Phenolics, depsides and triterpenes from the chilean lichen pseudocyphellaria nudata (zahlbr.) D.J. Galloway

Indexación: ScieloThe lichen Pseudocyphellaria nudata is a species endemic to southern South América. From the lichen tallus, methyl orsellinate, 2-methoxy-3,6-dimethyl-4-hydroxybenzaldehyde, methyl-evernate, tenuiorin, hopan-6ß,22-diol and hopan-6α,76,22-triol were isolated and identified as the main lichen constituents. This is the first report of the occurrence of 2-methoxy-3,6-dimethyl-4-hydroxybenzaldehyde in lichens.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=s0717-97072008000300017&nrm=is

The enigmatic spin evolution of PSR J0537-6910: r-modes, gravitational waves and the case for continued timing

We discuss the unique spin evolution of the young X-ray pulsar PSR J0537-6910, a system in which the regular spin down is interrupted by glitches every few months. Drawing on the complete timing data from the Rossi X-ray Timing Explorer (RXTE, from 1999-2011), we argue that a trend in the inter-glitch behaviour points to an effective braking index close to $n=7$, much larger than expected. This value is interesting because it would accord with the neutron star spinning down due to gravitational waves from an unstable r-mode. We discuss to what extent this, admittedly speculative, scenario may be consistent and if the associated gravitational-wave signal would be within reach of ground based detectors. Our estimates suggest that one may, indeed, be able to use future observations to test the idea. Further precision timing would help enhance the achievable sensitivity and we advocate a joint observing campaign between the Neutron Star Interior Composition ExploreR (NICER) and the LIGO-Virgo network.Comment: 10 pages, 4 figures, emulate ApJ forma

Neutron star glitches have a substantial minimum size

Glitches are sudden spin-up events that punctuate the steady spin down of pulsars and are thought to be due to the presence of a superfluid component within neutron stars. The precise glitch mechanism and its trigger, however, remain unknown. The size of glitches is a key diagnostic for models of the underlying physics. While the largest glitches have long been taken into account by theoretical models, it has always been assumed that the minimum size lay below the detectability limit of the measurements. In this paper we define general glitch detectability limits and use them on 29 years of daily observations of the Crab pulsar, carried out at Jodrell Bank Observatory. We find that all glitches lie well above the detectability limits and by using an automated method to search for small events we are able to uncover the full glitch size distribution, with no biases. Contrary to the prediction of most models, the distribution presents a rapid decrease of the number of glitches below ~0.05 $\mu$Hz. This substantial minimum size indicates that a glitch must involve the motion of at least several billion superfluid vortices and provides an extra observable which can greatly help the identification of the trigger mechanism. Our study also shows that glitches are clearly separated from all the other rotation irregularities. This supports the idea that the origin of glitches is different to that of timing noise, which comprises the unmodelled random fluctuations in the rotation rates of pulsars.Comment: 8 pages; 4 figures. Accepted for publication in MNRA

The glitch activity of neutron stars

We present a statistical study of the glitch population and the behaviour of the glitch activity across the known population of neutron stars. An unbiased glitch database was put together based on systematic searches of radio timing data of 898 rotation-powered pulsars obtained with the Jodrell Bank and Parkes observatories. Glitches identified in similar searches of 5 magnetars were also included. The database contains 384 glitches found in the rotation of 141 of these neutron stars. We confirm that the glitch size distribution is at least bimodal, with one sharp peak at approximately $20\, \rm{\mu\,Hz}$, which we call large glitches, and a broader distribution of smaller glitches. We also explored how the glitch activity $\dot{\nu}_{\rm{g}}$, defined as the mean frequency increment per unit of time due to glitches, correlates with the spin frequency $\nu$, spin-down rate $|\dot{\nu}|$, and various combinations of these, such as energy loss rate, magnetic field, and spin-down age. It is found that the activity is insensitive to the magnetic field and that it correlates strongly with the energy loss rate, though magnetars deviate from the trend defined by the rotation-powered pulsars. However, we find that a constant ratio $\dot\nu_{\rm{g}}/|\dot\nu| = 0.010 \pm 0.001$ is consistent with the behaviour of all rotation-powered pulsars and magnetars. This relation is dominated by large glitches, which occur at a rate directly proportional to $|\dot{\nu}|$. The only exception are the rotation-powered pulsars with the highest values of $|\dot{\nu}|$, such as the Crab pulsar and PSR B0540$-$69, which exhibit a much smaller glitch activity, intrinsically different from each other and from the rest of the population. The activity due to small glitches also shows an increasing trend with $|\dot\nu|$, but this relation is biased by selection effects.Comment: Accepted for publication in A&

X-ray Observations of High-B Radio Pulsars

The study of high-magnetic-field pulsars is important for examining the relationships between radio pulsars, magnetars, and X-ray-isolated neutron stars (XINSs). Here we report on X-ray observations of three such high-magnetic-field radio pulsars. We first present the results of a deep XMM-Newton observation of PSR J1734-3333, taken to follow up on its initial detection in 2009. The pulsar's spectrum is well fit by a blackbody with a temperature of 300 +/- 60 eV, with bolometric luminosity L_bb = 2.0(+2.2 -0.7)e+32 erg/s = 0.0036E_dot for a distance of 6.1 kpc. We detect no X-ray pulsations from the source, setting a 1 sigma upper limit on the pulsed fraction of 60% in the 0.5-3 keV band. We compare PSR J1734-3333 to other rotation-powered pulsars of similar age and find that it is significantly hotter, supporting the hypothesis that the magnetic field affects the observed thermal properties of pulsars. We also report on XMM-Newton and Chandra observations of PSRs B1845-19 and J1001-5939. We do not detect either pulsar, setting 3 sigma upper limits on their blackbody temperatures of 48 and 56 eV, respectively. Despite the similarities in rotational properties, these sources are significantly cooler than all but one of the XINSs, which we attribute to the two groups having been born with different magnetic fields and hence evolving differently.Comment: 18 pages, 2 tables, 5 figures, accepted for publication in the Astrophysical Journa

New long-term braking index measurements for glitching pulsars using a glitch-template method

Braking index measurements offer the opportunity to explore the processes affecting the long-term spin evolution of pulsars and possible evolutionary connections between the various pulsar populations. For young pulsars the long-term trends are generally obscured by short term phenomena such as timing noise and the recoveries form large glitches. Here we present a new method to overcome the latter and report on braking index measurements for the Vela-like pulsars PSR B1800-21 and PSR B1823-13, an updated measurement for Vela and new estimates for four more glitching pulsars observed at Jodrell Bank Observatory. The values of braking indices describe the long-term evolution of the pulsars across the P-P' diagram. Despite some measurements being affected by considerable uncertainties, there is evidence for a common trend involving low braking indices (n<=2) among young glitching pulsars. Such values introduce a new variant in the evolution of young pulsars and their relationship with other populations in the P-P' diagram. Low braking indices also imply that these pulsars could be a few times older than their characteristic ages. We consider PSR B1757-24 and conclude that the pulsar could be old enough to be related to the supernova remnant G5.4-1.2. Between glitches, the short-term evolution of Vela-like pulsars is characterised by large inter-glitch braking indices n_ig > 10. We interpret both short and long term trends as signatures of the large glitch activity, and speculate that they are driven by short-term post-glitch re-coupling and a cumulative long-term decoupling of superfluid to the rotation of the star.Comment: 16 pages, 6 figures. Accepted for publication in MNRA

Topical treatment of actinic keratoses with potassium dobesilate 5% cream. A preliminary open-label study

<p>Abstract</p> <p>Background</p> <p>Fibroblast growth factor (FGF) is involved in skin tumorigenesis: it promotes cell viability, induces angiogenesis and stimulates invasiveness. Dobesilate is a drug that blocks the activity of FGF. The primary objective was to evaluate the efficacy and tolerability of potassium dobesilate 5% cream in the treatment of actinic keratoses.</p> <p>Methods</p> <p>Potassium dobesilate 5% cream was applied twice daily for 16 weeks to actinic keratosis lesions in 30 patients. The lesions were evaluated clinically at an initial baseline visit, at intermediate visits, and at 16 weeks of treatment.</p> <p>Results</p> <p>The use of potassium dobesilate 5% cream for 16 weeks induced complete regression in 70% of evaluated actinic keratoses, corresponding to grade I, II and III clinical variants, and a partial response (at least 75% reduction of lesions) in 20% of the cases.</p> <p>Conclusion</p> <p>Our preliminary trial shows that potassium dobesilate exerts anti-tumorigenic effects and may play a useful role in the chemoprevention of skin cancers.</p

Unusual formations of the free electromagnetic field in vacuum

It is shown that there are exact solutions of the free Maxwell equations (FME) in vacuum allowing an existence of stable spherical formations of the free magnetic field and ring-like formations of the free electric field. It is detected that a form of these spheres and rings does not change with time in vacuum. It is shown that these convergent solutions are the result of an interference of some divergent solutions of FME. One can surmise that these electromagnetic formations correspond to Kapitsa's hypothesis about interference origin and a structure of fireball.Comment: Revtex-file, without figures. To get lournal-pdf-copy with figures contact with [email protected]