Nutrient - Organic Matter Dynamics in Stormwater Ponds: Implications for Stormwater Management and the Role of Ponds as Sources of Coastal Water Quality Impairment

2012 S.C. Water Resources Conference - Exploring Opportunities for Collaborative Water Research, Policy and Managemen

Concerns with AED conversion: comparison of patient and physician perspectives.

When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clinician's perspective of patient concerns. Findings of a literature review of articles that report patient-expressed concerns regarding their epilepsy and treatment were also reviewed. Results showed that the specialist panel appropriately identified patient-reported concerns of driving ability, medication cost, seizure control, and medication side effects. Additionally, patient-reported concerns of independence, employment issues, social stigma, medication dependence, and undesirable cognitive effects are important to address when considering and initiating AED conversion

Kadison-Kastler stable factors

A conjecture of Kadison and Kastler from 1972 asks whether sufficiently close operator algebras in a natural uniform sense must be small unitary perturbations of one another. For n≥3 and a free, ergodic, probability measure-preserving action of SL<sub>n</sub>(Z) on a standard nonatomic probability space (X,μ), write M=(L<sup>∞</sup>(X,μ)⋊SL<sub>n</sub>(Z))⊗¯¯¯R, where R is the hyperfinite II1-factor. We show that whenever M is represented as a von Neumann algebra on some Hilbert space H and N⊆B(H) is sufficiently close to M, then there is a unitary u on H close to the identity operator with uMu∗=N. This provides the first nonamenable class of von Neumann algebras satisfying Kadison and Kastler’s conjecture. We also obtain stability results for crossed products L<sup>∞</sup>(X,μ)⋊Γ whenever the comparison map from the bounded to usual group cohomology vanishes in degree 2 for the module L<sup>2</sup>(X,μ). In this case, any von Neumann algebra sufficiently close to such a crossed product is necessarily isomorphic to it. In particular, this result applies when Γ is a free group

A remark on the similarity and perturbation problems

In this note we show that Kadison's similarity problem for C*-algebras is equivalent to a problem in perturbation theory: must close C*-algebras have close commutants?Comment: 6 Pages, minor typos fixed. C. R. Acad. Sci. Canada, to appea

Long-Distance Dispersal Potential for Onion Thrips (Thysanoptera: Thripidae) and Iris yellow spot virus (Bunyaviridae: Tospovirus) in an Onion Ecosystem

Onion thrips, Thrips tabaci Lindeman, is a worldwide pest of onion whose feeding damage and transmission of Iris yellow spot virus (IYSV) may reduce onion yields. Little is known about the seasonal dynamics of T. tabaci dispersal, the distance of dispersal, or the movement of thrips infected with IYSV during the onion-growing season. To address these questions, T. tabaci adults were collected using transparent sticky card traps in commercial onion fields three times during the onion-growing season (June, July, and late August) at varying heights above the canopy (0.5-6 m above soil surface) and with trap-equipped unmanned aircraft (UAVs) flying 50-60 m above onion fields during August sampling periods in 2012 and 2013. Randomly selected subsamples of captured T. tabaci were tested for IYSV using RT-PCR. Most T. tabaci adults were captured in late August and near the onion canopy (<2 m) throughout the season. However, 4% of T. tabaci adults captured on sticky cards were at altitudes ≥2 m, and T. tabaci were also captured on UAV-mounted traps. These data strongly suggest that long-distance dispersal occurs. More T. tabaci captured on sticky cards tested positive for IYSV in August (53.6%) than earlier in the season (2.3 to 21.5% in June and July, respectively), and 20 and 15% of T. tabaci captured on UAV-mounted traps tested positive for IYSV in 2012 and 2013, respectively. Our results indicate that T. tabaci adults, including viruliferous individuals, engage in long-distance dispersal late in the season and likely contribute to the spread of IYS

Weed Hosts for Onion Thrips (Thysanoptera: Thripidae) and Their Potential Role in the Epidemiology of Iris Yellow Spot Virus in an Onion Ecosystem

Onion thrips, Thrips tabaci Lindeman, is a key foliage-feeding pest of onion worldwide and the principal vector of a serious onion pathogen, Iris yellow spot virus (IYSV). Long-term management of T. tabaci and IYSV will require an understanding of T. tabaci ecology and IYSV epidemiology in onion ecosystems. This study focused on identifying winter-annual, biennial and perennial weed species that host both T. tabaci and IYSV. Unlike summer-annual weeds, weeds with these habits survive overwinter and could serve as a green bridge for IYSV to survive between onion-growing seasons. T. tabaci larvae and adults were sampled every two weeks from 69 weed species in five areas located adjacent to onion fields in western New York in 2008 and 2009. Twenty-five of the 69 weed species were identified as hosts for T. tabaci larvae and populations were highest on the Brassicaceous weeds, Barbarea vulgaris Ait. f., Sinapis arvensis L., and Thalspi arvense L. None of these species are hosts for IYSV. Four of the 25 weed species were hosts for both T. tabaci larval populations and IYSV: common burdock, Arctium minus Bernh., dandelion, Taraxacum officinale G.H. Weber ex Wiggers, curly dock, Rumex crispus L., and chicory, Cichorium intybus L. Of these four weed species, T. officinale and A. minus may play an important role in the epidemiology of IYSV in New York onion fields because they may survive between onion-growing seasons, they are relatively abundant in the landscape, and they support relatively high densities of T. tabac

A two-parameter random walk with approximate exponential probability distribution

We study a non-Markovian random walk in dimension 1. It depends on two parameters eps_r and eps_l, the probabilities to go straight on when walking to the right, respectively to the left. The position x of the walk after n steps and the number of reversals of direction k are used to estimate eps_r and eps_l. We calculate the joint probability distribution p_n(x,k) in closed form and show that, approximately, it belongs to the exponential family.Comment: 12 pages, updated reference to companion paper cond-mat/060126

Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcoma.

BackgroundIncreasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, such as tyrosine kinase inhibitors (TKIs). We hypothesized that TKIs would have differential effects on CSC populations depending on their mechanism of action (anti-proliferative vs. anti-angiogenic).MethodsWe exposed human sarcoma cell lines to sorafenib, regorafenib, and pazopanib and assessed cell viability and expression of CSC markers (ALDH, CD24, CD44, and CD133). We evaluated survival and CSC phenotype in mice harboring sarcoma metastases after TKI therapy. We exposed dissociated primary sarcoma tumors to sorafenib, regorafenib, and pazopanib, and we used tissue microarray (TMA) and primary sarcoma samples to evaluate the frequency and intensity of CSC markers after neoadjuvant therapy with sorafenib and pazopanib. Parametric and non-parametric statistical analyses were performed as appropriate.ResultsAfter functionally validating the CSC phenotype of ALDHbright sarcoma cells, we observed that sorafenib and regorafenib were cytotoxic to sarcoma cell lines (P &lt; 0.05), with a corresponding 1.4 - 2.8 fold increase in ALDHbright cells from baseline (P &lt; 0.05). In contrast, we observed negligible effects on viability and CSC sub-populations with pazopanib. At low doses, there was progressive CSC enrichment in vitro after longer term exposure to sorafenib although the anti-proliferative effects were attenuated. In vivo, sorafenib improved median survival by 11 days (P &lt; 0.05), but enriched ALDHbright cells 2.5 - 2.8 fold (P &lt; 0.05). Analysis of primary human sarcoma samples revealed direct cytotoxicity following exposure to sorafenib and regorafenib with a corresponding increase in ALDHbright cells (P &lt; 0.05). Again, negligible effects from pazopanib were observed. TMA analysis of archived specimens from sarcoma patients treated with sorafenib demonstrated significant enrichment for ALDHbright cells in the post-treatment resection specimen (P &lt; 0.05), whereas clinical specimens obtained longitudinally from a patient treated with pazopanib showed no enrichment for ALDHbright cells (P &gt; 0.05).ConclusionsAnti-proliferative TKIs appear to enrich for sarcoma CSCs while anti-angiogenic TKIs do not. The rational selection of targeted therapies for sarcoma patients may benefit from an awareness of the differential impact of TKIs on CSC populations

Foam/aerogel composite materials for thermal and acoustic insulation and cryogen storage

The invention involves composite materials containing a polymer foam and an aerogel. The composite materials have improved thermal insulation ability, good acoustic insulation, and excellent physical mechanical properties. The composite materials can be used, for instance, for heat and acoustic insulation on aircraft, spacecraft, and maritime ships in place of currently used foam panels and other foam products. The materials of the invention can also be used in building construction with their combination of light weight, strength, elasticity, ability to be formed into desired shapes, and superior thermal and acoustic insulation power. The materials have also been found to have utility for storage of cryogens. A cryogenic liquid or gas, such as N.sub.2 or H.sub.2, adsorbs to the surfaces in aerogel particles. Thus, another embodiment of the invention provides a storage vessel for a cryogen