PENYELESAIAN SENGKETA PERTANAHAN ANTAR MASYARAKAT DESA OLEH KEPALA DESA DITINJAU DARI TEORI KEADILAN (Studi di Desa Donowarih dan Desa Landungsari)

The object of this research is the role of village heads in resolving land disputes between village communities in terms of the theory of justice. The purpose of this study is to know the implementation of the village head's obligations in resolving disputes between village communities, especially in the land sector and to analyze the types of land disputes in the village that can be resolved by the village head. The method used in this legal research is the sociological juridical method, by taking the research location in Malang Regency which is precisely in Donowarih Village, Karangploso District and in Landungsari Village, Dau District. The data in this study were obtained from the results of interviews and literature studies as material for analysis. The data analysis technique used is descriptive qualitative. The results of this study indicate: First: Land disputes that can be resolved by the head is based on the Decree of the Head of the National Land Agency of the Republic of Indonesia Number 34 of 2007 about the Technical Guidelines for Handling and Resolving the Problems of Typology Land that have occurred in Landungsari and Donowarih Villages namely Land mastery and land Ownership, Limits or Land Plots. Second: The obligation of the village head to resolve disputes between village communities, especially in the land sector, is carried out through alternative mediation dispute resolution, through several stages of deliberation, then if the parties are dissatisfied with the meditation result then they can submit other legal efforts through litigation channels, and in practice the settlement of disputes between villagers by the village head, especially in the land sector, has not fully brought justice to the community. Third: There are several problems in the implementation of land dispute resolution between village communities by the village head due to the lack of professionalism of the village head as a mediato

Characterization of DAG binding to TRPC channels by target-dependent cis–trans isomerization of OptoDArG

Azobenzene-based photochromic lipids are valuable probes for the analysis of ion channel–lipid interactions. Rapid photoisomerization of these molecules enables the analysis of lipid gating kinetics and provides information on lipid sensing. Thermal relaxation of the metastable cis conformation to the trans conformation of azobenzene photolipids is rather slow in the dark and may be modified by ligand–protein interactions. Cis photolipid-induced changes in pure lipid membranes as visualized from the morphological response of giant unilamellar vesicles indicated that thermal cis–trans isomerization of both PhoDAG-1 and OptoDArG is essentially slow in the lipid bilayer environment. While the currents activated by cis PhoDAG remained stable upon termination of UV light exposure (dark, UV-OFF), cis OptoDArG-induced TRPC3/6/7 activity displayed a striking isoform-dependent exponential decay. The deactivation kinetics of cis OptoDArG-induced currents in the dark was sensitive to mutations in the L2 lipid coordination site of TRPC channels. We conclude that the binding of cis OptoDArG to TRPC channels promotes transition of cis OptoDArG to the trans conformation. This process is suggested to provide valuable information on DAG–ion channel interactions and may enable highly selective photopharmacological interventions

Close Binary System GO Cyg

In this study, we present long term photometric variations of the close binary system \astrobj{GO Cyg}. Modelling of the system shows that the primary is filling Roche lobe and the secondary of the system is almost filling its Roche lobe. The physical parameters of the system are $M_1 = 3.0\pm0.2 M_{\odot}$, $M_2 = 1.3 \pm 0.1 M_{\odot}$, $R_1 = 2.50\pm 0.12 R_{\odot}$, $R_2 = 1.75 \pm 0.09 R_{\odot}$, $L_1 = 64\pm 9 L_{\odot}$, $L_2 = 4.9 \pm 0.7 L_{\odot}$, and $a = 5.5 \pm 0.3 R_{\odot}$. Our results show that \astrobj{GO Cyg} is the most massive system near contact binary (NCB). Analysis of times of the minima shows a sinusoidal variation with a period of $92.3\pm0.5$ years due to a third body whose mass is less than 2.3$M_{\odot}$. Finally a period variation rate of $-1.4\times10^{-9}$ d/yr has been determined using all available light curves.Comment: Accepted for publication in New Astronomy, 18 pages, 4 figures, 7 table

Investment efficiency of floating platforms desalination technology in Egypt

Over 2,000 km of sea coasts with different environmental conditions may provide Egypt with alternative energy solution that may be used for electricity production and water desalination, required for the vast urban expansion, mainly along the coastal areas to relieve population pressure from the old valley and delta, and to create new community opportunities in new regions. The proposed platform discussed in this paper is a mobile platform in order to supply any costal city with fresh water to prevent any water crisis. The aim of this research paper is to make an economic comparison between floating stations and fixed stations on the ground and to determine the extent of the preference of one over the other to take the appropriate investment decision that can benefit the vast Egyptian coasts. The result of the study showed the possibility of recovering the invested capital during a period of 5 years and 5 months for the floating platform and 5 years and 8 months for the fixed ground station. Economic indicators have also been used to conduct comparison such as net present value of cash flows, cost-to-cost standard, internal rate of return, sensitivity analysis ([10% cost increase] [10% decrease in revenue] [both together]). All results were positive in favour of the floating platform of the desalination plant

βIII-tubulin: a novel mediator of chemoresistance and metastases in pancreatic cancer

Pancreatic cancer is a leading cause of cancer-related deaths in Western societies. This poor prognosis is due to chemotherapeutic drug resistance and metastatic spread. Evidence suggests that microtubule proteins namely, β-tubulins are dysregulated in tumor cells and are involved in regulating chemosensitivity. However, the role of β-tubulins in pancreatic cancer are unknown. We measured the expression of different β-tubulin isotypes in pancreatic adenocarcinoma tissue and pancreatic cancer cells. Next, we used RNAi to silence βIII-tubulin expression in pancreatic cancer cells, and measured cell growth in the absence and presence of chemotherapeutic drugs. Finally, we assessed the role of βIII-tubulin in regulating tumor growth and metastases using an orthotopic pancreatic cancer mouse model. We found that βIII-tubulin is highly expressed in pancreatic adenocarcinoma tissue and pancreatic cancer cells. Further, we demonstrated that silencing βIII-tubulin expression reduced pancreatic cancer cell growth and tumorigenic potential in the absence and presence of chemotherapeutic drugs. Finally, we demonstrated that suppression of βIII-tubulin reduced tumor growth and metastases in vivo. Our novel data demonstrate that βIII-tubulin is a key player in promoting pancreatic cancer growth and survival, and silencing its expression may be a potential therapeutic strategy to increase the long-term survival of pancreatic cancer patients