Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product

Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were recruited in this cross-sectional study. The main outcome measures were systolic and diastolic blood pressure (SBP and DBP) and carotid intima-media thickness (cIMT). Additional assessments were body-mass index (BMI), waist circumference, homeostatic model assessment of insulin resistance (HOMA-IR) and fasting lipids, ALP, serum calcium, phosphorus and Ca*P. ALP was directly correlated with BMI (p < 0.0001), waist circumference (p < 0.0001), SBP (p < 0.0001), cIMT (p = 0.005), HOMA-IR (p < 0.0001), and fasting triglycerides (p = 0.0001). Among them, in children with Ca*P values above the median the associations were BMI (r = 0.231; p = 0.001), waist (r = 0.252; p < 0.0001), SBP (r = 0.324; p < 0.0001), cIMT (r = 0.248; p = 0.001) and HOMA-IR (r = 0.291; p < 0.0001)]. ALP independently associated with SBP (β = 0.290, p < 0.001) and cIMT (β = 0.179, p = 0.013) in children with higher Ca*P, after adjusting for confounding variables. Circulating ALP is associated with a more adverse cardiovascular profile in children with higher Ca*P. We suggest that serum ALP and Ca*P levels could contribute to the assessment of risk for cardiovascular disease in children

TFG 2015/2016

Amb aquesta publicació, EINA, Centre universitari de Disseny i Art adscrit a la Universitat Autònoma de Barcelona, dóna a conèixer el recull dels Treballs de Fi de Grau presentats durant el curs 2015-2016. Voldríem que un recull com aquest donés una idea més precisa de la tasca que es realitza a EINA per tal de formar nous dissenyadors amb capacitat de respondre professionalment i intel·lectualment a les necessitats i exigències de la nostra societat. El treball formatiu s’orienta a oferir resultats que responguin tant a paràmetres de rigor acadèmic i capacitat d’anàlisi del context com a l’experimentació i la creació de nous llenguatges, tot fomentant el potencial innovador del disseny.Con esta publicación, EINA, Centro universitario de diseño y arte adscrito a la Universidad Autónoma de Barcelona, da a conocer la recopilación de los Trabajos de Fin de Grado presentados durante el curso 2015-2016. Querríamos que una recopilación como ésta diera una idea más precisa del trabajo que se realiza en EINA para formar nuevos diseñadores con capacidad de responder profesional e intelectualmente a las necesidades y exigencias de nuestra sociedad. El trabajo formativo se orienta a ofrecer resultados que respondan tanto a parámetros de rigor académico y capacidad de análisis, como a la experimentación y la creación de nuevos lenguajes, al tiempo que se fomenta el potencial innovador del diseño.With this publication, EINA, University School of Design and Art, affiliated to the Autonomous University of Barcelona, brings to the public eye the Final Degree Projects presented during the 2015-2016 academic year. Our hope is that this volume might offer a more precise idea of the task performed by EINA in training new designers, able to speak both professionally and intellectually to the needs and demands of our society. The educational task is oriented towards results that might respond to the parameters of academic rigour and the capacity for contextual analysis, as well as to considerations of experimentation and the creation of new languages, all the while reinforcing design’s innovative potential

Les molècules que modulen el dolor. Analgèsia i drogodependència, vint-i-cinc anys després del descobriment de les encefalines

7 pages, 8 figures.[CAT] La sensació de dolor és una de les experiències comunes a tot ésser humà. Entre els estímuls dolorosos, n’hi ha que estan adreçats a mantenir la integritat del cos advertint la presència d’agressions externes, però és sovint desitjable poder-los controlar, especialment quan són de naturalesa crònica. S’ha demostrat que el control del dolor no és una tasca fàcil, perquè, malgrat el gran esforç investigador fet en els darrers cent anys per tal de trobar noves substàncies analgèsiques, el millor remei continua essent avui la morfina. Tanmateix les expectatives derivades del descobriment dels opiacis endògens, les encefalines, no han conduït tampoc al desenvolupament d’un analgèsic ideal lliure de problemes greus com la tolerància i l’addicció.[ENG] The sensation of pain is a common human experience. Although pain stimuli also serve as a warning system against external body aggressions, it is always desirable to control them, especially when they are chronic. During the past century, a great deal of effort was devoted to finding new substances to alleviate pain. However, this proved to be a difficult task and, to date, morphine, is the best remedy. Moreover, the expectations raised from the discovery of the endogenous opioids, the enkephalins, have not been fulfilled and the ideal analgesic lacking tolerance and addictive effects is still eagerly awaited.Peer reviewe

Regioselective postsynthetic modification of phenylalanine side chains of peptides leading to uncommon ortho-iodinated analogues

5 pages, 4 schemes, 3 tables.-- Availcable online Dec 29, 2003.-- Supporting information available at: http://www.wiley-vch.de/contents/jc_2002/2004/z52464_s.pdfThis research was partially supportedby the Spanish MCYT (Grant BQU2001-3853) andthe FundaciGn la Caixa (Project Reference 00/ 010-00 of the IV Program of Grants for Research on Neurodegenarative Diseases of the FundaciGn La Caixa).Peer reviewe

Owner-Perception of the Effects of Two Long-Lasting Dog-Appeasing Pheromone Analog Devices on Situational Stress in Dogs

Devices that release a synthetic analog of the canine-appeasing pheromone can help to relax dogs during stressful situations, but they usually last for only one month. Two new devices with this analog were tested by owners of dogs showing signs of stress in a range of everyday situations: Zenidog&trade; collar, lasting three months, and Zenidog&trade; diffusing gel, lasting two months (Virbac, Carros, France). They were compared against reference products that last for one month. In the three-month study with collars, one group received Zenidog&trade; collar, one received the reference collar, and one group of dogs wore an antiparasitic collar alongside a Zenidog&trade; collar. In the two-month study with diffusers, groups received either the unpowered Zenidog&trade; gel diffuser or the reference electric diffuser. Owners regularly completed a questionnaire that assessed seventeen general behaviors and sources of fear and eleven specific signs of stress. Global scores for these two main scales were calculated, and the evolution of scores was compared between groups. Non-parametric tests with a Bonferroni correction were used for statistical analysis. An improvement of all global scores was observed in all groups (p &lt; 0.001), including in puppies, and there was no difference between groups. Zenidog&trade; devices were as effective as the reference devices and lasted longer