The Role of Diet during Pregnancy in Protecting against Gestational Diabetes Mellitus in a Population with Mediterranean Dietary Habits: A Cross-Sectional Study

Gestational diabetes mellitus (GDM) is a common metabolic disorder among pregnant women. Dietary habits during pregnancy might alter the risk of GDM development, and populations following the Mediterranean diet are relatively understudied. This was a cross-sectional, observational study of 193 low-risk women admitted to a private maternity hospital in Greece to give birth. Food frequency data on specific food categories, selected based on previous research, were analyzed. Logistic regression models, both crude and adjusted for maternal age, body mass index before pregnancy, and gestational weight gain, were fitted. We observed no association of carbohydrate-rich meals, sweets, soft drinks, coffee, rice, pasta, bread and crackers, potatoes, lentils, and juices with GDM diagnosis. Cereals (crude p = 0.045, adjusted p = 0.095) and fruits and vegetables (crude p = 0.07, adjusted p = 0.04) appeared to have a protective effect against GDM, while frequent tea consumption was linked to higher risk of GDM development (crude p = 0.067, adjusted p = 0.035). These results strengthen previously identified associations and underline the importance and potential impact of changing dietary habits even during pregnancy in adjusting one’s risk of metabolic pregnancy complications, such as GDM. The importance of healthy dietary habits is highlighted, with the goal of raising awareness amongst obstetric care specialists regarding the provision of systematic nutrition recommendations to pregnant women

Η αμφιλεγόμενη αλληλεπίδραση του εντερικού μικροβιώματος με την ανθρώπινη αναπαραγωγή

Εισαγωγή:Aρκετές υποθέσεις έχουν διατυπωθεί σχετικά με την αμφίδρομη σχέση του εντερικού μικροβιώματος με την αναπαραγωγική λειτουργία, τις μαιευτικές και γυναικολογικές εκβάσεις στον άνθρωπο. Στη βιολογική διασύνδεση των ανωτέρω έχει προταθεί ότι συμμετέχουν οι στεροειδείς ορμόνες του φύλου, τα λιπαρά οξέα βραχείας αλύσου, η ομοιοστασία των αμινοξέων, η βιοσύνθεση των βιταμινών, η απορρόφηση του σιδήρου και η μετατόπιση βακτηρίων εκτός του εντέρου.Σκοπός:Η συστηματική ανασκόπηση της βιβλιογραφίας σχετικά με τη συσχέτιση του εντερικού μικροβιώματος με την αναπαραγωγική λειτουργία, τις μαιευτικές και γυναικολογικές εκβάσεις στον άνθρωπο.Μέθοδοι:Έγινε αναζήτηση για σχετικές δημοσιευμένες ερευνητικές εργασίες στη Medline, η οποία προσπελάστηκε μέσω του PubMed.Αποτελέσματα:Σε αυτή την ανασκόπηση συμπεριλαμβάνονται 59μελέτες σε ανθρώπους, στις οποίες μελετήθηκε η σχέση του εντερικού μικροβιώματος με τη φυσιολογική εγκυμοσύνη, τις ανεπιθύμητες μαιευτικές εκβάσεις (π.χ. προεκλαμψία, σακχαρώδης διαβήτης κύησης και πρόωρος τοκετός),την κεντρική πρώιμη ήβη,το σύνδρομο πολυκυστικών ωοθηκών, την ενδομητρίωση, τη χρόνια ανωοθυλακιορρηξία, τη περιγεννητική ψυχική υγεία, την υγεία των απογόνων και τις γυναικολογικές κακοήθειες. Πειραματικά δεδομένα υποστηρίζουν ότιη μεταμόσχευση εντερικού μικροβιώματος σε ζωικά μοντέλα επάγει μεταβολικά και αναπαραγωγικά χαρακτηριστικά, τα οποία είναι παρόμοια με εκείνα που παρατηρούνται στις γυναίκες από τις οποίες ελήφθη το δείγμα του εντερικού μικροβιώματος. Ωστόσο, οι μελέτες παρατήρησης ασθενών μαρτύρων είχαν ετερογενή αποτελέσματα.Συμπεράσματα:Με βάση τα διαθέσιμα έως σήμερα δεδομένα, η ανάλυση του εντερικού μικροβιώματος δεν μπορεί να χρησιμοποιηθεί στη μαιευτική και τη γυναικολογία για τη διάγνωση ή 5τη διαστρωμάτωση κινδύνου και η αλληλεπίδραση του εντερικού μικροβιώματος με την ανθρώπινη αναπαραγωγική λειτουργία παραμένει αμφιλεγόμενη.Introduction:Several hypotheses exist regarding the bidirectional association of gut microbiome with reproductive function, obstetrical, and gynecological outcomes in humans. Steroid sex hormones, short chain fatty acids, amino acids, vitamin synthesis, iron absorption, and bacterial translocation from the gut have been proposed to facilitate this association. Aim:The study’s aim was to systematically review the literature regarding the association of gut microbiome characteristics with reproductive function, obstetrical and gynecological outcomes in humans. Methods:Medline, accessed via PubMed, was searched for relevant published research papers.Results:In this review 59human studies are included, where normal pregnancy, adverse pregnancy outcomes (e.g. preeclampsia, gestational diabetes mellitus, and preterm birth), central precocious puberty, polycystic ovary syndrome, endometriosis, chronic anovulation, perinatal mental health, offspring health, and gynecological cancers werestudied in relation to the gut microbiome. Experimental data support that gut microbiometransplant toanimal models can induce metabolic and reproductive features, which are similar with the ones observed in humans from which the gut microbiome samples were obtained. However, observational case-control studies have yield heterogeneous results.Conclusions:Based on currently available data, gut microbiome analysis cannot be used in obstetrics and gynecology for diagnosis or risk stratification, and the interplay of the gut microbiome with reproductive function in humans remains controversial

The role of gut microbiome in prevention, diagnosis and treatment of gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is a common metabolic disease associated with maternal and foetal complications; gut microbiome might participate in GDM pathogenesis. Possible biological links include short chain fatty acids, incretin hormones, bile acids homeostasis and peroxisome proliferator-activated receptor gamma deficiency. Gut microbiome differs in patients with GDM even in early pregnancy, but no differences are observed five years postpartum. Patients have enriched Verrucomicrobia phylum, Christensenellaceae and Lachnospiraceae families, Haemophilus, Prevotella, Actinomyces, Collinsella and Ruminococcus genera during pregnancy. Clostridiales order, Alistipes, Faecalibacterium, Blautia, Eubacterium and Roseburia genera are depleted. However, there is great heterogeneity in the reviewed studies and scientific data on the use of gut microbiome characteristics and related biomarkers in GDM risk stratification and diagnosis are scarce. Probiotics and synbiotics have been tested for prevention and treatment for GDM with limited efficacy. Future studies should explore the effect of probiotics administration at first trimester of pregnancy and their value as adjuvant therapy

The role of gut microbiome in prevention, diagnosis and treatment of gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is a common metabolic disease associated with maternal and foetal complications; gut microbiome might participate in GDM pathogenesis. Possible biological links include short chain fatty acids, incretin hormones, bile acids homeostasis and peroxisome proliferator-activated receptor gamma deficiency. Gut microbiome differs in patients with GDM even in early pregnancy, but no differences are observed five years postpartum. Patients have enriched Verrucomicrobia phylum, Christensenellaceae and Lachnospiraceae families, Haemophilus, Prevotella, Actinomyces, Collinsella and Ruminococcus genera during pregnancy. Clostridiales order, Alistipes, Faecalibacterium, Blautia, Eubacterium and Roseburia genera are depleted. However, there is great heterogeneity in the reviewed studies and scientific data on the use of gut microbiome characteristics and related biomarkers in GDM risk stratification and diagnosis are scarce. Probiotics and synbiotics have been tested for prevention and treatment for GDM with limited efficacy. Future studies should explore the effect of probiotics administration at first trimester of pregnancy and their value as adjuvant therapy

The impact of Mayer–Rokitansky–Küster–Hauser Syndrome on Psychology, Quality of Life, and Sexual Life of Patients: A Systematic Review

Background: Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome is a rare congenital syndrome characterized by uterovaginal agenesis. Most patients are diagnosed during adolescence, when body image and sexual identity are shaped. Our main objective was to investigate how MRKH syndrome affects psychology, quality of life (QoL), and the sexual life of patients compared with non-affected individuals. Methods: Original peer-reviewed research papers examining psychological outcomes, QoL, and sexual function of MRKH patients were searched in PubMed. Titles, abstracts, and full text from potentially eligible records were reviewed by two independent reviewers. Case reports and papers published not in English were excluded. Results: Our search identified 63 records, of which 20 were included: 10 examined psychological and psychosocial outcomes, 14 examined sexual function outcomes, and 6 examined QoL outcomes. Results may be affected by selection bias and confounding due to differences between MRKH patients and controls. Conclusions: MRKH could be associated with a higher prevalence of anxiety and depression symptoms and social insecurity compared with women of a similar age without the condition. MRKH could also be associated with greater pain and discomfort during sexual intercourse and limitations in arousal, lubrication, and orgasm. MRKH patients more commonly experience impairment of mental-health-related QoL, but physical-health-related QoL is not affected

The impact of Mayer–Rokitansky–Küster–Hauser Syndrome on Psychology, Quality of Life, and Sexual Life of Patients: A Systematic Review

Background: Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome is a rare congenital syndrome characterized by uterovaginal agenesis. Most patients are diagnosed during adolescence, when body image and sexual identity are shaped. Our main objective was to investigate how MRKH syndrome affects psychology, quality of life (QoL), and the sexual life of patients compared with non-affected individuals. Methods: Original peer-reviewed research papers examining psychological outcomes, QoL, and sexual function of MRKH patients were searched in PubMed. Titles, abstracts, and full text from potentially eligible records were reviewed by two independent reviewers. Case reports and papers published not in English were excluded. Results: Our search identified 63 records, of which 20 were included: 10 examined psychological and psychosocial outcomes, 14 examined sexual function outcomes, and 6 examined QoL outcomes. Results may be affected by selection bias and confounding due to differences between MRKH patients and controls. Conclusions: MRKH could be associated with a higher prevalence of anxiety and depression symptoms and social insecurity compared with women of a similar age without the condition. MRKH could also be associated with greater pain and discomfort during sexual intercourse and limitations in arousal, lubrication, and orgasm. MRKH patients more commonly experience impairment of mental-health-related QoL, but physical-health-related QoL is not affected

Medical and Behavioral Aspects of Adolescent Endometriosis: A Review of the Literature

The majority of young women will experience discomfort associated with menstrual cycles and miss out on education and social opportunities. Endometriosis, the presence of endometrial glands and stroma outside of uterus, is the most common cause of secondary dysmenorrhea and characterized by pain despite treatment with nonsteroidal anti-inflammatory drugs and hormonal agents. The true prevalence of adolescent endometriosis is not clear. Delay in diagnosis leads to persistent pain, affects quality of life, and potentially contributes to disease progression and subfertility. A laparoscopic diagnosis is the gold standard, but the surgical appearance may differ from adults, as endometriotic lesions are usually red or clear, making their identification a challenge for gynecologists who are unexperienced with endometriosis in adolescents. A personalized medical–surgical treatment is regarded as the most effective therapeutic strategy to achieve remission of symptoms, suppress disease progression, and protect future fertility. Studies have demonstrated how adolescent endometriosis negatively affects patients’ quality of life and psychosocial functioning. Development of therapeutic interventions targeting psychosocial function and quality of life is imperative for adolescent patients

Conjoined Twins Complicating a Dichorionic Triplet Pregnancy after Intracytoplasmic Sperm Injection: A Case Report and Review of the Literature

Conjoined twins represent a rare type of monoamniotic twins. Ultrasound assessment during the first trimester can facilitate the diagnosis, however further assessment by colour Doppler studies, 3D imaging, fetal echocardiography and fetal magnetic resonance imaging (MRI) is usually required in order to determine the specific fetal abnormalities and to guide appropriate pregnancy management. This case report presents a rare case of conjoined twins complicating a dichorionic-diamniotic triplet pregnancy, achieved after intracytoplasmic sperm injection (ICSI) and blastocyst transfer. A 44-year-old woman was referred for chorionicity determination to our Fetal Medicine Centre due to suspicion of conjoined twins in a triplet pregnancy. Ultrasound assessment at 11 weeks demonstrated a dichorionic triplet pregnancy which was also complicated by a rare type of conjoined twins (thoracoomphalopagus) and after a successful embryo reduction a neonate of 2200 g was delivered by caesarean section at term. The accurate diagnosis and early detection of conjoined twins by a fetal medicine specialist is crucial, especially as far as multiple pregnancies with three or more fetuses are concerned

Associations of maternal cell-phone use during pregnancy with pregnancy duration and fetal growth in 4 birth cohorts

Results from studies evaluating potential effects of prenatal exposure to radio-frequency electromagnetic fields from cell phones on birth outcomes have been inconsistent. Using data on 55,507 pregnant women and their children from Denmark (1996-2002), the Netherlands (2003-2004), Spain (2003-2008), and South Korea (2006-2011), we explored whether maternal cell-phone use was associated with pregnancy duration and fetal growth. On the basis of self-reported number of cell-phone calls per day, exposure was grouped as none, low (referent), intermediate, or high. We examined pregnancy duration (gestational age at birth, preterm/postterm birth), fetal growth (birth weight ratio, small/large size for gestational age), and birth weight variables (birth weight, low/high birth weight) and meta-analyzed cohort-specific estimates. The intermediate exposure group had a higher risk of giving birth at a lower gestational age (hazard ratio = 1.04, 95% confidence interval: 1.01, 1.07), and exposure-response relationships were found for shorter pregnancy duration (P < 0.001) and preterm birth (P = 0.003). We observed no association with fetal growth or birth weight. Maternal cell-phone use during pregnancy may be associated with shorter pregnancy duration and increased risk of preterm birth, but these results should be interpreted with caution, since they may reflect stress during pregnancy or other residual confounding rather than a direct effect of cell-phone exposure.The Generalized EMF Research Using Novel Methods (GERoNiMO) Project was supported by the European Union (grant 603794). The Amsterdam Born Children and Their Development Study (ABCD) was supported by the Netherlands Organization for Health Research and Development (grant 2100.0076) and the Electromagnetic Fields and Health Research program (grants 85600004 and 85800001). The Danish National Birth Cohort Study (DNBC) was supported by the Danish Epidemiology Science Centre, the Lundbeck Foundation (grant 195/04), the Egmont Foundation, the March of Dimes Birth Defect Foundation, the Augustinus Foundation, and the Medical Research Council (grant SSVF 0646). The Spanish Environment and Childhood Project (INMA) was supported by the European Union (grants FP7-ENV-2011, 282957, and HEALTH.2010.2.4.5-1); Instituto de Salud Carlos III (grants G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, 11/01007, 11/02591, CP11/00178, FIS-PI06/0867, FIS-PS09/00090, FIS-PI041436, FIS-PI081151, FIS-PI042018, FIS-PI09/02311, FISPI13/1944, FIS-PI13/2429, FIS-PI14/0981, FIS-PI13/141687, CP13/00054 (including FEDER funds), and MS13/00054); the Conselleria de Sanitat Generalitat Valenciana; the Generalitat de Catalunya (grants CIRIT1999SGR and 00241); Obra Social Cajastur; the Universidad de Oviedo; the Department of Health of the Basque Government (grants 2005111093 and 2009111069); and the Provincial Government of Gipuzkoa (grants DFG06/004 and DFG08/001). The Korean Mothers and Children’s Environment Health Study (MOCEH) was supported by the National Institute of Environmental Research, the Ministry of the Environment, and the Information and Communication Technology (ICT) research and development program of the Ministry of Science and ICT (grants 2017-0-00961 and 2019-0-00102), South Korea

Associations of maternal cell-phone use during pregnancy with pregnancy duration and fetal growth in 4 birth cohorts

Results from studies evaluating potential effects of prenatal exposure to radio-frequency electromagnetic fields from cell phones on birth outcomes have been inconsistent. Using data on 55,507 pregnant women and their children from Denmark (1996-2002), the Netherlands (2003-2004), Spain (2003-2008), and South Korea (2006-2011), we explored whether maternal cell-phone use was associated with pregnancy duration and fetal growth. On the basis of self-reported number of cell-phone calls per day, exposure was grouped as none, low (referent), intermediate, or high. We examined pregnancy duration (gestational age at birth, preterm/postterm birth), fetal growth (birth weight ratio, small/large size for gestational age), and birth weight variables (birth weight, low/high birth weight) and meta-analyzed cohort-specific estimates. The intermediate exposure group had a higher risk of giving birth at a lower gestational age (hazard ratio = 1.04, 95% confidence interval: 1.01, 1.07), and exposure-response relationships were found for shorter pregnancy duration (P < 0.001) and preterm birth (P = 0.003). We observed no association with fetal growth or birth weight. Maternal cell-phone use during pregnancy may be associated with shorter pregnancy duration and increased risk of preterm birth, but these results should be interpreted with caution, since they may reflect stress during pregnancy or other residual confounding rather than a direct effect of cell-phone exposure.The Generalized EMF Research Using Novel Methods (GERoNiMO) Project was supported by the European Union (grant 603794). The Amsterdam Born Children and Their Development Study (ABCD) was supported by the Netherlands Organization for Health Research and Development (grant 2100.0076) and the Electromagnetic Fields and Health Research program (grants 85600004 and 85800001). The Danish National Birth Cohort Study (DNBC) was supported by the Danish Epidemiology Science Centre, the Lundbeck Foundation (grant 195/04), the Egmont Foundation, the March of Dimes Birth Defect Foundation, the Augustinus Foundation, and the Medical Research Council (grant SSVF 0646). The Spanish Environment and Childhood Project (INMA) was supported by the European Union (grants FP7-ENV-2011, 282957, and HEALTH.2010.2.4.5-1); Instituto de Salud Carlos III (grants G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, 11/01007, 11/02591, CP11/00178, FIS-PI06/0867, FIS-PS09/00090, FIS-PI041436, FIS-PI081151, FIS-PI042018, FIS-PI09/02311, FISPI13/1944, FIS-PI13/2429, FIS-PI14/0981, FIS-PI13/141687, CP13/00054 (including FEDER funds), and MS13/00054); the Conselleria de Sanitat Generalitat Valenciana; the Generalitat de Catalunya (grants CIRIT1999SGR and 00241); Obra Social Cajastur; the Universidad de Oviedo; the Department of Health of the Basque Government (grants 2005111093 and 2009111069); and the Provincial Government of Gipuzkoa (grants DFG06/004 and DFG08/001). The Korean Mothers and Children’s Environment Health Study (MOCEH) was supported by the National Institute of Environmental Research, the Ministry of the Environment, and the Information and Communication Technology (ICT) research and development program of the Ministry of Science and ICT (grants 2017-0-00961 and 2019-0-00102), South Korea