Morphological Assessment of Basic Multicellular Unit Resorption Parameters in Dogs Shows Additional Mechanisms of Bisphosphonate Effects on Bone

Bisphosphonates (BPs) slow bone loss by reducing initiation of new basic multicellular units (BMUs). Whether or not BPs simply prevent osteoclasts from initiating new BMUs that resorb bone or also reduce the amount of bone they resorb at the BMU level is not clear. The goal of this study was to determine the effects of BPs on three morphological parameters of individual BMUs, resorption depth (Rs.De), area (Rs.Ar), and width (Rs.Wi). After 1 year of treatment with vehicle (VEH), alendronate (ALN; 0.10, 0.20, or 1.00 mg/kg/day), or risedronate (RIS; 0.05, 0.10, or 0.50 mg/kg/day), resorption cavity morphology was assessed in vertebral trabecular bone of beagle dogs by histology. Animals treated with ALN or RIS at the doses representing those used to treat postmenopausal osteoporosis (0.20 and 0.10 mg/kg/day, respectively) had significantly lower Rs.Ar (−27%) and Rs.Wi (−17%), with no difference in Rs.De, compared to VEH-treated controls. Low doses of ALN and RIS did not affect any parameters, whereas higher doses resulted in similar changes to those of the clinical dose. There were no significant differences in the resorption cavity measures between RIS and ALN at any of the dose equivalents. These results highlight the importance of examining parameters beyond erosion depth for assessment of resorption parameters. Furthermore, these results suggest that in addition to the well-known effects of BPs on reducing the number of active BMUs, these drugs also reduce the activity of osteoclasts at the individual BMU level at doses at and above those used clinically for the treatment of postmenopausal osteoporosis

Effects of Corn Bran and Degradable Protein Source on Microbial Protein Estimated From Spot Urine Samples in Heifers

A metabolism trial was conducted in finishing heifers to determine if allantoin in spot urine samples could be a predictor of microbial CP (MCP) supply. When corn bran replaced high moisture corn, ruminal pH was higher and microbial efficiency and flow were greater. Estimated microbial efficiency and flow were not different for SBM compared to urea as a source of degradable protein. Daily variation in intake was reflected in MCP estimates. Within day variation for MCP estimates was consistent and small. Estimates of MCP from allantoin in spot urine samples followed NRC estimates. Results demonstrate that allantoin is an effective predictor of MCP flow

Effects of Corn Bran and Degradable Protein Source on Microbial Protein Estimated From Spot Urine Samples in Heifers

A metabolism trial was conducted in finishing heifers to determine if allantoin in spot urine samples could be a predictor of microbial CP (MCP) supply. When corn bran replaced high moisture corn, ruminal pH was higher and microbial efficiency and flow were greater. Estimated microbial efficiency and flow were not different for SBM compared to urea as a source of degradable protein. Daily variation in intake was reflected in MCP estimates. Within day variation for MCP estimates was consistent and small. Estimates of MCP from allantoin in spot urine samples followed NRC estimates. Results demonstrate that allantoin is an effective predictor of MCP flow

Space VLBI at Low Frequencies

At sufficiently low frequencies, no ground-based radio array will be able to produce high resolution images while looking through the ionosphere. A space-based array will be needed to explore the objects and processes which dominate the sky at the lowest radio frequencies. An imaging radio interferometer based on a large number of small, inexpensive satellites would be able to track solar radio bursts associated with coronal mass ejections out to the distance of Earth, determine the frequency and duration of early epochs of nonthermal activity in galaxies, and provide unique information about the interstellar medium. This would be a "space-space" VLBI mission, as only baselines between satellites would be used. Angular resolution would be limited only by interstellar and interplanetary scattering.Comment: To appear in "Astrophysical Phenomena Revealed by Space VLBI", ed. H. Hirabayashi, P. Edwards, and D. Murphy (ISAS, Japan

Opportunistic or event-driven maintenance at the Stanford Linear Accelerator Center

The Stanford Linear Accelerator Center (SLAC) uses a maintenance management philosophy that is best described as opportunistic or event-driven. Opportunistic maintenance can be defined as a systematic method of collecting, investigating, pre-planning, and publishing a set of proposed maintenance tasks and acting on them when there is an unscheduled failure or repair ``opportunity``. Opportunistic maintenance can be thought of as a modification of the run-to-fail maintenance management philosophy. This maintenance plan was adopted and developed to improve the overall availability of SLAC`s linear accelerator, beam delivery systems, and associated controls, power systems, and utilities. In the late 1980`s, as the technical complexity of the accelerator facility increased, variations on a conventional maintenance plan were used with mixed results. These variations typically included some type of regular periodic interruption to operations. The periodic shutdowns and unscheduled failures were additive and resulted in unsatisfactory availability. Maintenance issues are evaluated in a daily meeting that includes the accelerator managers, maintenance supervisors and managers, safety office personnel, program managers, and accelerator operators. Lists of pending maintenance tasks are made available to the general SLAC population by a World Wide Web site on a local internet. A conventional information system which pre-dates the WWW site is still being used to provide paper copies to groups that are not yet integrated into the WWW system. The local internet provides real time maintenance information, allowing people throughout the facility to track progress on tasks with essentially real-time status updates. With the introduction of opportunistic maintenance, the accelerator`s availability has been measurably better. This paper will discuss processes, rolls and responsibilities of key maintenance groups, and management tools developed to support opportunistic maintenance

Gradual diffusion and punctuated phase space density enhancements of highly relativistic electrons: Van Allen Probes observations

Abstract The dual-spacecraft Van Allen Probes mission has provided a new window into mega electron volt (MeV) particle dynamics in the Earth\u27s radiation belts. Observations (up to E ~10 MeV) show clearly the behavior of the outer electron radiation belt at different timescales: months-long periods of gradual inward radial diffusive transport and weak loss being punctuated by dramatic flux changes driven by strong solar wind transient events. We present analysis of multi-MeV electron flux and phase space density (PSD) changes during March 2013 in the context of the first year of Van Allen Probes operation. This March period demonstrates the classic signatures both of inward radial diffusive energization and abrupt localized acceleration deep within the outer Van Allen zone (L ~4.0 ± 0.5). This reveals graphically that both competing mechanisms of multi-MeV electron energization are at play in the radiation belts, often acting almost concurrently or at least in rapid succession. Key Points Clear observations to higher energy than ever before Precise detection of where and how acceleration takes place Provides new eyes on megaelectron Volt

The Initial Mass Function and Disk Frequency of the Rho Ophiuchi Cloud: An Extinction-Limited Sample

We have completed an optical spectroscopic survey of an unbiased, extinction-limited sample of candidate young stars covering 1.3 square degrees of the Rho Ophiuchi star forming region. While infrared, X-ray, and optical surveys of the cloud have identified many young stellar objects (YSOs), these surveys are biased towards particular stages of stellar evolution and are not optimal for studies of the disk frequency and initial mass function.We have obtained over 300 optical spectra to help identify 135 association members based on the presence of H-alpha in emission, lithium absorption, X-ray emission, a mid-infrared excess, a common proper motion, reflection nebulosity, and/or extinction considerations. Spectral types along with R and I band photometry were used to derive effective temperatures and bolometric luminosities for association members to compare with theoretical tracks and isochrones for pre-main-sequence stars. An average age of 3.1 Myr is derived for this population which is intermediate between that of objects embedded in the cloud core of Rho Ophiuchi and low mass stars in the Upper Scorpius subgroup. Consistent with this age we find a circumstellar disk frequency of 27% plus or minus 5%. We also constructed an initial mass function for an extinction-limited sample of 123 YSOs (A_v less than or equal to 8 mag), which is consistent with the field star initial mass function for YSOs with masses > 0.2 M_sun. There may be a deficit of brown dwarfs but this result relies on completeness corrections and requires confirmation.Comment: 46 pages, 7 figures, 4 table

Summing Up All Genus Free Energy of ABJM Matrix Model

The localization technique allows us to compute the free energy of the U(N)_k x U(N)_{-k} Chern-Simons-matter theory dual to type IIA strings on AdS_4 x CP^3 from weak to strong 't Hooft coupling \lambda = N / k at finite N, as demonstrated by Drukker, Marino, and Putrov. In this note we study further the free energy at large 't Hooft coupling with the aim of testing AdS/CFT at the quantum gravity level and, in particular, sum up all the 1/N corrections, apart from the worldsheet instanton contributions. The all genus partition function takes a remarkably simple form -- the Airy function, Ai (k^{4/3} \lambda_r), with the renormalized 't Hooft coupling \lambda_r.Comment: 18 pages, no figures, v2: typos corrected and references adde

Determination of Matter Surface Distribution of Neutron-rich Nuclei

We demonstrate that the matter density distribution in the surface region is determined well by the use of the relatively low-intensity beams that become available at the upcoming radioactive beam facilities. Following the method used in the analyses of electron scattering, we examine how well the density distribution is determined in a model-independent way by generating pseudo data and by carefully applying statistical and systematic error analyses. We also study how the determination becomes deteriorated in the central region of the density, as the quality of data decreases. Determination of the density distributions of neutron-rich nuclei is performed by fixing parameters in the basis functions to the neighboring stable nuclei. The procedure allows that the knowledge of the density distributions of stable nuclei assists to strengthen the determination of their unstable isotopes.Comment: 41 pages, latex, 27 figure