Modeling and Production of Solid Model of South Panel, Tuncbilek Open Pit by 3D Printer

Three-dimensional printers have begun to be widely used in machinery, architecture, construction, education, mould design, medical and dental fields to produce visual and functional parts. With this technology, manufacturing is realized jointly layer by layer, and there is no restriction in terms of part shape and detailing. Objects are scanned with optical scanning devices at first by means of reverse engineering and then converted to the computer aided design (CAD) data by making necessary arrangements on the scanning data. In this study, the CAD data of the open pit area of South Panel, Tuncbilek, Turkish Coal Board was formed by mapping and reverse engineering software of topographical points, and then colored solid modeling was formed with 3D printers

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

A retrospective study of the causes and results of renal rebiopsy in renal rebiopsy cases

Böbrek biyopsisi, böbrek hastalığının tanısında, tıbbi tedavinin yönlendirilmesinde ve prognoz tayininde kullanılan değerli bir yöntemdir. Çalışmamızda hastanemizin nefroloji kliniğinde yapılmış olan böbrek biyopsileri incelenerek daha önce böbrek biyopsisi yapılmış olan hastalara tekrar böbrek biyopsisi yapılma oranları, nedenleri ve sonuçlarının incelenmesi amaçlandı. Çalışmamıza 1986-2022 yılları arasında Bursa Uludağ Üniversitesi Tıp Fakültesi Hastanesi Nefroloji Kliniği’nde böbrek biyopsisi yapılmış 3285 hasta taranarak rebiyopsi yapılmış olan 346 hasta dahil edilmiştir. En sık nativ böbrek rebiyopsi nedeni de önceki biyopside yetersizlik olarak saptandı (%67,3). Diğer nativ böbrek rebiyopsi nedenleri sıklık sırasına göre klinikopatolojik korelasyonu araştırmak amaçlı (%16,7), ilk tanıya ilaveten koinsidans-nüks şüphesi (%8,2), hastalığın aktivitesi-kronisitesi ayrımı (%4,9), klinik tablo ile histopatolojik uyumsuzluk (%2,9) şeklindeydi. En sık transplant böbrek rebiyopsi nedeni reject şüphesi olarak saptandı (%81,0). Nativ böbrek rebiyopsileri neden-sonuç açısından karşılaştırıldığında 7 kez klinik tablo ile histopatolojik uyumsuzluk nedenli rebiyopsi yapılmış. Bu rebiyopsilerden 6’sinde tanı değişirken 1’inde mevcut tanının aynı kaldığı saptandı. 12 kez hastalığın aktivitesi-kronisitesi ayrımı nedenli rebiyopsi yapılmış, bu rebiyopsilerden 2’sinde hastalık aktivitesi saptanırken 7’sinde kronisite saptanmış. Diğer 3 rebiyopsi de yetersiz olarak sonuçlandı. 20 kez ilk tanıya ilaveten koinsidans şüphesi-nüks şüphesi ile rebiyopsi yapılmış, bu rebiyopsilerden 9’unda mevcut tanıya ek olarak koinsidans saptanırken 11’inde mevcut hastalık nüksü saptandı. Sonuç olarak, böbrek biyopsilerine ait verilerin incelenmesi böbrek hastalıklarının epidemiyolojisi açısından önemli bilgiler sunmaktadır. Çalışmamızda 1986-2022 yılları arasında yapılmış olan ve verilerine ulaşılabilen 400 renal rebiyopsi olgusunu inceledik. Tüm renal rebiyopsiler incelendiğinde en sık rebiyopsi nedeni biyopsi materyalinin yetersizliği (%5,2) olarak saptandı. Yetersiz biyopsi oranı literatür ile karşılaştırıldığında benzer olarak saptandı.Renal biopsy is a valuable method used in the diagnosis of kidney disease, directing medical treatment and determining prognosis. In our study, we aimed to analyze the renal biopsies performed in the nephrology clinic of our hospital and to examine the rates, reasons and results of repeat renal biopsy in patients who had previously undergone renal biopsy. In our study, 3285 patients who underwent renal biopsy in the Nephrology Clinic of Bursa Uludag University Faculty of Medicine Hospital between 1986 and 2022 were screened and 346 patients who underwent rebiopsy were included. The most common reason for native kidney rebiopsy was failure of the previous biopsy (67,3%). Other reasons for native kidney rebiopsy were, in order of frequency, to investigate clinicopathologic correlation (16,7%), suspicion of coincidence-recurrence in addition to the initial diagnosis (8,2%), differentiation of disease activity-chronicity (4,9%), and histopathologic discordance with clinical picture (2,9%). The most common reason for transplant kidney rebiopsy was suspicion of reject (81,0%). When native kidney rebiopsies were compared in terms of cause and effect, 7 rebiopsies were performed due to histopathologic discordance with clinical picture. While the diagnosis changed in 6 of these rebiopsies, the current diagnosis remained the same in 1 of them. 12 rebiopsies were performed due to differentiation between disease activity and chronicity; disease activity was detected in 2 of these rebiopsies, while chronicity was detected in 7. The other 3 rebiopsies were inadequate. In addition to the initial diagnosis, 20 rebiopsies were performed with suspicion of coincidence/recurrence, 9 of these rebiopsies showed coincidence in addition to the current diagnosis, while 11 showed recurrence of the current disease. In conclusion, the analysis of renal biopsy data provides important information about the epidemiology of renal diseases. In our study, we analyzed 400 renal rebiopsies performed between 1986 and 2022 for which data were available. When all renal rebiopsies were analyzed, the most common reason for rebiopsy was inadequate biopsy material (5,2%). The rate of inadequate biopsy was found to be similar when compared with the literature

Omitting of bougie appears to be safe for the performance of the fundal wrap at laparoscopic Nissen fundoplication

Aim. Some operative techniques in fundoplication seem to increase the incidence of obstructive symptoms. Some authors believe that using intraesophageal bougie and preparing a short and floppy valve in laparoscopic Nissen fundoplication will help to decrease any possible tight crus repair and wrap and so it is effective to decrease the prevalence of postoperative dysphagia. The aim of this study is to show that there is no absolute benefit of routine insertion of a bougie during laparoscopic Nissen fundoplication in relation to post-operative dysphagia

Diagnostic value of terminal ileum biopsies in patients with abnormal terminal ileum mucosal appearance

Objective: To investigate the necessity of obtaining routine ileal biopsy during colonoscopy in the patients with abnormal terminal ileum mucosal appearance if the inflammatory bowel disease is not considered

The Relationships Between Otolith Dimensions-Total Length of Chub (Squalius cephalus, L.1758) Sampled from Some Inland Waters of the Middle Black Sea Region

In this study, the relationships between otolith dimensions and total length of chub (Squalius cephalus, L.1758) sampled from a few inland waters of Black Sea was researched. Chub samples were obtained from the four different localities (Abdal, Akçay, Terme and Yedikır). Power models were applied to estimate the relationships between the otolith measurements and total length (TL). Paired t-test, independent t test and ANOVA were done to test the data statistically. The average total length of individuals sampled from Abdal, Akçay and Terme Streams, Yedikır Dam Lake varies between 11.49 ± 0.79 cm, 10.31 ± 0.52 cm, 10.33 ± 0.29 cm and 11.11 ± 0.33 cm, respectively. When all the data were evaluated according to localities, it was found that there was no difference in terms of otolith breadth (OB) and otolith length (OL) for asteriscus and lapillus otoliths. There were differences in terms of otolith weight of lapillus in localities. There were no differences of asteriscus otolith weight of chub between localities. The relationships between TL and OB, OL and OW were determined using the power regression equation and best fit was obtained between TL and OW for Terme (r2 =0.936) and Yedikır (r2 =0.912), OL for Akçay and Abdal Streams (r2=0.973)

Long-Term Results of Immunogenicity of Booster Vaccination against SARS-CoV-2 (Hybrid COV-RAPEL TR Study) in Turkiye: A Double-Blind, Randomized, Controlled, Multicenter Phase 2 Clinical Study

The immunogenicity of vaccines decreases over time, causing a need for booster doses. This study aimed to present the long-term (Day 84) immunogenicity results of the double-blind, randomized, controlled, phase II Hybrid COV-RAPEL TR Study (NCT04979949), in which the TURKOVAC or CoronaVac vaccines were used as a booster after the second dose of primary vaccination with CoronaVac. A total of 190 participants from the Hybrid COV-RAPEL TR Study, who had both Day 28 and Day 84 immunogenicity results, were included. The immunogenicity on Day 84, regarding the neutralizing antibody positivity (Wuhan and Delta variants) and anti-spike immunoglobulin (Ig) G (IgG) antibody positivity, was compared between TURKOVAC and CoronaVac vaccine arms according to sex and age groups. Overall, antibody positivity showed a slight decrease on Day 84 vs. Day 28, but was not different between TURKOVAC and CoronaVac arms either for sexes or for age groups. However, TURKOVAC produced better antibody response against the Delta variant than CoronaVac, while CoronaVac was superior over TURKOVAC regarding neutralizing antibody positivity in the 50–60 years age group, regardless of the variant. A single booster dose, after the completion of the primary vaccination, increases antibody positivity on Day 28 which persists until Day 84 with a slight decrease. However, an additional booster dose may be required thereafter, since the decrease in antibody titer may be faster over time

Safety and immunogenicity of inactive vaccines as booster doses for COVID-19 in Turkey: A randomized trial

Plain Language Summary What is the context? The timing of the primary and booster doses for each vaccine differs. We aimed to evaluate the safety and immunogenicity of CoronaVac and TURKOVAC vaccines used as homologous booster dose after CoronaVac primary vaccination. What is new? The neutralizing antibody titers against the Wuhan variant decreased below 1/6- the seropositivity threshold value- in more than 55% of the participants 4 months after administration of two doses of CoronaVac vaccine. Immunogenicity was re-stimulated and the neutralizing antibody titers increased rapidly and markedly with the administration of the CoronaVac or TURKOVAC as a booster dose 4 months after the second dose. While the increase in neutralizing antibodies against the Wuhan variant was similar with both CoronaVac and TURKOVAC, more antibodies developed against the Delta variant with TURKOVAC. What is the impact? With the Hybrid COV-RAPEL TR study, after the primary vaccination consisting of two doses of inactivated vaccine, antibody titers decreased in the long term; however, higher antibody titers are achieved than the primary vaccination after the booster dose administered after 4-6 month interval. Booster application with TURKOVAC provides antibodies at least as much as the CoronaVac booster dose, with an acceptable safety profile