Analytical modeling of spindle-tool dynamics on machine tools using Timoshenko beam model and receptance coupling for the prediction of tool point FRF

Regenerative chatter is a well-known machining problem that results in unstable cutting process, poor surface quality and reduced material removal rate. This undesired self-excited vibration problem is one of the main obstacles in utilizing the total capacity of a machine tool in production. In order to obtain a chatter-free process on a machining center, stability diagrams can be used. Numerically or analytically, constructing the stability lobe diagram for a certain spindleholdertool combination implies knowing the system dynamics at the tool tip; i.e., the point frequency response function (FRF) that relates the dynamic displacement and force at that point. This study presents an analytical method that uses Timoshenko beam theory for calculating the tool point FRF of a given combination by using the receptance coupling and structural modication methods. The objective of the study is two fold. Firstly, it is aimed to develop a reliable mathematical model to predict tool point FRF in a machining center so that chatter stability analysis can be done, and secondly to make use of this model in studying the effects of individual bearing and contact parameters on tool point FRF so that better approaches can be found in predicting contact parameters from experimental measurements. The model can also be used to study the effects of several spindle, holder and tool parameters on chatter stability. In this paper, the mathematical model, as well as the details of obtaining the system component (spindle, holder and tool) dynamics and coupling them to obtain the tool point FRF are given. The model suggested is veried by comparing the natural frequencies of an example spindleholdertool assembly obtained from the model with those obtained from a nite element software

Effect analysis of bearing and interface dynamics on tool point FRF for chatter stability in machine tools by using a new analytical model for spindle-tool assemblies

Self-excited vibration of the tool, regenerative chatter, can be predicted and eliminated if the stability lobe diagram of the spindle–holder–tool assembly is known. Regardless of the approach being used, analytically or numerically, forming the stability lobe diagram of an assembly implies knowing the point frequency response function (FRF) in receptance form at the tool tip. In this paper, it is aimed to study the effects of spindle–holder and holder–tool interface dynamics, as well as the effects of individual bearings on the tool point FRF by using an analytical model recently developed by the authors for predicting the tool point FRF of spindle–holder–tool assemblies. It is observed that bearing dynamics control the rigid body modes of the assembly, whereas, spindle–holder interface dynamics mainly affects the first elastic mode, while holder–tool interface dynamics alters the second elastic mode. Individual bearing and interface translational stiffness and damping values control the natural frequency and the peak of their relevant modes, respectively. It is also observed that variations in the values of rotational contact parameters do not affect the resulting FRF considerably, from which it is concluded that rotational contact parameters of both interfaces are not as crucial as the translational ones and therefore average values can successfully be used to represent their effects. These observations are obtained for the bearing and interface parameters taken from recent literature, and will be valid for similar assemblies. Based on the effect analysis carried out, a systematic approach is suggested for identifying bearing and interface contact parameters from experimental measurements

Effect of atrazine on algal contamination and sugarcane shoots during photoautotrophic micropropagation

A laboratory procedure was developed for obtaining and maintaining photoautotrophic cultures ofsugarcane shoots in vitro for three generations. Algae contamination in vessels was a problem for photoautotrophic growth under septic conditions. Atrazine, a herbicide, was effective in controlling algae at a concentration of 10 ppm, but the growth of shoots in herbicide-treated sugarless Murashige and Skoog (MS) medium decreased to about half of the growth in untreated medium. As a result, atrazine was not considered to be a practical solution for algae control. Additional work is needed to optimize photoautotrophic micropropagation of sugarcane for both septic and aseptic conditions. Photoautotrophic micropropagation of sugarcane may be economical only if culture can be perfected under septic conditions

Analytical modeling of spindle-tool dynamics on machine tools using Timoshenko beam model and receptance coupling for the prediction of tool point FRF

Regenerative chatter is a well-known machining problem that results in unstable cutting process, poor surface quality and reduced material removal rate. This undesired self-excited vibration problem is one of the main obstacles in utilizing the total capacity of a machine tool in production. In order to obtain a chatter-free process on a machining center, stability diagrams can be used. Numerically or analytically, constructing the stability lobe diagram for a certain spindle-holder-tool combination implies knowing the system dynamics at the tool tip; i.e., the point frequency response function (FRF) that relates the dynamic displacement and force at that point. This study presents an analytical method that uses Timoshenko beam theory for calculating the tool point FRF of a given combination by using the receptance coupling and structural modification methods. The objective of the study is two fold. Firstly, it is aimed to develop a reliable mathematical model to predict tool point FRF in a machining center so that chatter stability analysis can be done, and secondly to make use of this model in studying the effects of individual bearing and contact parameters on tool point FRF so that better approaches can be found in predicting contact parameters from experimental measurements. The model can also be used to study the effects of several spindle, holder and tool parameters on chatter stability. In this paper, the mathematical model, as well as the details of obtaining the system component (spindle, holder and tool) dynamics and coupling them to obtain the tool point FRF are given. The model suggested is verified by comparing the natural frequencies of an example spindle-holder-tool assembly obtained from the model with those obtained from a finite element software

Concordance of LDL-C Estimating Equations with Direct Enzymatic Measurement in Diabetic and Prediabetic Subjects

Low-density lipoprotein cholesterol (LDL-C) is a well-established biomarker in the management of dyslipidemia. Therefore, we aimed to evaluate the concordance of LDL-C-estimating equations with direct enzymatic measurement in diabetic and prediabetic populations. The data of 31,031 subjects included in the study were divided into prediabetic, diabetic, and control groups according to HbA1c values. LDL-C was measured by direct homogenous enzymatic assay and calculated by Martin-Hopkins, Martin-Hopkins extended, Friedewald, and Sampson equations. The concordance statistics between the direct measurements and estimations obtained by the equations were evaluated. All equations evaluated in the study had lower concordance with direct enzymatic measurement in diabetic and prediabetic groups compared to the non-diabetic group. Even so, the Martin-Hopkins extended approach demonstrated the highest concordance statistic in diabetic and prediabetic patients. Further, Martin-Hopkins extended was found to have the highest correlation with direct measurement compared with other equations. Over the 190 mg/dL LDL-C concentrations, the equation with the highest concordance was again Martin-Hopkins extended. In most scenarios, the Martin-Hopkins extended performed best in prediabetic and diabetic groups. Additionally, direct assay methods can be used at low values of the non-HDL-C/TG ratio (<2.4), as the performance of the equations in LDL-C estimation decreases as non-HDL-C/TG decreases

3-Amino-4-[4-(dimethyl­amino)­phen­yl]-4,5-dihydro-1,2,5-thia­diazole 1,1-dioxide

The title compound, C10H14N4O2S, exists in the amine tautomeric form. The dihedral angle between the benzene and thia­diazo­lidine rings is 66.54 (19)°. In the crystal, mol­ecules are linked by N—H⋯O and N—H⋯N hydrogen bonds into a layer parallel to the ac plane. The layers are further linked by C—H⋯O hydrogen bonds

The role of the family in attributing meaning to living with HIV and its stigma in Turkey

Stigma attached to HIV/AIDS remains a global problem, with severe negative consequences for people living with HIV (PLHIV). Family support is fundamental for PLHIV’s psychological and physical well-being. HIV-related stigma is high in Turkey, where HIV/AIDS prevalence is low and the epidemic is not considered a priority. Based on qualitative data generated with HIV-positive women and men, this article explores the process of stigmatization, as experienced and perceived by PLHIV in Turkey, focusing on the institution of the family. Results indicated that enacted stigma from family members is lower than anticipated. While most participants’ narratives showed patterns of support rather than rejection from families, the strong expectations around the cultural value attributed to “the family” are found to be the main facilitators of internalized stigma. The article critically discusses the meaning and implications of family support, addressing the role of patriarchal values attributed to womanhood, manhood, and sexuality in Turkey

Deconstructing the lesbian, gay, bisexual, transgender victim of sex trafficking: Harm, exceptionality and religion–sexuality tensions

Contrary to widespread belief, sex trafficking also targets lesbian, gay, bisexual, transgender (LGBT) communities. Contemporary social and political constructions of victimhood lie at the heart of regulatory policies on sex trafficking. Led by the US Department of State, knowledge about LGBT victims of trafficking constitutes the newest frontier in the expansion of criminalization measures. These measures represent a crucial shift. From a burgeoning range of preemptive measures enacted to protect an amorphous class of ‘all potential victims’, now policies are heavily premised on the risk posed by traffickers to ‘victims of special interest’. These constructed identities, however, are at odds with established structures. Drawing on a range of literatures, the core task of this article is to confront some of the complexities and tensions surrounding constructions of LGBT trafficking victims. Specifically, the article argues that discourses of ‘exceptional vulnerability’ and the polarized notions of ‘innocence’ and ‘guilt’ inform hierarchies of victimhood. Based on these insights, the article argues for the need to move beyond monolithic understandings of victims, by reframing the politics of harm accordingly

Tissue Clearing and Deep Imaging of the Kidney Using Confocal and Two-Photon Microscopy

Microscopic and macroscopic evaluation of biological tissues in three dimensions is becoming increasingly popular. This trend is coincident with the emergence of numerous tissue clearing strategies, and advancements in confocal and two-photon microscopy, enabling the study of intact organs and systems down to cellular and sub-cellular resolution. In this chapter, we describe a wholemount immunofluorescence technique for labeling structures in renal tissue. This technique combined with solvent-based tissue clearing and confocal imaging, with or without two-photon excitation, provides greater structural information than traditional sectioning and staining alone. Given the addition of paraffin embedding to our method, this hybrid protocol offers a powerful approach to combine confocal or two-photon findings with histological and further immunofluorescent analysis within the same tissue

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons

The perspective of neuroinflammation as an epiphenomenon following neuron damage is being replaced by the awareness of glia and their importance in neural functions and disorders. Systemic inflammation generates signals that communicate with the brain and leads to changes in metabolism and behavior, with microglia assuming a pro-inflammatory phenotype. Identification of potential peripheral-to-central cellular links is thus a critical step in designing effective therapeutics. Mast cells may fulfill such a role. These resident immune cells are found close to and within peripheral nerves and in brain parenchyma/meninges, where they exercise a key role in orchestrating the inflammatory process from initiation through chronic activation. Mast cells and glia engage in crosstalk that contributes to accelerate disease progression; such interactions become exaggerated with aging and increased cell sensitivity to stress. Emerging evidence for oligodendrocytes, independent of myelin and support of axonal integrity, points to their having strong immune functions, innate immune receptor expression, and production/response to chemokines and cytokines that modulate immune responses in the central nervous system while engaging in crosstalk with microglia and astrocytes. In this review, we summarize the findings related to our understanding of the biology and cellular signaling mechanisms of neuroinflammation, with emphasis on mast cell-glia interactions