Evidence for CP violation in time-integrated D0 -> h-h+ decay rates

A search for time-integrated CP violation in D0 -> h-h+ (h=K, pi) decays is presented using 0.62 fb^-1 of data collected by LHCb in 2011. The flavor of the charm meson is determined by the charge of the slow pion in the D*+ -> D0 pi+ and D*- -> D0bar pi- decay chains. The difference in CP asymmetry between D0 -> K-K+ and D0 -> pi-pi+, Delta ACP = ACP(K-K+) - ACP(pi-pi+), is measured to be [-0.82 \pm 0.21(stat.) \pm 0.11(syst.)]%. This differs from the hypothesis of CP conservation by 3.5 standard deviations.Comment: 8 pages, 3 figures, 2 tables; v2 minor updates after journal revie

EUROCARE-3 summary: cancer survival in Europe at the end of the 20th century.

No abstract availabl

Childhood cancer survival in Europe.

BACKGROUND: EUROCARE-3 collected data from 45 population-based cancer registries in 20 countries on 24 620 European children aged from 0 to 14 years diagnosed with malignancy in the period 1990-1994. METHODS: Five-year survival between countries was compared for all malignancies and for the major diagnostic categories, adjusting for age, and estimated average European survival weighting for differences in childhood populations. RESULTS: For all cancers combined, survival variation was large (45% in Estonia to 90% in Iceland), and was generally low (60-70%) in eastern Europe and high (> or =75%) in Switzerland, Germany and the Nordic countries (except Denmark). The Nordic countries had the highest survival for four of the seven major tumour types: nephroblastoma (92%), acute lymphoid leukaemia (85%), CNS tumours (73%) and acute non-lymphocytic leukaemia (62%). The eastern countries had lowest survival: 89% for Hodgkin's disease, 71% for nephroblastoma, 68% for acute lymphoid leukaemia, 61% for non-Hodgkin's lymphoma, 57% for central nervous system (CNS) tumours and 29% for acute non-lymphocytic leukaemia. CONCLUSIONS: The Nordic countries represent a survival gold standard to which other countries can aspire. Since most childhood cancers respond well to treatment, survival differences are attributable to differences in access (including referral and timely diagnosis) and use of modern treatments; however, the obstacles to access and application of standard treatments probably vary markedly with country

Erratum to "Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)" [Gynecol. Oncol. 144 (2017) 396-404]

Objective. Ovarian cancer comprises several histological groups with widely differing levels of survival. We aimed to explore international variation in survival for each group to help interpret international differences in survival from all ovarian cancers combined. We also examined differences in stage-specific survival. Methods. The CONCORD programme is the largest population-based study of global trends in cancer survival, including data from 60 countries for 695,932 women (aged 15\u201399 years) diagnosed with ovarian cancer during 1995\u20132009. We defined six histological groups: type I epithelial, type II epithelial, germ cell, sex cord-stromal, other specific non-epithelial and non-specific morphology, and estimated age-standardised 5-year net survival for each country by histological group. We also analysed data from67 cancer registries for 233,659 women diagnosed from 2001 to 2009, for whom information on stage at diagnosis was available. We estimated agestandardised 5-year net survival by stage at diagnosis (localised or advanced). Results. Survival fromtype I epithelial ovarian tumours for women diagnosed during 2005\u201309 ranged from40 to 70%. Survival from type II epithelial tumours was much lower (20\u201345%). Survival fromgermcell tumours was higher than that of type II epithelial tumours, but also varied widely between countries. Survival for sex-cord stromal tumours was higher than for the five other groups. Survival from localised tumours was much higher than for advanced disease (80% vs. 30%). Conclusions. There is wide variation in survival between histological groups, and stage at diagnosis remains an important factor in ovarian cancer survival. International comparisons of ovarian cancer survival should incorporate histology

Erratum to "The histology of ovarian cancer: Worldwide distribution and implications for international survival comparisons (CONCORD-2)" [Gynecol. Oncol. 144 (2017) 405-413]

Objective. Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. Methods. The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995\u20132009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included.We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. Results. During 2005\u20132009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. Conclusions. The distribution of ovarian cancer histology varieswidely worldwide. Type I epithelial, germcell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions

Letter of Intent for the LHCb Upgrade

The primary goal of LHCb is to measure the effects of new particles or forces beyond the Standard Model. Results obtained from data collected in 2010 show that the detector is robust and functioning well. While LHCb will be able to measure a host of interesting channels in heavy flavour decays in the upcoming few years, a limit of about 1 fb^ 121 of data per year cannot be overcome without upgrading the detector. The LHC machine does not face such a limitation. With the upgraded detector, read out at 40MHz, a much more flexible software-based triggering strategy will allow a large increase not only in data rate, as the detector would collect 5 fb^ 121 per year, but also the ability to increase trigger efficiencies especially in decays to hadronic final states. In addition, it will be possible to change triggers to explore different physics as LHC discoveries point us to the most interesting channels. Our physics scope extends beyond that of flavour. Possibilities for interesting discoveries exist over a whole variety of phenomena including searches for Majorana neutrinos, exotic Higgs decays and precision electroweak measurements. Here we describe the physics motivations and proposed detector changes for exploring new phenomena in proton-proton collisions near 14 TeV centre-of-mass energy