The survey of the effect of ginger extract on gastric residual volume in mechanically ventilated patients hospitalized in the Intensive Care Units

Background and purpose: Delayed gastric emptying in mechanically ventilated patients is common. According to evidences, Ginger can accelerate gastric emptying. This study aimed to determine the effect of ginger extract on gastric residual volume of patients admitted to the Intensive Care Unit. Materials and Methods: In this double-blind randomized controlled clinical trial with before and after schematization, 24 mechanically ventilated patients hospitalized in ICUs were divided into two groups, intervention group (12 patients) and control group (n = 12) after matching for sex and severity of disease. After 48 hours of feeding with a standard gavage solution, the intervention group received 120mg of ginger extract in 4 days and the control group received 5 ml water as placebo in 4 days. The mean residual volume was recorded in the fifth and the sixth days. Data analysis was done with independent and paired T-tests at a significance level of 0.05. Results: The mean residual volume in the first 48 hours was not significantly different between the groups. But after 48 hours of starting treatment, the average of mean and standard deviation of the residual volume in the fifth and sixth days were (24.58±16.81) in intervention group and (108.33±15.09) in control group that according to the Independent T-test showed a significant difference (P <0.0001). Discussion and Conclusion: The result of this study showed that ginger extract reduces gastric residual volume in mechanically ventilated patients hospitalized in intensive care units compared with placebo. © 2013 AENSI Publisher All rights reserved

A review and report of peripheral giant cell granuloma in a 4-year-old child

Peripheral giant cell granuloma is a common benign and reactive gingival epulis in oral cavity. It is often difficult to make a clinical diagnosis; thereby definitive diagnosis depends on histopathologic features. We report a case of a 4-year-old Caucasian boy presenting with a five-month history a 20 × 15 × 12 mm pedunculated, lobular soft tissue mass of the left anterior maxilla gingiva which was misdiagnosed and maltreated before his referral. An excisional biopsy of the lesion followed by histopathologic examination of the biopsy specimen revealed distinctive features of peripheral giant cell granuloma. Early detection and excision of this hyperplastic nodule especially in children are important to minimize potential dentoalveolar complications

Establishment of a New Urban Solid Waste Management Programs in Mazandaran Province, North of Iran

This study reports residents’ preferences to establish a new urban solid waste management programs results from a double-bounded dichotomous choice contingent valuation method and choice experiment in Mazandaran province, north of Iran. In order to analysis the residents’ preferences, a dichotomous hypothetical market and a choice sets with different attributes and options were used For estimation of two mentioned methods, the normal logit and conditional logit were applied. In addition, an empirical comparison of the welfare measures derived from the doublebounded DC-CVM and CE is conducted. The main results show that there is no significant difference between the values derived from the two methods. The mean of WTP to establish a new solid waste management programs in CV and CE were estimated 2.45 and 2.61 US$, respectively, per a person per a month. Also the estimated marginal WTP for all attributes in CE was 8.1 US$ per a month. The results suggest that both double-bounded DC-CVM and CE can be successfully stablished for improvement environmental level quality in Mazandaran province. This paper could provide the basis for further development of other new programs on sustainable urban management of solid waste in Mazandaran province.Keywords: Dichotomous choice, Willingness to pay, Solid waste management, Mazandaran province, Ira

Efficiency of BclI restriction fragment length polymorphism for detection of hemophilia A carriers in Sistan and Baluchestan province, Southeast of Iran

Background: Indirect genetic diagnosis using polymorphic DNA markers can detect carriers of hemophilia A. This technique is preferable in developing countries because of its simplicity and cost effectiveness compared to direct mutation analysis. In the present study, we examined usefulness of intragenic marker BclI restriction fragment length polymorphism (RFLP) at intron 18, for carrier detection. How this marker is informative was tested in 102 members of 16 hemophiliac families from Sistan and Baluchestan province, Southeast of Iran. Methods: Blood samples were obtained from 29 hemophilia A patients and 73 of their relatives, after taking informed consents. DNA was extracted using proteinase K digestion followed by DNA precipitation. Factor VIII gene polymorphism was identified by the polymerase chain reaction/RFLP which is both sensitive and economical. Results: Our results showed that almost 69.8 of Xchromosomes had restriction site for BclI enzyme. The heterozygosity rate for BclI polymorphism in tested women was 61.4, signifying the usefulness of this marker in carrier detection. The informative rate respecting this polymorphism was 43.7 meaning that a remarkable percent of families from the target population could be diagnosed using this marker alone. Conclusion: In Sistan and Baluchestan province where there is limited access to sophisticated facilities of molecular diagnosis, use of PCR-based analysis of DNA polymorphism in the BclI locus can be used to identify a remarkable percentage of the carriers and even for prenatal diagnosis. Meanwhile, it is necessary to evaluate the effectiveness of other polymorphic DNA markers to enhance the informative rate

Exploring break-points and interaction effects among predictors of the international digital divide

Cataloged from PDF version of article.The deepening of the digital divide between countries has prompted international organizations and governments to work together toward reducing the problem over the next 15 years. However, such efforts will likely succeed only if they are based on a firm grasp of the divide's underlying causes. In this paper we report the results of a comprehensive analysis of the determinants of the international digital divide. Our results confirm many findings of past research, but also extend existing knowledge in important ways. By employing Multivariate Adaptive Regression Splines (MARS), we discover non-linearities and interaction effects among the predictors. We then articulate significant policy implications based upon these findings

Allometric Scaling Reveals Evolutionary Constraint on Odonata Wing Cellularity via Critical Crack Length

Scaling in insect wings is a complex phenomenon that seems pivotal in maintaining wing functionality. In this study, the relationship between wing size and the size, location, and shape of wing cells in dragonflies and damselflies (Odonata) is investigated, aiming to address the question of how these factors are interconnected. To this end, WingGram, the recently developed computer‐vision‐based software, is used to extract the geometric features of wing cells of 389 dragonflies and damselfly wings from 197 species and 16 families. It has been found that the cell length of the wings does not depend on the wing size. Despite the wide variation in wing length (8.42 to 56.5 mm) and cell length (0.1 to 8.5 mm), over 80% of the cells had a length ranging from 0.5 to 1.5 mm, which was previously identified as the critical crack length of the membrane of locust wings. An isometric scaling of cells is also observed with maximum size in each wing, which increased as the size increased. Smaller cells tended to be more circular than larger cells. The results have implications for bio‐mimetics, inspiring new materials and designs for artificial wings with potential applications in aerospace engineering and robotics

Endothelin-1 regulation is entangled in a complex web of epigenetic mechanisms in diabetes

Endothelial cells (ECs) are primary targets of glucose-induced tissue damage. As a result of hyperglycemia, endothelin-1 (ET-1) is upregulated in organs affected by chronic diabetic complications. The objective of the present study was to identify novel transcriptional mechanisms that influence ET-1 regulation in diabetes. We carried out the investigation in microvascular ECs using multiple approaches. ECs were incubated with 5 mM glucose (NG) or 25 mM glucose (HG) and analyses for DNA methylation, histone methylation, or long non-coding RNA- mediated regulation of ET-1 mRNA were then performed. DNA methylation array analyses demonstrated the presence of hypomethylation in the proximal promoter and 5\u27 UTR/first exon regions of EDN1 following HG culture. Further, globally blocking DNA methylation or histone methylation significantly increased ET-1 mRNA expressions in both NG and HG-treated HRECs. While, knocking down the pathogenetic lncRNAs ANRIL, MALAT1, and ZFAS1 subsequently prevented the glucose-induced upregulation of ET-1 transcripts. Based on our past and present findings, we present a novel paradigm that reveals a complex web of epigenetic mechanisms regulating glucose-induced transcription of ET-1. Improving our understanding of such processes may lead to better targeted therapies

A Comparison between Recombinant Activated Factor VII (Aryoseven) and Novoseven in Patients with Congenital Factor VII Deficiency

In order to establish the efficacy and biosimilar nature of AryoSeven to NovoSeven in the treatment of congenital factor VII (FVII) deficiency, patients received either agent at 30 1/4g/kg, intravenously per week for 4 weeks, in a randomized fashion. The primary aim was to compare FVII:coagulation activity (FVII:C), 20 minutes after recombinant activated FVII (rFVIIa) injection, in the 2 groups. A secondary measure was self-reported bleeding. The median interquartile baseline range of the plasma level of activated FVII (FVIIa) activity in the 2 groups was 1.6 (1.1-14.0) IU/dL and 5.0 (1.1-25.5) IU/dL. All patients achieved levels of FVIIa (FVII:C) >30 IU/dL, 20 minutes after the injection of rFVIIa. Bleeding was similar between the 2 groups, with a comparable decrease in severity and frequency compared to the last month prior to treatment. AryoSeven is similar to NovoSeven in increasing postinjection FVIIa activity as well as in clinical safety and efficacy. © The Author(s) 2014

Down-regulation of Plasminogen Activator Inhibitor 1 Expression Promotes Myocardial Neovascularization by Bone Marrow Progenitors

Human adult bone marrow–derived endothelial progenitors, or angioblasts, induce neovascularization of infarcted myocardium via mechanisms involving both cell surface urokinase-type plasminogen activator, and interactions between β integrins and tissue vitronectin. Because each of these processes is regulated by plasminogen activator inhibitor (PAI)-1, we selectively down-regulated PAI-1 mRNA in the adult heart to examine the effects on postinfarct neovascularization and myocardial function. Sequence-specific catalytic DNA enzymes inhibited rat PAI-1 mRNA and protein expression in peri-infarct endothelium within 48 h of administration, and maintained down-regulation for at least 2 wk. PAI-1 inhibition enhanced vitronectin-dependent transendothelial migration of human bone marrow–derived CD34+ cells, and resulted in a striking augmentation of angioblast-dependent neovascularization. Development of large, thin-walled vessels at the peri-infarct region was accompanied by induction of proliferation and regeneration of endogenous cardiomyocytes and functional cardiac recovery. These results identify a causal relationship between elevated PAI-1 levels and poor outcome in patients with myocardial infarction through mechanisms that directly inhibit bone marrow–dependent neovascularization. Strategies that reduce myocardial PAI-1 expression appear capable of enhancing cardiac neovascularization, regeneration, and functional recovery after ischemic insult