Nuevo género de avispa agallícola del encino, Kokkocynips Pujade-Villar & Melika, gen. n., con descripción de una nueva especies de México (Hymenoptera, Cynipidae)

A new genus of oak gallwasp, Kokkocynips Pujade-Villar & Melika gen.n., is described from Mexico. Diagnostic characters and generic limits of the new genus are discussed in detail. Galls were found on branches of Quercus acutifolia Née. Diagnostic characters, distribution and biology of the new species are described and illustrated.Se describe un nuevo género de cinípido agallícola, Kokkocynips Pujade-Villar & Melika n. gen. (Hymenoptera: Cynipidae: Cynipini) de México. Se discuten en detalle los caracteres diagnósticos y los límites genéricos de este nuevo género. Las agallas se encuentran en las ramas de Quercus acutifolia Née. Se describen e ilustran los caracteres diagnósticos, su distribución y la biología de la nueva especie

Amplified Genes May Be Overexpressed, Unchanged, or Downregulated in Cervical Cancer Cell Lines

Several copy number-altered regions (CNAs) have been identified in the genome of cervical cancer, notably, amplifications of 3q and 5p. However, the contribution of copy-number alterations to cervical carcinogenesis is unresolved because genome-wide there exists a lack of correlation between copy-number alterations and gene expression. In this study, we investigated whether CNAs in the cell lines CaLo, CaSki, HeLa, and SiHa were associated with changes in gene expression. On average, 19.2% of the cell-line genomes had CNAs. However, only 2.4% comprised minimal recurrent regions (MRRs) common to all the cell lines. Whereas 3q had limited common gains (13%), 5p was entirely duplicated recurrently. Genome-wide, only 15.6% of genes located in CNAs changed gene expression; in contrast, the rate in MRRs was up to 3 times this. Chr 5p was confirmed entirely amplified by FISH; however, maximum 33.5% of the explored genes in 5p were deregulated. In 3q, this rate was 13.4%. Even in 3q26, which had 5 MRRs and 38.7% recurrently gained SNPs, the rate was only 15.1%. Interestingly, up to 19% of deregulated genes in 5p and 73% in 3q26 were downregulated, suggesting additional factors were involved in gene repression. The deregulated genes in 3q and 5p occurred in clusters, suggesting local chromatin factors may also influence gene expression. In regions amplified discontinuously, downregulated genes increased steadily as the number of amplified SNPs increased (p<0.01, Spearman's correlation). Therefore, partial gene amplification may function in silencing gene expression. Additional genes in 1q, 3q and 5p could be involved in cervical carcinogenesis, specifically in apoptosis. These include PARP1 in 1q, TNFSF10 and ECT2 in 3q and CLPTM1L, AHRR, PDCD6, and DAP in 5p. Overall, gene expression and copy-number profiles reveal factors other than gene dosage, like epigenetic or chromatin domains, may influence gene expression within the entirely amplified genome segments

Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

Background: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools. Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following: Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications should be followed; in multi-allergic patients 2 simultaneous injections can be given (100% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50–200% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added. Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico. Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed

Primeras citas fidedignas del género Aceria Asociado a Quercus ilex L. y Q. coccifera L. para el nordeste de la Península Ibérica.

Se realizó la determinación taxonómica de ejemplares adultos de ácaros eriófidos obtenidos de dos erineos de hojas de Quercus ilex y Q. coccifera. Se cita Aceria ilicis (Canestrini, 1890) en Quercus ilex y Q. coccifera, y Aceria trichophila Keifer, 1955 en Q. ilex. Ambas especies fueron colectadas en el Parque Natural de Collserola (Barcelona, Cataluña). Se reporta a A. trichophila por primera vez en el Paleártico y por primera vez sobre Q. ilex. Se confirma la presencia de A. ilicis en el noreste ibérico, especie ampliamente citada con presencia en la Península Ibérica a partir únicamente de los erineos colectados

Artisanal shark fishery at "Tres Marias" Islands and Isabel Island in the Central Mexican Pacific

There is a lack of basic biological information on the shark species caught in the region around the "Tres Marias" Islands and Isabel Island in the Central Mexican Pacific. Intensive monitoring was undertaken from October 1995 to March 1996 of shark landings by the artisanal fleet at La Cruz de Huanacaxtle, Nayarit, that fished south of "Tres Marias" Islands and, from November 2000 to February 2001, of landings by another fleet that fished around Isabel Island and close to the "Tres Marias". Smooth hammerhead Sphyrna zygaena (35%), silky shark Carcharhinus falciformis (27%) and blue shark Prionace glauca (25%) were the most important species of 2 004 sharks observed at La Cruz de Huanacaxtle. At Isabel Island, the most important species of 7 464 sharks sampled were S. lewini (49%) and Pacific sharpnose shark Rhizoprionodon longurio (45%). This paper describes the shark species caught at these islands, the catch per unit effort of the principal species throughout the fishing season, their length frequency distributions and percent mature, and gear selectivity issues

Una especie nueva de avispa gallícola para México: Andricus sphaericus Pujade-Villar n. sp. (Hymenoptera: Cynipidae: Cynipini)

Se describe una nueva especie de cinípido gallícola de México, Andricus sphaericus Pujade-Villar n. sp., solo conocida por su forma sexual. Induce agallas en las hojas de Quercus rugosa Née. Representa la segunda colecta de una generación sexual del género Andricus para México. Se proporcionan datos referidos a la diagnosis, distribución y biología de esta nueva especie

Repertorio Americano. Edición del 30-ABRIL-1923

Sin autor, A propósito del 1 de mayo, 33* J. García Monge, Repertorio Americano, 34* García Cabral, Mira cuanto catarro tengo, mamá...,35* Sin autor, Búsquelo ya salió el convivio de los niños, 36* Federico Beltrán, La copla Española, 37* Andrés Avelino, Del movimiento postumista hispanoamericano, 38* D. Moreno Jiménez, Estados del alma, 38* Rafael Estrada, Si sé que me amas,38* D. Moreno Jiménez, Paisajes, 39* Andrés Avelino, Estabilidad, 39* Andrés Avelino, Fragmentos, 39* Vigil-Diaz, Profesión de fe, 39* Odón de Buen, Antes de que se marche Einstein, 39* Sin autor, Club de muebles, 40* Rafael Estrada, Cantares en la ausencia, 40* Omar Dengo, Reflexiones, 40* Sin autor, Tienda Escalante, 40* Sin autor, El poema vivo del amor, 41* Miguel de Unamuno, Para la biliosidad Diablitos, 41* Sin autor, Botica Española, 42* Repertorio Americano, En lo sucesivo señores agentes y suscriptores de provincias sírvanse remitir invariablemente los fondos bajo cubierta certificada o en forma de Giro, 42* Sin autor, Cervecería Traube, 43* Juan Luis Campos, La mejor, 43* Pablo A. Pizzurno, Radiotelefonía y la educación, 43* Luis de Zulueta, Contra el poder de las tinieblas Los niños delincuentes, 44* O. Thompsom & Co., Taller electromecánico, 44* Alfonso Fabila, Guaca, 44* Sin autor, Una sorpresa de Mr. Hughes,45* Mariano Jiménez R., Nueva botica de San José, 45* Baltasar Brum, Solidaridad americana, 46* Luis Carlos López, Por el atajo, 46* Sin autor, Jorge R. Aguilar, 47* Sin autor, Romanticismos de adolescente, 47* Alfonso Badilla Ritual, 47* Rafael Estrada, Cantares olvidados, 47* Sin autor, El convivio, 48* Sin autor, Libros y folletos de ocasión a precios módicos, 48* Sin autor, Un aspecto muy interesante del Hispanoamericanismo: designación de escuelas con nombres de naciones, 48