend conspicuously on the nature of the oxide support/promoter at the metal periphery. However, a major challenge is the achievement of a quantitative description of such metal/oxide promotion effects, which is an essential step toward a rational catalyst design. We investigate structure-performance relationships with a series of model catalysts consisting of Cu nanoparticles dispersed on a mesoporous gamma-Al2O3 carrier overlaid with different transition metal oxides spanning a broad range of Lewis acidity (YOx, ScOx, ZrOx, TaOx). Remarkably, the apparent activation energy (E-a) for methanol formation is found to downscale linearly with the relative Lewis acidity of coordinatively unsaturated metal surface sites (cus) exposed on the oxide support, making this single physicochemical parameter a suitable reactivity descriptor in the whole study space. In correspondence with this performance trend, in situ Fourier transform infrared spectroscopy reveals that both the ionic character and the relative reactivity of bidentate formate species, developed on the catalyst surface under reaction conditions, vary systematically with the surface Lewis acidity of the oxide support. These findings support the involvement of oxide-adsorbed bidentate formate species as reaction intermediates and point to the relative electron-accepting character of the Lewis cus on the oxide surface as the factor determining the stability of these intermediates and the overall energy barrier for the reaction. Our results contribute a unifying and quantitative description for support effects in CO2 hydrogenation to methanol on oxide-supported copper nanoparticles and provide a blueprint for a predictive description of metal-oxide promotion effects, which are ubiquitous in heterogeneous catalysis.The authors are grateful to P. Bussian and Sasol for providing the alumina precursor. S. Ruthe and K. Jeske (MPI-KOFO) are acknowledged for assistance with chromatographic product quantification. J. M. Salas (ITQ) and J. P. Holgado (ICMS-CSIC, Spain) are acknowledged for contributions to the in situ FTIR and XPS experiments, respectively. This research received funding from the Max Planck Society, the Bundesministerium ffir Bildung and Forschung (project 01DG17019), the Spanish Ministry of Science, Innovation and Universities (Severo Ochoa Excellence award SEV-20160683), and the Generalitat Valenciana (Scientific Excellence of Junior Researchers, SEJI2018/011). B.S. acknowledges the Humboldt foundation for a postdoctoral fellowship.Kim, J.; Sarma, BB.; Andres-Marcos, E.; Pfaender, N.; Concepción Heydorn, P.; Prieto González, G. (2019). Surface Lewis Acidity of Periphery Oxide Species as a General Kinetic Descriptor for CO2 Hydrogenation to Methanol on Supported Copper Nanoparticles. ACS Catalysis. 9(11):10409-10417. https://doi.org/10.1021/acscatal.9b02412S104091041791

Validation of the Spanish versions of the long (26 items) and short (12 items) forms of the Self-Compassion Scale (SCS)

Background: Self-compassion is a key psychological construct for assessing clinical outcomes in mindfulness-based interventions. the aim of this study was to validate the Spanish versions of the long (26 item) and short (12 item) forms of the Self-Compassion Scale (SCS).Methods: the translated Spanish versions of both subscales were administered to two independent samples: Sample 1 was comprised of university students (n = 268) who were recruited to validate the long form, and Sample 2 was comprised of Aragon Health Service workers (n = 271) who were recruited to validate the short form. in addition to SCS, the Mindful Attention Awareness Scale (MAAS), the State-Trait Anxiety Inventory-Trait (STAI-T), the Beck Depression Inventory (BDI) and the Perceived Stress Questionnaire (PSQ) were administered. Construct validity, internal consistency, test-retest reliability and convergent validity were tested.Results: the Confirmatory Factor Analysis (CFA) of the long and short forms of the SCS confirmed the original six-factor model in both scales, showing goodness of fit. Cronbach's a for the 26 item SCS was 0.87 (95% CI = 0.85-0.90) and ranged between 0.72 and 0.79 for the 6 subscales. Cronbach's a for the 12-item SCS was 0.85 (95% CI = 0.81-0.88) and ranged between 0.71 and 0.77 for the 6 subscales. the long (26-item) form of the SCS showed a test-retest coefficient of 0.92 (95% CI = 0.89-0.94). the Intraclass Correlation (ICC) for the 6 subscales ranged from 0.84 to 0.93. the short (12-item) form of the SCS showed a test-retest coefficient of 0.89 (95% CI: 0.87-0.93). the ICC for the 6 subscales ranged from 0.79 to 0.91. the long and short forms of the SCS exhibited a significant negative correlation with the BDI, the STAI and the PSQ, and a significant positive correlation with the MAAS. the correlation between the total score of the long and short SCS form was r = 0.92.Conclusion: the Spanish versions of the long (26-item) and short (12-item) forms of the SCS are valid and reliable instruments for the evaluation of self-compassion among the general population. These results substantiate the use of this scale in research and clinical practice.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Miguel Servet Hosp, Aragon Inst Hlth Sci I CS, Dept Psychiat, Zaragoza, SpainPrimary Care Prevent & Hlth Promot Res Network Re, Zaragoza, SpainBit&Brain Technol, Zaragoza, Spain12 Octubre Res Inst, Madrid, SpainUniv Zaragoza, Fac Hlth Sci & Sports, Huesca, SpainLozano Blesa Univ, Clin Hosp, Zaragoza, SpainUniversidade Federal de São Paulo UNIFESP, Escola Paulista Med, Dept Prevent Med, Ctr Mindfulness & Hlth Promot, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Escola Paulista Med, Dept Prevent Med, Ctr Mindfulness & Hlth Promot, São Paulo, BrazilWeb of Scienc