Auditoría de gestión a la Cooperativa de Ahorro y Crédito “Unión Ferroviaria Ecuatoriana” Ltda., de la ciudad de Riobamba, provincia de Chimborazo durante el período 2011

La presente investigación es de una Auditoría de Gestión a la Cooperativa de Ahorro y Crédito Unión Ferroviaria Ecuatoriana, de la ciudad de Riobamba, provincia de Chimborazo durante el período 2011. La propuesta de la presente investigación es una Auditoría de Gestión a la Cooperativa de Ahorro y Crédito Unión Ferroviaria Ecuatoriana para determinar la eficacia y eficiencia en el desempeño de sus directivos y colaboradores, esta investigación fue realizada con información real obtenida directamente de cada uno de los trabajadores de la Institución a través de cuestionarios de control interno, la observación directa, en el período comprendido entre 01 de enero al 31 de diciembre de 2011. Para la comprobación de la hipótesis se aplicó el método de chi cuadrado (X²) donde se comprobó que la Auditoría de Gestión influye en la eficiencia y eficacia del personal de la Institución. Los resultados obtenidos fueron a través de una auditoría de gestión se puede medir el desempeño de los directivos y colaboradores de la Institución, el 61% de los encuestados dijeron que si, mientras el 39% dijo que no, las personas que contestaron que no es básicamente porque no tienen mucho conocimiento del tema investigado, esta encuesta se realizó a una muestra de 147 socios. En conclusión el personal de la COAC UFE no tiene el perfil profesional para desempeñar cada uno de los cargos, especialmente sus directivos; además que la Institución no cuenta con una imagen corporativa que le permita identificarse con sus socios y trabajadores. Las recomendaciones a los directivos de la COAC UFE es que deberían recibir una capacitación de forma urgente, además de capacitar a los demás empleados de la Institución de acuerdo al cargo que desempeñan, también se debería tomar en cuenta la misión, visión y organigrama estructural que se propone en la presente investigación, para que la Cooperativa muestre una imagen corporativa adecuada al público.This research is about an Audit Management in the Cooperativa de Ahorro y Crédito Unión Ferroviaria Ecuatoriana, in the city of Riobamba, Chimborazo province during the period 2011. The proposal of this research is a Performance Audit of Cooperativa de Ahorro y Crédito Unión Ferroviaria Ecuatoriana to determine the effectiveness and efficiency in the performance of its managers and employees; this reseach was done with real information obtained directly from each Institution workers through internal control questionnaires, direct observation, in the period from January 1st to December 31st, 2011. For testing the hypothesis the method of chi square (X²) was applied, where it was shown that the Audit Management influences in the efficiency and effectiveness of staff of the institution. The results obtained were through an Audit Management which can measure the performance of managers and employees of the institution, 61% of respondents said yes, while 39% said no, the respondents who said no are basically because they do not have much knowledge of the research, this survey was conducted on a sample of 147 members. In conclusion the COAC UFE staff has no the professional profile to perform each of the positions, especially their managers; further that the institution does not have a corporate image that allows to identify with their partners and employees. The recommendations to the managers of the COAC UFE is that they should be trained urgently, in addition to training other employees of the institution according to the position they play, should also take into account the mission, vision and structural chart proposed in the present investigation show that the Cooperative adequate public corporate image

Genomic analyses of microdissected Hodgkin and Reed-Sternberg cells: mutations in epigenetic regulators and p53 are frequent in refractory classic Hodgkin lymphoma

This work was supported by grants from the Plan Nacional de I + D + I cofinanced by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER), PI12/1832, the Spanish Association for Cancer Research (AECC), and Programas para Grupos de Investigación de la Comunidad Autónoma de Madrid (Biomedicina 2017)

Cholinesterase and phenyl valerate-esterase activities sensitive to organophosphorus compounds in membranes of chicken brain

Some effects of organophosphorus compounds (OPs) esters cannot be explained by action on currently recognized targets acetylcholinesterase or neuropathy target esterase (NTE). In previous studies, in membrane chicken brain fractions, four components (EPα, EPβ, EPγ and EPδ) of phenyl valerate esterase activity (PVase) had been kinetically discriminated combining data of several inhibitors (paraoxon, mipafox, PMSF). EPγ is belonging to NTE. The relationship of PVase components and acetylcholine-hydrolyzing activity (cholinesterase activity) is studied herein. Only EPα PVase activity showed inhibition in the presence of acetylthiocholine, similarly to a non-competitive model. EPα is highly sensitive to mipafox and paraoxon, but is resistant to PMSF, and is spontaneously reactivated when inhibited with paraoxon. In this papers we shows that cholinesterase activities showed inhibition kinetic by PV, which does not fit with a competitive inhibition model when tested for the same experimental conditions used to discriminate the PVase components. Four enzymatic components (CP1, CP2, CP3 and CP4) were discriminated in cholinesterase activity in the membrane fraction according to their sensitivity to irreversible inhibitors mipafox, paraoxon, PMSF and iso-OMPA. Components CP1 and CP2 could be related to EPα as they showed interactions between substrates and similar inhibitory kinetic properties to the tested inhibitors

Synthesis, characterization, and cytotoxicity studies of N-(4-methoxybenzyl) thiosemicarbazone derivatives and their ruthenium(II)-p-cymene complexes

The reaction of [Ru2Cl2(μ-Cl)2(η6-p-cymene)2] with two thiosemicarbazones obtained by the condensation of N-(4-methoxybenzyl) thiosemicarbazide and 1,4-hydroxy-3-methoxyphenyl)ethan-1-one (HL1) or 2-fluoro-4-hydroxybenzaldehyde (HL2) was studied. The cationic complexes of formula [RuCl(η6-p-cymene)(HL)]+ were isolated as solid chloride and trifluoromethylsulfate (TfO) salts. A study of the solid state and NMR spectra suggests the presence in the material of two isomers that differ in the configuration in the iminic bond, C2=N3, of the coordinated thiosemicarbazone in the triflate salts and only the E isomer in the chloride. An X-ray study of single crystals of the complexes supports this hypothesis. The thiosemicarbazone ligand coordinates with the ruthenium center through the iminic and sulfur atoms to form a five-membered chelate ring. Furthermore, the isolation of single crystals containing the thiosemicarbazonate complex [Ru2(μ-L2)2(η6-p-cymene)2]2+ suggests the easy labilization of the coordinated chloride in the complex. The redox behavior of the ligands and complexes was evaluated by cyclic voltammetry. It seems to be more difficult to oxidize the complex derived from HL1 than HL2. The ability of the complexes to inhibit cell growth against the NCI-H460, A549 and MDA-MB-231 lines was evaluated. The complexes did not show greater potency than cisplatin, although they did have greater efficacy, especially for the complex derived from HL1.Ministerio de Ciencia e Innovación | Ref. PID2019-110218RB-I0

I-MATH map of company demand for mathematical technology: TransMATH

This document details a Spanish prospectus on the level of knowledge, use and demand for mathematical technology by commercial companies. It is aimed at detecting problems in the corporate field for which Mathematicians could provide the complementary or fundamental tools, determine the demand for mathematical training, and define where necessary new lines of research in Mathematics aimed at solving these problem

El Conflicto entre la Necesidad física y psíquica del contacto humano y el Miedo a las personas

One of the psychological effects of the measures that have been taken to deal with the spread of the SARS-CoV-2 virus, to which less attention has been paid so far, is the fear of interpersonal relationships. For this reason, the need to adapt to coexistence with covid-19 and the measures that have been taken in this regard, also responding to the needs of relationship and emotional closeness between people is urgent. Although the need for distance between people has been highlighted, no indications have been given on how closer relationships can continue to be maintained safely and securely. This lack of information has turned into a great fear of personal closeness and can produce, especially in vulnerable people, a devastating “fear of others” and even “fear of oneself”, because they feel that they can become the source of illness and death for those close to you. The objectives try to respond to these needs, describing some of the intrapersonal conflicts derived from the current situation and, proposing a series of measures from both the social and psychotherapeutic fields to help people who need it.Uno de los efectos psicológicos de las medidas que se han tomado para hacer frente a la expansión del virus SARS-CoV-2 a los que, por el momento se ha prestado menos atención, es el miedo a las relaciones interpersonales. Por ello, se hace acuciante la necesidad de adaptación a la convivencia con la covid-19 y las medidas que se han tomado al respecto, respondiendo también a las necesidades de relación y cercanía emocional entre las personas. Aunque se ha puesto de manifiesto la necesidad de la distancia entre las personas, no se han dado indicaciones sobre cómo se pueden seguir manteniendo las relaciones más cercanas con seguridad y protección. Esta falta de información ha devenido en un gran miedo a la cercanía personal y puede llegar a producir, especialmente en personas vulnerables, un devastador “miedo a los demás” e incluso “miedo a uno mismo”, por sentir que se puede llegar a ser la fuente de enfermedad y muerte para los seres cercanos. Los objetivos intentan responder a estas necesidades, describiendo, algunos de los conflictos intrapersonales derivados de la situación actual y, proponiendo una serie de medidas tanto desde el ámbito social como psicoterapéutico para ayudar a las personas que lo necesiten

El estudio de la Inteligencia Espiritual II: un instrumento de evaluación de su desempeño competencial

This study is about the 1983 Howard Gardner's theory of multiple intelligences (Gardner, 1983), in 2012 incorporates Spiritual Intelligence (SI or SQ) and demonstrates that it meets all the criteria that define each intelligence. The qualitative study of Spiritual Intelligence (IES) made it possible to determine its competences: consciousness, transcendence, love, forgiveness, freedom, pain-suffering, meaning, gratitude and effects. After such identification a 68 questions Spiritual Intelligence Questionnaire (SIQ) was built and validated with Spanish population with a sample of 528 participants. Results show the reliability and content, construct and criteria validity. Unidimensionality of the questionnaire was tested as well as his prediction capacity. The conclusions are important at the intervention level because they allow the identification of key competencies to evaluate and develop SI through programs applied in different educational, social, and business environments.Este artículo se enmarca en la teoría de las Inteligencias Múltiples de Gardner (1983) que en 2012, demuestra que esta inteligencia cumple todos los criterios que determinan su incorporación al elenco de inteligencias. El estudio cualitativo de la Inteligencia Espiritual (IES) permitió determinar sus competencias: consciencia, transcendencia, amor, perdón, libertad, dolor-sufrimiento, sentido, gratitud y efectos. Tras la identificación de las competencias básicas, se ha construido el Cuestionario de Inteligencia Espiritual (CIES) de 68 ítems y se ha validado en población española con una muestra de 528 participantes. Los resultados ponen de manifiesto su fiabilidad así como su validez de contenido, de constructo y de criterio. Se ha comprobado la unidimensionalidad del CIES y su capacidad de predicción. Las conclusiones son importantes en el nivel de intervención porque permiten identificar competencias claves para evaluar y desarrollar la IES mediante programas aplicados en distintos ámbitos educativos, sociales o empresariales

Definición y Competencias de la Inteligencia Espiritual. Estudio Cualitativo

This study is about the 1983 Howard Gardner's theory of multiple intelligences (Gardner, 1983), in 2012 incorporates Spiritual Intelligence (SI or SQ) and demonstrates that it meets all the criteria that define each intelligence. The purpose of this research is to define the concept of Spiritual Intelligence and its competencies, and to elaborate and validate a measurement questionnaire. The concept and the basic competencies of Spiritual Intelligence have been defined through the systematic review of existing literature and the qualitative analysis of semi-structured interviews carried out with outstanding people representing different spiritualities. The sample consisted of 22 adults of different religions and spiritual currents, mostly belonging to the Association for Interreligious Dialogue of Madrid (ADIM). The ages of the interviewees are between 30 and 76 years old; the mean age was 51 years. The distribution by sex was eight women and fourteen men. The selection of the informants was made according to criteria of experience, position, responsibility, information, communication skills, availability and predisposition to the interview. The semi-structured interview was used and for the analysis, the Content Analysis method, defined by Krippendorff (1990). Once the interviews were transcribed and reviewed, they were transferred to the qualitative analysis computer program Atlas.Ti 7.0 in the analytical phase of the segmentation of the texts, coding and grouping into categories. In the phase of verification and contrast of the data obtained, a double triangulation of the same was carried out. In the first, coincidences were searched and, in the second, the information was analyzed looking for the differences between the transcripts and categories determined in the bibliographic review by means of triangulation in the analysis of the texts. The results show the high confluence of the data collected and allow to define the IES and determining their competences: consciousness, transcendence, love, forgiveness, freedom, pain-suffering, meaning, gratitude and effects. The conclusions are important because they can serve as the basis for the development of an assessment instrument for the SI.Este artículo se enmarca en la teoría de las Inteligencias Múltiples de Gardner (1983) que en 2012, demuestra que esta inteligencia cumple todos los criterios que determinan su incorporación al elenco de inteligencias. Esta investigación tiene como objeto definir el concepto de Inteligencia Espiritual (IES) y sus competencias mediante la revisión sistemática de la literatura existente y el análisis cualitativo de 22 entrevistas semiestructuradas realizadas a informantes destacados de distintas religiones y corrientes espirituales. Los resultados ponen de manifiesto la alta confluencia de los datos recogidos y permiten determinar las competencias: consciencia, transcendencia, amor, perdón, libertad, dolor-sufrimiento, sentido, gratitud y efectos. Las conclusiones son importantes ya que estas competencias pueden servir de base para desarrollar un instrumento de medida de la IES

Physical symptoms and brain morphology:a population neuroimaging study in 12,286 pre-adolescents

Physical symptoms, also known as somatic symptoms, are those for which medical examinations do not reveal a sufficient underlying root cause (e.g., pain and fatigue). The extant literature of the neurobiological underpinnings of physical symptoms is largely inconsistent and primarily comprises of (clinical) case-control studies with small sample sizes. In this cross-sectional study, we studied the association between dimensionally measured physical symptoms and brain morphology in pre-adolescents from two population-based cohorts; the Generation R Study (n = 2649, 10.1 ± 0.6 years old) and ABCD Study (n = 9637, 9.9 ± 0.6 years old). Physical symptoms were evaluated using continuous scores from the somatic complaints syndrome scale from the parent-reported Child Behavior Checklist (CBCL). High‐resolution structural magnetic resonance imaging (MRI) was collected using 3-Tesla MRI systems. Linear regression models were fitted for global brain metrics (cortical and subcortical grey matter and total white matter volume) and surface-based vertex-wise measures (surface area and cortical thickness). Results were meta-analysed. Symptoms of anxiety/depression were studied as a contrasting comorbidity. In the meta-analyses across cohorts, we found negative associations between physical symptoms and surface area in the (i) left hemisphere; in the lateral orbitofrontal cortex and pars triangularis and (ii) right hemisphere; in the pars triangularis, the pars orbitalis, insula, middle temporal gyrus and caudal anterior cingulate cortex. However, only a subset of regions (left lateral orbitofrontal cortex and right pars triangularis) were specifically associated with physical symptoms, while others were also related to symptoms of anxiety/depression. No significant associations were observed for cortical thickness. This study in preadolescents, the most representative and well-powered to date, showed that more physical symptoms are modestly related to less surface area of the prefrontal cortex mostly. While these effects are subtle, future prospective research is warranted to understand the longitudinal relationship of physical symptoms and brain changes over time. Particularly, to elucidate whether physical symptoms are a potential cause or consequence of distinct neurodevelopmental trajectories.</p

Adult entero-enteric intussusception caused by small bowel submucosal lipoma

Introduction: Intussusception is the prolapse of one gastrointestinal segment into an adjacent part. Its incidence in adults is less than 10%. Objective: To presents a case of adult entero-enteric intussusception caused by small bowel submucosal lipoma. Clinical case: A 66-year-old male patient with vague clinical manifestation that presented in a computed tomography scan typical invagination image, it showed the classical "target" and "sausage-like" images. He underwent surgery, where the diagnosis of adult entero-enteric intussusception was confirmed and then an en-bloc resection was performed. Anatomopathological examination revealed a submucosal lipoma of the jejunum. Gastrointestinal lipomas have an incidence of 0.035% - 4.4%. Conclusion: This is a rare case, not only because the intussusception is uncommon in adults but for the lead point found in it