Granting Austrian citizenship to German-speaking Italians would not be a victory for South Tyrol's separatists

Austria's new government has proposed to offer Austrian citizenship to German-speakers in the province of South Tyrol in Italy. Stephen J. Larin and Alice Engl argue that although the proposal has been welcomed by separatist parties in South Tyrol, it does not threaten Italy's territorial integrity, and it would not have happened without the close relationship between the Austrian ÖVP and the autonomist-but-not-separatist South Tyrolean People’s Party (SVP)

Regularization independent of the noise level: an analysis of quasi-optimality

The quasi-optimality criterion chooses the regularization parameter in inverse problems without taking into account the noise level. This rule works remarkably well in practice, although Bakushinskii has shown that there are always counterexamples with very poor performance. We propose an average case analysis of quasi-optimality for spectral cut-off estimators and we prove that the quasi-optimality criterion determines estimators which are rate-optimal {\em on average}. Its practical performance is illustrated with a calibration problem from mathematical finance.Comment: 18 pages, 3 figure

Development of Muon Drift-Tube Detectors for High-Luminosity Upgrades of the Large Hadron Collider

The muon detectors of the experiments at the Large Hadron Collider (LHC) have to cope with unprecedentedly high neutron and gamma ray background rates. In the forward regions of the muon spectrometer of the ATLAS detector, for instance, counting rates of 1.7 kHz/square cm are reached at the LHC design luminosity. For high-luminosity upgrades of the LHC, up to 10 times higher background rates are expected which require replacement of the muon chambers in the critical detector regions. Tests at the CERN Gamma Irradiation Facility showed that drift-tube detectors with 15 mm diameter aluminum tubes operated with Ar:CO2 (93:7) gas at 3 bar and a maximum drift time of about 200 ns provide efficient and high-resolution muon tracking up to the highest expected rates. For 15 mm tube diameter, space charge effects deteriorating the spatial resolution at high rates are strongly suppressed. The sense wires have to be positioned in the chamber with an accuracy of better than 50 ?micons in order to achieve the desired spatial resolution of a chamber of 50 ?microns up to the highest rates. We report about the design, construction and test of prototype detectors which fulfill these requirements

Ions in Fluctuating Channels: Transistors Alive

Ion channels are proteins with a hole down the middle embedded in cell membranes. Membranes form insulating structures and the channels through them allow and control the movement of charged particles, spherical ions, mostly Na+, K+, Ca++, and Cl-. Membranes contain hundreds or thousands of types of channels, fluctuating between open conducting, and closed insulating states. Channels control an enormous range of biological function by opening and closing in response to specific stimuli using mechanisms that are not yet understood in physical language. Open channels conduct current of charged particles following laws of Brownian movement of charged spheres rather like the laws of electrodiffusion of quasi-particles in semiconductors. Open channels select between similar ions using a combination of electrostatic and 'crowded charge' (Lennard-Jones) forces. The specific location of atoms and the exact atomic structure of the channel protein seems much less important than certain properties of the structure, namely the volume accessible to ions and the effective density of fixed and polarization charge. There is no sign of other chemical effects like delocalization of electron orbitals between ions and the channel protein. Channels play a role in biology as important as transistors in computers, and they use rather similar physics to perform part of that role. Understanding their fluctuations awaits physical insight into the source of the variance and mathematical analysis of the coupling of the fluctuations to the other components and forces of the system.Comment: Revised version of earlier submission, as invited, refereed, and published by journa

Cellular and molecular phenotypes depending upon the RNA repair system RtcAB of Escherichia coli

Biotechnology and Biological Sciences Research Council (BBSRC) [BB/J00717X/1]; Medical Research Council (MRC) [MR/M017672/1]; Queen's Fellowship (Queen's University Belfast, UK) (to C.E.); Antimicrobial Resistance Cross Council Initiative. Funding for open access charge: BBSRC [BB/J00717X/1]; MRC [MR/M017672/1]

Effect of food-related stress conditions and loss of agr and sigB on seb promoter activity in S. aureus

Staphylococcal enterotoxin B (SEB) causes staphylococcal food poisoning and is produced in up to ten times higher quantities than other major enterotoxins. While Staphylococcus aureus growth is often repressed by competing flora, the organism exhibits a decisive growth advantage under some stress conditions. So far, data on the influence of food-related stressors and regulatory mutations on seb expression is limited and largely based on laboratory strains, which were later reported to harbor mutations. Therefore, the aim of this study was to investigate the influence of stress and regulatory mutations on seb promoter activity. To this end, transcriptional fusions were created in two strains, USA300 and HG003, carrying different seb upstream sequences fused to a blaZ reporter. NaCl, nitrite, and glucose stress led to significantly decreased seb promoter activity, while lactic acid stress resulted in significantly increased seb promoter activity. Loss of agr decreased seb promoter activity and loss of sigB increased promoter activity, with the magnitude of change depending on the strain. These results demonstrate that mild stress conditions encountered during food production and preservation can induce significant changes in seb promoter activity

The density of states of chaotic Andreev billiards

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity effects, particularly the appearance, predicted by random matrix theory, of a hard gap in the excitation spectrum of quantum chaotic systems. Andreev billiards are interesting examples of such structures built with superconductors connected to a ballistic normal metal billiard since each time an electron hits the superconducting part it is retroreflected as a hole (and vice-versa). Using a semiclassical framework for systems with chaotic dynamics, we show how this reflection, along with the interference due to subtle correlations between the classical paths of electrons and holes inside the system, are ultimately responsible for the gap formation. The treatment can be extended to include the effects of a symmetry breaking magnetic field in the normal part of the billiard or an Andreev billiard connected to two phase shifted superconductors. Therefore we are able to see how these effects can remold and eventually suppress the gap. Furthermore the semiclassical framework is able to cover the effect of a finite Ehrenfest time which also causes the gap to shrink. However for intermediate values this leads to the appearance of a second hard gap - a clear signature of the Ehrenfest time.Comment: Refereed version. 23 pages, 19 figure

Adaptive Covariance Estimation with model selection

We provide in this paper a fully adaptive penalized procedure to select a covariance among a collection of models observing i.i.d replications of the process at fixed observation points. For this we generalize previous results of Bigot and al. and propose to use a data driven penalty to obtain an oracle inequality for the estimator. We prove that this method is an extension to the matricial regression model of the work by Baraud