Antibacterial and healing effect of chicha gum hydrogel (sterculia striata) with nerolidol

Chicha gum is a natural polymer obtained from the Sterculia striata plant. The hydroxyl groups of its structure have a chemical affinity to form hydrogels, which favors the association with biologically active molecules, such as nerolidol. This association improves the biological properties and allows the material to be used in drug delivery systems. Chicha gum hydrogels associated with nerolidol were produced at two concentrations: 0.01 and 0.02 g mL−1. Then, the hydrogels were characterized by thermogravimetry (TG), Fourier Transform Infrared spectroscopy (FTIR), and rheological analysis. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. The cytotoxicity was evaluated against Artemia salina. Finally, an in vivo healing assay was carried out. The infrared characterization indicated that interactions were formed during the gel reticulation. This implies the presence of nerolidol in the regions at 3100–3550 cm−1. The rheological properties changed with an increasing concentration of nerolidol, which resulted in less viscous materials. An antibacterial 83.6% growth inhibition effect was observed using the hydrogel with 0.02 g mL−1 nerolidol. The in vivo healing assay showed the practical activity of the hydrogels in the wound treatment, as the materials promoted efficient re-epithelialization. Therefore, it was concluded that the chicha hydrogels have the potential to be used as wound-healing products.info:eu-repo/semantics/publishedVersio

Estudo do creme de buriti (Mauritia flexuosa L.) no processo de cicatrização

AbstractObjective:To evaluate the effect of buriti (Mauritia flexuosaL.) cream on thehealing of skin lesions in mice.Methods:Fifty-six mice underwent surgicalprocedure of excision of the skin in the dorsal region. After surgery, the groupswere treated with saline 0.9%, buriti cream 5% and 10% and Fibrase®.Results:On the seventh day was observed a significant reduction of the wound areain the animals treated with cream buriti 5% and Fibrase® when compared tocontrol. No differences were observed between groups on the 14thday of treat-ment. Histological examination showed the presence of granulation issue moreevolved, fibroblasts and collagen fibers in the samples buriti cream 5% andFibrase® from the seventh day of treatment.Conclusion:The buriti cream 5% isable to accelerate the healing process

Estudo experimental dos efeitos do óleo de buriti em lesões diabéticas

Objetivo: Analisar os efeitos do óleo na cicatrização de lesões em diabéticos tipo I e analisar comparativamente o efeito do óleo de girassol. Métodos: Consiste em uma pesquisa experimental de análise quantitativa, utilizando quatro grupos de ratos da linhagem Wistar (Ratus norvegicus). Os grupos A, B e C foram induzidos ao diabetes com a administração de uma dose única (50 mg/ Kg de peso corporal) de estreptozotocina, droga diabetogênica (Sigma Chemical Company, St. Louis, MO, EUA), dissolvida em 0,01 M tampão citrato (pH 4,5). Posteriormente, todos grupos foram lesionados na região dorso-lombar e tratados com soro (A), óleo de buriti (B e D) e óleo de girassol (C). Resultados: A análise através do software revelou que não houve resultados significativos para comprovar uma melhora da cicatrização com o uso do óleo de buriti. Conclusão: O uso do óleo de buriti apresentou, de modo geral, vantagens quando comparado aos demais grupos. Porém, com o resultado do “p Valor” fora dos padrões de confiabilidade e credulidade, esta pesquisa não apresentou grau de relevância para afirmar que o óleo de buriti traga reais benefícios ao tratamento de lesões dos pacientes diabéticos

Índices glicêmicos de ratos após a ingestão de fibras solúveis de quiabo (Abelmoschus esculentus)

Diabetes mellitus is a growing and important health problem for all countries. Frequently related to diabetes are the highest rates of hospitalization, as well as greater need for medical care, higher incidence of cardiovascular and cerebrovascular diseases, blindness, renal failure and non-traumatic lower limb amputations.The polar portion of A. esculentus, known as okra water, provides a large amount of soluble fiber. Studies show a large decrease in glycaemia in rats treated with okra. The present work aims to analyze the effects of okra on the glycemic indexes of rats with diabetes mellitus. For the analysis of the aforementioned okra effects, experiments were performed on 21 rats, from the vivariumof the Facid Differential Faculty | Wyden of Wistar rats (Rattus Norvegicus), aged between 30 and 60 days, of both sexes and with average weight of 200 to 250g. The random distribution of the rats occurred in order to form three groups - A, B, C. All rats were induced to diabetes, however, only those from group B received okra water, those from group C water of okra associated with glibenclamide 5mg, serving group A as a control group, which received only water. At the end of the study it was possible to observe that the use of A. esculentus fibers is able to improve the glycemic profile of rats with DM2.However, the association of fibers with glibenclamide prevents the hypoglycemic action of the fibers and the oral antidiabetic agent.O Diabetes mellitus (DM) é um crescente e importante problema de saúde para todos os países. Estão frequentemente relacionados ao diabetes as maiores taxas de hospitalização, bem como maiores necessidades de cuidados médicos, maior incidência de doenças cardiovasculares e cerebrovasculares, cegueira, insuficiência renal e amputações não traumáticas de membros inferiores. A porção polar de A. esculentus, conhecida como água de quiabo, proporciona uma grande quantidade de fibras solúveis. Estudos mostram uma grande diminuição da glicemia de ratos que foram tratados com a água do quiabo. O presente trabalho tem como objetivo analisar os efeitos do quiabo sobre os índices glicêmicos de ratos com diabetes mellitus. Para a análise dos efeitos do quiabo já mencionados foram realizados experimentos com 21 ratos, provenientes do biotério da Faculdade Integral Diferencial Facid|Wyden, da raça Wistar (Rattusnorvegicus), com idade entre 30 e 60 dias, de ambos os sexos e com peso médio de 200 a 250g. A distribuição aleatória dos ratos ocorreu a fim de formar três grupos – A, B,C. Todos os ratos foram induzidos ao diabetes, porém, apenas aqueles do grupo B receberam a água de quiabo, os do grupo C água de quiabo associado a glibenclamida 5mg, servindo o grupo A como grupo controle, o qual recebeu apenas água. Ao final do estudo foi possível observar que o uso de fibras de A. esculentos é capaz de melhorar o perfil glicêmico de ratos com DM2. Entretanto, a associação das fibras com glibenclamida impede a ação hipoglicemiante das fibras e do antidiabético oral.La diabetes mellitus (DM) es un problema de salud creciente e importante para todos los países. Las tasas más altas de hospitalización a menudo están relacionadas con la diabetes, así como con mayores necesidades de atención médica, mayor incidencia de enfermedades cardiovasculares y cerebrovasculares, ceguera, insuficiencia renal y amputaciones no traumáticas de las extremidades inferiores. La porción polar de A. esculentus, conocida como agua de okra, proporciona una gran cantidad de fibras solubles. Los estudios muestran una gran disminución en la glucemia de las ratas que fueron tratadas con agua de okra. El presente trabajo tiene como objetivo analizar los efectos de la okra en los índices glucémicos de ratas con diabetes mellitus. Para el análisis de los efectos de la okra ya mencionados, se realizaron experimentos con 21 ratas, del vivero de Facid | Wyden Integral Differential College, de la raza Wistar (Rattusnorvegicus), con edades comprendidas entre 30 y 60 días, de ambos sexos y con un peso promedio de 200 a 250 g. La distribución aleatoria de las ratas ocurrió para formar tres grupos: A, B, C. Todas las ratas fueron inducidas a diabetes, sin embargo, solo las del grupo B recibieron agua de quimbombó, las del agua de quimbombó del grupo C asociadas con 5 mg de glibenclamida, sirviendo al grupo A como grupo de control, que recibió solo agua. Al final del estudio, se observó que el uso de fibras de A. esculentos puede mejorar el perfil glucémico de las ratas con DM2. Sin embargo, la asociación de las fibras con la glibenclamida impide la acción hipoglucémica de las fibras y los antidiabéticos orales

Topical action of Buriti oil (Mauritia flexuosa L.) in myositis induced in rats

<div><p>Abstract Purpose: To analyze the topical effects of Buriti oil (Mauritia flexuosa L.) in induced myositis in rats. Methods: Thirty six male rats divided into three groups: Control group (C), induced myositis group (MI) and induced myositis group reated with Mauritia flexuosa L. (MT). After inducing myositis with 1% acetic acid, was topically applied 0.5 ml of Mauritia flexuosa L.extract on the posterior region of the right gastrocnemius muscle in animals belonging to group MT, for 7 and 14 days. Results: The neutrophil number there was statistically significant difference, after 7 and 14 days, between groups C and MI (p <0.001) (p<0.01). The group MT there was a significant difference in relation to MI group in both experimental times with (p<0.001). The number of fibroblasts in the 14 days showed that when comparing the groups M and MT the differences were also significant (p<0.001). As for the DLL, in 7 days, there was a significant difference between group C and MI group (p <0.001). When considering the MT group, there was a significant difference in relation to the MI group (p <0.001). Conclusion: The extract of Mauritia flexuosa L. leaves lessened acute and chronic inflammation, increased fibroblast proliferation and reduced macroscopically edema.</p></div

Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study

Background Acute capsaicinoid and capsinoid supplementation has endurance and resistance exercise benefits; however, if these short-term performance benefits translate into chronic benefits when combined with resistance training is currently unknown. This study investigated changes of chronic Capsiate supplementation on muscular adaptations, inflammatory response and performance in untrained men. Methods Twenty untrained men were randomized to ingest 12 mg Capsiate (CAP) or placebo in a parallel, double-blind design. Body composition and performance were measured at pre-training and after 6 weeks of resistance training. An acute resistance exercise session test was performed pre and post-intervention. Blood samples were collected at rest and post-resistance exercise to analyze Tumor necrosis factor- (TNF-), Soluble TNF- receptor (sTNF-r), Interleukin-6 (IL-6) and Interleukin-10 (IL-10). Results Exercise and CAP supplementation increased fat-free mass in comparison to baseline by 1.5 kg (P  0.05). Conclusion Chronic Capsiate supplementation combined with resistance training during short period (6 weeks) increased fat-free mass and upper body strength but not inflammatory response and performance in young untrained men