Consistent dynamical and stellar masses with potential light IMF in massive quiescent galaxies at 3<z<43 < z < 4 using velocity dispersions measurements with MOSFIRE

We present the velocity dispersion measurements of four massive $\sim10^{11}M_\odot$ quiescent galaxies at $3.2 < z < 3.7$ based on deep H and K$-$band spectra using the Keck/MOSFIRE near-infrared spectrograph. We find high velocity dispersions of order $\sigma_e\sim250$ km/s based on strong Balmer absorption lines and combine these with size measurements based on HST/WFC3 F160W imaging to infer dynamical masses. The velocity dispersion are broadly consistent with the high stellar masses and small sizes. Together with evidence for quiescent stellar populations, the spectra confirm the existence of a population of massive galaxies that formed rapidly and quenched in the early universe $z>4$. Investigating the evolution at constant velocity dispersion between $z\sim3.5$ and $z\sim2$, we find a large increase in effective radius $0.35\pm0.12$ dex and in dynamical-to-stellar mass ratio of 0.33$\pm0.08$ dex, with low expected contribution from dark matter. The dynamical masses for our $z\sim3.5$ sample are consistent with the stellar masses for a Chabrier initial mass function (IMF), with the ratio = -0.13$\pm$0.10 dex suggesting an IMF lighter than Salpeter may be common for massive quiescent galaxies at $z>3$. This is surprising in light of the Salpeter or heavier IMFs found for high velocity dispersion galaxies at $z\sim2$ and cores of present-day ellipticals, which these galaxies are thought to evolve into. Future imaging and spectroscopic observations with resolved kinematics using the upcoming James Webb Space Telescope could rule out potential systematics from rotation, and confirm these results.Comment: 11 pages, 3 figures. Accepted to ApJ Letter

Deciphering Museums, Politics and Impact

This paper makes a contribution towards deciphering the relationship between museums, politics and impact. I suggest that this is akin to that between three languages in the early nineteenth century: Greek, Demotic and Hieroglyphs. I argue that museums should be taken much more seriously by the discipline of politics and international relations. This paper begins with an analysis of the REF 2014 Impact Case Studies submitted under the Politics and International Studies Unit of Assessment. Thereafter, it looks at how museums have been examined in the field of politics and international relations. Finally, it outlines some of the benefits and opportunities of scholars in the field engaging with museums in terms of their research, as potential collaborators, and as partners for knowledge transfer and impactful activities – within and outwith the strictures of the UK Research Excellence Framework (REF)

Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre parallel group assessor-blinded clinical trial

Background Conventional systemic drugs are used to treat children and young people (CYP) with severe atopic dermatitis (AD) worldwide, but no robust randomized controlled trial (RCT) evidence exists regarding their efficacy and safety in this population. While novel therapies have expanded therapeutic options, their high cost means traditional agents remain important, especially in lower-resource settings. Objectives To compare the safety and efficacy of ciclosporin (CyA) with methotrexate (MTX) in CYP with severe AD in the TREatment of severe Atopic Eczema Trial (TREAT) trial. Methods We conducted a parallel group assessor-blinded RCT in 13 UK and Irish centres. Eligible participants aged 2–16 years and unresponsive to potent topical treatment were randomized to either oral CyA (4 mg kg–1 daily) or MTX (0.4 mg kg–1 weekly) for 36 weeks and followed-up for 24 weeks. Co-primary outcomes were change from baseline to 12 weeks in Objective Severity Scoring of Atopic Dermatitis (o-SCORAD) and time to first significant flare (relapse) after treatment cessation. Secondary outcomes included change in quality of life (QoL) from baseline to 60 weeks; number of participant-reported flares following treatment cessation; proportion of participants achieving ≥ 50% improvement in Eczema Area and Severity Index (EASI 50) and ≥ 75% improvement in EASI (EASI 75); and stratification of outcomes by filaggrin status. Results In total, 103 participants were randomized (May 2016–February 2019): 52 to CyA and 51 to MTX. CyA showed greater improvement in disease severity by 12 weeks [mean difference in o-SCORAD –5.69, 97.5% confidence interval (CI) –10.81 to –0.57 (P = 0.01)]. More participants achieved ≥ 50% improvement in o-SCORAD (o-SCORAD 50) at 12 weeks in the CyA arm vs. the MTX arm [odds ratio (OR) 2.60, 95% CI 1.23–5.49; P = 0.01]. By 60 weeks MTX was superior (OR 0.33, 95% CI 0.13–0.85; P = 0.02), a trend also seen for ≥ 75% improvement in o-SCORAD (o-SCORAD 75), EASI 50 and EASI 75. Participant-reported flares post-treatment were higher in the CyA arm (OR 3.22, 95% CI 0.42–6.01; P = 0.02). QoL improved with both treatments and was sustained after treatment cessation. Filaggrin status did not affect outcomes. The frequency of adverse events (AEs) was comparable between both treatments. Five (10%) participants on CyA and seven (14%) on MTX experienced a serious AE. Conclusions Both CyA and MTX proved effective in CYP with severe AD over 36 weeks. Participants who received CyA showed a more rapid response to treatment, while MTX induced more sustained disease control after discontinuation

What is damaging the kidney in lupus nephritis?

Despite marked improvements in the survival of patients with severe lupus nephritis over the past 50 years, the rate of complete clinical remission after immune suppression therapy i