Prospectus, March 29, 1990

https://spark.parkland.edu/prospectus_1990/1009/thumbnail.jp

Prospectus, February 7, 1990

https://spark.parkland.edu/prospectus_1990/1003/thumbnail.jp

Estimate population projections in the metropolitan area of the Valley of Mexico. Years 2010-2020-2050

The task of projecting the number of inhabitants is based on rigorous calculations, on prior knowledge about the behavior of demographic variables that imply population entries or exits. The objective of this article was to present a statistical method for estimating demographic projections, showing its methodological and technical aspects, so that non-demographers have the necessary elements for their estimation. The above was achieved through the use of the Logistics Function, taking the reader step by step in order to make the procedure to follow clear; Subsequently, for this purpose, a projection exercise is carried out using data for the young population (15 to 29 years old) in the Metropolitan Zone of the Valley of Mexico (ZMVM) as an example. The results show that in 2050 the number of young people in the ZMVM will reach 5.2 million, which corresponds to a decrease of 0.76%. This indicates that, within approximately 30 years, the number of young people in the ZMVM will still be high (22.27% of the total population of said area). It is concluded that by using the logistic function an acceptable estimate can be obtained in population projections, in general and by large age groups

Prospectus, March 7, 1990

https://spark.parkland.edu/prospectus_1990/1007/thumbnail.jp

Characterization of polydactyly chondrocytes and their use in cartilage engineering

Treating cartilage injuries and degenerations represents an open surgical challenge. The recent advances in cell therapies have raised the need for a potent off-the-shelf cell source. Intra-articular injections of TGF-beta transduced polydactyly chondrocytes have been proposed as a chronic osteoarthritis treatment but despite promising results, the use of gene therapy still raises safety concerns. In this study, we characterized infant, polydactyly chondrocytes during in vitro expansion and chondrogenic redifferentiation. Polydactyly chondrocytes have a steady proliferative rate and re-differentiate in 3D pellet culture after up to five passages. Additionally, we demonstrated that polydactyly chondrocytes produce cartilage-like matrix in a hyaluronan-based hydrogel, namely transglutaminase cross-linked hyaluronic acid (HA-TG). We utilized the versatility of TG cross-linking to augment the hydrogels with heparin moieties. The heparin chains allowed us to load the scaffolds with TGF-beta 1 which induced cartilage-like matrix deposition both in vitro and in vivo in a subcutaneous mouse model. This strategy introduces the possibility to use infant, polydactyly chondrocytes for the clinical treatment of joint diseases.Peer reviewe

Prospectus, February 14, 1990

https://spark.parkland.edu/prospectus_1990/1004/thumbnail.jp

El modelo “golf-resort” en la Región de Murcia: nivel de implantación y perspectivas de futuro

[SPA] Durante la primera década del presente siglo en la Región de Murcia se han realizado unas actuaciones territoriales aisladas que responden a un modelo de ordenación disperso y de baja densidad, reconocidas con el nombre de “golf-resort” o complejo turístico-residencial con campo de golf. Resulta ser algo más que un modelo urbanístico y turístico: constituye todo un fenómeno social, económico y ambiental en la región, un producto importado de la cultura anglosajona, ajeno a nuestra tradición y concebido inicialmente para un perfil de usuario con origen europeo. En el 2009 y dentro del ámbito de estudio (zona oriental de la comarca Campo de Cartagena) estaban planificados 28 resorts, que iban a ocupar una superficie total de 4.515 ha. y a ofrecer 45.039 viviendas, 19 hoteles y 24 campos de golf. En la actualidad, tan sólo se han construido 11 resorts, de los cuales 5 se encuentran totalmente terminados y 6 parcialmente, lo que equivale aproximadamente a un 40% de las expectativas iniciales. Los objetivos de esta investigación son conocer su estado actual, sus rasgos definidores y analizar sus relaciones territoriales, así como contrastar la realidad existente con la oferta planificada. El estudio muestra la necesidad de aplicar políticas de gestión y administración bajo criterios de sostenibilidad que garanticen su calidad y viabilidad futura. Las únicas perspectivas de futuro pasan por una regeneración sostenible de aquellos golf-resorts que con actuaciones posteriores puedan mejorar desde lo ambiental, lo social, lo económico y lo institucional. [ENG] During the first decade of this century in the Region of Murcia they have made some isolated territorial developments that respond to the model of dispersed and low density urbanism recognized by the name of "golf-resort" or tourist-residential complex with golf course. They become more than an urban and tourist model, is all a social, economic and environmental phenomenon in the region, a imported product from foreign culture, alien to our tradition and a supply initially designed to user profile of european origin. In 2009 and within the scope of study (eastern part of the Campo de Cartagena) were planned 28 golf resorts, which would occupy a total area of 4.515 ha. and to provide 45.039 housing, 19 hotels and 24 golf courses. Today, they've only built 11 resorts, of which 5 are completely finished and 6 partially. It equivalent approximately 40% of initial expectations. The research aims are know his real state, their defining features and analyze the territorial relations, as well as compare the existing reality with the planned offer. The study shows the need to implement management and administration policies under sustainability criteria to ensure their quality and future viability. The unique perspectives of future undergo a sustainable regeneration about those golf-resorts with subsequent performances can improve from environmental, social ,economic and institutional aspects

Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival

© 2021 by the authors.Pancreatic ductal adenocarcinoma (PDAC) presents many challenges in the clinic and there are many areas for improvement in diagnostics and patient management. The five-year survival rate is around 7.2% as the majority of patients present with advanced disease at diagnosis that is treatment resistant. Approximately 10–15% of PDAC cases have a hereditary basis or Familial Pancreatic Cancer (FPC). Here we demonstrate the use of circulating free DNA (cfDNA) in plasma as a prognostic biomarker in PDAC. The levels of cfDNA correlated with disease status, disease stage, and overall survival. Furthermore, we show for the first time via BEAMing that the majority of hereditary or familial PDAC cases (around 84%) are negative for a KRAS somatic mutation. In addition, KRAS mutation negative cases harbor somatic mutations in potentially druggable genes such as KIT, PDGFR, MET, BRAF, and PIK3CA that could be exploited in the clinic. Finally, familial or hereditary cases have a longer overall survival compared to sporadic cases (10.2 vs. 21.7 months, respectively). Currently, all patients are treated the same in the clinic with cytotoxic agents, although here we demonstrate that there are different subtypes of tumors at the genetic level that could pave the way to personalized treatment.This study was funded by the Instituto de Salud Carlos III (Plan Estatal de I+D+i 2013– 2016): ISCIII (PI09/02221, PI12/01635, PI15/02101, and PI18/0135) and co-financed by the European Development Regional Fund “A way to achieve Europe” (ERDF), the Biomedical Research Network in Cancer: CIBERONC (CB16/12/00446), Red Temática de investigación cooperativa en cáncer: RTICC (RD12/0036/0073), La Asociación Española contra el Cáncer: AECC (Grupos Coordinados Estables 2016), Fundación Mutua Madrileña (FMM) / XVI Convocatoria de Ayudas a la Investigación en Salud 2019 and Asociación Cáncer de Páncreas (ACanPan); Asociación Española de Pancreatología (AESPANC) / IV Becas de Investigación Carmen Delgado/Miguel Pérez-Mateo 2019. The European Union’s Horizon 2020 research and innovation program under grant agreement No 857381, project VISION (Strategies to strengthen scientific excellence and innovation capacity for early diagnosis of gastrointestinal cancers).Peer reviewe