889 research outputs found
Connectivity-Driven Coherence in Complex Networks
We study the emergence of coherence in complex networks of mutually coupled
non-identical elements. We uncover the precise dependence of the dynamical
coherence on the network connectivity, on the isolated dynamics of the elements
and the coupling function. These findings predict that in random graphs, the
enhancement of coherence is proportional to the mean degree. In locally
connected networks, coherence is no longer controlled by the mean degree, but
rather on how the mean degree scales with the network size. In these networks,
even when the coherence is absent, adding a fraction s of random connections
leads to an enhancement of coherence proportional to s. Our results provide a
way to control the emergent properties by the manipulation of the dynamics of
the elements and the network connectivity.Comment: 4 pages, 2 figure
2000 Families: identifying the research potential of an origins - of migration study
Despite extensive recent advances in the empirical and theoretical study of migration, certain critical areas in the analysis of European migration remain relatively underdeveloped both theoretically and empirically. Specifically, we lack studies that both incorporate an origin comparison and trace processes of intergenerational transmission across migrants over multiple generations and incorporating family migration trajectories. This paper outlines the development, data and design of such a study, the 2000 Families study, framed within a theoretical perspective of ?dissimilation? from origins and over generations. We term the study an origins-of-migration study, in that it captures the country of origin, the family origins and potentially the originating causes of migration processes and outcomes. The resulting data comprised nearly 2,000 migrant and non-migrant Turkish families with members across three or more generations, covering. 50,000 individuals. We reflect on the potential of this study for migration research
Comparison of a thigh worn accelerometer algorithm with diary estimates of time in bed and time asleep: the 1970 British Cohort Study
Background: Thigh-worn accelerometers have established reliability and validity for measurement of free-living physical activity-related behaviors. However, comparisons of methods for measuring sleep and time in bed using the thigh-worn accelerometer are rare. The authors compared the thigh-worn accelerometer algorithm that estimates time in bed with the output of a sleep diary (time in bed and time asleep). Methods: Participants (N = 5,498), from the 1970 British Cohort Study, wore an activPAL device on their thigh continuously for 7 days and completed a sleep diary. Bland–Altman plots and Pearson correlation coefficients were used to examine associations between the algorithm derived and diary time in bed and asleep. Results: The algorithm estimated acceptable levels of agreement with time in bed when compared with diary time in bed (mean bias of −11.4 min; limits of agreement −264.6 to 241.8). The algorithm-derived time in bed overestimated diary sleep time (mean bias of 55.2 min; limits of agreement −204.5 to 314.8 min). Algorithm and sleep diary are reasonably correlated (ρ = .48, 95% confidence interval [.45, .52] for women and ρ = .51, 95% confidence interval [.47, .55] for men) and provide broadly comparable estimates of time in bed but not for sleep time. Conclusions: The algorithm showed acceptable estimates of time in bed compared with diary at the group level. However, about half of the participants were outside of the ±30 min difference of a clinically relevant limit at an individual level
Accelerated diabetic wound healing by topical application of combination oral antidiabetic agents-loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study
The combination of oral antidiabetic drugs, pioglitazone, metformin, and glibenclamide, which also
exhibit the strongest anti-inflammatory action among oral antidiabetic drugs, were loaded into
chitosan/gelatin/polycaprolactone (PCL) by electrospinning and polyvinyl pyrrolidone (PVP)/PCL
composite nanofibrous scaffolds by pressurized gyration to compare the diabetic wound healing
effect. The combination therapies significantly accelerated diabetic wound healing in type-1
diabetic rats and organized densely packed collagen fibers in the dermis, it also showed better
regeneration of the dermis and epidermis than single drug-loaded scaffolds with less inflammatory
cell infiltration and edema. The formation of the hair follicles started in 14 days only in the
combination therapy and lower proinflammatory cytokine levels were observed compared to single
drug-loaded treatment groups. The combination therapy increased the wettability and hydrophilicity
of scaffolds, demonstrated sustained drug release over 14 days, has high tensile strength and
suitable cytocompatibility on L929 (mouse fibroblast) cell and created a suitable area for the
proliferation of fibroblast cells. Consequently, the application of metformin and pioglitazone-loaded
chitosan/gelatin/PCL nanofibrous scaffolds to a diabetic wound area offer high bioavailability,
fewer systemic side effects, and reduced frequency of dosage and amount of drug
Expression of CK-19 and CEA MRNA in peripheral blood of gastric cancer patients
The aim of this paper is to investigate the clinical and pathological relevance of detection of circulating tumor cells (CTC) in the peripheral blood of gastric carcinoma patients before operation
Systematic study of trace radioactive impurities in candidate construction materials for EXO-200
The Enriched Xenon Observatory (EXO) will search for double beta decays of
136Xe. We report the results of a systematic study of trace concentrations of
radioactive impurities in a wide range of raw materials and finished parts
considered for use in the construction of EXO-200, the first stage of the EXO
experimental program. Analysis techniques employed, and described here, include
direct gamma counting, alpha counting, neutron activation analysis, and
high-sensitivity mass spectrometry.Comment: 32 pages, 6 figures. Expanded introduction, added missing table
entry. Accepted for publication in Nucl. Instrum. Meth.
Thigh-worn accelerometry for measuring movement and posture across the 24-hour cycle : a scoping review and expert statement
The Prospective Physical Activity Sitting and Sleep consortium (ProPASS) is an international collaboration platform committed to harmonise thigh-worn accelerometry data. The aim of this paper is to (1) outline observational thigh-worn accelerometry studies and (2) summarise key strategic directions arising from the inaugural ProPASS meeting. (1) We performed a systematic scoping review for observational studies of thigh-worn triaxial accelerometers in free-living adults (n≥100, 24 hours monitoring protocols). (2)Attendees of the inaugural ProPASS meeting were sent a survey focused on areas related to developing ProPASS: important terminology (Q1); accelerometry constructs (Q2); advantages and distinct contribution of the consortium (Q3); data pooling and harmonisation (Q4); data access and sharing (Q5 and Q6). (1) Eighty eligible articles were identified (22 primary studies; n~17 685). The accelerometers used most often were the ActivPAL3 and ActiGraph GT3X. The most commonly collected health outcomes were cardiometabolic and musculoskeletal. (2) None of the survey questions elicited the predefined 60% agreement. Survey responses recommended that ProPASS: use the term physical behaviour or movement behaviour rather than 'physical activity' for the data we are collecting (Q1); make only minor changes to ProPASS's accelerometry construct (Q2); prioritise developing standardised protocols/tools (Q4); facilitate flexible methods of data sharing and access (Q5 and Q6). Thigh-worn accelerometry is an emerging method of capturing movement and posture across the 24 hours cycle. In 2020, the literature is limited to 22 primary studies from high-income western countries. This work identified ProPASS's strategic directions-indicating areas where ProPASS can most benefit the field of research: use of clear terminology, refinement of the measured construct, standardised protocols/tools and flexible data sharing. [Abstract copyright: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Thigh-worn accelerometry for measuring movement and posture across the 24-hour cycle: a scoping review and expert statement
Introduction: The Prospective Physical Activity Sitting and Sleep consortium (ProPASS) is an international collaboration platform committed to harmonise thigh-worn accelerometry data. The aim of this paper is to (1) outline observational thigh-worn accelerometry studies and (2) summarise key strategic directions arising from the inaugural ProPASS meeting.Methods: (1) We performed a systematic scoping review for observational studies of thigh-worn triaxial accelerometers in free-living adults (n≥100, 24 hours monitoring protocols). (2)Attendees of the inaugural ProPASS meeting were sent a survey focused on areas related to developing ProPASS: important terminology (Q1); accelerometry constructs (Q2); advantages and distinct contribution of the consortium (Q3); data pooling and harmonisation (Q4); data access and sharing (Q5 and Q6).Results: (1) Eighty eligible articles were identified (22 primary studies; n~17 685). The accelerometers used most often were the ActivPAL3 and ActiGraph GT3X. The most commonly collected health outcomes were cardiometabolic and musculoskeletal. (2) None of the survey questions elicited the predefined 60% agreement. Survey responses recommended that ProPASS: use the term physical behaviour or movement behaviour rather than 'physical activity' for the data we are collecting (Q1); make only minor changes to ProPASS's accelerometry construct (Q2); prioritise developing standardised protocols/tools (Q4); facilitate flexible methods of data sharing and access (Q5 and Q6).Conclusions: Thigh-worn accelerometry is an emerging method of capturing movement and posture across the 24 hours cycle. In 2020, the literature is limited to 22 primary studies from high-income western countries. This work identified ProPASS's strategic directions-indicating areas where ProPASS can most benefit the field of research: use of clear terminology, refinement of the measured construct, standardised protocols/tools and flexible data sharing.</p
A Large Hadron Electron Collider at CERN
This document provides a brief overview of the recently published report on
the design of the Large Hadron Electron Collider (LHeC), which comprises its
physics programme, accelerator physics, technology and main detector concepts.
The LHeC exploits and develops challenging, though principally existing,
accelerator and detector technologies. This summary is complemented by brief
illustrations of some of the highlights of the physics programme, which relies
on a vastly extended kinematic range, luminosity and unprecedented precision in
deep inelastic scattering. Illustrations are provided regarding high precision
QCD, new physics (Higgs, SUSY) and electron-ion physics. The LHeC is designed
to run synchronously with the LHC in the twenties and to achieve an integrated
luminosity of O(100) fb. It will become the cleanest high resolution
microscope of mankind and will substantially extend as well as complement the
investigation of the physics of the TeV energy scale, which has been enabled by
the LHC
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