Enfermedad granulomatosa eosinofílica con poliangeítis: presentación de caso y revisión de la literatura

La enfermedad granulomatosa eosinofílica con poliangeítis es una vasculitis necrotizante sistémica que afecta a vasos de pequeño y mediano calibre. Es una enfermedad rara con una incidencia y prevalencia de 0,5-6 y 7-14 casos por millón de habitantes por año, respectivamente. La etiología continúa sin conocerse; se han involucrado factores genéticos y ambientales y hay una relación con anticuerpos ANCA y anti-MPO. La enfermedad evoluciona en tres fases sucesivas: el primer estadio se caracteriza por pródromos, con manifestaciones alérgicas como rinitis, asma, pólipos nasales, entre otras; un segundo estadio donde aparece hipereosinofilia sanguínea e infiltrados tisulares de eosinófilos; y el tercer estadio donde se presenta vasculitis sistémica que afecta principalmente piel, sistema nervioso periférico y riñones. El diagnóstico se realiza sobre la base clínica, hallazgos de laboratorio (eosinofilia y otros), anticuerpos e histopatología; el pronóstico es bueno, pero hay alta morbilidad, el riesgo de recidivas es del 35%. El tratamiento debe ser individualizado y se realiza con corticoides y ciclofosfamida. Se presenta el caso de paciente masculino de 56 años de edad, con antecedentes de rinitis alérgica y alergia a betalactámicos, que acude a consulta por fiebre prolongada. Se le realizan exámenes de rutina y se aprecia hipereosinofilia, posterior a su ingreso presenta neuropatía periférica en miembros superiores e inferiores; se le efectúa estudios de extensión, encontrándose ANCA positivos y una biopsia de médula ósea mostrando predominio de gránulos eosinófilos; fue tratado con corticoides orales y pregabalina con mejoría evidente, a los nueve meses de seguimiento se encuentra en remisión, siendo valorado mensualmente

Mapping the intellectual structure of the International Journal of Computers Communications & Control: A content analysis from 2015 to 2019

International Journal of Computers Communications & Control (IJCCC) is an open access peer-reviewed journal publishing original research papers and it is considered by professionals, academics and researches as one of the main sources of knowledge in the integrated solutions in computer-based control and communications, computational intelligence methods and soft computing, and ad-vanced decision support systems fields. With this in mind, this research conducts a bibliometric performance and intellectual structure analysis of the IJCCC from 2015 to 2019. It provides a framework to support computer, communication and control researchers and professionals in the development and direction of future researches identifying core, transversal, emerging and declining themes. For this purpose, the IJCCC’s intellectual structure and thematic networks are analyzed according to the data retrieved from Web of Science Core Collection, putting the focus on the main research themes and its performance. Finally, this analysis has been developed using SciMAT, an open source (GPLv3) bibliometric software tool developed to perform a science mapping analysis under a longitudinal framework

Desarrollo de la planta de Agave tequilana mediante la tecnica de fertigacion en tamaulipas : Development of the Agave tequilana plant with fertigation in tamaulipas

Con el objetivo de estudiar las características agronómicas y la acumulación de nutrimentos en la materia seca (MS) durante un ciclo completo de la planta de agave, en un experimento establecido en el sur de Tamaulipas se plantaron hijuelos de agave en tres condiciones de manejo del fertilizante: a) En temporal y sin fertilizante, Testigo Absoluto (TA); b) Fertigación, además de la precipitación, recibieron agua y nutrimentos (N, P, K, Ca, Mg, y micronutrimentos) mediante un sistema de riego por goteo; y c) Fertilización de base (FB)+Fertigación, adicional a lo recibido en el tratamiento anterior, se aplicó a las plantas de agave FB con N, P, K y micronutrimentos. Cada tratamiento se estudió por triplicado en un diseño de bloques al azar. Durante el estudio se realizaron ocho evaluaciones destructivas utilizando una planta por unidad experimental; septiembre del 2004, febrero del 2005, octubre del 2005, 2006, 2007, 2008, 2009 y 2010. Las plantas desarrolladas con Fertigación y FB+Fertigación, en promedio superaron en 17 y 76 % la altura y número de hojas registradas en la planta del TA, respectivamente. En relación con la biomasa, se estimó que estas mismas plantas produjeron 491.4 y 456.1 t ha-1 en la planta total, y 218.1 y 252.4 t ha-1 en la piña, respectivamente. En plantas del TA la biomasa total fue 97 t ha-1 y 46.5 t ha-1 en la piña. La concentración de azucares reductores (AR) en la piña no fue modificada por el manejo con fertilizante (P≥0.05), su concentración fluctuó entre 26.8 y 29.0 %. La concentración de nutrimentos en la MS, tampoco fue modificada con el fertilizante (P≥0.05); en la MS de plantas desarrolladas con Fertigación y Fertigación+FB se registró la mayor cantidad de nutrimentos, los valores medios, fueron 182.7 g de N, 60.1 g de P, 165.1 g de K, 816.4 g de Ca y 54.1 g de Mg, los cuales fueron superiores y significativamente diferentes (P≤0.05) a los registrados en la MS de la planta del TA. Independientemente del manejo de la fertilización, la cantidad de nutrimentos determinados en la MS presentó el siguiente orden Ca>K>N>Mg>P

30th Anniversary of Applied Intelligence: A combination of bibliometrics and thematic analysis using SciMAT

Applied Intelligence is one of the most important international scientific journals in the field of artificial intelligence. From 1991, Applied Intelligence has been oriented to support research advances in new and innovative intelligent systems, methodologies, and their applications in solving real-life complex problems. In this way, Applied Intelligence hosts more than 2,400 publications and achieves around 31,800 citations. Moreover, Applied Intelligence is recognized by the industrial, academic, and scientific communities as a source of the latest innovative and advanced solutions in intelligent manufacturing, privacy-preserving systems, risk analysis, knowledge-based management, modern techniques to improve healthcare systems, methods to assist government, and solving industrial problems that are too complex to be solved through conventional approaches. Bearing in mind that Applied Intelligence celebrates its 30th anniversary in 2021, it is appropriate to analyze its bibliometric performance, conceptual structure, and thematic evolution. To do that, this paper conducts a bibliometric performance and conceptual structure analysis of Applied Intelligence from 1991 to 2020 using SciMAT. Firstly, the performance of the journal is analyzed according to the data retrieved from Scopus, putting the focus on the productivity of the authors, citations, countries, organizations, funding agencies, and most relevant publications. Finally, the conceptual structure of the journal is analyzed with the bibliometric software tool SciMAT, identifying the main thematic areas that have been the object of research and their composition, relationship, and evolution during the period analyzed

Evaluation of the Impact of Genetically Modified Cotton After 20 Years of Cultivation in Mexico

For more than 20 years cotton has been the most widely sown genetically modified (GM) crop in Mexico. Its cultivation has fulfilled all requirements and has gone through the different regulatory stages. During the last 20 years, both research-institutions and biotech-companies have generated scientific and technical information regarding GM cotton cultivation in Mexico. In this work, we collected data in order to analyze the environmental and agronomic effects of the use of GM cotton in Mexico. In 1996, the introduction of Bt cotton made it possible to reactivate this crop, which in previous years was greatly reduced due to pest problems, production costs and environmental concerns. Bt cotton is a widely accepted tool for cotton producers and has proven to be efficient for the control of lepidopteran pests. The economic benefits of its use are variable, and depend on factors such as the international cotton-prices and other costs associated with its inputs. So far, the management strategies used to prevent development of insect resistance to GM cotton has been successful, and there are no reports of insect resistance development to Bt cotton in Mexico. In addition, no effects have been observed on non-target organisms. For herbicide tolerant cotton, the prevention of herbicide resistance has also been successful since unlike other countries, the onset of resistance weeds is still slow, apparently due to cultural practices and rotation of different herbicides. Environmental benefits have been achieved with a reduction in chemical insecticide applications and the subsequent decrease in primary pest populations, so that the inclusion of other technologies—e.g., use of non-Bt cotton- can be explored. Nevertheless, control measures need to be implemented during transport of the bolls and fiber to prevent dispersal of volunteer plants and subsequent gene flow to wild relatives distributed outside the GM cotton growing areas. It is still necessary to implement national research programs, so that biotechnology and plant breeding advances can be used in the development of cotton varieties adapted to the Mexican particular environmental conditions and to control insect pests of regional importance

Plant characterization of genetically modified maize hybrids MON-89Ø34-3 × MON-88Ø17-3, MON-89Ø34-3 × MON-ØØ6Ø3-6, and MON-ØØ6Ø3-6: alternatives for maize production in Mexico

Environmental risk assessment (ERA) of genetically modified (GM) crops is a process to evaluate whether the biotechnology trait(s) in a GM crop may result in increased pest potential or harm to the environment. In this analysis, two GM insect-resistant (IR) herbicide-tolerant maize hybrids (MON-89Ø34-3 9 MON-88Ø17-3 and MON-89Ø34-3 9 MON-ØØ6Ø3-6) and one herbicide-tolerant GM hybrid (MON-ØØ6Ø3-6) were compared with conventional maize hybrids of similar genetic backgrounds. Two sets of studies, Experimental Phase and Pilot Phase, were conducted across five ecological regions (ecoregions) in Mexico during 2009–2013, and data were subject to meta-analysis. Results from the Experimental Phase studies, which were used for ERA, indicated that the three GM hybrids were not different from conventional maize for early stand count, days-tosilking, days-to-anthesis, root lodging, stalk lodging, or final stand count. Statistically significant differences were observed for seedling vigor, ear height, plant height, grain moisture, and grain yield, particularly in the IR hybrids; however, none of these phenotypic differences are expected to contribute to a biological or ecological change that would result in an increased pest potential or ecological risk when cultivating these GM hybrids. Overall, results from the Experimental Phase studies are consistent with those from other world regions, confirming that there are no additional risks compared to conventional maize. Results from Pilot Phase studies indicated that, compared to conventional maize hybrids, no differences were detected for the agronomic and phenotypic characteristics measured on the three GM maize hybrids, with the exception of grain moisture and grain yield in the IR hybrids. Since MON-89Ø34- 3 9 MON-88Ø17-3 and MON-89Ø34-3 9 MONØØ6Ø3- 6 confer resistance to target insect pests, they are an alternative for farmers in Mexico to protect the crop from insect damage. Additionally, the herbicide tolerance conferred by all three GM hybrids enables more cost-effective weed management

Adynaton 5

Revista de narrativa y poesía escrita en los talleres literarios de CETYS Universidad."Adynaton" es una revista del Círculo de Letras de CETYS Universidad

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection