495 research outputs found
Tyrosinase Activity in Melanocytes of Human Albinos11From the Dermatology Service, General Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, Public Health Service, U. S. Department of Health, Education and Welfare.
Young AGN outburst running over older X-ray cavities
Although the energetic feedback from active galactic nuclei (AGN) is believed
to have a profound effect on the evolution of galaxies and clusters of
galaxies, details of the AGN heating remain elusive. Here, we study NGC 193 - a
nearby lenticular galaxy - based on X-ray (Chandra) and radio (VLA and GMRT)
observations. These data reveal the complex AGN outburst history of the galaxy:
we detect a pair of inner X-ray cavities, an outer X-ray cavity, a shock front,
and radio lobes extending beyond the inner cavities. We suggest that the inner
cavities were produced ~78 Myr ago by a weaker AGN outburst, while the outer
cavity, the radio lobes, and the shock front are due to a younger (13-26 Myr)
and (4-8) times more powerful outburst. Combining this with the observed
morphology of NGC 193, we conclude that NGC 193 likely represents the first
example of a second, more powerful, AGN outburst overrunning an older, weaker
outburst. These results help to understand how the outburst energy is
dissipated uniformly in the core of galaxies, and therefore may play a crucial
role in resolving how AGN outbursts suppress the formation of large cooling
flows at cluster centers.Comment: 6 pages, 3 figures, 1 table, accepted for publication in ApJ
The behaviour of political parties and MPs in the parliaments of the Weimar Republic
Copyright @ 2012 The Authors. This is the author's accepted manuscript. The final published article is available from the link below.Analysing the roll-call votes of the MPs of the Weimar Republic we find: (1) that party competition in the Weimar parliaments can be structured along two dimensions: an economic left–right and a pro-/anti-democratic. Remarkably, this is stable throughout the entire lifespan of the Republic and not just in the later years and despite the varying content of votes across the lifespan of the Republic, and (2) that nearly all parties were troubled by intra-party divisions, though, in particular, the national socialists and communists became homogeneous in the final years of the Republic.Zukunftskolleg, University of Konstan
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 Ă— 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis
The James Webb Space Telescope Mission: Optical Telescope Element Design, Development, and Performance
The James Webb Space Telescope (JWST) is a large, infrared space telescope
that has recently started its science program which will enable breakthroughs
in astrophysics and planetary science. Notably, JWST will provide the very
first observations of the earliest luminous objects in the Universe and start a
new era of exoplanet atmospheric characterization. This transformative science
is enabled by a 6.6 m telescope that is passively cooled with a 5-layer
sunshield. The primary mirror is comprised of 18 controllable, low areal
density hexagonal segments, that were aligned and phased relative to each other
in orbit using innovative image-based wavefront sensing and control algorithms.
This revolutionary telescope took more than two decades to develop with a
widely distributed team across engineering disciplines. We present an overview
of the telescope requirements, architecture, development, superb on-orbit
performance, and lessons learned. JWST successfully demonstrates a segmented
aperture space telescope and establishes a path to building even larger space
telescopes.Comment: accepted by PASP for JWST Overview Special Issue; 34 pages, 25
figure
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