Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)

BACKGROUND: Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. METHODS: Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights. FINDINGS: 5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease. INTERPRETATION: International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems

Permeability changes in coal seams: the role of anisotropy

International audienceThe permeability of coal seams is pore pressure-dependent. A number of analytical models have been proposed to investigate this problem, but many disregard a crucial factor: the anisotropy of coal. This paper is devoted to investigating the role of anisotropy in modeling the change of horizontal permeability with pressure. Analysis is conducted using a fully anisotropic model that incorporates both the anisotropies of mechanical properties and of the permeability dependence on stresses. Analytical expressions of the pressure-permeability relationship are derived in oedometric and isochoric geomechanical conditions, and validations are conducted against both laboratory and field data. Then, the roles of the anisotropy of stiffness and of permeability dependence on stresses in the permeability-change model are explored. We demonstrate that the mechanical anisotropy can be simplified to an isotropic model without introducing significant errors in prediction of pressure-permeability relationship, while neglecting the anisotropy of permeability dependence on stresses leads to considerable errors. When both anisotropy sources are disregarded, the pressure-permeability curve can be exactly reproduced by a totally isotropic material in both oedometric and isotropic conditions. However, the material properties (e.g., bulk modulus) are skewed; moreover, such an equivalent material might lead to significant errors in other geomechanical conditions. Finally, the permeability change is investigated at the reservoir scale, and the reservoir simulation results confirm the conclusions obtained from the analytical analysis

Quantum polarization properties of two-mode energy eigenstates

We show that any pure, two-mode, N-photon state with N odd or equal to two can be transformed into an orthogonal state using only linear optics. According to a recently suggested definition of polarization degree, this implies that all such states are fully polarized. This is also found to be true for any pure, two-mode, energy eigenstate belonging to a two-dimensional SU(2) orbit. Complete two- and three-photon bases whose basis states are related by only phase shifts or geometrical rotations are also derived. © 2005 The American Physical Society

Quasi-probability distributions for the simplest dynamical groups

We show that any pure, two-mode, N-photon state with N odd or equal to two can be transformed into an orthogonal state using only linear optics. According to a recently suggested definition of polarization degree, this implies that all such states are fully polarized. This is also found to be true for any pure, two-mode, energy eigenstate belonging to a two-dimensional SU(2) orbit. Complete two- and three-photon bases whose basis states are related by only phase shifts or geometrical rotations are also derived. " 2005 The American Physical Society.",,,,,,"10.1103/PhysRevA.71.033818",,,"http://hdl.handle.net/20.500.12104/44014","http://www.scopus.com/inward/record.url?eid=2-s2.0-18444398958&partnerID=40&md5=18516ed3a68403bf26617a6070afcc58",,,,,,"3",,"Physical Review A - Atomic, Molecular, and Optical Physics",,,,"71",,"Scopu

Evidence of global demand for medication abortion information

Introduction The worldwide expansion of the Internet offers an important modality of disseminating medically accurate information about medication abortion. We chronicle the story of www.medicationabortion.com, an English-, Spanish-, Arabic- and French-language website dedicated to three early abortion regimens. Methods We evaluated the website use patterns from 2005 through 2009. We also conducted a content and thematic analysis of 1910 emails submitted during this period. Results The website experienced steady growth in use. In 2009, it received 35,000 visits each month from more than 20,000 unique visitors and was accessed by users in 208 countries and territories. More than half of all users accessed the website from a country in which abortion is legally restricted. Users from more than 40 countries sent emails with individual questions. Women often wrote in extraordinary detail about the circumstances of their pregnancies and attempts to obtain an abortion. These emails also reflect considerable demand for information about the use of misoprostol for self-induction. Conclusion The use patterns of www.medicationabortion.com indicate that there is significant demand for online information about abortion, and the findings suggest future priorities for research, collaboration and educational outreach.7 page(s

Оптимизация маркетинговых решений : учебно-метод. пособие для студентов специальности «Маркетинг» всех форм обучения

Пособие содержит систематизированный материал по основным темам курса «Оптимизация маркетинговых решений». Практическое применение методов показано на примерах. В конце каждой темы приведен список дополнительной литературы по рассматриваемым вопросам. Для студентов специальности «Маркетинг» высших учебных заведений, магистрантов, аспирантов

A protocol for an intercomparison of biodiversity and ecosystem services models using harmonized land-use and climate scenarios

To support the assessments of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES), the IPBES Expert Group on Scenarios and Models is carrying out an intercomparison of biodiversity and ecosystem services models using harmonized scenarios (BES-SIM). The goals of BES-SIM are (1) to project the global impacts of land-use and climate change on biodiversity and ecosystem services (i.e., nature's contributions to people) over the coming decades, compared to the 20th century, using a set of common metrics at multiple scales, and (2) to identify model uncertainties and research gaps through the comparisons of projected biodiversity and ecosystem services across models. BES-SIM uses three scenarios combining specific Shared Socio-economic Pathways (SSPs) and Representative Concentration Pathways (RCPs)-SSP1xRCP2.6, SSP3xRCP6.0, SSP5xRCP8.6-to explore a wide range of land-use change and climate change futures. This paper describes the rationale for scenario selection, the process of harmonizing input data for land use, based on the second phase of the Land Use Harmonization Project (LUH2), and climate, the biodiversity and ecosystem services models used, the core simulations carried out, the harmonization of the model output metrics, and the treatment of uncertainty. The results of this collaborative modeling project will support the ongoing global assessment of IPBES, strengthen ties between IPBES and the Intergovernmental Panel on Climate Change (IPCC) scenarios and modeling processes, advise the Convention on Biological Diversity (CBD) on its development of a post-2020 strategic plans and conservation goals, and inform the development of a new generation of nature-centred scenarios

JWST-TST DREAMS: Quartz Clouds in the Atmosphere of WASP-17b

Clouds are prevalent in many of the exoplanet atmospheres that have been observed to date. For transiting exoplanets, we know if clouds are present because they mute spectral features and cause wavelength-dependent scattering. While the exact composition of these clouds is largely unknown, this information is vital to understanding the chemistry and energy budget of planetary atmospheres. In this work, we observe one transit of the hot Jupiter WASP-17b with JWST’s Mid-Infrared Instrument Low Resolution Spectrometer and generate a transmission spectrum from 5 to 12 μm. These wavelengths allow us to probe absorption due to the vibrational modes of various predicted cloud species. Our transmission spectrum shows additional opacity centered at 8.6 μm, and detailed atmospheric modeling and retrievals identify this feature as SiO2(s) (quartz) clouds. The SiO2(s) clouds model is preferred at 3.5-4.2σ versus a cloud-free model and at 2.6σ versus a generic aerosol prescription. We find the SiO2(s) clouds are composed of small ∼0.01 μm particles, which extend to high altitudes in the atmosphere. The atmosphere also shows a depletion of H2O, a finding consistent with the formation of high-temperature aerosols from oxygen-rich species. This work is part of a series of studies by our JWST Telescope Scientist Team (JWST-TST), in which we will use Guaranteed Time Observations to perform Deep Reconnaissance of Exoplanet Atmospheres through Multi-instrument Spectroscopy (DREAMS). © 2023. The Author(s). Published by the American Astronomical Society.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]