278 research outputs found
A Microscopic Energy- and Density-Dependent Effective Interaction and its Test by Nucleus-Nucleus Scattering
An effective nucleon-nucleon interaction calculated in nuclear matter from
the Bonn potential has been parametrized in terms of a local density- and
energy-dependent two-body interaction. This allows to calculate the real part
of the nucleus-nucleus scattering potential and to test this effective
interaction over a wide region of densities () produced
dynamically in scattering experiments. Comparing our calculations with
empirical potentials extracted from data on light and heavy ion scattering by
model-unrestricted analysis methods, we find quantitative agreement with the
exception of proton scattering. The failure in this case may be traced back to
the properties of the effective interaction at low densities, for which the
nuclear matter results are not reliable. The success of the interaction at high
overlap densities confirms the empirical evidence for a soft equation of state
for cold nuclear matter.Comment: 8 pages 3 Figures included, to appear in Phys. Lett.
A systematic review of the safety of lisdexamfetamine dimesylate
BACKGROUND: Here we review the safety and tolerability profile of lisdexamfetamine dimesylate (LDX), the first long-acting prodrug stimulant for the treatment of attention-deficit/hyperactivity disorder (ADHD). METHODS: A PubMed search was conducted for English-language articles published up to 16 September 2013 using the following search terms: (lisdexamfetamine OR lisdexamphetamine OR SPD489 OR Vyvanse OR Venvanse OR NRP104 NOT review [publication type]). RESULTS: In short-term, parallel-group, placebo-controlled, phase III trials, treatment-emergent adverse events (TEAEs) in children, adolescents, and adults receiving LDX were typical for those reported for stimulants in general. Decreased appetite was reported by 25-39 % of patients and insomnia by 11-19 %. The most frequently reported TEAEs in long-term studies were similar to those reported in the short-term trials. Most TEAEs were mild or moderate in severity. Literature relating to four specific safety concerns associated with stimulant medications was evaluated in detail in patients receiving LDX. Gains in weight, height, and body mass index were smaller in children and adolescents receiving LDX than in placebo controls or untreated norms. Insomnia was a frequently reported TEAE in patients with ADHD of all ages receiving LDX, although the available data indicated no overall worsening of sleep quality in adults. Post-marketing survey data suggest that the rate of non-medical use of LDX was lower than that for short-acting stimulants and lower than or equivalent to long-acting stimulant formulations. Small mean increases were seen in blood pressure and pulse rate in patients receiving LDX. CONCLUSIONS: The safety and tolerability profile of LDX in individuals with ADHD is similar to that of other stimulants
Određivanje donepezil hidroklorida u humanoj plazmi i ljekovitim oblicima pomoću HPLC s detekcijom fluorescencije
A sensitive, isocratic reversed-phase high performance liquid chromatographic method involving fluorescence detection was developed for the determination of donepezil hydrochloride in tablets and in human plasma. Pindolol was successfully used as an internal standard. Good chromatographic separation was achieved by using analytical column C18. The system operated at room temperature using a mobile phase consisting of methanol, phosphate buffer (0.02 mol L1) and triethyl amine (pH 3.5) (55: 45: 0.5 V/V/V) at a flow rate 0.9 mL min1. The analyte and internal standard were extracted from human plasma via liquid-liquid extraction. The proposed method was validated for selectivity, linearity, accuracy and precision. The calibration curve was linear over the range of 5-2000 ng mL1 of donepezil with detection limit of 1.5 ng mL1. Intra- and inter-day relative standard deviations were less than 2.5 %. The method was found to be suitable for the quality control of donepezil hydrochloride in bulk drug as well as in human plasma.Ovaj rad opisuje HPLC metodu određivanja donepezil hidroklorida (DP) u tabletama i u ljudskoj plazmi u nano području. Postavljena je osjetljiva metoda izokratične HPLC s fluorescencijskom detekcijom. Kao unutarnji standard upotrebljen je pindolol. Dobro kromatografsko odjeljivanje postignuto je primjenom analitičke kolone C18. Radna temperatura bila je sobna, a kao mobilna faza upotrebljena je smjesa metanola, fosfatnog pufera (0,02 mol L1) i trietilamina (pH 3,5) (55:45:0.5 V/V/V). Analit i unutarnji standard su ekstrahirani iz ljudske plazme ekstrakcijom tekuće-tekuće. Predložena metoda je validirana s obzirom na selektivnost, područje linearnosti, ispravnost i preciznost. Kalibracijska funkcija bila je linearna u području od 5-2000 ng mL1 donepezila, a granica detekcije iznosila je 2 ng mL1. Relativna standardna devijacija za repetabilnost i intermedijarnu preciznost bila je manja od 2,5 %. Metoda je primjenljliva u kontroli kvalitete ljekovitih formulacija s DP-om i u praćenju DP-a u ljudskoj plazmi
Continuous symmetry of C60 fullerene and its derivatives
Conventionally, the Ih symmetry of fullerene C60 is accepted which is
supported by numerous calculations. However, this conclusion results from the
consideration of the molecule electron system, of its odd electrons in
particular, in a close-shell approximation without taking the electron spin
into account. Passing to the open-shell approximation has lead to both the
energy and the symmetry lowering up to Ci. Seemingly contradicting to a
high-symmetry pattern of experimental recording, particularly concerning the
molecule electronic spectra, the finding is considered in the current paper
from the continuous symmetry viewpoint. Exploiting both continuous symmetry
measure and continuous symmetry content, was shown that formal Ci symmetry of
the molecule is by 99.99% Ih. A similar continuous symmetry analysis of the
fullerene monoderivatives gives a reasonable explanation of a large variety of
their optical spectra patterns within the framework of the same C1 formal
symmetry exhibiting a strong stability of the C60 skeleton.Comment: 11 pages. 5 figures. 6 table
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Highly Efficient 32.3% Monolithic GaInP/GaAs/Ge Triple Junction Concentrator Solar Cells
Based on recent cell improvements for space applications, multijunction cells apear to be ideal candidates for high efficiency, cost effective, PV concentrator systems
Toward a global description of the nucleus-nucleus interaction
Extensive systematization of theoretical and experimental nuclear densities
and of optical potential strengths exctracted from heavy-ion elastic scattering
data analyses at low and intermediate energies are presented.The
energy-dependence of the nuclear potential is accounted for within a model
based on the nonlocal nature of the interaction.The systematics indicate that
the heavy-ion nuclear potential can be described in a simple global way through
a double-folding shape,which basically depends only on the density of nucleons
of the partners in the collision.The poissibility of extracting information
about the nucleon-nucleon interaction from the heavy-ion potential is
investigated.Comment: 12 pages,12 figure
Improved +He potentials by inversion, the tensor force and validity of the double folding model
Improved potential solutions are presented for the inverse scattering problem
for +He data. The input for the inversions includes both the data of
recent phase shift analyses and phase shifts from RGM coupled-channel
calculations based on the NN Minnesota force. The combined calculations provide
a more reliable estimate of the odd-even splitting of the potentials than
previously found, suggesting a rather moderate role for this splitting in
deuteron-nucleus scattering generally. The approximate parity-independence of
the deuteron optical potentials is shown to arise from the nontrivial
interference between antisymmetrization and channel coupling to the deuteron
breakup channels. A further comparison of the empirical potentials established
here and the double folding potential derived from the M3Y effective NN force
(with the appropriate normalisation factor) reveals strong similarities. This
result supports the application of the double folding model, combined with a
small Majorana component, to the description even of such a loosely bound
projectile as the deuteron. In turn, support is given for the application of
iterative-perturbative inversion in combination with the double folding model
to study fine details of the nucleus-nucleus potential. A -He tensor
potential is also derived to reproduce correctly the negative Li quadrupole
moment and the D-state asymptotic constant.Comment: 22 pages, 12 figures, in Revte
Open Database of Epileptic EEG with MRI and Postoperational Assessment of Foci—a Real World Verification for the EEG Inverse Solutions
This paper introduces a freely accessible database http://eeg.pl/epi, containing 23 datasets from patients diagnosed with and operated on for drug-resistant epilepsy. This was collected as part of the clinical routine at the Warsaw Memorial Child Hospital. Each record contains (1) pre-surgical electroencephalography (EEG) recording (10–20 system) with inter-ictal discharges marked separately by an expert, (2) a full set of magnetic resonance imaging (MRI) scans for calculations of the realistic forward models, (3) structural placement of the epileptogenic zone, recognized by electrocorticography (ECoG) and post-surgical results, plotted on pre-surgical MRI scans in transverse, sagittal and coronal projections, (4) brief clinical description of each case. The main goal of this project is evaluation of possible improvements of localization of epileptic foci from the surface EEG recordings. These datasets offer a unique possibility for evaluating different EEG inverse solutions. We present preliminary results from a subset of these cases, including comparison of different schemes for the EEG inverse solution and preprocessing. We report also a finding which relates to the selective parametrization of single waveforms by multivariate matching pursuit, which is used in the preprocessing for the inverse solutions. It seems to offer a possibility of tracing the spatial evolution of seizures in time
The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain–behavior relationships after stroke
The goal of the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well‐powered meta‐ and mega‐analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data. Specifically, the processes for scalable data intake and preprocessing, multisite data harmonization, and large‐scale stroke lesion analysis are described, and challenges unique to this type of big data collaboration in stroke research are discussed. Finally, future directions and limitations, as well as recommendations for improved data harmonization through prospective data collection and data management, are provided
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