2,741 research outputs found
A note on Fontaine theory using different Lubin-Tate groups
Using different Lubin-Tate groups, we compare modules
associated to a Galois representation via Fontaine's theory
Risk factors associated with the occurrence of autoimmune diseases in adult coeliac patients
Objectives. Autoimmune diseases (AD) may be associated with coeliac disease (CD), but specific risk factors have been poorly
investigated. The aim of this study was to assess the spectrum of AD and its specific risk factors associated in a series of adult
coeliac patients. Materials and Methods. We performed a single-center case-control study including adult newly diagnosed CD
patients. To evaluate the risk factors of the association between AD and CD, 341 coeliac patients included were categorized on
the basis of AD presence: 91 cases with at least one AD and 250 controls without AD were compared for clinical, serological,
and histological features. Eighty-seven cases were age-gender-matched with 87 controls. Results. Among 341 CD patients,
26.6% of CD patients had at least one AD. Endocrine and dermatological diseases were the most prevalent AD
encountered: autoimmune thyroiditis was present in 48.4% of cases, psoriasis in 17.6%, and type I diabetes and dermatitis
herpetiformis in 11%, respectively. At logistic regression, factors associated with AD were a positive 1st-degree family history of
AD (OR 3.7, 95% CI 1.93–7), a body mass index ≥ 25 kg/m2 at CD diagnosis (OR 2.95%, CI 1.1–3.8), and long standing
presentation signs/symptoms before CD diagnosis (>10 years) (OR 2.1, 95% CI 1.1–3.7). Analysis on age-gender-matched
patients confirmed these results. Conclusions. CD patients with family history of AD, overweight at CD diagnosis, and a delay of
CD diagnosis had an increased risk of having another AD. The benefit of CD screening in these specific subsets of patients with
AD awaits further investigation
Upper gastrointestinal symptoms in autoimmune gastritis. A cross-sectional study
Autoimmune gastritis is often suspected for its hematologic findings, and rarely the diagnosis is made for the presence of gastrointestinal symptoms. Aims of this cross-sectional study were to assess in a large cohort of patients affected by autoimmune gastritis the occurrence and the pattern of gastrointestinal symptoms and to evaluate whether symptomatic patients are characterized by specific clinical features. Gastrointestinal symptoms of 379 consecutive autoimmune gastritis patients were systematically assessed and classified following Rome III Criteria. Association between symptoms and anemia pattern, positivity to gastric autoantibodies, Helicobacter pylori infection, and concomitant autoimmune disease were evaluated. In total, 70.2% of patients were female, median age 55 years (range 17-83). Pernicious anemia (53.6%), iron deficiency anemia (34.8%), gastric autoantibodies (68.8%), and autoimmune disorders (41.7%) were present. However, 56.7% of patients complained of gastrointestinal symptoms, 69.8% of them had exclusively upper symptoms, 15.8% only lower and 14.4% concomitant upper and lower symptoms. Dyspepsia, subtype postprandial distress syndrome was the most represented, being present in 60.2% of symptomatic patients. Univariate and multivariate analyses showed that age <55 years (OR 1.6 [CI:1-2.5]), absence of smoking habit (OR 2.2 [CI:1.2-4]), and absence of anemia (OR 3.1 [CI:1.5-6.4]) were independent factors associated to dyspepsia. Autoimmune gastritis is associated in almost 60% of cases with gastrointestinal symptoms, in particular dyspepsia. Dyspepsia is strictly related to younger age, no smoking, and absence of anemia. © 2017 the Author(s). Published by Wolters Kluwer Health, Inc
Occurrence of acute oesophageal necrosis (black oesophagus) in a single tertiary centre
Acute oesophageal necrosis (AON) is a rare condition characterised by the endoscopic finding of diffuse, circumferential, black mucosal pigmentation of the oesophagus, which typically stops at the gastro-oesophageal junction. This observational study aimed to assess the occurrence, clinical characteristics and outcomes of AON in a consecutive endoscopic cohort in a single tertiary university centre. A retrospective analysis of endoscopic data of upper gastrointestinal endoscopy (UGE) was carried out from 2008 to 2018. Out of 25,970 UGE, 16 patients (0.06%) had AON; 75.0% were men with a median age of 75 years. Almost all patients underwent diagnosis during emergency UGE performed for gastrointestinal bleeding, but one patient was diagnosed during elective UGE for persistent vomiting and diarrhoea. All patients reported one or more pre-existing comorbidities and concomitant acute events. Two patients had AON as the first presentation of Zollinger-Ellison syndrome (ZES). One patient developed an oesophageal stenosis, and another patient presented a relapse of AON. Mortality was 50%, but no patient died as a direct consequence of AON. AON is a rare cause of gastrointestinal bleeding diagnosed mainly during emergency UGE. Our study showed that ZES might manifest with this critical presentation, and endoscopists must be aware of this evidence
Occurrence of gastric cancer and carcinoids in atrophic gastritis during prospective long-term follow up
Objective. Atrophic gastritis (AG) is a risk condition for gastric cancer and type I gastric carcinoids. Recent studies assessing the overall risk of gastric cancer and carcinoids in AG at long-term follow up are lacking. This study aimed to investigate in a prospective cohort of AG patients the occurrence of gastric cancer and carcinoids at long-term follow up. Methods. A total of 200 AG patients from a prospective cohort (67% female, median age 55 years) with a follow up of 7.5 (range: 4-23.4) years were included. Inclusion criteria were presence of AG and at least one follow-up gastroscopy with biopsies at ≥4 years after AG diagnosis. Follow-up gastroscopies at 4-year intervals were performed. Results. Overall, 22 gastric neoplastic lesions were detected (crude incidence 11%). Gastric cancer was diagnosed in four patients at a median follow up of 7.2 years (crude incidence 2%). Eleven type I gastric carcinoids were detected at a median follow up of 5.1 years (crude incidence of 5.5%). In seven patients, six low-grade and one high-grade dysplasia were found. The annual incidence rate person-year were 0.25% (95% confidence interval [CI]: 0.067-0.63%), 0.43% (95% CI: 0.17-0.89%), and 0.68% (95% CI: 0.34-1.21%) for gastric cancer, dysplasia, and type I-gastric carcinoids, respectively. The incidence rates of gastric cancer and carcinoids were not different (p = 0.07). Conclusion. This study shows an annual incidence rate of 1.36% person-year for gastric neoplastic lesions in AG patients at long-term follow up. AG patients are similarly exposed to gastric cancer and type I gastric carcinoids
A Hybrid AHP/FST Model for Regional Aircraft Evaluation
This paper presents a hybrid model for regional aircraft evaluation, based on the two main approaches
proposed in the literature, the Analytic Hierarchy Process (AHP) and the Fuzzy Set Theory (FST). The
proposed model combines the strengths of the two approaches, overcoming some of their weaknesses.
AHP is preserved for criteria weights determination whereas FST is adopted to deal with aircraft
performances. The hybrid model is implemented to compare three regional aircrafts. The results highlight
how the proposed model can be useful both for manufacturing companies, in their process of designing
future regional aircraft, and for airlines to support the choice of the aircraft that better satisfy their
requirements
Two-dimensional topological quantum walks in the momentum space of structured light
Quantum walks are powerful tools for quantum applications and for designing
topological systems. Although they are simulated in a variety of platforms,
genuine two-dimensional realizations are still challenging. Here we present an
innovative approach to the photonic simulation of a quantum walk in two
dimensions, where walker positions are encoded in the transverse wavevector
components of a single light beam. The desired dynamics is obtained by means of
a sequence of liquid-crystal devices, which apply polarization-dependent
transverse "kicks" to the photons in the beam. We engineer our quantum walk so
that it realizes a periodically-driven Chern insulator, and we probe its
topological features by detecting the anomalous displacement of the photonic
wavepacket under the effect of a constant force. Our compact, versatile
platform offers exciting prospects for the photonic simulation of
two-dimensional quantum dynamics and topological systems.Comment: Published version of the manuscrip
Presentación y comentario de la Constitución Apostólica "Veritatis gaudium" y de las "Ordinationes" anejas, sobre las Universidades y Facultades eclesiásticas
1. Preámbulo. 2. Motivación y estructura de la Veritatis gaudium y de las Ordinationes anejas. 3. Contenido de la nueva Constitución y de las normas aplicativas: continuidad e innovaciones. 4. Primera Parte: Normas comunes. 5. Segunda Parte: Normas especiales. 6. Normas finales. 7. Normas aplicativas. Variaciones, supresiones y añadidos en VG/Ord. respecto a SCh/Ord. 8. Conclusiones
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